Treatment planning optimisation in proton therapy

British Journal of Radiology

Volumn 86, Issue 1021, 2013, Pages

  McGowan, S E ^a,b   Burnet, N G ^a,b   Lomax, A J ^c  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b ADDENBROOKE S HOSPITAL   (United Kingdom)

^c PAUL SCHERRER INSTITUTE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ALGORITHM; COMPUTER ASSISTED TOMOGRAPHY; DOSIMETRY; ELECTRON; FOUR DIMENSIONAL ECHOCARDIOGRAPHY; GEOMETRY; HISTOGRAM; HUMAN; INTENSITY MODULATED PARTICLE THERAPY; INTENSITY MODULATED RADIATION THERAPY; MONTE CARLO METHOD; PHANTOM; PLANNING TARGET VOLUME; PROTON THERAPY; RADIATION DOSE; RADIATION DOSE DISTRIBUTION; RADIOLOGICAL PARAMETERS; RELATIVE BIOLOGIC EFFECTIVENESS; REVIEW; TARGET ORGAN; TREATMENT PLANNING; UNCERTAINTY; X RAY RADIOTHERAPY; COMPUTER ASSISTED RADIOTHERAPY; MEGAVOLTAGE RADIOTHERAPY; METHODOLOGY; NEOPLASM; RADIOMETRY;

PROTON;

HUMANS; NEOPLASMS; PROTONS; RADIOMETRY; RADIOTHERAPY DOSAGE; RADIOTHERAPY PLANNING, COMPUTER-ASSISTED; RADIOTHERAPY, HIGH-ENERGY;

EID: 85009399302     PISSN: 00071285     EISSN: None     Source Type: Journal    
DOI: 10.1259/bjr.20120288     Document Type: Review

References (66)

1. Bortfeld T. Optimized planning using physical objectives and constraints. Semin Radat Oncol 1999;9:20-34. (Pubitemid 29096021)
2. Bragg WH. On absorption of alpha rays and on the classification of the alpha rays from radium. Phil Mag 1904;6:719-25.
3. Merchant TE, Hua CH, Shukla H, Ying X, Nill S, Oelfke U. Proton versus photon radiotherapy for common pediatric brain tumors: comparison of models of dose characteristics and their relationship to cognitive function. Pediatr Blood Cancer 2008;51:110-17. (Pubitemid 351717400)
4. Ares C, Hug EB, Lomax AJ, Bolsi A, Timmermann B, Rutz HP, et al. Effectiveness and safety of spot scanning proton radiation therapy for chordomas and chondrosarcomas of the skull base: first long-term report. Int J Radiat Oncol Biol Phys 2009;75:1111-18.
5. De Ruysscher D, Lodge M, Jones B, Brada M, Munro A, Jefferson T, et al. Charged particles in radiotherapy: a 5-year update of a systematic review. Radiother Oncol 2012;103:5-7.
6. Allen AM, Pawlicki T, Dong L, Fourkal E, Buyyounouski M, Cengel K, et al. An evidence based review of proton beam therapy: the report of ASTRO's emerging technology committee. Radiother Oncol 2012;103:8-11.
7. Jones B. The potential clinical advantages of charged particle radiotherapy using protons or light ions. Clin Oncol (R Coll Radiol) 2008;20:555-63.
8. Durante M, Loeffler JS. Charged particles in radiation oncology. Nature 2010;7:37-43.
9. Lodge M, Pijls-Johannesma M, Stirk L, Munro AJ, De Ruysscher D, Jefferson T. A systematic literature review of the clinical and cost-effectiveness of hadron therapy in cancer. Radiother Oncol 2007;83:110-22. (Pubitemid 46776922)
10. van de Water T, Bijl HP, Schilstra C, Pijls-Johannesma M, Langendijk J. The potential benefit of radiotherapy with protons in head and neck cancer with respect to normal tissue sparing: a systematic review of literature. Oncologist 2011;16:366-77.
11. Ramaekers BL, Pijls-Johannesma M, Joore MA, van den Ende P, Langendijk JA, Lambin P, et al. Systematic review and meta-analysis of radiotherapy in various head and neck cancers: comparing photons, carbon-ions and protons. Cancer Treat Rev 2011;37:185-201.
12. Haberer T, Becher W, Schardt D, Kraft G. Magnetic scanning system for heavy ion therapy. Nucl Instrum Methods Phys Res A 1993;330:296-305.
13. Pedroni E, Bacher R, Blattmann H, Böhringer T, Coray A, Lomax A, et al. The 200-MeV proton therapy project at the Paul Scherrer Institute: conceptual design and practical realization. Med Phys 1995;22:37-53.
14. DeLaney TF, Hanne MK. Proton and charged particle radiotherapy. Philadelphia, PA: Lippincott Williams and Wilkins; 2009.
15. Lomax A. Intensity modulation methods for proton radiotherapy. Phys Med Biol 1999;44:185-205. (Pubitemid 29062235)
16. Deasy J. A proton dose calculation algorithm for conformal therapy simulations based on Moliere theory of lateral deflections. Med Phys 1998;25:476-83. (Pubitemid 28178353)
17. Oelfke U, Bortfeld T. Intensity modulated radiotherapy with charged particle beams: studies of inverse treatment planning for rotation therapy. Med Phys 2000;27:1246-57. (Pubitemid 30416092)
18. Nill S, Bortfeld T, Oelfke U. Inverse planning of intensity modulated proton therapy. Z Med Phys 2004;14:35-40. (Pubitemid 38435679)
19. Lomax A. Intensity modulated proton therapy and its sensitivity to treatment uncertainties 2: the potential effects of inter-fraction and inter-field motions. Phys Med Biol 2008;53:1043-56. (Pubitemid 351238122)
20. España S, Paganetti H. The impact of uncertainties in the CT conversion algorithm when predicting proton beam ranges in patients from dose and PET-activity distributions. Phys Med Biol 2010;55:7557-71.
21. International Commission on Radiation Units and Measurements: Prescribing, recording, and reporting photon beam therapy. ICRU Report no. 50. Bethesda, MD: ICRU; 1993.
22. International Commission on Radiation Units and Measurements: A review of the new supplement to ICRU Report 50. ICRU Report no. 62. Bethesda, MD: ICRU; 1999.
23. International Commission on Radiation Units and Measurements: Prescribing, recording, and reporting proton beam therapy. ICRU Report no. 78. Bethesda, MA: ICRU; 2007.
24. Chvetsov AV, Paige SL. The influence of CT image noise on proton range calculation in radiotherapy planning. Phys Med Biol 2010;55:N141-9.
25. Schaffner B, Pedroni E. The precision of proton range calculations in proton radiotherapy treatment planning: experimental verification of the relationship between CT-HU and proton stopping power. Phys Med Biol 1998;43:1579-92. (Pubitemid 28277296)
26. Schulte R, Bashkirov V, Li T, Liang Z, Mueller K, Heimann J, et al. Conceptual design of a proton computed tomography system for applications in proton therapy. IEEE Trans Nucl Sci 2004;51:866-72.
27. Moyers MF, Sardesai M, Sun S, Miller DW. Ion stopping powers and CT numbers. Med Dosim 2010;35:179-94.
28. Lomax A. Intensity modulated proton therapy and its sensitivity to treatment uncertainties 1: the potential effects of calculational uncertainties. Phys Med Biol 2008;53:1027-42. (Pubitemid 351238121)
29. Burnet NG, Adams EJ, Fairfoul J, Tudor GS, Hoole AC, Routsis DS, et al. Practical aspects of implementation of helical tomotherapy for intensity-modulated and image-guided radiotherapy. Clin Oncol 2010;22:294-312.
30. Booth JT, Zavgorodni SF. Set-up error and organ motion uncertainty: a review. Australas Phys Eng Sci Med 1999;22:29-47. (Pubitemid 30507149)
31. Langen KM, Jones DT. Organ motion and its management. Int J Radiat Oncol Biol Phys 2001;50:265-78.
32. Rimmer YL, Burnet NG, Routsis DS, Twyman N, Hoole A, Treeby J, et al. Practical issues in the implementation of image-guided radiotherapy for the treatment of prostate cancer within a UK department. Clin Oncol 2008;20:22-30.
33. Lambert J, Suchowerska N, McKenzie DR, Jackson M. Intrafractional motion during proton beam scanning. Phys Med Biol 2005;50:4853-62. (Pubitemid 41417008)
34. Phillips MH, Pedroni E, Blattmann H, Boehringer T, Coray A, Scheib S. Effects of respiratory motion on dose uniformity with a charged particle scanning method. Phys Med Biol 1992;37:223-34.
35. Zenklusen SM, Pedroni E, Meer D. A study on repainting strategies for treating moving targets with proton pencil beam scanning at the new Gantry 2 at PSI. Phys Med Biol 2010;55:5103-21.
36. Knopf AC, Hong TS, Lomax AJ. Scanned proton radiotherapy for mobile targets - the effectiveness of re-scanning in the context of different treatment planning approaches and for different motion characteristics. Phys Med Biol 2011;56:7257-71.
37. Seco J, Robertson D, Trofimov A, Paganetti H. Breathing interplay effects during proton beam scanning: simulation and statistical analysis. Phys Med Biol 2009;54:N283-94.
38. Grözinger SO, Rietzel E, Li Q, Bert C, Haberer T, Kraft G. Simulations to design an online motion compensation system for scanned particle beams. Phys Med Biol 2006;51:3517-31. (Pubitemid 44026415)
39. Bert C, Grözinger SO, Rietzel E. Quantification of interplay effects of scanned particle beams and moving targets. Phys Med Biol 2008;53:2253-65. (Pubitemid 351570909)
40. Carabe A, Moteabbed M, Depauw N, Schuemann J, Paganetti H. Range uncertainty in proton therapy due to variable biological effectiveness. Phys Med Biol 2012;57:1159-72.
41. Robertson J, Williams J, Schimdt R, Little J, Flynn D, Suit H. Radiobiological studies of high energymodulated proton beam utilizing cultured mammalian cells. Cancer 1975;35:1664-77.
42. Matsuura T, Egashira Y, Nishio T, Matsumoto Y, Wada M, Koike S, et al. Apparent absence of a proton beam dose rate effect and possible differences in RBE between Bragg peak and plateau. Med Phys 2010;37:5376.
43. Grassberger C, Trofimov A, Lomax A, Paganetti H. Variations in linear energy transfer within clinical proton therapy fields and the potential for biological treatment planning. Int J Radiat Oncol Biol Phys 2011;80:1559-66.
44. Bert C, Durante M. Motion in radiotherapy: particle therapy. Phys Med Biol 2011;56:R113-44.
45. Furukawa T, Inaniwa T, Sato S, Tomitani T, Minohara S, Noda K, et al. Design study of a raster scanning system for moving target irradiation in heavy-ion radiotherapy. Med Phys 2007;34:1085-97. (Pubitemid 46355643)
46. Bert C, Saito N, Schmidt A, Chaudhri N, Schardt D, Rietzel E. Target motion tracking with a scanned particle beam. Med Phys 2007;34:4768-71. (Pubitemid 350197715)
47. Saito N, Bert C, Chaudhri N, Gemmel A, Schardt D, Durante M, et al. Speed and accuracy of a beam tracking system for treatment of moving targets with scanned ion beams. Phys Med Biol 2009;54:4849-62.
48. Keall PJ, Kini VR, Vedam SS, Mohan R. Motion adaptive xray therapy: a feasibility study. Phys Med Biol 2001;46:1-10. (Pubitemid 32104867)
49. Grözinger SO, Li Q, Rietzel E, Haberer T, Kraft G. 3D online compensation of target motion with scanned particle beam. Radiother Oncol 2004;73(Suppl. 2):S77-9. (Pubitemid 41219120)
50. van Herk M. Errors and margins in radiotherapy. Semin Radiat Oncol 2004;14:52-64.
51. Grözinger SO, Bert C, Haberer T, Kraft G, Rietzel E. Motion compensation with a scanned ion beam: a technical feasibility study. Radiat Oncol 2008;3:34.
52. Thomas SJ. Margins for treatment planning of proton therapy. Phys Med Biol 2006;51:1491.
53. Albertini F, Hug EB, Lomax AJ. Is it necessary to plan with safety margins for actively scanned proton therapy? Phys Med Biol 2011;56:4399.
54. Unkelbach J, Chan T, Bortfield T. Accounting for range uncertainties in the optimisation of intensity modulated proton therapy. Phys Med Biol 2007;52:2755-73.
55. Pflugfelder D, Wilkens JJ, Oelfke U. Worst case optimization: a method to account for uncertainties in the optimization of intensity modulated proton therapy. Phys Med Biol 2008;53:1689-700. (Pubitemid 351423005)
56. Lomax AJ, Pedroni E, Rutz H, Goitein G. The clinical potential of intensity modulated proton therapy. Z Med Phys 2004;14:147-52. (Pubitemid 39221029)
57. Chen W, Unkelbach J, Tromfimov A, Madden T, Kooy H, Bortfeld T. Including robustness in multi-criteria optimization for intensity-modulated proton therapy. Phys Med Biol 2012;57:591-608.
58. Thieke C, Küfer K, Monz M, Scherrer A, Alonso F, Oelfke U, et al. A new concept for interactive radiotherapy planning with multicriteria optimization: first clinical evaluation. Radiother Oncol 2007;85:292-8. (Pubitemid 350160994)
59. Cotrutz C, Lahanas M, Kappas C, Baltas D. A multiobjective gradient-based dose optimization algorithm for external beam conformal radiotherapy. Phys Med Biol 2001;46:2161-75. (Pubitemid 32747069)
60. Craft D, Halabi T, Bortfeld T. Exploration of tradeoffs in intensity-modulated radiotherapy. Phys Med Biol 2005;50:5857-68. (Pubitemid 41795838)
61. Albertini F, Casiraghi M, Lorentini S, Rombi B, Lomax AJ. Experimental verification of IMPT treatment plans in an anthropomorphic phantom in the presence of delivery uncertainties. Phys Med Biol 2011;56:4415.
62. Safai S, Shixiong L, Pedroni E. Development of an inorganic scintillating mixture for proton beam verification dosimetry. Phys Med Biol 2004;49:4637-55. (Pubitemid 39378250)
63. Dosanjh M. Development of hadron therapy for cancer treatment in Europe. AIP Conf Proc 2008;1032:12-16.
64. www.nhs.uk [homepage on the internet]. London, UK: NHS Specialised Services; 2011. [cited May 2011]. Available from: www.specialisedservices.nhs. uk/serv/proton-beam-therapy
65. www.dh.gov.uk [homepage on the internet]. London, UK: Department of Health; 2012. [cited May 2011]. Available from: mediacentre.dh.gov.uk/2012/04/ 05/centres-selected-to-host-cutting-edge-cancer-services/
66. Burnet N, Taylor E, Kirkby K, Thorp N, Mackay R, McKenna G. Proton beam therapy for cancer: an important development for patients with an explicit agenda. BMJ 2012;344:e2488.