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Volumn 9, Issue 1, 2016, Pages 79-88

Tryptophan metabolism and its relationship with depression and cognitive impairment among HIV-infected individuals

Author keywords

Cognitive impairment; Depression; HIV; IDO; Kynurenine; Tryptophan

Indexed keywords


EID: 85009901979     PISSN: None     EISSN: 11786469     Source Type: Journal    
DOI: 10.4137/IJTR.S36464     Document Type: Article
Times cited : (46)

References (81)
  • 1
    • 21344455519 scopus 로고    scopus 로고
    • Cells of the central nervous system as targets and reservoirs of the human immunodeficiency virus
    • Kramer-Hammerle S, Rothenaigner I, Wolff H, Bell JE, Brack-Werner R. Cells of the central nervous system as targets and reservoirs of the human immunodeficiency virus. Virus Res. 2005;111(2):194-213.
    • (2005) Virus Res , vol.111 , Issue.2 , pp. 194-213
    • Kramer-Hammerle, S.1    Rothenaigner, I.2    Wolff, H.3    Bell, J.E.4    Brack-Werner, R.5
  • 4
    • 80051887909 scopus 로고    scopus 로고
    • Central nervous system opportunistic infections
    • Nelson M, Manjii H, Wilkins E. Central nervous system opportunistic infections. HIV Med. 2011;12(suppl 2):8-24.
    • (2011) HIV Med , vol.12 , pp. 8-24
    • Nelson, M.1    Manjii, H.2    Wilkins, E.3
  • 5
    • 33749426630 scopus 로고    scopus 로고
    • Neuropsychiatric complications of antiretroviral therapy
    • Cespedes MS, Aberg JA. Neuropsychiatric complications of antiretroviral therapy. Drug Saf. 2006;29(10):865-74.
    • (2006) Drug Saf , vol.29 , Issue.10 , pp. 865-874
    • Cespedes, M.S.1    Aberg, J.A.2
  • 6
    • 0036239287 scopus 로고    scopus 로고
    • Depressive and anxiety disorders in women with HIV infection
    • Morrison MF, Petitto JM, Ten Have T, et al. Depressive and anxiety disorders in women with HIV infection. Am J Psychiatry. 2002;159(5):789-96.
    • (2002) Am J Psychiatry , vol.159 , Issue.5 , pp. 789-796
    • Morrison, M.F.1    Petitto, J.M.2    Ten Have, T.3
  • 7
    • 0033004613 scopus 로고    scopus 로고
    • Nature and consequences of stressful life events in homosexual HIV-positive men: a review
    • Nott KH, Vedhara K. Nature and consequences of stressful life events in homosexual HIV-positive men: a review. AIDS Care. 1999;11(2):235-43.
    • (1999) AIDS Care , vol.11 , Issue.2 , pp. 235-243
    • Nott, K.H.1    Vedhara, K.2
  • 8
    • 0036158793 scopus 로고    scopus 로고
    • Chronic sorrow in the HIV-positive patient: issues of race, gender, and social support
    • Lichtenstein B, Laska MK, Clair JM. Chronic sorrow in the HIV-positive patient: issues of race, gender, and social support. AIDS Patient Care STDS. 2002;16(1):27-38.
    • (2002) AIDS Patient Care STDS , vol.16 , Issue.1 , pp. 27-38
    • Lichtenstein, B.1    Laska, M.K.2    Clair, J.M.3
  • 9
    • 0034710203 scopus 로고    scopus 로고
    • Depression is a risk factor for noncompliance with medical treatment: meta-analysis of the effects of anxiety and depression on patient adherence
    • DiMatteo MR, Lepper HS, Croghan TW. Depression is a risk factor for noncompliance with medical treatment: meta-analysis of the effects of anxiety and depression on patient adherence. Arch Intern Med. 2000;160(14):2101-7.
    • (2000) Arch Intern Med , vol.160 , Issue.14 , pp. 2101-2107
    • DiMatteo, M.R.1    Lepper, H.S.2    Croghan, T.W.3
  • 10
    • 0036157491 scopus 로고    scopus 로고
    • The effect of changes in depression on health related quality of life (HRQoL) in HIV infection
    • Elliott AJ, Russo J, Roy-Byrne PP. The effect of changes in depression on health related quality of life (HRQoL) in HIV infection. Gen Hosp Psychiatry. 2002;24(1):43-47.
    • (2002) Gen Hosp Psychiatry , vol.24 , Issue.1 , pp. 43-47
    • Elliott, A.J.1    Russo, J.2    Roy-Byrne, P.P.3
  • 11
    • 34248575650 scopus 로고    scopus 로고
    • The effect of adherence on the association between depressive symptoms and mortality among HIV-infected individuals first initiating HAART
    • Lima VD, Geller J, Bangsberg DR, et al. The effect of adherence on the association between depressive symptoms and mortality among HIV-infected individuals first initiating HAART. AIDS. 2007;21(9):1175-83.
    • (2007) AIDS , vol.21 , Issue.9 , pp. 1175-1183
    • Lima, V.D.1    Geller, J.2    Bangsberg, D.R.3
  • 12
    • 0029295139 scopus 로고
    • The HNRC 500-neuropsychology of HIV infection at different disease stages
    • Heaton RK, Grant I, Butters N, et al. The HNRC 500-neuropsychology of HIV infection at different disease stages. J Int Neuropsychol Soc. 1995;1(3): 231-51.
    • (1995) J Int Neuropsychol Soc , vol.1 , Issue.3 , pp. 231-251
    • Heaton, R.K.1    Grant, I.2    Butters, N.3
  • 13
    • 34548208844 scopus 로고    scopus 로고
    • The prevalence and incidence of neurocognitive impairment in the HAART era
    • Robertson KR, Smurzynski M, Parsons TD, et al. The prevalence and incidence of neurocognitive impairment in the HAART era. AIDS. 2007;21:1915-21.
    • (2007) AIDS , vol.21 , pp. 1915-1921
    • Robertson, K.R.1    Smurzynski, M.2    Parsons, T.D.3
  • 14
    • 77952938752 scopus 로고    scopus 로고
    • Cognitive dysfunction in HIV patients despite long-standing suppression of viremia
    • Simioni S, Cavassini M, Annoni JM, et al. Cognitive dysfunction in HIV patients despite long-standing suppression of viremia. AIDS. 2010;24:1243-50.
    • (2010) AIDS , vol.24 , pp. 1243-1250
    • Simioni, S.1    Cavassini, M.2    Annoni, J.M.3
  • 15
    • 79952921819 scopus 로고    scopus 로고
    • HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors
    • Heaton RK, Franklin DR, Ellis RJ, et al. HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors. J Neurovirol. 2011;17:3-16.
    • (2011) J Neurovirol , vol.17 , pp. 3-16
    • Heaton, R.K.1    Franklin, D.R.2    Ellis, R.J.3
  • 16
    • 78650834306 scopus 로고    scopus 로고
    • HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER study
    • Heaton RK, Clifford DB, Franklin DR Jr, et al. HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER study. Neurology. 2010;75:2087-96.
    • (2010) Neurology , vol.75 , pp. 2087-2096
    • Heaton, R.K.1    Clifford, D.B.2    Franklin, D.R.3
  • 17
    • 84255188718 scopus 로고    scopus 로고
    • Low rates of neurocognitive impairment are observed in neuro-asymptomatic HIV-infected subjects on effective antiretroviral therapy
    • Garvey L, Surendrakumar V, Winston A. Low rates of neurocognitive impairment are observed in neuro-asymptomatic HIV-infected subjects on effective antiretroviral therapy. HIV Clin Trials. 2011;12:333-8.
    • (2011) HIV Clin Trials , vol.12 , pp. 333-338
    • Garvey, L.1    Surendrakumar, V.2    Winston, A.3
  • 18
    • 67349236698 scopus 로고    scopus 로고
    • Cognitive neuropsychology of HIV-associated neurocognitive disorders
    • Woods SP, Moore DJ, Weber E, Grant I. Cognitive neuropsychology of HIV-associated neurocognitive disorders. Neuropsychol Rev. 2009;19:152-68.
    • (2009) Neuropsychol Rev , vol.19 , pp. 152-168
    • Woods, S.P.1    Moore, D.J.2    Weber, E.3    Grant, I.4
  • 19
    • 84881474722 scopus 로고    scopus 로고
    • HIV and neurocognitive dysfunction
    • Spudich S. HIV and neurocognitive dysfunction. Curr HIV/AIDS Rep. 2013;10:235-43.
    • (2013) Curr HIV/AIDS Rep , vol.10 , pp. 235-243
    • Spudich, S.1
  • 20
    • 39549083229 scopus 로고    scopus 로고
    • NeuroAIDS: characteristics and diagnosis of the neurological complications of AIDS
    • Minagar A, Commins D, Alexander JS, et al. NeuroAIDS: characteristics and diagnosis of the neurological complications of AIDS. Mol Diagn Ther. 2008;12(1):25-43.
    • (2008) Mol Diagn Ther , vol.12 , Issue.1 , pp. 25-43
    • Minagar, A.1    Commins, D.2    Alexander, J.S.3
  • 21
    • 70449717860 scopus 로고    scopus 로고
    • Are circulating monocytes as microglia orthologues appropriate biomarker targets for neuronal diseases?
    • Schmitz G, Leuthauser-Jaschinski K, Oros E. Are circulating monocytes as microglia orthologues appropriate biomarker targets for neuronal diseases? Cent Nerv Syst Agents Med Chem. 2009;9:307-30.
    • (2009) Cent Nerv Syst Agents Med Chem , vol.9 , pp. 307-330
    • Schmitz, G.1    Leuthauser-Jaschinski, K.2    Oros, E.3
  • 22
    • 0027486072 scopus 로고
    • Neuropharmacology of quinolinic acid and kynurenic acids
    • Stone TW. Neuropharmacology of quinolinic acid and kynurenic acids. Pharmacol Rev. 1993;45(3):309-79.
    • (1993) Pharmacol Rev , vol.45 , Issue.3 , pp. 309-379
    • Stone, T.W.1
  • 25
    • 34247350014 scopus 로고    scopus 로고
    • How does indoleamine 2, 3-dioxygenase contribute to HIV-mediated immune dysregulation
    • Boasso A, Shearer GM. How does indoleamine 2, 3-dioxygenase contribute to HIV-mediated immune dysregulation. Curr Drug Metab. 2007;8:217-23.
    • (2007) Curr Drug Metab , vol.8 , pp. 217-223
    • Boasso, A.1    Shearer, G.M.2
  • 26
    • 85009922696 scopus 로고    scopus 로고
    • Tryptophan catabolism and chronic viral infections: handling uninvited guests
    • Mehraj V, Routy J-P. Tryptophan catabolism and chronic viral infections: handling uninvited guests. Int J Tryptophan Res. 2015;8:41-8.
    • (2015) Int J Tryptophan Res , vol.8 , pp. 41-48
    • Mehraj, V.1    Routy, J.-P.2
  • 27
    • 11144314849 scopus 로고    scopus 로고
    • Expression of indoleamine 2, 3-dioxygenase and production of quinolinic acid by human microglia, astrocytes, and neurons
    • Guillemin GJ, Smythe G, Takikawa O, Brew BJ. Expression of indoleamine 2, 3-dioxygenase and production of quinolinic acid by human microglia, astrocytes, and neurons. Glia. 2004;49:15-23.
    • (2004) Glia , vol.49 , pp. 15-23
    • Guillemin, G.J.1    Smythe, G.2    Takikawa, O.3    Brew, B.J.4
  • 28
    • 84859577726 scopus 로고    scopus 로고
    • Tryptophan, neurodegeneration and HIV-associated neurocognitive disorder
    • Davies NWS, Guillemin G, Brew BJ. Tryptophan, neurodegeneration and HIV-associated neurocognitive disorder. Int J Tryptophan Res. 2010;3: 121-40.
    • (2010) Int J Tryptophan Res , vol.3 , pp. 121-140
    • Davies, N.W.S.1    Guillemin, G.2    Brew, B.J.3
  • 29
    • 79959740393 scopus 로고    scopus 로고
    • Chronic low-grade inflammation in elderly persons is associated with altered tryptophan and tyrosine metabolism: role in neuropsychiatric symptoms
    • Capuron L, Schroecksnadel S, Feart C, et al. Chronic low-grade inflammation in elderly persons is associated with altered tryptophan and tyrosine metabolism: role in neuropsychiatric symptoms. Biol Psychiatry. 2011;70:175-82.
    • (2011) Biol Psychiatry , vol.70 , pp. 175-182
    • Capuron, L.1    Schroecksnadel, S.2    Feart, C.3
  • 30
    • 0141533178 scopus 로고    scopus 로고
    • Tryptophan depletion and HIV infection: a metabolic link to pathogenesis
    • Murray M. Tryptophan depletion and HIV infection: a metabolic link to pathogenesis. Lancet Infect Dis. 2003;3:644-52.
    • (2003) Lancet Infect Dis , vol.3 , pp. 644-652
    • Murray, M.1
  • 31
    • 0025673813 scopus 로고
    • Immune activation and decreased tryptophan in patients with HIV-1 infection
    • Fuchs D, Forsman A, Hagberg L, et al. Immune activation and decreased tryptophan in patients with HIV-1 infection. J Interferon Res. 1990;10: 599-603.
    • (1990) J Interferon Res , vol.10 , pp. 599-603
    • Fuchs, D.1    Forsman, A.2    Hagberg, L.3
  • 32
    • 0025964263 scopus 로고
    • Neopterin and interferon-gamma in serum and cerebrospinal fluid of patients with HIV-associated neurologic disease
    • Griffin DE, McArthur JC, Cornblath DR. Neopterin and interferon-gamma in serum and cerebrospinal fluid of patients with HIV-associated neurologic disease. Neurology. 1991;41:69-74.
    • (1991) Neurology , vol.41 , pp. 69-74
    • Griffin, D.E.1    McArthur, J.C.2    Cornblath, D.R.3
  • 33
    • 0026655828 scopus 로고
    • Interrelationships between quinolinic acid, neuroactive kynurenines, neopterin and β2-microglobulin in cerebrospinal fluid and serum of HIV-1 infected patients
    • Heyes MP, Brew BJ, Saito K, et al. Interrelationships between quinolinic acid, neuroactive kynurenines, neopterin and β2-microglobulin in cerebrospinal fluid and serum of HIV-1 infected patients. J Neuroimmunol. 1992;40:71-80.
    • (1992) J Neuroimmunol , vol.40 , pp. 71-80
    • Heyes, M.P.1    Brew, B.J.2    Saito, K.3
  • 35
    • 0022332458 scopus 로고
    • Tryptophan to competing amino acids ratio in depressive disorder: relation to efficacy of antidepressive treatments
    • Møller SE. Tryptophan to competing amino acids ratio in depressive disorder: relation to efficacy of antidepressive treatments. Acta Psychiatr Scand Suppl. 1985;325:3-31.
    • (1985) Acta Psychiatr Scand Suppl , vol.325 , pp. 3-31
    • Møller, S.E.1
  • 36
    • 0028170062 scopus 로고
    • Tryptophan concentrations increase in cerebrospinal fluid and blood after zidovudine treatment in patients with HIV type 1 infection
    • Gisslen M, Larsson M, Norkrans G, Fuchs D, Wachter H, Hagberg L. Tryptophan concentrations increase in cerebrospinal fluid and blood after zidovudine treatment in patients with HIV type 1 infection. AIDS Res Hum Retroviruses. 1994;10:947-51.
    • (1994) AIDS Res Hum Retroviruses , vol.10 , pp. 947-951
    • Gisslen, M.1    Larsson, M.2    Norkrans, G.3    Fuchs, D.4    Wachter, H.5    Hagberg, L.6
  • 37
    • 0031900585 scopus 로고    scopus 로고
    • Serum kynurenine-to-tryptophan ratio increases with progressive disease in HIV-infected patients
    • Huengsberg M, Winer JB, Gompels M, Round R, Ross J, Shahmanesh M. Serum kynurenine-to-tryptophan ratio increases with progressive disease in HIV-infected patients. Clin Chem. 1998;44:858-62.
    • (1998) Clin Chem , vol.44 , pp. 858-862
    • Huengsberg, M.1    Winer, J.B.2    Gompels, M.3    Round, R.4    Ross, J.5    Shahmanesh, M.6
  • 38
    • 85009914331 scopus 로고    scopus 로고
    • Reversal of IDO-induced tryptophan catabolism may mediate antiretroviral therapy-related improvements in HIV-infected Ugandans
    • March 5-8. Seattle, WA
    • Martinez P, Tsai AC, Muzoora C, et al. Reversal of IDO-induced tryptophan catabolism may mediate antiretroviral therapy-related improvements in HIV-infected Ugandans. 19th Conference on Retroviruses and Opportunistic Infections, March 5-8. Seattle, WA: 2012:462.
    • (2012) 19th Conference on Retroviruses and Opportunistic Infections , pp. 462
    • Martinez, P.1    Tsai, A.C.2    Muzoora, C.3
  • 39
    • 46049089647 scopus 로고    scopus 로고
    • Quality of life and immune activation in patients with HIV-infection
    • Schroeksnadel K, Sarcletti M, Winkler C, et al. Quality of life and immune activation in patients with HIV-infection. Brain Behav Immun. 2008;22:881-9.
    • (2008) Brain Behav Immun , vol.22 , pp. 881-889
    • Schroeksnadel, K.1    Sarcletti, M.2    Winkler, C.3
  • 40
    • 0024994054 scopus 로고
    • Decreased serum tryptophan in patients with HIV-1 infection correlates with increased serum neopterin and with neurologic/psychiatric symptoms
    • Fuchs D, Möller AA, Reibnegger G, Stöckle E, Werner ER, Wachter H. Decreased serum tryptophan in patients with HIV-1 infection correlates with increased serum neopterin and with neurologic/psychiatric symptoms. J Acquir Immune Defic Syndr. 1990;3(9):873-6.
    • (1990) J Acquir Immune Defic Syndr , vol.3 , Issue.9 , pp. 873-876
    • Fuchs, D.1    Möller, A.A.2    Reibnegger, G.3    Stöckle, E.4    Werner, E.R.5    Wachter, H.6
  • 41
    • 77953017654 scopus 로고    scopus 로고
    • Cerebrospinal fluid neopterin: an informative biomarker of central nervous system immune activation in HIV-1 infection
    • Hagberg L, Cinque P, Gisslén M, et al. Cerebrospinal fluid neopterin: an informative biomarker of central nervous system immune activation in HIV-1 infection. AIDS Res Ther. 2010;7:15.
    • (2010) AIDS Res Ther , vol.7 , pp. 15
    • Hagberg, L.1    Cinque, P.2    Gisslén, M.3
  • 42
    • 85009869870 scopus 로고    scopus 로고
    • Kynurenine-tryptophan and phenylalanine-tyrosine levels in cerebrospinal fluid in HIV infection
    • March 5-8. Seattle, WA
    • Grill M, Gisslen M, Cinque P, et al. Kynurenine-tryptophan and phenylalanine-tyrosine levels in cerebrospinal fluid in HIV infection. 19th Conference on Retroviruses and Opportunistic Infections, March 5-8. Seattle, WA: 2012:463.
    • (2012) 19th Conference on Retroviruses and Opportunistic Infections , pp. 463
    • Grill, M.1    Gisslen, M.2    Cinque, P.3
  • 44
    • 0025819142 scopus 로고
    • Increased endogenous interferon-gamma and neopterin correlate with increased degradation of tryptophan in human immunodeficiency virus type 1 infection
    • Fuchs D, Möller AA, Reibnegger G, et al. Increased endogenous interferon-gamma and neopterin correlate with increased degradation of tryptophan in human immunodeficiency virus type 1 infection. Immunol Lett. 1991;28(3):207-12.
    • (1991) Immunol Lett , vol.28 , Issue.3 , pp. 207-212
    • Fuchs, D.1    Möller, A.A.2    Reibnegger, G.3
  • 45
    • 84893774157 scopus 로고    scopus 로고
    • The veterans aging cohort study index is associated with concurrent risk for neurocognitive impairment
    • Marquine MJ, Umlauf A, Rooney AS, et al. The veterans aging cohort study index is associated with concurrent risk for neurocognitive impairment. J Acquir Immune Defic Syndr. 2014;65:190-7.
    • (2014) J Acquir Immune Defic Syndr , vol.65 , pp. 190-197
    • Marquine, M.J.1    Umlauf, A.2    Rooney, A.S.3
  • 46
    • 84870469320 scopus 로고    scopus 로고
    • 4th ed. American Psychiatric Association, Washington, DC;
    • American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. American Psychiatric Association, Washington, DC; 2000.
    • (2000) Diagnostic and Statistical Manual of Mental Disorders
  • 47
  • 49
    • 4644336047 scopus 로고    scopus 로고
    • Predictive validity of global deficit scores in detecting neuropsychological impairment in HIV infection
    • Carey CL, Woods SP, Gonzalez R, et al. Predictive validity of global deficit scores in detecting neuropsychological impairment in HIV infection. J Clin Exp Neuropsychol. 2004;26(3):307-19.
    • (2004) J Clin Exp Neuropsychol , vol.26 , Issue.3 , pp. 307-319
    • Carey, C.L.1    Woods, S.P.2    Gonzalez, R.3
  • 50
    • 0031451315 scopus 로고    scopus 로고
    • Simultaneous measurement of serum tryptophan and kynurenine by HPLC
    • Widner B, Werner ER, Schennach H, Wachter H, Fuchs D. Simultaneous measurement of serum tryptophan and kynurenine by HPLC. Clin Chem. 1997;43:2424-6.
    • (1997) Clin Chem , vol.43 , pp. 2424-2426
    • Widner, B.1    Werner, E.R.2    Schennach, H.3    Wachter, H.4    Fuchs, D.5
  • 51
    • 0036176273 scopus 로고    scopus 로고
    • More rapid method for simultaneous measurement of tryptophan and kynurenine by HPLC
    • Laich A, Neurauter G, Widner B, Fuchs D. More rapid method for simultaneous measurement of tryptophan and kynurenine by HPLC. Clin Chem. 2002;48:579-81.
    • (2002) Clin Chem , vol.48 , pp. 579-581
    • Laich, A.1    Neurauter, G.2    Widner, B.3    Fuchs, D.4
  • 52
    • 84889676194 scopus 로고    scopus 로고
    • Simultaneous measurement of phenylalanine and tyrosine by high performance liquid chromatography (HPLC) with fluorescence detection
    • Neurauter G, Scholl-Bürgi S, Haara A, et al. Simultaneous measurement of phenylalanine and tyrosine by high performance liquid chromatography (HPLC) with fluorescence detection. Clin Biochem. 2013;46:1848-51.
    • (2013) Clin Biochem , vol.46 , pp. 1848-1851
    • Neurauter, G.1    Scholl-Bürgi, S.2    Haara, A.3
  • 53
    • 84979132832 scopus 로고
    • Bemerkungen zu der Abhandlung der HH. Weselky und Benedikt "Ueber einige Azoverbindungen"
    • Griess P. Bemerkungen zu der Abhandlung der HH. Weselky und Benedikt "Ueber einige Azoverbindungen". Chem Ber. 1879;12:426-8.
    • (1879) Chem Ber , vol.12 , pp. 426-428
    • Griess, P.1
  • 57
    • 17344362228 scopus 로고    scopus 로고
    • Suppression of inflammatory neurotoxins by highly active antiretroviral therapy in human immunodeficiency virus-associated dementia
    • Gendelman HE, Zheng J, Coulter CL, et al. Suppression of inflammatory neurotoxins by highly active antiretroviral therapy in human immunodeficiency virus-associated dementia. J Infect Dis. 1998;178(4):1000-7.
    • (1998) J Infect Dis , vol.178 , Issue.4 , pp. 1000-1007
    • Gendelman, H.E.1    Zheng, J.2    Coulter, C.L.3
  • 59
    • 0025151457 scopus 로고
    • Cerebrospinal fluid neopterin in human immunodeficiency virus type 1 infection
    • Brew BJ, Bhalla RB, Paul M, et al. Cerebrospinal fluid neopterin in human immunodeficiency virus type 1 infection. Ann Neurol. 1990;28(4):556-60.
    • (1990) Ann Neurol , vol.28 , Issue.4 , pp. 556-560
    • Brew, B.J.1    Bhalla, R.B.2    Paul, M.3
  • 60
    • 0037045074 scopus 로고    scopus 로고
    • Continuing intrathecal immunoactivation despite two years of effective antiretroviral therapy against HIV-1 infection
    • Abdulle S, Hagberg L, Svennerholm B, Fuchs D, Gisslen M. Continuing intrathecal immunoactivation despite two years of effective antiretroviral therapy against HIV-1 infection. AIDS. 2002;16(16):2145-9.
    • (2002) AIDS , vol.16 , Issue.16 , pp. 2145-2149
    • Abdulle, S.1    Hagberg, L.2    Svennerholm, B.3    Fuchs, D.4    Gisslen, M.5
  • 61
    • 0029892999 scopus 로고    scopus 로고
    • Predictive markers of AIDS dementia complex: CD4 cell count and cerebrospinal fluid concentrations of beta 2-microglobulin and neopterin
    • Brew BJ, Dunbar N, Pemberton L, Kaldor J. Predictive markers of AIDS dementia complex: CD4 cell count and cerebrospinal fluid concentrations of beta 2-microglobulin and neopterin. J Infect Dis. 1996;174(2):294-8.
    • (1996) J Infect Dis , vol.174 , Issue.2 , pp. 294-298
    • Brew, B.J.1    Dunbar, N.2    Pemberton, L.3    Kaldor, J.4
  • 62
    • 84927913280 scopus 로고    scopus 로고
    • Low levels of HIV-1 RNA detected in the cerebrospinal fluid after up to 10 years of suppressive therapy are associated with local immune activation
    • Dahl V, Peterson J, Fuchs D, Gisslen M, Palmer S, Price RW. Low levels of HIV-1 RNA detected in the cerebrospinal fluid after up to 10 years of suppressive therapy are associated with local immune activation. AIDS. 2014;28(15):2251-8.
    • (2014) AIDS , vol.28 , Issue.15 , pp. 2251-2258
    • Dahl, V.1    Peterson, J.2    Fuchs, D.3    Gisslen, M.4    Palmer, S.5    Price, R.W.6
  • 63
    • 36849077601 scopus 로고    scopus 로고
    • IDO expression in the brain: a double-edged sword
    • Kwidzinski E, Bechmann I. IDO expression in the brain: a double-edged sword. J Mol Med. 2007;85:1351-9.
    • (2007) J Mol Med , vol.85 , pp. 1351-1359
    • Kwidzinski, E.1    Bechmann, I.2
  • 65
    • 77952968839 scopus 로고    scopus 로고
    • Insights into therapy: tryptophan oxidation and HIV infection
    • Murray MF. Insights into therapy: tryptophan oxidation and HIV infection. Sci Transl Med. 2010;2(32):32 s23.
    • (2010) Sci Transl Med , vol.2 , Issue.32
    • Murray, M.F.1
  • 66
    • 80054737026 scopus 로고    scopus 로고
    • Glutaminase dysregulation in HIV-1-infected human microglia mediates neurotoxicity: relevant to HIV-1-associated neurocognitive disorders
    • Huang Y, Zhao L, Jia B, et al. Glutaminase dysregulation in HIV-1-infected human microglia mediates neurotoxicity: relevant to HIV-1-associated neurocognitive disorders. J Neurosci. 2011;31(42):15195-204.
    • (2011) J Neurosci , vol.31 , Issue.42 , pp. 15195-15204
    • Huang, Y.1    Zhao, L.2    Jia, B.3
  • 67
    • 70349754448 scopus 로고    scopus 로고
    • Mechanism for quinolinic acid cytotoxicity in human astrocytes and neurons
    • Braidy N, Grant R, Adams S, Brew BJ, Guillemin GJ. Mechanism for quinolinic acid cytotoxicity in human astrocytes and neurons. Neurotox Res. 2009;16:77-86.
    • (2009) Neurotox Res , vol.16 , pp. 77-86
    • Braidy, N.1    Grant, R.2    Adams, S.3    Brew, B.J.4    Guillemin, G.J.5
  • 68
    • 0036128148 scopus 로고    scopus 로고
    • Quinolinic acid stimulates synaptosomal glutamate release and inhibits glutamate uptake into astrocytes
    • Tavares RG, Tasca CI, Santos CE, et al. Quinolinic acid stimulates synaptosomal glutamate release and inhibits glutamate uptake into astrocytes. Neurochem Int. 2002;40:621-7.
    • (2002) Neurochem Int , vol.40 , pp. 621-627
    • Tavares, R.G.1    Tasca, C.I.2    Santos, C.E.3
  • 69
    • 0025992743 scopus 로고
    • Cerebrospinal fluid quinolinic acid concentrations are increased in acquired immune deficiency syndrome
    • Heyes MP, Brew B, Martin A, et al. Cerebrospinal fluid quinolinic acid concentrations are increased in acquired immune deficiency syndrome. Adv Exp Med Biol. 1991;294:687-690.
    • (1991) Adv Exp Med Biol , vol.294 , pp. 687-690
    • Heyes, M.P.1    Brew, B.2    Martin, A.3
  • 70
    • 38849193303 scopus 로고    scopus 로고
    • Biomarkers of HIV-related central nervous system disease
    • Brew BJ, Letendre SL. Biomarkers of HIV-related central nervous system disease. Int Rev Psychiatry. 2008;20(1):73-88.
    • (2008) Int Rev Psychiatry , vol.20 , Issue.1 , pp. 73-88
    • Brew, B.J.1    Letendre, S.L.2
  • 71
    • 0026754753 scopus 로고
    • Progressive slowing of reaction time and increasing cerebrospinal fluid concentrations of quinolinic acid in HIV-infected individuals
    • Martin A, Heyes MP, Salazar AM, et al. Progressive slowing of reaction time and increasing cerebrospinal fluid concentrations of quinolinic acid in HIV-infected individuals. J Neuropsychiatry Clin Neurosci. 1992;4:270-9.
    • (1992) J Neuropsychiatry Clin Neurosci , vol.4 , pp. 270-279
    • Martin, A.1    Heyes, M.P.2    Salazar, A.M.3
  • 72
    • 2442423349 scopus 로고    scopus 로고
    • CSF quinolinic acid levels are determined by local HIV infection: cross-sectional analysis and modelling of dynamics following antiretroviral therapy
    • Valle M, Price RW, Nilsson A, Heyes M, Verotta D. CSF quinolinic acid levels are determined by local HIV infection: cross-sectional analysis and modelling of dynamics following antiretroviral therapy. Brain. 2004;127:1047-60.
    • (2004) Brain , vol.127 , pp. 1047-1060
    • Valle, M.1    Price, R.W.2    Nilsson, A.3    Heyes, M.4    Verotta, D.5
  • 73
    • 0036750583 scopus 로고    scopus 로고
    • Effective antiretroviral therapy reduces degradation of tryptophan in patients with HIV-1 infection
    • Zangerle R, Widner B, Quirchmair G, Neurauter G, Sarcletti M, Fuchs D. Effective antiretroviral therapy reduces degradation of tryptophan in patients with HIV-1 infection. Clin Immunol. 2002;104:242-7.
    • (2002) Clin Immunol , vol.104 , pp. 242-247
    • Zangerle, R.1    Widner, B.2    Quirchmair, G.3    Neurauter, G.4    Sarcletti, M.5    Fuchs, D.6
  • 74
    • 0021186590 scopus 로고
    • Kynurenic acid blocks neurotoxicity and seizures induced in rats by the related brain metabolite quinolinic acid
    • Foster AC, Vezzani A, Frencg ED, Schwarz R. Kynurenic acid blocks neurotoxicity and seizures induced in rats by the related brain metabolite quinolinic acid. Neurosci Lett. 1984;48:273-8.
    • (1984) Neurosci Lett , vol.48 , pp. 273-278
    • Foster, A.C.1    Vezzani, A.2    Frencg, E.D.3    Schwarz, R.4
  • 75
    • 0023934896 scopus 로고
    • The excitatory amino acid antagonist kynurenic acid administered after hypoxic-ischemia in neonatal rats offers neuroprotection
    • Andine P, Lehmann A, Ellren K, et al. The excitatory amino acid antagonist kynurenic acid administered after hypoxic-ischemia in neonatal rats offers neuroprotection. Neurosci Lett. 1988;90:208-12.
    • (1988) Neurosci Lett , vol.90 , pp. 208-212
    • Andine, P.1    Lehmann, A.2    Ellren, K.3
  • 76
    • 0024238107 scopus 로고
    • Decreased whole blood 5-hydroxytryptamine (serotonin) in AIDS patients
    • Launay JM, Copel L, Callebert J, et al. Decreased whole blood 5-hydroxytryptamine (serotonin) in AIDS patients. J Acquir Immune Defic Syndr. 1988;1(4):324-5.
    • (1988) J Acquir Immune Defic Syndr , vol.1 , Issue.4 , pp. 324-325
    • Launay, J.M.1    Copel, L.2    Callebert, J.3
  • 77
    • 0024462238 scopus 로고
    • Indoleamine deficiency in blood and cerebrospinal fluid from patients with human immunodeficiency virus infection
    • Larsson M, Hagberg L, Norkrans G, Forsman A. Indoleamine deficiency in blood and cerebrospinal fluid from patients with human immunodeficiency virus infection. J Neurosci Res. 1989;23(4):441-446.
    • (1989) J Neurosci Res , vol.23 , Issue.4 , pp. 441-446
    • Larsson, M.1    Hagberg, L.2    Norkrans, G.3    Forsman, A.4
  • 78
    • 11144238371 scopus 로고    scopus 로고
    • Use of selective serotonin-reuptake inhibitors in the treatment of depression in adults with HIV
    • Caballero J, Nahata MC. Use of selective serotonin-reuptake inhibitors in the treatment of depression in adults with HIV. Ann Pharmacother. 2005;39(1):141-5.
    • (2005) Ann Pharmacother , vol.39 , Issue.1 , pp. 141-145
    • Caballero, J.1    Nahata, M.C.2
  • 79
    • 34247267836 scopus 로고    scopus 로고
    • The human indoleamine 2, 3-dioxygenase gene and related human genes
    • Murray MF. The human indoleamine 2, 3-dioxygenase gene and related human genes. Curr Drug Metab. 2007;8:197-200.
    • (2007) Curr Drug Metab , vol.8 , pp. 197-200
    • Murray, M.F.1


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