IDH1 deficiency attenuates gluconeogenesis in mouse liver by impairing amino acid utilization

Proceedings of the National Academy of Sciences of the United States of America

Volumn 114, Issue 2, 2017, Pages 292-297

  Ye, Jing ^a,b   Gua, Yu ^a,b   Zhang, Feng ^b   Zhao, Yuanlin ^b   Yuan, Yuan ^b   Hao, Zhenyue ^a   Sheng, Yi ^a   Li, Wanda Y ^a   Wakeham, Andrew ^a   Cairns, Rob A ^a   Mak, Tak W ^a  

^a PRINCESS MARGARET HOSPITAL   (Canada)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Gluconeogenesis; Isocitrate dehydrogenase 1; Liver; Transamination; ketoglutarate

Indexed keywords

2 OXOGLUTARIC ACID; ALANINE; AMMONIA; ASPARTIC ACID; GLUCOSE; GLUTAMIC ACID; GLUTAMINE; GLYCINE; GLYCOGEN; ISOCITRATE DEHYDROGENASE 1; ISOCITRATE DEHYDROGENASE 2; ISOCITRATE DEHYDROGENASE 3; LIPID; MESSENGER RNA; PROLINE; PYRUVIC ACID; UNCLASSIFIED DRUG; UREA; ALPHA-KETOGLUTARIC ACID; AMINO ACID; ISOCITRATE DEHYDROGENASE;

ADIPOCYTE; AMINO ACID BLOOD LEVEL; AMINO ACID METABOLISM; AMMONIA FORMATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; BODY WEIGHT; CELL DIFFERENTIATION; CELL VIABILITY; CONFERENCE PAPER; CONTROLLED STUDY; CRISPR CAS SYSTEM; EMBRYO; GENE EXPRESSION; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE INTAKE; GLUCOSE METABOLISM; GLYCOGEN ANALYSIS; HEP-G2 CELL LINE; LIVER CELL; LIVER TISSUE; MALE; MOUSE; NITROGEN METABOLISM; NONHUMAN; PRIORITY JOURNAL; PROTEIN DIET; UPREGULATION; WEIGHT GAIN; ANIMAL; C57BL MOUSE; DEFICIENCY; DIET RESTRICTION; HUMAN; KNOCKOUT MOUSE; LIVER; METABOLISM; PHYSIOLOGY; TUMOR CELL LINE;

AMINO ACIDS; ANIMALS; BLOOD GLUCOSE; CELL LINE, TUMOR; FASTING; GLUCONEOGENESIS; GLUCOSE; GLUTAMIC ACID; HEP G2 CELLS; HEPATOCYTES; HUMANS; ISOCITRATE DEHYDROGENASE; KETOGLUTARIC ACIDS; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; UP-REGULATION;

EID: 85009259942     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1618605114     Document Type: Article

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