Effect of age on neocortical brain cells in 90+ year old human females-a cell counting study

Neurobiology of Aging

Volumn 34, Issue 1, 2013, Pages 91-99

  Fabricius, Katrine ^a   Jacobsen, Jette Stub ^a   Pakkenberg, Bente ^a  

^a BISPEBJERG HOSPITAL   (Denmark)

Author keywords

Cell count; Human; Neocortex; Normal aging; Stereology

Indexed keywords

AGE; AGE DISTRIBUTION; AGING; ARTICLE; ASTROCYTE; BRAIN CELL; BRAIN SIZE; CELL COUNT; FEMALE; FRONTAL LOBE; HUMAN; HUMAN CELL; HUMAN TISSUE; LONGEVITY; MICROGLIA; NEOCORTEX; NORMAL HUMAN; OCCIPITAL LOBE; OLIGODENDROGLIA; PARIETAL LOBE; PRIORITY JOURNAL; STEREOLOGY; TEMPORAL LOBE; WOMEN'S HEALTH;

AGE FACTORS; AGED; AGED, 80 AND OVER; AGING; CELL COUNT; FEMALE; HUMANS; NEOCORTEX; NEUROGLIA; NEURONS; STEREOTAXIC TECHNIQUES;

EID: 84868108022     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2012.06.009     Document Type: Article

References (31)

1. Austad S.N. Comparative biology of aging. J. Gerontol. A Biol. Sci. Med. Sci 2009, 64:199-201.
2. Baumann N., Pham-Dinh D. Biology of oligodendrocyte and myelin in the mammalian central nervous system. Physiol. Rev 2001, 81:871-927.
3. Berg L., McKeel D.W., Miller J.P., Storandt M., Rubin E.H., Morris J.C., Baty J., Coats M., Norton J., Goate A.M., Price J.L., Gearing M., Mirra S.S., Saunders A.M. Clinicopathologic studies in cognitively healthy aging and Alzheimer's disease: relation of histologic markers to dementia severity, age, sex, and apolipoprotein E genotype. Arch. Neurol 1998, 55:326-335.
4. Berry M., Butt A.M. Structure and Function of Glia in the Central Nervous System. Greenfield's Neuropathology 1997, Arnold, London. sixth ed.
5. Christensen K., McGue M., Petersen I., Jeune B., Vaupel J.W. Exceptional longevity does not result in excessive levels of disability. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:13274-13279.
6. Duffy P.E. Astrocytes: Normal, Reactive, and Neoplastic 1983, Raven, New York.
7. Ezekiel F., Chao L., Kornak J., Du A.T., Cardenas V., Truran D., Jagust W., Chui H., Miller B., Yaffe K., Schuff N., Weiner M. Comparisons between global and focal brain atrophy rates in normal aging and Alzheimer disease: Boundary Shift Integral versus tracing of the entorhinal cortex and hippocampus. Alzheimer Dis. Assoc. Disord 2004, 18:196-201.
8. Fuller G.N., Burger P.C. Central nervous system. Histology for Pathologists 1997, 243-282. Lippincott Williams & Wilkins, Philadelphia. 2nd ed. S.S. Sternberg (Ed.).
9. Gredal O., Pakkenberg H., Karlsborg M., Pakkenberg B. Unchanged total number of neurons in motor cortex and neocortex in amyotrophic lateral sclerosis: a stereological study. J. Neurosci. Methods 2000, 95:171-176.
10. Gundersen H.J., Jensen E.B. The efficiency of systematic sampling in stereology and its prediction. J. Microsc 1987, 147:229-263.
11. Gundersen H.J., Jensen E.B., Kiêu K., Nielsen J. The efficiency of systematic sampling in stereology-reconsidered. J. Microsc 1999, 193:199-211.
12. Gundersen H.J. Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson. J. Microsc 1986, 143:3-45.
13. Halliday G.M., McRitchie D.A., Cartwright H., Pamphlett R., Hely M.A., Morris J.G. Midbrain neuropathology in idiopathic Parkinson's disease and diffuse Lewy body disease. J. Clin. Neurosci 1996, 3:52-60.
14. Hou J., Pakkenberg B. Age-related degeneration of corpus callosum in the 90+ years measured with stereology. Neurobiol. Aging 2012, 33:e1-e9.
15. Jensen G.B., Pakkenberg B. Do alcoholics drink their neurons away?. Lancet 1993, 13:1201-1204.
16. Jeune B., Andersen-Ranberg K. Hvad kan vi lære af de hundredeårige?. Ugeskr. Laeger 1999, 161:6321-6325. [Danish with English summary].
17. Kubis N., Faucheux B.A., Ransmayr G., Damier P., Duyckaerts C., Henin D., Forette B., Le Charpentier Y., Hauw J.J., Agid Y., Hirsch E.C. Preservation of midbrain catecholaminergic neurons in very old human subjects. Brain 2000, 123:366-373.
18. Lubitz J., Cai L., Kramarow E., Lentzner H. Health, life expectancy, and health care spending among the elderly. N Engl J. Med 2003, 349:1048-1055.
19. Marner L., Nyengaard J.R., Tang Y., Pakkenberg B. Marked loss of myelinated nerve fibers in the human brain with age. J. Comp. Neurol 2003, 462:144-152.
20. Ohira K. Injury-induced neurogenesis in the mammalian forebrain. Cell. Mol. Life Sci 2011, 68:1645-1656.
21. Oster S., Christoffersen P., Gundersen H.J., Nielsen J.O., Pakkenberg B., Pedersen C. Cerebral atrophy in AIDS: a stereological study. Acta Neuropathol 1993, 85:617-622.
22. Pakkenberg B. Total nerve cell number in neocortex in chronic schizophrenics and controls estimated using optical disectors. Biol. Psychiatry 1993, 34:768-772.
23. Pakkenberg B., Gundersen H.J. Neocortical neuron number in humans: effect of sex and age. J. Comp. Neurol 1997, 384:312-320.
24. Pakkenberg B., Pelvig D., Marner L., Bundgaard M.J., Gundersen H.J., Nyengaard J.R., Regeur L. Aging and the human neocortex. Exp. Gerontol 2003, 38:95-99.
25. Pedersen K.M., Marner L., Pakkenberg H., Pakkenberg B. No global loss of neocortical neurons in Parkinson's disease: a quantitative stereological study. Mov. Disord 2005, 20:164-171.
26. Pelvig D.P., Pakkenberg H., Regeur L., Oster S., Pakkenberg B. Neocortical glial cell numbers in Alzheimer's disease. A stereological study. Dement. Geriatr. Cogn. Disord 2003, 16:212-219.
27. Regeur L., Jensen G.B., Pakkenberg H., Evans S.M., Pakkenberg B. No global neocortical nerve cell loss in brains from patients with senile dementia of Alzheimer's type. Neurobiol. Aging 1994, 15:347-352.
28. Rudow G., O'Brien R., Savonenko A.V., Resnick S.M., Zonderman A.B., Pletnikova O., Marsh L., Dawson T.M., Crain B.J., West M.J. Morphometry of the human substantia nigra in ageing and Parkinson's disease. Acta Neuropathol 2008, 115:461-470.
29. Scahill R.I., Frost C., Jenkins R., Whitwell J.L., Rossor M.N., Fox N.C. A longitudinal study of brain volume changes in normal aging using serial registered magnetic resonance imaging. Arch. Neurol 2003, 60:989-994.
30. Simić G., Kostović I., Winblad B., Bogdanović N. Volume and number of neurons of the human hippocampal formation in normal aging and Alzheimer's disease. J. Comp. Neurol 1997, 379:482-494.
31. West M.J., Gundersen H.J. Unbiased stereological estimation of the number of neurons in the human hippocampus. J. Comp. Neurol 1990, 296:1-22.