메뉴 건너뛰기




Volumn 1, Issue 5, 2013, Pages

Metaplastic LTP inhibition after LTD induction in CA1 hippocampal slices involves NMDA receptor-mediated neurosteroidogenesis

Author keywords

Allopregnanolone; Finasteride; Long term depression; Metaplasticity; NMDA receptors

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 4 AMINOBUTYRIC ACID; FINASTERIDE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROSTEROID; PICROTOXIN; STEROID 5ALPHA REDUCTASE INHIBITOR;

EID: 85009102979     PISSN: None     EISSN: 2051817X     Source Type: Journal    
DOI: 10.1002/phy2.133     Document Type: Article
Times cited : (21)

References (46)
  • 1
    • 42349089481 scopus 로고    scopus 로고
    • Metaplasticity: Tuning synapses and networks for plasticity
    • Abraham, W. C. 2008. Metaplasticity: tuning synapses and networks for plasticity. Nature Rev. Neurosci. 9: 387–399.
    • (2008) Nature Rev. Neurosci. , vol.9 , pp. 387-399
    • Abraham, W.C.1
  • 2
    • 0029984320 scopus 로고    scopus 로고
    • Methaplasticity: The plasticity of synaptic plasticity
    • Abraham, W. C., and M. F. Bear. 1996. Methaplasticity: the plasticity of synaptic plasticity. TINS 19: 126–130.
    • (1996) TINS , vol.19 , pp. 126-130
    • Abraham, W.C.1    Bear, M.F.2
  • 3
    • 33749235692 scopus 로고    scopus 로고
    • Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis
    • Agis-Balboa, R. C., G. Pinna, A. Zhubi, E. Maloku, M. Veldic, E. Costa, et al. 2006. Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis. Proc. Natl. Acad. Sci. (USA) 103: 14602–14607.
    • (2006) Proc. Natl. Acad. Sci. (USA) , vol.103 , pp. 14602-14607
    • Agis-Balboa, R.C.1    Pinna, G.2    Zhubi, A.3    Maloku, E.4    Veldic, M.5    Costa, E.6
  • 5
    • 33845886090 scopus 로고    scopus 로고
    • Differential roles of NR2A and NR2B-containing NMDA receptors in LTP and LTD in the CA1 region of two-week old rat hippocampus
    • Bartlett, T. E., N. J. Bannister, V. J. Collett, S. L. Dargan, P. V. Massey, Z. A. Bortolotto, et al. 2007. Differential roles of NR2A and NR2B-containing NMDA receptors in LTP and LTD in the CA1 region of two-week old rat hippocampus. Neuropharmacology 52: 60–70.
    • (2007) Neuropharmacology , vol.52 , pp. 60-70
    • Bartlett, T.E.1    Bannister, N.J.2    Collett, V.J.3    Dargan, S.L.4    Massey, P.V.5    Bortolotto, Z.A.6
  • 6
    • 22544450154 scopus 로고    scopus 로고
    • Lack of NMDA receptor subtype selectivity for hippocampal long-term potentiation
    • Berberich, S., P. Punnakkal, V. Jensen, V. Pawlak, P. H. Seeburg, O. Hvalby, et al. 2005. Lack of NMDA receptor subtype selectivity for hippocampal long-term potentiation. J. Neurosci. 25: 6907–6910.
    • (2005) J. Neurosci , vol.25 , pp. 6907-6910
    • Berberich, S.1    Punnakkal, P.2    Jensen, V.3    Pawlak, V.4    Seeburg, P.H.5    Hvalby, O.6
  • 7
    • 0027991388 scopus 로고
    • The molecular basis of NMDA receptor subtypes: Native receptor diversity is predicted by subunit composition
    • Buller, A. L., H. C. Larson, B. E. Schneider, J. A. Beaton, R. A. Morrisett, and D. T. Monaghan. 1994. The molecular basis of NMDA receptor subtypes: native receptor diversity is predicted by subunit composition. J. Neurosci. 14: 5471–5484.
    • (1994) J. Neurosci , vol.14 , pp. 5471-5484
    • Buller, A.L.1    Larson, H.C.2    Schneider, B.E.3    Beaton, J.A.4    Morrisett, R.A.5    Monaghan, D.T.6
  • 9
    • 0024421743 scopus 로고
    • Low frequency activation of the NMDA receptor system can prevent the induction of LTP
    • Coan, E. J., A. J. Irving, and G. L. Collingridge. 1989. Low frequency activation of the NMDA receptor system can prevent the induction of LTP. Neurosci. Lett. 105: 205–210.
    • (1989) Neurosci. Lett. , vol.105 , pp. 205-210
    • Coan, E.J.1    Irving, A.J.2    Collingridge, G.L.3
  • 10
    • 16544376850 scopus 로고    scopus 로고
    • Role of distinct NMDA receptor subtypes at central synapses
    • Cull-Candy, S. G., and D. N. Leszkiewicz. 2004. Role of distinct NMDA receptor subtypes at central synapses. Sci. STKE 255: re16.
    • (2004) Sci. STKE , vol.255
    • Cull-Candy, S.G.1    Leszkiewicz, D.N.2
  • 11
    • 0026579349 scopus 로고
    • Homosynaptic long-term depression in area CA1 of hippocampus and effects of N-methyl-D-aspartate receptor blockade
    • Dudek, S. M., and M. F. Bear. 1992. Homosynaptic long-term depression in area CA1 of hippocampus and effects of N-methyl-D-aspartate receptor blockade. Proc. Natl. Acad. Sci. (USA) 89: 4363–4367.
    • (1992) Proc. Natl. Acad. Sci. (USA) , vol.89 , pp. 4363-4367
    • Dudek, S.M.1    Bear, M.F.2
  • 12
    • 84857024927 scopus 로고    scopus 로고
    • Neurosteroids and GABAA receptor interactions: A focus on stress
    • Gunn, B. G., A. R. Brown, J. J. Lambert, and D. Belelli. 2011. Neurosteroids and GABAA receptor interactions: a focus on stress. Front Neurosci. 5: 1–20.
    • (2011) Front Neurosci , vol.5 , pp. 1-20
    • Gunn, B.G.1    Brown, A.R.2    Lambert, J.J.3    Belelli, D.4
  • 13
    • 0026535860 scopus 로고
    • The influence of prior synaptic activity on the induction of long-term potentiation
    • Huang, Y.-Y., A. Colino, D. K. Selig, and R. C. Malenka. 1992. The influence of prior synaptic activity on the induction of long-term potentiation. Science 255: 730–733.
    • (1992) Science , vol.255 , pp. 730-733
    • Huang, Y.-Y.1    Colino, A.2    Selig, D.K.3    Malenka, R.C.4
  • 14
    • 0030957611 scopus 로고    scopus 로고
    • Involvement of nitric oxide in low glucose-mediated inhibition of hippocampal long-term potentiation
    • Izumi, Y., and C. F. Zorumski. 1997. Involvement of nitric oxide in low glucose-mediated inhibition of hippocampal long-term potentiation. Synapse 25: 258–262.
    • (1997) Synapse , vol.25 , pp. 258-262
    • Izumi, Y.1    Zorumski, C.F.2
  • 15
    • 84855909190 scopus 로고    scopus 로고
    • NMDA receptors, mGluR5 and endocannabinoids are involved in a cascade leading to hippocampal long-term depression
    • Izumi, Y., and C. F. Zorumski. 2012. NMDA receptors, mGluR5 and endocannabinoids are involved in a cascade leading to hippocampal long-term depression. Neuropsychopharmacol 37: 609–617.
    • (2012) Neuropsychopharmacol , vol.37 , pp. 609-617
    • Izumi, Y.1    Zorumski, C.F.2
  • 16
    • 0026503093 scopus 로고
    • Low concentrations of N-methyl-D-aspartate inhibit the induction of long-term potentiation in rat hippocampal slices
    • Izumi, Y., D. B. Clifford, and C. F. Zorumski. 1992. Low concentrations of N-methyl-D-aspartate inhibit the induction of long-term potentiation in rat hippocampal slices. Neurosci. Lett. 137: 245–248.
    • (1992) Neurosci. Lett. , vol.137 , pp. 245-248
    • Izumi, Y.1    Clifford, D.B.2    Zorumski, C.F.3
  • 17
    • 0031975111 scopus 로고    scopus 로고
    • Oxygen deprivation produces delayed inhibition of LTP by activation of NMDA receptors and nitric oxide synthase
    • Izumi, Y., H. Katsuki, A. M. Benz, and C. F. Zorumski. 1998. Oxygen deprivation produces delayed inhibition of LTP by activation of NMDA receptors and nitric oxide synthase. J. Cereb. Bl. Fl. Metab. 18: 97–108.
    • (1998) J. Cereb. Bl. Fl. Metab , vol.18 , pp. 97-108
    • Izumi, Y.1    Katsuki, H.2    Benz, A.M.3    Zorumski, C.F.4
  • 18
    • 26944437887 scopus 로고    scopus 로고
    • Ammonia-mediated LTP inhibition: Effects of NMDA receptor antagonists and L-carnitine. Neurobiol
    • Izumi, Y., M. Izumi, M. Matsukawa, M. Funatsu, and C. F. Zorumski. 2005a. Ammonia-mediated LTP inhibition: effects of NMDA receptor antagonists and L-carnitine. Neurobiol. Disease 20: 615–624.
    • (2005) Disease , vol.20 , pp. 615-624
    • Izumi, Y.1    Izumi, M.2    Matsukawa, M.3    Funatsu, M.4    Zorumski, C.F.5
  • 19
    • 27744568293 scopus 로고    scopus 로고
    • Acute effects of ethanol on hippocampal LTP and LTD are mediated by different mechanisms
    • Izumi, Y., K. Nagashima, K. Murayama, and C. F. Zorumski. 2005 b. Acute effects of ethanol on hippocampal LTP and LTD are mediated by different mechanisms. Neuroscience 136: 509–517.
    • (2005) Neuroscience , vol.136 , pp. 509-517
    • Izumi, Y.1    Nagashima, K.2    Murayama, K.3    Zorumski, C.4
  • 20
    • 33746223009 scopus 로고    scopus 로고
    • Zinc modulates bidirectional hippocampal plasticity by effects on NMDA receptors
    • Izumi, Y., Y. P. Auberson, and C. F. Zorumski. 2006. Zinc modulates bidirectional hippocampal plasticity by effects on NMDA receptors. J. Neurosci. 26: 7181–7188.
    • (2006) J. Neurosci , vol.26 , pp. 7181-7188
    • Izumi, Y.1    Auberson, Y.P.2    Zorumski, C.F.3
  • 21
    • 34848875684 scopus 로고    scopus 로고
    • GABAergic neurosteroids mediate the effects of ethanol on long-term potentiation in rat hippocampal slices
    • Izumi, Y., K. Murayama, K. Tokuda, K. Krishnan, D. F. Covey, and C. F. Zorumski. 2007. GABAergic neurosteroids mediate the effects of ethanol on long-term potentiation in rat hippocampal slices. Eur. J. Neurosci. 26: 1881–1888.
    • (2007) Eur. J. Neurosci , vol.26 , pp. 1881-1888
    • Izumi, Y.1    Murayama, K.2    Tokuda, K.3    Krishnan, K.4    Covey, D.F.5    Zorumski, C.F.6
  • 22
    • 40849139482 scopus 로고    scopus 로고
    • Long-term potentiation inhibition by low-level N-methyl-D-aspartate receptor activation involves calcineurin, nitric oxide and p38 mitogen-activated protein kinase
    • Izumi, Y., K. Tokuda, and C. F. Zorumski. 2008. Long-term potentiation inhibition by low-level N-methyl-D-aspartate receptor activation involves calcineurin, nitric oxide and p38 mitogen-activated protein kinase. Hippocampus 18: 258–265.
    • (2008) Hippocampus , vol.18 , pp. 258-265
    • Izumi, Y.1    Tokuda, K.2    Zorumski, C.F.3
  • 23
    • 84873748944 scopus 로고    scopus 로고
    • Ammonia inhibits long-term potentiation via neurosteroid synthesis in hippocampal pyramidal neurons
    • Izumi, Y., N. Svrakic, K. O’Dell, and C. F. Zorumski. 2013. Ammonia inhibits long-term potentiation via neurosteroid synthesis in hippocampal pyramidal neurons. Neuroscience 233: 166–173.
    • (2013) Neuroscience , vol.233 , pp. 166-173
    • Izumi, Y.1    Svrakic, N.2    O’Dell, K.3    Zorumski, C.F.4
  • 24
    • 33847228347 scopus 로고    scopus 로고
    • Hippocampal long-term depression: Master or minion in declarative memory processes?
    • Kemp, A., and D. Manahan-Vaughan. 2007. Hippocampal long-term depression: master or minion in declarative memory processes? Trends Neurosci. 30: 111–118.
    • (2007) Trends Neurosci , vol.30 , pp. 111-118
    • Kemp, A.1    Manahan-Vaughan, D.2
  • 25
    • 0029978497 scopus 로고    scopus 로고
    • Behavioral stress modifies hippocampal plasticity through N-methyl-D-aspartate receptor activation
    • Kim, J. J., M. R. Foy, and R. F. Thompson. 1996. Behavioral stress modifies hippocampal plasticity through N-methyl-D-aspartate receptor activation. Proc. Natl. Acad. Sci. (USA) 93: 4750–4753.
    • (1996) Proc. Natl. Acad. Sci. (USA) , vol.93 , pp. 4750-4753
    • Kim, J.J.1    Foy, M.R.2    Thompson, R.F.3
  • 26
    • 0034913104 scopus 로고    scopus 로고
    • Neurosteroid synthesis by cytochrome P450-containing systems localized in the rat brain hippocampal neurons: N-methyl-D-aspartate and calcium-dependent synthesis
    • Kimoto, T., T. Tsurugizawa, Y. Ohta, J. Makino, H.-O. Tamura, Y. Hojo, et al. 2001. Neurosteroid synthesis by cytochrome P450-containing systems localized in the rat brain hippocampal neurons: N-methyl-D-aspartate and calcium-dependent synthesis. Endocrinology 142: 3578–3589.
    • (2001) Endocrinology , vol.142 , pp. 3578-3589
    • Kimoto, T.1    Tsurugizawa, T.2    Ohta, Y.3    Makino, J.4    Tamura, H.-O.5    Hojo, Y.6
  • 27
    • 0037115040 scopus 로고    scopus 로고
    • An essential component in steroid synthesis, the steroidogenic acute regulatory protein, is expressed in discrete regions of the brain
    • King, S. R., P. R. Manna, T. Ishii, P. J. Syapin, S. D. Ginsberg, K. Wilson, et al. 2002. An essential component in steroid synthesis, the steroidogenic acute regulatory protein, is expressed in discrete regions of the brain. J. Neurosci. 22: 10613–10620.
    • (2002) J. Neurosci , vol.22 , pp. 10613-10620
    • King, S.R.1    Manna, P.R.2    Ishii, T.3    Syapin, P.J.4    Ginsberg, S.D.5    Wilson, K.6
  • 28
    • 0032214513 scopus 로고    scopus 로고
    • NMDA induces long-term depression and dephosphorylation of the GluR1 subunit of AMPA receptors in hippocampus
    • Lee, H.-K., K. Kameyama, R. L. Huganir, and M. F. Bear. 1998. NMDA induces long-term depression and dephosphorylation of the GluR1 subunit of AMPA receptors in hippocampus. Neuron 21: 1151–1162.
    • (1998) Neuron , vol.21 , pp. 1151-1162
    • Lee, H.-K.1    Kameyama, K.2    Huganir, R.L.3    Bear, M.F.4
  • 29
    • 17744382762 scopus 로고    scopus 로고
    • 2+ levels affect plasticity differently: The LTP zone, the LTD zone and no man’s land
    • 2+ levels affect plasticity differently: the LTP zone, the LTD zone and no man’s land. J. Physiol. 532: 1469–1473.
    • (2001) J. Physiol , vol.532 , pp. 1469-1473
    • Lisman, J.E.1
  • 30
    • 2342637165 scopus 로고    scopus 로고
    • Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity
    • Liu, L., T. P. Wong, M. F. Pozza, K. Lingenhoehl, Y. Wang, M. Sheng, et al. 2004. Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity. Science 304: 1021–1024.
    • (2004) Science , vol.304 , pp. 1021-1024
    • Liu, L.1    Wong, T.P.2    Pozza, M.F.3    Lingenhoehl, K.4    Wang, Y.5    Sheng, M.6
  • 31
    • 5344241223 scopus 로고    scopus 로고
    • LTP and LTD: An embarrassment of riches
    • Malenka, R. C., and M. F. Bear. 2004. LTP and LTD: an embarrassment of riches. Neuron 44: 5–21.
    • (2004) Neuron , vol.44 , pp. 5-21
    • Malenka, R.C.1    Bear, M.F.2
  • 32
    • 0034042406 scopus 로고    scopus 로고
    • Synaptic plasticity and memory: An evaluation of the hypothesis. Annu
    • Martin, S. J., P. D. Grimwood, and R. G. M. Morris. 2000. Synaptic plasticity and memory: an evaluation of the hypothesis. Annu. Rev. Neurosci. 23: 649–711.
    • (2000) Rev. Neurosci , vol.23 , pp. 649-711
    • Martin, S.J.1    Grimwood, P.D.2    Morris, R.G.M.3
  • 33
    • 4544373236 scopus 로고    scopus 로고
    • Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and long-term depression
    • Massey, P. V., B. E. Johnson, P. R. Moult, Y. P. Auberson, M. W. Brown, E. Molnar, et al. 2004. Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and long-term depression. J. Neurosci. 24: 7821–7828.
    • (2004) J. Neurosci , vol.24 , pp. 7821-7828
    • Massey, P.V.1    Johnson, B.E.2    Moult, P.R.3    Auberson, Y.P.4    Brown, M.W.5    Molnar, E.6
  • 34
    • 18144428396 scopus 로고    scopus 로고
    • NR2B subtype-selective NMDA receptor antagonists: 2001-2004
    • McCauley, J. A. 2005. NR2B subtype-selective NMDA receptor antagonists: 2001-2004. Expert Opin. Ther. Pat. 15: 389–407.
    • (2005) Expert Opin. Ther. Pat. , vol.15 , pp. 389-407
    • McCauley, J.A.1
  • 35
    • 0036460447 scopus 로고    scopus 로고
    • NMDA receptor-mediated metaplasticity during the induction of long-term depression by low frequency stimulation
    • Mockett, B., C. Coussens, and W. C. Abraham. 2002. NMDA receptor-mediated metaplasticity during the induction of long-term depression by low frequency stimulation. Eur. J. Neurosci. 15: 1819–1826.
    • (2002) Eur. J. Neurosci , vol.15 , pp. 1819-1826
    • Mockett, B.1    Coussens, C.2    Abraham, W.C.3
  • 36
    • 33845872541 scopus 로고    scopus 로고
    • Activation of NR2B-containing NMDA receptors is not required for NMDA receptordependent long-term depression
    • Morishita, W., W. Lu, G. B. Smith, R. A. Nicoll, M. F. Bear, and R. C. Malenka. 2007. Activation of NR2B-containing NMDA receptors is not required for NMDA receptordependent long-term depression. Neuropharmacol 52: 71–76.
    • (2007) Neuropharmacol , vol.52 , pp. 71-76
    • Morishita, W.1    Lu, W.2    Smith, G.B.3    Nicoll, R.A.4    Bear, M.F.5    Malenka, R.C.6
  • 37
    • 0027432518 scopus 로고
    • An essential role for protein phosphatases in hippocampal long-term depression
    • Mulkey, R. M., C. E. Herron, and R. C. Malenka. 1993. An essential role for protein phosphatases in hippocampal long-term depression. Science 261: 1051–1055.
    • (1993) Science , vol.261 , pp. 1051-1055
    • Mulkey, R.M.1    Herron, C.E.2    Malenka, R.C.3
  • 38
    • 33847113902 scopus 로고    scopus 로고
    • LTP inhibits LTD in the hippocampus via regulation of GSK3b
    • Peineau, S., C. Taghibiglou, C. Bradley, T. P. Wong, L. Liu, J. Lu, et al. 2007. LTP inhibits LTD in the hippocampus via regulation of GSK3b. Neuron 53: 703–717.
    • (2007) Neuron , vol.53 , pp. 703-717
    • Peineau, S.1    Taghibiglou, C.2    Bradley, C.3    Wong, T.P.4    Liu, L.5    Lu, J.6
  • 39
    • 33847742669 scopus 로고    scopus 로고
    • Cellular distribution of the GABAA receptor-modulating 3a-hydrox, 5a-reduced pregnane steroids in the adult rat brain
    • Saalman, Y. B., M. T. Kirkcaldie, S. Waldron, and M. B. Calford. 2007. Cellular distribution of the GABAA receptor-modulating 3a-hydrox, 5a-reduced pregnane steroids in the adult rat brain. J. Neuroendocrinol. 19: 272–284.
    • (2007) J. Neuroendocrinol , vol.19 , pp. 272-284
    • Saalman, Y.B.1    Kirkcaldie, M.T.2    Waldron, S.3    Calford, M.B.4
  • 40
    • 78650353488 scopus 로고    scopus 로고
    • Midazolam inhibits hippocampal long-term potentiation and learning through dual central and peripheral benzodiazepine receptor activation and neurosteroidogenesis
    • Tokuda, K., K. A. O’Dell, Y. Izumi, and C. F. Zorumski. 2010. Midazolam inhibits hippocampal long-term potentiation and learning through dual central and peripheral benzodiazepine receptor activation and neurosteroidogenesis. J. Neurosci. 30: 16788–16795.
    • (2010) J. Neurosci , vol.30 , pp. 16788-16795
    • Tokuda, K.1    O’Dell, K.A.2    Izumi, Y.3    Zorumski, C.F.4
  • 41
    • 79960068474 scopus 로고    scopus 로고
    • Ethanol enhances neurosteroidogenesis in hippocampal pyramidal neurons by paradoxical NMDA receptor activation
    • Tokuda, K., Y. Izumi, and C. F. Zorumski. 2011. Ethanol enhances neurosteroidogenesis in hippocampal pyramidal neurons by paradoxical NMDA receptor activation. J. Neurosci. 31: 9905–9909.
    • (2011) J. Neurosci , vol.31 , pp. 9905-9909
    • Tokuda, K.1    Izumi, Y.2    Zorumski, C.F.3
  • 42
    • 77954948477 scopus 로고    scopus 로고
    • Cholesterol homeostasis markers are localized to mouse hippocampal pyramidal and granule layers
    • Valdez, C. M., M. A. Smith, G. Perry, C. F. Phelix, and F. Santamaria. 2010. Cholesterol homeostasis markers are localized to mouse hippocampal pyramidal and granule layers. Hippocampus 20: 902–905.
    • (2010) Hippocampus , vol.20 , pp. 902-905
    • Valdez, C.M.1    Smith, M.A.2    Perry, G.3    Phelix, C.F.4    Santamaria, F.5
  • 43
    • 0028954506 scopus 로고
    • GABAergic and developmental influences o n homosynaptic LTD and depotentiation in rat hippocampus
    • Wagner, J. J., and B. E. Alger. 1995. GABAergic and developmental influences o n homosynaptic LTD and depotentiation in rat hippocampus. J. Neurosci. 15: 1577–1586.
    • (1995) J. Neurosci , vol.15 , pp. 1577-1586
    • Wagner, J.J.1    Alger, B.E.2
  • 44
    • 0027221606 scopus 로고
    • Priming of homosynaptic long-term depression in hippocampus by previous synaptic activity
    • Wexler, E. M., and P. K. Stanton. 1993. Priming of homosynaptic long-term depression in hippocampus by previous synaptic activity. NeuroReport 4: 591–594.
    • (1993) Neuroreport , vol.4 , pp. 591-594
    • Wexler, E.M.1    Stanton, P.K.2
  • 45
    • 41449088031 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase activation is required for stress protocol-induced modification of hippocampal synaptic plasticity
    • Yang, P.-C., C.-H. Yang, C.-C. Huang, and K.-S. Hsu. 2008. Phosphatidylinositol 3-kinase activation is required for stress protocol-induced modification of hippocampal synaptic plasticity. J. Biol. Chem. 283: 2631–2643.
    • (2008) J. Biol. Chem , vol.283 , pp. 2631-2643
    • Yang, P.-C.1    Yang, C.-H.2    Huang, C.-C.3    Hsu, K.-S.4
  • 46
    • 84856180208 scopus 로고    scopus 로고
    • NMDA receptors and metaplasticity: Mechanisms and possible roles in neuropsychiatric disorders
    • Zorumski, C. F., and Y. Izumi. 2012. NMDA receptors and metaplasticity: mechanisms and possible roles in neuropsychiatric disorders. Neurosci. Biobehav. Rev. 36: 989–1000.
    • (2012) Neurosci. Biobehav. Rev. , vol.36 , pp. 989-1000
    • Zorumski, C.F.1    Izumi, Y.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.