Apparent absence of a proton beam dose rate effect and possible differences in RBE between Bragg peak and plateau

Medical Physics

Volumn 37, Issue 10, 2010, Pages 5376-5381

  Matsuura, Taeko ^a   Egashira, Yusuke ^b   Nishio, Teiji ^a   Matsumoto, Yoshitaka ^c   Wada, Mami ^c   Koike, Sachiko ^c   Furusawa, Yoshiya ^c   Kohno, Ryosuke ^a   Nishioka, Shie ^a   Kameoka, Satoru ^a   Tsuchihara, Katsuya ^a   Kawashima, Mitsuhiko ^a   Ogino, Takashi ^a  

^a NATIONAL CANCER CENTER HOSPITAL EAST   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

Author keywords

dose rate; proton therapy; relative biological effectiveness

Indexed keywords

CLOCK AND DATA RECOVERY CIRCUITS (CDR CIRCUITS); ENERGY TRANSFER; PROTON BEAMS;

CLINICAL PRACTICES; DOSE RATE; LINEAR ENERGY TRANSFER; LINEAR-QUADRATIC MODELS; PROTON RADIOTHERAPY; PROTON THERAPY; RELATIVE BIOLOGICAL EFFECTIVENESS; TREATMENT PLANNING;

PROTON BEAM THERAPY;

EID: 77957705882     PISSN: 00942405     EISSN: None     Source Type: Journal    
DOI: 10.1118/1.3490086     Document Type: Article

References (24)

1. K. Nihei, T. Ogino, S. Ishikura, and H. Nishimura, " High-dose proton beam therapy for stage I non-small-cell lung cancer.," Int. J. Radiat. Oncol., Biol., Phys. IOBPD3 0360-3016 65, 107-111 (2006). 10.1016/j.ijrobp.2005.10.031
2. M. Kawashima, J. Furuse, T. Nishio, M. Konishi, H. Ishii, T. Kinoshita, M. Nagase, K. Nihei, and T. Ogino, " Phase II study of radiotherapy employing proton beam for hepatocellular carcinoma.," J. Clin. Oncol. JCONDN 0732-183X 23, 1839-1846 (2005). 10.1200/JCO.2005.00.620
3. H. Tsujii, T. Kamada, M. Baba, H. Tsuji, H. Kato, S. Kato, S. Yamada, S. Yasuda, T. Yanagi, H. Kato, R. Hara, N. Yamamoto, and J. Mizoe, " Clinical advantages of carbon-ion radiotherapy.," New J. Phys. NJOPFM 1367-2630 10, 075009-075024 (2008). 10.1088/1367-2630/10/7/075009
4. T. Miyamoto, M. Baba, M. Nakajima,. T. Yashiro, K. Kagei, N. Hirasawa, T. Sugawara, N. Yamamoto, M. Koto, H. Ezawa, K. Kadono, H. Tsujii, J. Mizoe, K. Yoshikawa, S. Kandatsu, and T. Fujisawa, " Carbon ion radiotherapy for stage I non-small cell lung cancer using a regimen of four fractions during 1 week.," J. Thorac. Oncol. 2 (10), 916-926 (2007). 10.1097/JTO. 0b013e3181560a68 1556-0864
5. E. Pedroni, " The PSI Gantry 2: A second generation proton scanning gantry.," Med. Phys. MPHYA6 0094-2405 14, 25-34 (2004).
6. K. Ando, Y. Furusawa, M. Suzuki, K. Nojima, H. Majima, S. Koike, M. Aoki, W. Shimizu, Y. Futami, T. Ogino, S. Murayama, and H. Ikeda, " Relative biological effectiveness of the 235 MeV proton beams at the National Cancer Center Hospital East.," J. Radiat. Res. (Tokyo) ZZZZZZ 0449-3060 42, 79-89 (2001). 10.1269/jrr.42.79
7. Y. Furusawa, M. Aoki, Y. Shino, R. Lee, G. Zhou, N. Takai, M. Monobe, T. Fukawa, Y. Miyato, and G. Kagiya, " Intercomparison of radiobiological RBE among Japanese proton therapy facilities.," in Proceedings of the World Congress on Medical Physics and Biomedical Engineering, Sydney, Australia, August 2003.
8. T. E. Schmid, G. Dollinger, A. Hauptner, V. Hable, C. Greubel, S. Auer, A. A. Friedl, M. Molls, and B. Röper, " No evidence for a different RBE between pulsed and continuous 20 MeV protons.," Radiat. Res. RAREAE 0033-7587 172, 567-574 (2009). 10.1667/RR1539.1
9. T. E. Schmid, G. Dollinger, V. Hable, C. Greubel, O. Zlobinskaya, D. Michalski, M. Molls, and B. Röper, " Relative biological effectiveness of pulsed and continuous 20 MeV protons for micronucleus induction in 3D human reconstructed skin tissue.," Radiother. Oncol. RAONDT 0167-8140 95, 66-72 (2010). 10.1016/j.radonc.2010.03.010
10. K. Shinohara, H. Nakano, N. Miyazaki, M. Tsgo, and R. Kodama, " Effects of single-pulse (1 ps) x-rays from laser-produced plasmas on mammalian cells.," J. Radiat. Res. (Tokyo) ZZZZZZ 0449-3060 45 (4), 509-514 (2004). 10.1269/jrr.45.509
11. H. B. Michaels, E. R. Epp, C. C. Ling, and E. C. Peterson, " Oxygen sensitization of CHO cells at ultrahigh dose rates: Prelude to oxygen diffusion studies.," Radiat. Res. RAREAE 0033-7587 76, 510-521 (1978). 10.2307/3574800
12. C. C. Ling, L. E. Gerweck, M. Zaider, and E. Yorke, " Dose-rate effects in external beam radiotherapy redux.," Radiother. Oncol. RAONDT 0167-8140 95 (3), 261-268 (2010). 10.1016/j.radonc.2010.03.014
13. T. Nishio, " Present status and planning of facilities for proton and heavy ion cancer treatment in Japan. III. Present state of proton beam treatment facility in the National Cancer Center Hospital East.," J. At. Energy Soc. 41, 1134-1138 (1999).
14. T. Tachikawa, T. Sato, T. Ogino, and T. Nishio, " Proton beam therapy facilities of the National Cancer Center East Hospital.," Radiat. Indust. 84, 48-53 (1999).
15. T. Aso, A. Kimura, S. Tanaka, H. Yoshida, N. Kanematsu, T. Sasaki, and T. Akagi, " Verification of the dose distributions with Geant4 simulation for proton therapy.," IEEE Trans. Nucl. Sci. IETNAE 0018-9499 52, 896-901 (2005). 10.1109/TNS.2005.852697
16. J. F. Janni, " Calculations of energy loss, range, path length, straggling, multiple scattering, and the probability of inelastic nuclear collisions for 0.1- to 1000-MeV protons.," AFWL Technical Report No. 65-150 (Kirtland AFB, 1966).
17. D. Kirby, S. Green, H. Palmans, R. Hugtenburg, C. Wojnecki, and D. Parker, " LET dependence of GafChromic films and an ion chamber in low-energy proton dosimetry.," Phys. Med. Biol. PHMBA7 0031-9155 55, 417-433 (2010). 10.1088/0031-9155/55/2/006
18. H. J. Baek, T. H. Kim, D. Shin, J. W. Kwak, D. W. Choo, S. B. Lee, Y. Furusawa, K. Ando, S. S. Kim, and K. H. Cho, " Radiobiological characterization of proton beam at the National Cancer Center in Korea.," J. Radiat. Res. (Tokyo) ZZZZZZ 0449-3060 49 (5), 509-515 (2008). 10.1269/jrr.08017
19. Y. Shibamoto, M. Ito, C. Sugie, H. Ogino, and M. Hara, " Recovery from sublethal damage during intermittent exposures in cultured tumor cells: Implications for dose modification in radiosurgery and IMRT.," Int. J. Radiat. Oncol., Biol., Phys. IOBPD3 0360-3016 59, 1484-1490 (2004). 10.1016/j.ijrobp.2004.04.039
20. H. Ogino, Y. Shibamoto, C. Sugie, and M. Ito, " Biological effects of intermittent radiation in cultured tumor cells: Influence of fraction number and dose per fraction.," J. Radiat. Res. (Tokyo) ZZZZZZ 0449-3060 46, 401-406 (2005). 10.1269/jrr.46.401
21. D. Bettega, M. Bombana, T. Pelucchi, A. Poli, L. Tallone Lombardi, and A. M. Fuhrman Conti, " Multinucleate cells and micronucleus formation in cultured human cells exposed to 12MeV protons and c-rays.," Int. J. Radiat. Biol. IJRBE7 0955-3022 37, 1-9 (1980). 10.1080/09553008014550011
22. D. Bettega, S. Dubini, A. M. Fuhrman Conti, T. Pelucchi, and L. Tallone Lombardi, " Chromosome aberrations induced by protons up to 31 MeV in cultured human cells.," Radiat. Environ. Biophys. REBPAT 0301-634X 19, 91-100 (1981). 10.1007/BF01324225
23. J. J. Wilkens and U. Oelfke, " A phenomenological model for the relative biological effectiveness in therapeutic proton beams.," Phys. Med. Biol. PHMBA7 0031-9155 49, 2811-2825 (2004). 10.1088/0031-9155/49/13/004
24. J. Gueulette, H. Blattmann, E. Pedroni, A. Coray, B. M. De Coster, P. Mahy, A. Wambersie, and G. Goitein, " Relative biologic effectiveness determination in mouse intestine for scanning proton beam at Paul Scherrer Institute, Switzerland. Influence of motion.," Int. J. Radiat. Oncol., Biol., Phys. IOBPD3 0360-3016 62 (3), 838-845 (2005).