Bifunctional bisphosphonate derivatives and platinum complexes with high affinity for bone hydroxyapatite

Bioorganic and Medicinal Chemistry Letters

Volumn 27, Issue 4, 2017, Pages 1070-1075

  Sun, Yanyan ^a   Chen, Lei ^a   Wu, Xiwen ^a   Ding, Qian ^a  

^a SUZHOU UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Apoptosis; Bisphosphonate; Cytotoxicity; Hydroxyapatite binding; Platinum(II) complexes

Indexed keywords

BISPHOSPHONIC ACID DERIVATIVE; CISPLATIN; HYDROXYAPATITE; PLATINUM COMPLEX; ZOLEDRONIC ACID; PLATINUM;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; EXPERIMENTAL STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; MG-63 CELL LINE; ANTAGONISTS AND INHIBITORS; APOPTOSIS; BONE; CHEMISTRY; DRUG EFFECTS; IC50; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; TUMOR CELL LINE;

APOPTOSIS; BONE AND BONES; CELL LINE, TUMOR; DIPHOSPHONATES; HUMANS; HYDROXYAPATITES; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; PLATINUM;

EID: 85009206629     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2016.12.050     Document Type: Article

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