Inhibition of TRPC6 channels ameliorates renal fibrosis and contributes to renal protection by soluble klotho

Kidney International

Volumn 91, Issue 4, 2017, Pages 830-841

  Wu, Yueh Lin ^a,b,c   Xie, Jian ^a   An, Sung Wan ^a   Oliver, Noelynn ^d   Barrezueta, Nestor X ^d   Lin, Mei Hsiang ^e   Birnbaumer, Lutz ^f,g   Huang, Chou Long ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b TAIPEI MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^d BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

^e TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^f NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^g PONTIFICIA UNIVERSIDAD CATÓLICA ARGENTINA   (Argentina)

Author keywords

BTP2; fibrosis; klotho; TRPC3; TRPC6; UUO

Indexed keywords

4 METHYL 4 [3,5 BIS(TRIFLUOROMETHYL) 1H PYRAZOL 1 YL] 1,2,3 THIADIAZOLE 5 CARBOXANILIDE; CARBACHOL; KLOTHO PROTEIN; MESSENGER RNA; PYRAZOLE DERIVATIVE; TRANSIENT RECEPTOR POTENTIAL CHANNEL 3; TRANSIENT RECEPTOR POTENTIAL CHANNEL 6; UNCLASSIFIED DRUG; 4-METHYL-4'-(3,5-BIS(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL)-1,2,3-THIADIAZOLE-5-CARBOXANILIDE; ANILIDE; BETA GLUCURONIDASE; THIADIAZOLE DERIVATIVE; TRANSIENT RECEPTOR POTENTIAL CHANNEL C; TRPC6 PROTEIN, MOUSE; URINARY TRACT AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG TARGETING; GENE DELETION; GENE EXPRESSION REGULATION; HEK293 CELL LINE; KIDNEY FIBROSIS; KNOCKOUT MOUSE; MALE; MOUSE; MYOFIBROBLAST; NONHUMAN; PATHOGENESIS; PROTEIN FUNCTION; RENAL PROTECTION; UPREGULATION; WILD TYPE MOUSE; 129 MOUSE; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL PROTECTION; DEFICIENCY; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; FIBROSIS; GENETIC PREDISPOSITION; GENETIC TRANSFECTION; GENETICS; HUMAN; KIDNEY; KIDNEY DISEASES; METABOLISM; PATHOLOGY; PHENOTYPE; SIGNAL TRANSDUCTION; URETERAL OBSTRUCTION;

ANILIDES; ANIMALS; CYTOPROTECTION; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBROSIS; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION TO DISEASE; GLUCURONIDASE; HEK293 CELLS; HUMANS; KIDNEY; KIDNEY DISEASES; MALE; MICE, 129 STRAIN; MICE, KNOCKOUT; PHENOTYPE; RNA, MESSENGER; SIGNAL TRANSDUCTION; THIADIAZOLES; TRANSFECTION; TRPC CATION CHANNELS; URETERAL OBSTRUCTION; UROLOGICAL AGENTS;

EID: 85009206198     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1016/j.kint.2016.09.039     Document Type: Article

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