Effect of Leptin on Regulation of Renal 25-hydroxyvitamin D3 Metabolism and Maintenance of Calcium Homeostasis

Journal of Oral Biosciences

Volumn 49, Issue 2, 2007, Pages 97-104

  Matsunuma, Ayako ^a   Horiuchi, Noboru ^a  

^a OHU UNIVERSITY   (Japan)

Author keywords

1 hydroxylase; bone mineral density; leptin; vitamin D

Indexed keywords

EID: 85010117486     PISSN: 13490079     EISSN: None     Source Type: Journal    
DOI: 10.2330/joralbiosci.49.97     Document Type: Article

References (21)

1. Sahu, A.: Minireview: A hypothalamic role in energy balance with special emphasis on leptin. Endocrinology 145: 2613–2620, 2004.
2. Chehab, F.F., Qiu, J. and Ogus, S.: The use of animal models to dissect the biology of leptin. Recent Prog. Horm. Res. 59: 245–266, 2004.
3. Considine, R. V., Sinha, M. K., Heiman, M. L., Kriauciunas, A., Stephens, T. W., Nyce, M. R., Ohannesian, J. P., Marco, C. C., McKee, L. J., Bauer, T. L. and Caro, J. F.: Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N. Engl. J. Med. 334: 292–295, 1996.
4. Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L. and Friedman, J. M.: Positional cloning of the mouse obese gene and its human homologue. Nature 372: 425–432, 1994.
5. Riggs, B. L. and Melton, L. J. 3rd.: The prevention and treatment of osteoporosis. N. Engl. J. Med. 327: 620–627, 1992.
6. Glauber, H. S., Vollmer, W. M., Nevitt, M. C., Ensrud, K. E. and Orwoll, E. S.: Body weight versus body fat distribution, adiposity, and frame size as predictors of bone density. J. Clin. Endocrinol. Metab. 80: 1118–1123, 1995.
7. Revilla, M., Villa, L. F., Hernandez, E. R., Sanchez-Atrio, A., Cortes, J. and Rico, H.: Influence of weight and gonadal status on total and regional bone mineral content and on weight-bearing and non-weight-bearing bones, measured by dual-energy X-ray absosorptiometry. Maturitas 28: 69–74, 1997.
8. Takeda, S., Elefteriou, F., Levasseur, R., Liu, X., Zhao, L., Parker, K. L., Armstrong, D., Ducy, P. and Karsenty, G.: Leptin regulates bone formation via the sympathetic nervous system. Cell 111: 305–317, 2002.
9. Steppan, C. M., Crawford, D. T., Chidsey-Frink, K. L., Ke, H. and Swick, A. G.: Leptin is a potent stimulator of bone growth in ob/ob mice. Regul. Pept. 92: 73–78, 2000.
10. Burguera, B., Hofbauer, L. C., Thomas, T., Gori, F., Evans, G. L., Khosla, S., Riggs, B. L. and Turner, R. T.: Leptin reduces ovariectomy-induced bone loss in rats. Endocrinology 142: 3546–3553, 2001.
11. 3-lalpha-hydroxylase and-24-hydroxylase in leptin-deficient, ob/ob mice. Endocrinology 145: 1367–1375, 2004.
12. Behre, H. M., Kliesch, S., Leifke, E., Link, T. M. and Nieschlag, E.: Long-term effect of testosterone therapy on bone mineral density in hypogonadal men. J. Clin. Endocrinol. Metab. 82: 2386–2390, 1997.
13. Vanderschueren, D., Vandenput, L., Boonen, S., Van Herck, E., Swinnen, J. V. and Bouillon, R.: An aged rat model of partial androgen deficiency: prevention of both loss of bone and lean body mass by low-dose androgen replacement. Endocrinology 141: 1642–1647, 2000.
14. Ewart-Toland, A., Mounzih, K., Qiu, J. and Chehab, F. F.: Effect of the genetic background on the reproduction of leptin-deficient obese mice. Endocrinology 140: 732–738, 1999.
15. Khosla, S.: Leptin-central or peripheral to the regulation of bone metabolism?. Endocrinology 143: 4161–4164, 2002.
16. Boyle, W. J., Simonet, W. S. and Lacey, D. L.: Osteoclast differentiation and activation. Nature 423: 337–342, 2003.
17. Holloway, W. R., Collier, F. M., Aitken, C. J., Myers, D. E., Hodge, J. M., Malakellis, M., Gough, T. J., Collier, G. R. and Nicholson, G. C.: Leptin inhibits osteoclast generation. J. Bone Miner. Res. 17: 200–209, 2002.
18. Horwood, N. J., Elliott, J., Martin, T. J. and Gillespie, M. T.: Osteotropic agents regulate the expression of osteoclast differentiation factor and osteoprotegerin in osteoblastic stromal cells. Endocrinology 139: 4743–4746, 1998.
19. Gordeladze, J. O., Drevon, C. A., Syversen, U. and Reseland, J. E.: Leptin stimulates human osteoblastic cell proliferation, de novo collagen synthesis, and mineralization: Impact on differentiation markers, apoptosis, and osteoclastic signaling. J. Cell. Biochem. 85: 825–836, 2002.
20. Dusso, A. S., Brown, A. J. and Slatopolsky, E.: Vitamin D. Am. J. Physiol. Renal. Physiol. 289: F8–F28, 2005.
21. 3. Endocrinology 138: 2233–2240, 1997.