Adenovirus Vectors Target Several Cell Subtypes of Mammalian Inner Ear in Vivo

Neural Plasticity

Volumn 2016, Issue , 2016, Pages

  Shu, Yilai ^a,b,c   Tao, Yong ^a   Li, Wenyan ^a,b,c   Shen, Jun ^d,e   Wang, Zhengmin ^b   Chen, Zheng Yi ^a  

^a MASSACHUSETTS EYE AND EAR INFIRMARY   (United States)

^b FUDAN UNIVERSITY   (China)

^c National Health and Family Planning Commission   (China)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

^e Partners Center for Personalized Genomic Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; CRE RECOMBINASE; GREEN FLUORESCENT PROTEIN;

AGE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; COCHLEA DUCT; COCHLEAR HAIR CELL; CONTROLLED STUDY; GENE EXPRESSION; GENE TARGETING; IN VIVO STUDY; INNER EAR; LABYRINTH SUPPORTING CELLS; MAMMAL CELL; MOUSE; NEUROEPITHELIUM; NEWBORN; NONHUMAN; REPORTER GENE; TARGET CELL; UTRICLE; VIRAL GENE DELIVERY SYSTEM; ADENOVIRIDAE; ADMINISTRATION AND DOSAGE; ANIMAL; COCHLEA; CYTOLOGY; DRUG EFFECTS; GENE VECTOR; GENETICS; PHYSIOLOGY; PROCEDURES;

ADENOVIRIDAE; ANIMALS; ANIMALS, NEWBORN; COCHLEA; EAR, INNER; GENE TARGETING; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; MICE;

EID: 85009446767     PISSN: 20905904     EISSN: 16875443     Source Type: Journal    
DOI: 10.1155/2016/9409846     Document Type: Article

References (26)

1. C. Sage, M. Huang, K. Karimi et al., "Proliferation of functional hair cells in vivo in the absence of the retinoblastoma protein," Science, vol. 307, no. 5712, pp. 1114-1118, 2005.
2. J. V. Brigande and S. Heller, "Quo vadis, hair cell regeneration?"Nature Neuroscience, vol. 12, no. 6, pp. 679-685, 2009.
3. J. A. Zuris, D. B. Thompson, Y. Shu et al., "Cationic lipidmediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo," Nature Biotechnology, vol. 33, no. 1, pp. 73-80, 2014.
4. J.M. Jørgensen and C.Mathiesen, "The avian inner ear. Continuous production of hair cells in vestibular sensory organs, but not in the auditory papilla," Naturwissenschaften, vol. 75, no. 6, pp. 319-320, 1988.
5. J. T. Corwin and D. A. Cotanche, "Regeneration of sensory hair cells after acoustic trauma," Science, vol. 240, no. 4860, pp. 1772-1774, 1988.
6. B. M. Ryals and E. W. Rubel, "Hair cell regeneration after acoustic trauma in adult coturnix quail," Science, vol. 240, no. 4860, pp. 1774-1776, 1988.
7. P.M.White, A. Doetzlhofer, Y. S. Lee, A. K. Groves, andN. Segil, "Mammalian cochlear supporting cells can divide and transdifferentiate into hair cells," Nature, vol. 441, no. 7096, pp. 984-987, 2006.
8. Y. Shu, Y. Tao, Z. Wang et al., "Identification of Adeno-associated viral vectors (AAV) that target neonatal and adult mammalian inner ear cell subtypes," Human Gene Therapy, vol. 27, no. 9, pp. 687-699, 2016.
9. L. A. Kilpatrick,Q. Li, J. Yang, J.C.Goddard,D.M. Fekete, and H. Lang, "Adeno-associated virus-mediated gene delivery into the scala media of the normal and deafened adult mouse ear," GeneTherapy, vol. 18, no. 6, pp. 569-578, 2011.
10. O. Akil, R. P. Seal, K. Burke et al., "Restoration of hearing in the VGLUT3 knockout mouse using virallymediated gene therapy," Neuron, vol. 75, no. 2, pp. 283-293, 2012.
11. C. Askew, C. Rochat, B. Pan et al., "Tmc gene therapy restores auditory function in deaf mice," Science TranslationalMedicine, vol. 7, no. 295, Article ID 295ra108, 2015.
12. W.W. Chien, K. Isgrig, S. Roy et al., "Gene therapy restores hair cell stereocilia morphology in inner ears of deaf whirler mice," MolecularTherapy, vol. 24, no. 1, pp. 17-25, 2016.
13. Q. Yu, Y.Wang, Q. Chang et al., "Virally expressed connexin26 restores gap junction function in the cochlea of conditional Gjb2 knockout mice," Gene Therapy, vol. 21, no. 1, pp. 71-80, 2014.
14. Y.Wang, Y. Sun,Q.Chang et al., "Early postnatal virus inoculation into the scala media achieved extensive expression of exogenous green fluorescent protein in the inner ear and preserved auditory brainstemresponse thresholds," Journal of Gene Medicine, vol. 15, no. 3-4, pp. 123-133, 2013.
15. Y. Raphael, J. C. Frisancho, and B. J. Roessler, "Adenoviralmediated gene transfer into guinea pig cochlear cells in vivo," Neuroscience Letters, vol. 207, no. 2, pp. 137-141, 1996.
16. A. E. Luebke, J. D. Steiger, B. L. Hodges, and A. Amalfitano, "A modified adenovirus can transfect cochlear hair cells in vivo without compromising cochlear function," Gene Therapy, vol. 8, no. 10, pp. 789-794, 2001.
17. K. Kawamoto, S.-H.Oh, S. Kanzaki, N. Brown, and Y. Raphael, "The functional and structural outcome of inner ear gene transfer via the vestibular and cochlear fluids in mice," Molecular Therapy, vol. 4, no. 6, pp. 575-585, 2001.
18. S.-I. Ishimoto,K.Kawamoto, S. Kanzaki, andY.Raphael, "Gene transfer into supporting cells of the organ of Corti," Hearing Research, vol. 173, no. 1-2, pp. 187-197, 2002.
19. T. Iizuka, S. Kanzaki, H. Mochizuki et al., "Noninvasive in vivo delivery of transgene via adeno-associated virus into supporting cells of the neonatal mouse cochlea," Human GeneTherapy, vol. 19, no. 4, pp. 384-390, 2008.
20. V. Lin, J. S. Golub, T. B. Nguyen, C. R.Hume, E. C.Oesterle, and J. S. Stone, "Inhibition of notch activity promotes nonmitotic regeneration of hair cells in the adult mouse utricles," Journal of Neuroscience, vol. 31, no. 43, pp. 15329-15339, 2011.
21. H.Staecker,D. Li,B.W.O'Malley, andT.R.VanDeWater, "Gene expression in themammalian cochlea: a study ofmultiple vector systems," Acta Oto-Laryngologica, vol. 121, no. 2, pp. 157-163, 2001.
22. A. E. Luebke, P. K. Foster, C.D.Muller, and A. L. Peel, "Cochlear function and transgene expression in the guinea pig cochlea, using adenovirus-and adeno-associated virus-directed gene transfer," Human GeneTherapy, vol. 12, no. 7, pp. 773-781, 2001.
23. J. L. Zheng and W.-Q. Gao, "Overexpression of Math1 induces robust production of extra hair cells in postnatal rat inner ears," Nature Neuroscience, vol. 3, no. 6, pp. 580-586, 2000.
24. A. K. Lalwani, J. Jero, and A.N. Mhatre, "Current issues in cochlear gene transfer," Audiology & Neurotology, vol. 7, no. 3, pp. 146-151, 2002.
25. Y. Raphael, "Evidence for supporting cell mitosis in response to acoustic trauma in the avian inner ear," Journal of Neurocytology, vol. 21, no. 9, pp. 663-671, 1992.
26. J. S. Stone and D. A. Cotanche, "Hair cell regeneration in the avian auditory epithelium," International Journal of Developmental Biology, vol. 51, no. 6-7, pp. 633-647, 2007.