CD8+ T cells of chronic HCV-infected patients express multiple negative immune checkpoints following stimulation with HCV peptides

Cellular Immunology

Volumn 313, Issue , 2017, Pages 1-9

  Barathan, Muttiah ^a   Mohamed, Rosmawati ^a   Vadivelu, Jamuna ^a   Chang, Li Yen ^a   Vignesh, Ramachandran ^b   Krishnan, Jayalakshmi ^c   Sigamani, Panneer ^c   Saeidi, Alireza ^a   Ram, M Ravishankar ^a   Velu, Vijayakumar ^d   Larsson, Marie ^e   Shankar, Esaki M ^a,c  

^a UNIVERSITY OF MALAYA   (Malaysia)

^b UNIVERSITI KUALA LUMPUR   (Malaysia)

^c CENTRAL UNIVERSITY OF TAMIL NADU   (India)

^d EMORY UNIVERSITY   (United States)

^e LINKÖPING UNIVERSITY   (Sweden)

Author keywords

Co inhibitory receptors; HCV; Immune checkpoint; PD 1; T cell exhaustion; TIM 3

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; HEPATITIS A VIRUS CELLULAR RECEPTOR 2; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 2; INTERLEUKIN 6; PEPTIDE; PHYTOHEMAGGLUTININ; PROGRAMMED DEATH 1 LIGAND 1; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; VIRAL PROTEIN; AUTACOID; CYTOKINE; PEPTIDE FRAGMENT; T LYMPHOCYTE RECEPTOR; VIRUS ANTIGEN;

ADULT; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; FEMALE; FLOW CYTOMETRY; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; IN VITRO STUDY; LYMPHOCYTE ACTIVATION; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; TH1 CELL; TH17 CELL; TH2 CELL; UPREGULATION; AGED; CELL CULTURE; CHRONIC HEPATITIS C; GENETICS; HEPACIVIRUS; IMMUNOLOGY; IMMUNOSENESCENCE; METABOLISM; MIDDLE AGED; VERY ELDERLY; VIROLOGY; VIRUS LOAD; YOUNG ADULT;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, VIRAL; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; COSTIMULATORY AND INHIBITORY T-CELL RECEPTORS; CYTOKINES; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; IMMUNOSENESCENCE; INFLAMMATION MEDIATORS; MIDDLE AGED; PEPTIDE FRAGMENTS; VIRAL LOAD; YOUNG ADULT;

EID: 85009476034     PISSN: 00088749     EISSN: 10902163     Source Type: Journal    
DOI: 10.1016/j.cellimm.2016.12.002     Document Type: Article

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