Adjuvant-active aqueous extracts from Artemisia rupestris L. improve immune responses through TLR4 signaling pathway

Vaccine

Volumn 35, Issue 7, 2017, Pages 1037-1045

  Zhang, Ailian ^a   Yang, Yu ^a   Wang, Yan ^b   Zhao, Gan ^c   Yang, Xiumei ^a   Wang, Danyang ^a   Wang, Bin ^c  

^a XINJIANG UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

^c FUDAN UNIVERSITY   (China)

Author keywords

Adjuvant effect; Aqueous extract; Artemisia rupestris L.; Dendritic cells; TLR4

Indexed keywords

ARTEMISIA RUPESTRIS EXTRACT; B7 ANTIGEN; CD40 ANTIGEN; CD86 ANTIGEN; CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; INTERLEUKIN 12; INTERLEUKIN 4; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PLANT EXTRACT; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; HLA ANTIGEN CLASS 2; IMMUNOGLOBULIN G; IMMUNOLOGICAL ADJUVANT; LEUKOCYTE ANTIGEN; OVALBUMIN; TLR4 PROTEIN, MOUSE;

ADJUVANT THERAPY; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY SPECIFICITY; ANTIGEN SPECIFICITY; AQUEOUS SOLUTION; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL MATURATION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; FEMALE; IMMUNE RESPONSE; IMMUNOSTIMULATION; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE; ANIMAL; ARTEMISIA; BIOSYNTHESIS; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; INSTITUTE FOR CANCER RESEARCH MOUSE; LYMPHOCYTE ACTIVATION; SIGNAL TRANSDUCTION; SPLEEN;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIGENS, CD; ARTEMISIA; DENDRITIC CELLS; FEMALE; GENE EXPRESSION REGULATION; HISTOCOMPATIBILITY ANTIGENS CLASS II; IMMUNOGLOBULIN G; INTERFERON-GAMMA; INTERLEUKIN-12; INTERLEUKIN-4; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED ICR; OVALBUMIN; PLANT EXTRACTS; SIGNAL TRANSDUCTION; SPLEEN; T-LYMPHOCYTES, REGULATORY; TOLL-LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR-ALPHA;

EID: 85009724488     PISSN: 0264410X     EISSN: 18732518     Source Type: Journal    
DOI: 10.1016/j.vaccine.2017.01.002     Document Type: Article

References (43)

1. [1] Levast, B., Awate, S., Babiuk, L., Mutwiri, G., Gerdts, V., Vaccine potentiation by combination adjuvants. Vaccine 2 (2014), 611–615.
2. [2] Guy, B., The perfect mix: recent progress in adjuvant research. Nat Rev Microbio 5 (2007), 505–517.
3. [3] Tagliabue, A., Appuoli, R., Vaccines adjuvants: the dream becomes real. Human Vacc 4 (2008), 347–349.
4. [4] Lindblad, E.B., Aluminium compounds for use in vaccines. Immunol Cell Biol 82 (2004), 497–505.
5. [5] Reed, S.G., Orr, M.T., Fox, C.B., Key roles of adjuvants in modern vaccines. Nat Med 19 (2013), 1597–1608.
6. [6] Schultze, V., D'Agosto, V., Wack, A., Novicki, D., Zorn, J., Hennig, R., Safety of MF59™ adjuvant. Vaccine 26:26 (2008), 3209–3222.
7. [7] Leroux-Roels, G., Prepandemic H5N1 influenza vaccine adjuvanted with AS03: a review of the pre-clinical and clinical data. Exp Opin Biol Therapy 8 (2009), 1057–1071.
8. [8] Petrovsky, N., Novel human polysaccharide adjuvants with dual Th1 and Th2 potentiating activity. Vaccine 24:Suppl. 2 (2006), 26–29.
9. [9] Rey-Ladino, J., Ross, A.G., Cripps, A.W., McManus, D.P., Quinn, R., Natural products and the search for novel vaccine adjuvants. Vaccine 29 (2011), 6464–6471.
10. [10] Yang, L.C., Lu, T.J., Hsieh, C.C., Lin, W.C., Characterization and immunomodulatory activity of polysaccharides derived from Dendrobium tosaense. Carbohyd Polym 111 (2014), 856–863.
11. [11] Chen, X., Yang, L., Howard, O.M., Oppenheim, J.J., Dendritic cells as a pharmacological target of traditional Chinese medicine. Cell Mol Immunol 3 (2006), 401–410.
12. [12] Granell, A., Fernández-del-Carmen, A., Orzáez, D., In planta production of plant-derived and non-plant-derived adjuvants. Exp Rev Vacc 9 (2010), 843–858.
13. [13] Kouakou, K., Schepetkin, I.A., Yapi, A., Kirpotina, L.N., Jutila, M.A., Quinn, M.T., Immunomodulatory activity of polysaccharides isolated from Alchornea cordifolia. J Ethnopharmacol 146 (2013), 232–242.
14. [14] Licciardi, P.V., Underwood, J.R., Plant-derived medicines: a novel class of immunological adjuvants. Int Immunopharmacol 11 (2011), 390–398.
15. [15] Xiao, W., Aibai, S., Li, Z., Study on the anti-inflammatory effect of the extract of Artemisia rupestris L. Lish Med Mater Med Res, 12, 2008, 004.
16. [16] Fang, M., Chao, Q., Lan, Y., Liu, X., Xu, X., Fan, Y., Antibacterial effect of the extract from Artemisia rupestris L. Food Sci Technol, 1, 2011, 050.
17. [17] Guo, X.P., Tian, C.R., Gao, C.Y., Meng, Y.W., Study on removal process of proteins from crude Sphallerocarpus gracilis polysaccharides and its scavenging capability to nitrite. Sci Tech Food Ind 32:2 (2011), 274–276.
18. [18] Dubois, M., Gilles, K., Hamilton, J.K., Rebers, P.A., Smith, F.A., Colorimetric method for the determination of sugars. Nature, 168(4265), 1951, 167.
19. [19] Kim, J.Y., Yoon, Y.D., Ji, M.A., Kang, J.S., Park, S.K., Lee, K., et al. Angelan isolated from Angelica gigas Nakai induces dendritic cell maturation through toll-like receptor 4. Int Immunopharmacol 7:1 (2007), 78–87.
20. [20] Kim, J.Y., Kim, Y.J., Kim, J.S., Ryu, H.S., Lee, H.K., Kang, J.S., et al. Adjuvant effect of a natural TLR4 ligand on dendritic cell-based cancer immunotherapy. Cancer Lett 313:2 (2011), 226–234.
21. [21] Li, J., Wang, X., Wang, W., Luo, J., Aipire, A., Li, J., et al. Pleurotus ferulae water extract enhances the maturation and function of murine bone marrow-derived dendritic cells through TLR4 signaling pathway. Vaccine 33:16 (2015), 1923–1933.
22. [22] Ii, M., Matsunaga, N., Hazeki, K., Nakamura, K., Takashima, K., Seya, T., et al. A novel cyclohexene derivative, ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl) sulfamoyl] cyclohex-1-ene-1-carboxylate (TAK-242), selectively inhibits Toll-like receptor 4-mediated cytokine production through suppression of intracellular signaling. Mol Pharmacol 69:4 (2006), 1288–1295.
23. [23] Barr, T.A., Carlring, J., Heath, A.W., Co-stimulatory agonists as immunological adjuvants. Vaccine 24 (2006), 3399–3407.
24. [24] Mbow, M.L., Gregorio, E.D., Valiante, N.M., Rappuoli, R., New adjuvants for human vaccines. Curr Opin Immunol 22 (2010), 411–416.
25. [25] Pellegrino, P., Clementi, E., Radice, S., On vaccine's adjuvants and autoimmunity: current evidence and future perspectives. Autoimmun Rev 14 (2015), 880–888.
26. [26] Wu, G.J., Shiu, S.M., Hsieh, M.C., Tsai, G.J., Anti-inflammatory activity of a sulfated polysaccharide from the brown alga Sargassum cristaefolium. Food Hydrocolloid 53 (2016), 16–23.
27. [27] Petrovsky, N., Cooper, P.D., Carbohydrate-based immune adjuvants. Exp Rev Vacc 10 (2011), 523–537.
28. [28] Jiang, M.H., Zhu, L., Jiang, J.G., Immunoregulatory actions of polysaccharides from Chinese herbal medicine. Exp Opin Ther Targets 14 (2010), 1367–1402.
29. [29] Li, P., Wang, F., Polysaccharides: candidates of promising vaccine adjuvants. Drug Discov Ther 9 (2015), 88–93.
30. [30] Shao, B., Xu, W., Dai, H., Tu, P., Li, Z.H., Gao, X., A study on the immune receptors for polysaccharides from the roots of Astragalus membranaceus, a Chinese medicinal herb. Bioch Bioph Res Co 320 (2004), 1103–1111.
31. [31] Li, L.J., Li, M.Y., Li, Y.T., Fend, J.J., Hao, F.Q., Zhang, L., Adjuvant activity of sargassum pallidum polysaccharides against combined newcastle disease, infectious bronchitis and avian influenza inactivated. Vaccines 10 (2012), 2648–2660.
32. [32] Jiang, J., Wu, C., Gao, H., Song, J., Li, H., Effects of astragalus polysaccharides on immunologic function of erythrocyte in chickens infected with infectious bursa disease virus. Vaccine 28 (2010), 5614–5616.
33. [33] Zhang, N., Li, J., Hu, Y., Cheng, G., Zhu, X., Liu, F., et al. Effects of astragalus polysaccharide on the immune response to foot-and-mouth disease vaccine in mice. Carbohyd Polym 82 (2010), 680–686.
34. [34] Sun, Y., Liu, J., Adjuvant effect of water-soluble polysaccharide (PAP) from the mycelium of polyporus albicans on the immune responses to ovalbumin in mice. Vaccine 26 (2008), 3932–3936.
35. [35] Li, J.Y., Li, J.Y., Zhang, F.C., The immunoregulatory effects of Chinese herbal medicine on the maturation and function of dendritic cells. J Eth Opharmacol 171 (2015), 184–195.
36. [36] Groux, H., Fournier, N., Cottrez, F., Role of dendritic cells in the generation of regulatory T cells. Semin Immunol 16 (2004), 99–106.
37. [37] Du, X., Zhao, B., Li, J., Cao, X., Diao, M., Feng, H., et al. Astragalus polysaccharides enhance immune responses of HBV DNA vaccination via promoting the dendritic cell maturation and suppressing Treg frequency in mice. Int Immunopharmacol 14 (2012), 463–470.
38. [38] Hart, D.N., Dendritic cells: unique leukocyte populations which control the primary immune response. Blood 90 (1997), 3245–3287.
39. [39] Chan, W.K., Law, H.K., Lin, Z.B., Lau, Y.L., Chan, G.C., Response of human dendritic cells to different immunomodulatory polysaccharides derived from mushroom and barley. Int Immunol 19 (2007), 891–899.
40. [40] Silva, D.G., Cooper, P.D., Petrovsky, N., Inulin-derived adjuvants efficiently promote both Th1 and Th2 immune responses. Immunol Cell Biol 82 (2004), 611–616.
41. [41] Aguilar, J.C., Vaccine adjuvants revisited. Vaccine 25:19 (2007), 3752–3762.
42. [42] Petrovsky, N., Aguilar, J.C., Vaccine adjuvants: current state and future trends. Immunol Cell Biol 82:5 (2004), 488–496.
43. [43] Gordon, D., Kelley, P., Heinzel, S., Cooper, P., Petrovsky, N., Immunogenicity and safety of advax™, a novel polysaccharide adjuvant based on delta inulin, when formulated with hepatitis B surface antigen: a randomized controlled phase 1 study. Vaccine 32:48 (2014), 6469–6477.