An epigenome-wide association analysis of cardiac autonomic responses among a population of welders

Epigenetics

Volumn 12, Issue 2, 2017, Pages 71-76

  Zhang, Jinming ^a   Liu, Zhonghua ^a   Umukoro, Peter E ^a   Cavallari, Jennifer M ^b   Fang, Shona C ^c   Weisskopf, Marc G ^a   Lin, Xihong ^a   Mittleman, Murray A ^a,d   Christiani, David C ^a,e  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^c New England Research Institute   (United States)

^d BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Acceleration; deceleration; epigenetics; EWAS; GPR133; heart rate

Indexed keywords

ACCELERATION CAPACITY; ADULT; AGED; ARTICLE; CARDIAC AUTONOMIC RESPONSE; CARDIOVASCULAR PARAMETERS; CPG ISLAND; DECELERATION CAPACITY; DNA METHYLATION; DNA METHYLATION ASSAY; ELECTROCARDIOGRAPHY; EPIGENETICS; EPIGENOME WIDE ASSOCIATION STUDY; GENE; GENE LOCATION; GENETIC ASSOCIATION STUDY; GPR133 GENE; GRANULOCYTE; HEART FUNCTION; HUMAN; HUMAN EXPERIMENT; MALE; MONOCYTE; NATURAL KILLER CELL; NORMAL HUMAN; WELDING; AUTONOMIC NERVOUS SYSTEM; GENETIC EPIGENESIS; GENETICS; GENOME; HEART; HEART RATE; INNERVATION; MIDDLE AGED; PHYSIOLOGY;

G PROTEIN COUPLED RECEPTOR; GPR133 PROTEIN, HUMAN;

ADULT; AUTONOMIC NERVOUS SYSTEM; CPG ISLANDS; DNA METHYLATION; EPIGENESIS, GENETIC; GENOME; HEART; HEART RATE; HUMANS; MALE; MIDDLE AGED; RECEPTORS, G-PROTEIN-COUPLED; WELDING;

EID: 85010693168     PISSN: 15592294     EISSN: 15592308     Source Type: Journal    
DOI: 10.1080/15592294.2016.1270486     Document Type: Article

References (47)

1. Fuster V. Global burden of cardiovascular disease:time to implement feasible strategies and to monitor results. J Am Coll Cardiol 2014; 64:520-2; PMID:25082587; http://dx.doi.org/10.1016/j.jacc.2014.06.1151
2. Yusuf S, Reddy S, Ounpuu S, Anand S. Global burden of cardiovascular diseases:part I:general considerations, the epidemiologic transition, risk factors, and impact of urbanization. Circulation 2001; 104:2746-53; PMID:11723030; http://dx.doi.org/10.1161/hc4601.099487
3. Mensah GA, Brown DW. An overview of cardiovascular disease burden in the United States. Health Aff (Millwood) 2007; 26:38-48; PMID:17211012; http://dx.doi.org/10.1377/hlthaff.26.1.38
4. Shen MJ, Zipes DP. Role of the autonomic nervous system in modulating cardiac arrhythmias. Circ Res 2014; 114:1004-21; PMID:24625726; http://dx.doi.org/10.1161/CIRCRESAHA.113.302549
5. Heart rate variability for risk stratification of life-threatening arrhythmias. American College of Cardiology Cardiovascular Technology Assessment Committee. J Am Coll Cardiol 1993; 22:948-50; PMID:8354837; http://dx.doi.org/10.1016/0735-1097(93)90217-O
6. Heart rate variability:standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Circulation 1996; 93:1043-65; PMID:8598068; http://doi.org/10.1161/01.CIR.93.5.1043
7. Colhoun HM, Francis DP, Rubens MB, Underwood SR, Fuller JH. The association of heart-rate variability with cardiovascular risk factors and coronary artery calcification:a study in type 1 diabetic patients and the general population. Diabetes Care 2001; 24:1108-14; PMID:11375379; http://dx.doi.org/10.2337/diacare.24.6.1108
8. Tsuji H, Venditti FJ, Jr., Manders ES, Evans JC, Larson MG, Feldman CL, Levy D. Reduced heart rate variability and mortality risk in an elderly cohort. The Framingham Heart Study. Circulation 1994; 90:878-83; PMID:8044959; http://dx.doi.org/10.1161/01.CIR.90.2.878
9. Gold DR, Litonjua A, Schwartz J, Lovett E, Larson A, Nearing B, Allen G, Verrier M, Cherry R, Verrier R. Ambient pollution and heart rate variability. Circulation 2000; 101:1267-73; PMID:10725286; http://dx.doi.org/10.1161/01.CIR.101.11.1267
10. de Hartog JJ, Lanki T, Timonen KL, Hoek G, Janssen NA, Ibald-Mulli A, Peters A, Heinrich J, Tarkiainen TH, van Grieken R, et al. Associations between PM2.5 and heart rate variability are modified by particle composition and beta-blocker use in patients with coronary heart disease. Environ Health Perspect 2009; 117:105-11; PMID:19165395; http://dx.doi.org/10.1289/ehp.11062
11. Jia X, Song X, Shima M, Tamura K, Deng F, Guo X. Acute effect of ambient ozone on heart rate variability in healthy elderly subjects. J Expo Sci Environ Epidemiol 2011; 21:541-7; PMID:21522190; http://dx.doi.org/10.1038/jes.2011.18
12. Feng W, He X, Chen M, Deng S, Qiu G, Li X, Liu C, Li J, Deng Q, Huang S, et al. Urinary metals and heart rate variability:a cross-sectional study of urban adults in Wuhan, China. Environ Health Perspect 2015; 123:217-22; PMID:25356836; http://dx.doi.org/10.1289/ehp.123-A217
13. Marroni F, Pfeufer A, Aulchenko YS, Franklin CS, Isaacs A, Pichler I, Wild SH, Oostra BA, Wright AF, Campbell H, et al. A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations:the EUROSPAN project. Circ Cardiovasc Genet 2009; 2:322-8; PMID:20031603; http://dx.doi.org/10.1161/CIRCGENETICS.108.833806
14. Arking DE, Pfeufer A, Post W, Kao WH, Newton-Cheh C, Ikeda M, West K, Kashuk C, Akyol M, Perz S, et al. A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization. Nat Genet 2006; 38:644-51; PMID:16648850; http://dx.doi.org/10.1038/ng1790
15. Kile ML, Fang S, Baccarelli AA, Tarantini L, Cavallari J, Christiani DC. A panel study of occupational exposure to fine particulate matter and changes in DNA methylation over a single workday and years worked in boilermaker welders. Environ Health 2013; 12:47; PMID:23758843; http://dx.doi.org/10.1186/1476-069X-12-47
16. Madrigano J, Baccarelli A, Mittleman MA, Sparrow D, Spiro A, 3rd, Vokonas PS, Cantone L, Kubzansky L, Schwartz J. Air pollution and DNA methylation:interaction by psychological factors in the VA Normative Aging Study. Am J Epidemiol 2012; 176:224-32; PMID:22798479; http://dx.doi.org/10.1093/aje/kwr523
17. Umukoro PE, Cavallari JM, Fang SC, Lu C, Lin X, Mittleman MA, Christiani DC. Short-term metal particulate exposures decrease cardiac acceleration and deceleration capacities in welders:a repeated-measures panel study. Occup Environ Med 2016; 73:91-6; PMID:26644456; http://dx.doi.org/10.1136/oemed-2015-103052
18. Cavallari JM, Eisen EA, Fang SC, Schwartz J, Hauser R, Herrick RF, Christiani DC. PM2.5 metal exposures and nocturnal heart rate variability:a panel study of boilermaker construction workers. Environ Health 2008; 7:36; PMID:18613971; http://dx.doi.org/10.1186/1476-069X-7-36
19. Fan T, Fang SC, Cavallari JM, Barnett IJ, Wang Z, Su L, Byun HM, Lin X, Baccarelli AA, Christiani DC. Heart rate variability and DNA methylation levels are altered after short-term metal fume exposure among occupational welders:a repeated-measures panel study. BMC Public Health 2014; 14:1279; PMID:25512264; http://dx.doi.org/10.1186/1471-2458-14-1279
20. Bjarnadottir TK, Fredriksson R, Hoglund PJ, Gloriam DE, Lagerstrom MC, Schioth HB. The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Genomics 2004; 84:23-33; PMID:15203201; http://dx.doi.org/10.1016/j.ygeno.2003.12.004
21. Vanti WB, Nguyen T, Cheng R, Lynch KR, George SR, O'Dowd BF. Novel human G-protein-coupled receptors. Biochem Biophys Res Commun 2003; 305:67-71; PMID:12732197; http://dx.doi.org/10.1016/S0006-291X(03)00709-5
22. Bohnekamp J, Schoneberg T. Cell adhesion receptor GPR133 couples to Gs protein. J Biol Chem 2011; 286:41912-6; PMID:22025619; http://dx.doi.org/10.1074/jbc.C111.265934
23. Rockman HA, Koch WJ, Lefkowitz RJ. Seven-transmembrane-spanning receptors and heart function. Nature 2002; 415:206-12; PMID:11805844; http://dx.doi.org/10.1038/415206a
24. Xiang Y, Kobilka BK. Myocyte adrenoceptor signaling pathways. Science 2003; 300:1530-2; PMID:12791980; http://dx.doi.org/10.1126/science.1079206
25. Koch WJ, Rockman HA, Samama P, Hamilton RA, Bond RA, Milano CA, Lefkowitz RJ. Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor. Science 1995; 268:1350-3; PMID:7761854; http://dx.doi.org/10.1126/science.7761854
26. Robinson RB, Siegelbaum SA. Hyperpolarization-activated cation currents:from molecules to physiological function. Annu Rev Physiol 2003; 65:453-80; PMID:12471170; http://dx.doi.org/10.1146/annurev.physiol.65.092101.142734
27. Kuhnert F, Mancuso MR, Shamloo A, Wang HT, Choksi V, Florek M, Su H, Fruttiger M, Young WL, Heilshorn SC, et al. Essential regulation of CNS angiogenesis by the orphan G protein-coupled receptor GPR124. Science 2010; 330:985-9; PMID:21071672; http://dx.doi.org/10.1126/science.1196554
28. Patra C, van Amerongen MJ, Ghosh S, Ricciardi F, Sajjad A, Novoyatleva T, Mogha A, Monk KR, Muhlfeld C, Engel FB. Organ-specific function of adhesion G protein-coupled receptor GPR126 is domain-dependent. Proc Natl Acad Sci U S A 2013; 110:16898-903; PMID:24082093; http://dx.doi.org/10.1073/pnas.1304837110
29. Gouveia LO, Sobral J, Vicente AM, Ferro JM, Oliveira SA. Replication of the CELSR1 association with ischemic stroke in a Portuguese case-control cohort. Atherosclerosis 2011; 217:260-2; PMID:21511255; http://dx.doi.org/10.1016/j.atherosclerosis.2011.03.022
30. Qi L, Ma J, Qi Q, Hartiala J, Allayee H, Campos H. Genetic risk score and risk of myocardial infarction in Hispanics. Circulation 2011; 123:374-80; PMID:21242481; http://dx.doi.org/10.1161/CIRCULATIONAHA.110.976613
31. Newton-Cheh C, Guo CY, Wang TJ, O'Donnell C J, Levy D, Larson MG. Genome-wide association study of electrocardiographic and heart rate variability traits:the Framingham Heart Study. BMC Med Genet 2007; 8(Suppl 1):S7; PMID:17903306; http://dx.doi.org/10.1186/1471-2350-8-S1-S7
32. Jones PA. Functions of DNA methylation:islands, start sites, gene bodies and beyond. Nat Rev Genet 2012; 13:484-92; PMID:22641018; http://dx.doi.org/10.1038/nrg3230
33. Payer B, Lee JT. X chromosome dosage compensation:how mammals keep the balance. Annu Rev Genet 2008; 42:733-72; PMID:18729722; http://dx.doi.org/10.1146/annurev.genet.42.110807.091711
34. Jones PA. The DNA methylation paradox. Trends Genet 1999; 15:34-7; PMID:10087932; http://dx.doi.org/10.1016/S0168-9525(98)01636-9
35. Bauer A, Kantelhardt JW, Barthel P, Schneider R, Makikallio T, Ulm K, Hnatkova K, Schomig A, Huikuri H, Bunde A, et al. Deceleration capacity of heart rate as a predictor of mortality after myocardial infarction:cohort study. Lancet 2006; 367:1674-81; PMID:16714188; http://dx.doi.org/10.1016/S0140-6736(06)68735-7
36. Kantelhardt JW, Bauer A, Schumann AY, Barthel P, Schneider R, Malik M, Schmidt G. Phase-rectified signal averaging for the detection of quasi-periodicities and the prediction of cardiovascular risk. Chaos 2007; 17:015112; PMID:17411269; http://dx.doi.org/10.1063/1.2430636
37. Ruhrberg C, Hajibagheri MA, Parry DA, Watt FM. Periplakin, a novel component of cornified envelopes and desmosomes that belongs to the plakin family and forms complexes with envoplakin. J Cell Biol 1997; 139:1835-49; PMID:9412476; http://dx.doi.org/10.1083/jcb.139.7.1835
38. Matsumoto K, Ikeda M, Sato Y, Kuruma H, Kamata Y, Nishimori T, Tomonaga T, Nomura F, Egawa S, Iwamura M. Loss of periplakin expression is associated with pathological stage and cancer-specific survival in patients with urothelial carcinoma of the urinary bladder. Biomed Res 2014; 35:201-6; PMID:24942859; http://dx.doi.org/10.2220/biomedres.35.201
39. Matsumoto K, Ikeda M, Matsumoto T, Nagashio R, Nishimori T, Tomonaga T, Nomura F, Sato Y, Kitasato H, Iwamura M. Serum periplakin as a potential biomarker for urothelial carcinoma of the urinary bladder. Asian Pac J Cancer Prev 2014; 15:9927-31; PMID:25520130; http://dx.doi.org/10.7314/APJCP.2014.15.22.9927
40. Ghanemi A. Targeting G protein coupled receptor-related pathways as emerging molecular therapies. Saudi Pharm J 2015; 23:115-29; PMID:25972730; http://dx.doi.org/10.1016/j.jsps.2013.07.007
41. Exner DV, Reiffel JA, Epstein AE, Ledingham R, Reiter MJ, Yao Q, Duff HJ, Follmann D, Schron E, Greene HL, et al. Beta-blocker use and survival in patients with ventricular fibrillation or symptomatic ventricular tachycardia:the Antiarrhythmics Versus Implantable Defibrillators (AVID) trial. J Am Coll Cardiol 1999; 34:325-33; PMID:10440140; http://dx.doi.org/10.1016/S0735-1097(99)00234-X
42. Umukoro PE, Fan T, Zhang J, Cavallari JM, Fang SC, Lu C, Lin X, Mittleman MA, Schmidt G, Christiani DC. Long-Term Metal PM2.5 Exposures Decrease Cardiac Acceleration and Deceleration Capacities in Welders. J Occup Environ Med 2016; 58:227-31; PMID:26949871; http://dx.doi.org/10.1097/JOM.0000000000000661
43. Houseman EA, Accomando WP, Koestler DC, Christensen BC, Marsit CJ, Nelson HH, Wiencke JK, Kelsey KT. DNA methylation arrays as surrogate measures of cell mixture distribution. BMC Bioinformatics 2012; 13:86; PMID:22568884; http://dx.doi.org/10.1186/1471-2105-13-86
44. Aryee MJ, Jaffe AE, Corrada-Bravo H, Ladd-Acosta C, Feinberg AP, Hansen KD, Irizarry RA. Minfi:a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays. Bioinformatics 2014; 30:1363-9; PMID:24478339; http://dx.doi.org/10.1093/bioinformatics/btu049
45. Teschendorff AE, Marabita F, Lechner M, Bartlett T, Tegner J, Gomez-Cabrero D, Beck S. A beta-mixture quantile normalization method for correcting probe design bias in Illumina Infinium 450 k DNA methylation data. Bioinformatics 2013; 29:189-96; PMID:23175756; http://dx.doi.org/10.1093/bioinformatics/bts680
46. Johnson WE, Li C, Rabinovic A. Adjusting batch effects in microarray expression data using empirical Bayes methods. Biostatistics 2007; 8:118-27; PMID:16632515; http://dx.doi.org/10.1093/biostatistics/kxj037
47. Devlin B, Roeder K. Genomic control for association studies. Biometrics 1999; 55:997-1004; PMID:11315092; http://dx.doi.org/10.1111/j.0006-341X.1999.00997.x