Major Shifts in Glial Regional Identity Are a Transcriptional Hallmark of Human Brain Aging

Cell Reports

Volumn 18, Issue 2, 2017, Pages 557-570

  Soreq, Lilach ^a,b   Rose, Jamie ^c   Soreq, Eyal ^d   Hardy, John ^a,e   Trabzuni, Daniah ^a,f   Cookson, Mark R ^g   Smith, Colin ^c   Ryten, Mina ^a,i   Patani, Rickie ^a,b,e,h,j   Ule, Jernej ^a,b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b THE FRANCIS CRICK INSTITUTE   (United Kingdom)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

^d IMPERIAL COLLEGE LONDON   (United Kingdom)

^e UNIVERSITY COLLEGE LONDON   (United Kingdom)

^f KING FAISAL SPECIALIST HOSPITAL AND RESEARCH CENTER   (Saudi Arabia)

^g NATIONAL INSTITUTE ON AGING   (United States)

^h UNIVERSITY OF EDINBURGH   (United Kingdom)

ⁱ GUY S HOSPITAL   (United Kingdom)

^j UNIVERSITY OF CAMBRIDGE   (United Kingdom)

more..

Author keywords

aging; brain; exon microarrays; gene expression; immunohistochemistry; machine learning; microglia; neurons; olgiodendrocytes; RNA seq

Indexed keywords

VON WILLEBRAND FACTOR;

ADOLESCENT; ADULT; AGED; AGING; ARTICLE; ASTROCYTE; BRAIN AGING; BRAIN CELL; CELL COUNT; CELL SUBPOPULATION; CEREBELLUM; CONTROLLED STUDY; CP GENE; DOWN REGULATION; FRONTAL CORTEX; GENE; GENE EXPRESSION REGULATION; GLIA; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTRALOBULAR WHITE MATTER; MEDULLA OBLONGATA; MICROGLIA; OCCIPITAL CORTEX; OLIGODENDROGLIA; PRIORITY JOURNAL; PUTAMEN; SGPP1 GENE; SUBSTANTIA NIGRA; TEMPORAL CORTEX; THALAMUS; UPREGULATION; VWF GENE; WHITE MATTER; ANTIBODY SPECIFICITY; BRAIN; CYTOLOGY; GENE EXPRESSION PROFILING; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; MIDDLE AGED; NERVE CELL; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AGING; BRAIN; CELL COUNT; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; MICROGLIA; MIDDLE AGED; NEUROGLIA; NEURONS; OLIGODENDROGLIA; ORGAN SPECIFICITY; TRANSCRIPTION, GENETIC; UP-REGULATION; YOUNG ADULT;

EID: 85009209113     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2016.12.011     Document Type: Article

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