CCL2-driven inflammation increases mammary gland stromal density and cancer susceptibility in a transgenic mouse model

Breast Cancer Research

Volumn 19, Issue 1, 2017, Pages

  Sun, Xuan ^a,b   Glynn, Danielle J ^a,b,c   Hodson, Leigh J ^b,c   Huo, Cecilia ^d   Britt, Kara ^d,e   Thompson, Erik W ^d,f   Woolford, Lucy ^a   Evdokiou, Andreas ^c   Pollard, Jeffrey W ^g   Robertson, Sarah A ^a,b   Ingman, Wendy V ^b,c  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b UNIVERSITY OF ADELAIDE   (Australia)

^c QUEEN ELIZABETH HOSPITAL   (Australia)

^d UNIVERSITY OF MELBOURNE   (Australia)

^e PETER MACCALLUM CANCER CENTRE   (Australia)

^f QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

^g UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Chemokine (C C motif) ligand 2; Development; Macrophage; Mammary gland; Mammographic density; Mouse model

Indexed keywords

7,12 DIMETHYLBENZ[A]ANTHRACENE; CARCINOGEN; COLLAGEN; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN LYSINE 6 OXIDASE; TISSUE INHIBITOR OF METALLOPROTEINASE 3;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; BREAST DENSITY; BREAST EPITHELIUM; BREAST TISSUE; CANCER RISK; CANCER SUSCEPTIBILITY; CELL DEATH; CELL PROLIFERATION; CHRONIC INFLAMMATION; COHORT ANALYSIS; COLLAGEN DEGRADATION; CONTROLLED STUDY; EPITHELIUM CELL; ESTRUS CYCLE; EXTRACELLULAR MATRIX; FEMALE; HUMAN; HUMAN TISSUE; INFLAMMATION; MACROPHAGE; MAMMARY GLAND; MOUSE; MOUSE MAMMARY TUMOR VIRUS; NONHUMAN; PROTEIN EXPRESSION; STROMA; TRANSGENIC MOUSE; TUMOR GROWTH; ANIMAL; BREAST NEOPLASMS; DISEASE MODEL; DISEASE PREDISPOSITION; EPITHELIUM; EXPERIMENTAL MAMMARY NEOPLASM; GENE EXPRESSION; GENETICS; IMMUNOLOGY; KAPLAN MEIER METHOD; METABOLISM; MORTALITY; NEUTROPHIL CHEMOTAXIS; PATHOLOGY; PROGNOSIS; STROMA CELL;

ANIMALS; BREAST DENSITY; BREAST NEOPLASMS; CHEMOKINE CCL2; CHEMOTAXIS, LEUKOCYTE; DISEASE MODELS, ANIMAL; DISEASE SUSCEPTIBILITY; EPITHELIUM; ESTROUS CYCLE; FEMALE; GENE EXPRESSION; HUMANS; INFLAMMATION; KAPLAN-MEIER ESTIMATE; MACROPHAGES; MAMMARY GLANDS, HUMAN; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, TRANSGENIC; PROGNOSIS; RNA, MESSENGER; STROMAL CELLS;

EID: 85009265618     PISSN: 14655411     EISSN: 1465542X     Source Type: Journal    
DOI: 10.1186/s13058-016-0796-z     Document Type: Article

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