Scutellarin suppresses growth and causes apoptosis of human colorectal cancer cells by regulating the p53 pathway

Molecular Medicine Reports

Volumn 15, Issue 2, 2017, Pages 929-935

  Yang, Ning ^a   Zhao, Yuying ^a   Wang, Zhipeng ^a   Liu, Yu ^b   Zhang, Yanqiao ^b  

^a Departments of Oncology   (China)

^b HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Bcl 2; P53; Proliferation; Scutellarin

Indexed keywords

CASPASE 3; PIFITHRIN ALPHA; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; SCUTELLARIN; ANTINEOPLASTIC AGENT; APIGENIN; GLUCURONIC ACID;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER GROWTH; CANCER INHIBITION; CELL GROWTH; CELL VIABILITY; CELL VIABILITY ASSAY; COLORECTAL CANCER; CONTROLLED STUDY; DOSE RESPONSE; HCT 116 CELL LINE; HUMAN; HUMAN CELL; MTT ASSAY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; TUNEL ASSAY; WESTERN BLOTTING; CELL PROLIFERATION; CHEMISTRY; COLON; COLORECTAL NEOPLASMS; DRUG EFFECTS; METABOLISM; PATHOLOGY; RECTUM; SCUTELLARIA; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APIGENIN; APOPTOSIS; CELL PROLIFERATION; COLON; COLORECTAL NEOPLASMS; GLUCURONATES; HCT116 CELLS; HUMANS; RECTUM; SCUTELLARIA; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 85009101134     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2016.6081     Document Type: Article

References (22)

1. Goldberg RM, Sargent DJ, Morton RF, Fuchs CS, Ramanathan RK, Williamson SK, Findlay BP, Pitot HC and Alberts SR: A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer. J Clin Oncol 22: 23-30, 2004.
2. Sadahiro S, Suzuki T, Ishikawa K, Nakamura T, Tanaka Y, Masuda T, Mukoyama S, Yasuda S, Tajima T, Makuuchi H and Murayama C: Recurrence patterns after curative resection of colorectal cancer in patients followed for a minimum of ten years. Hepatogastroenterology 50: 1362-1366, 2003.
3. Kim Di, Lee TK, Lim IS, Kim H, Lee YC and Kim CH: Regulation of IGF-I production and proliferation of human leiomyomal smooth muscle cells by Scutellaria barbata D. Don in vitro: Isolation of flavonoids of apigenin and luteolin as acting compounds. Toxicol Appl Pharmacol 205: 213-224, 2005.
4. Dai ZJ, Wang XJ, Li ZF, Ji ZZ, Ren HT, Tang W, Liu XX, Kang HF, Guan HT and Song LQ: Scutellaria barbate extract induces apoptosis of hepatoma H22 cells via the mitochondrial pathway involving caspase-3. World J Gastroenterol 14: 7321-7328, 2008.
5. Hong H and Liu GQ: Protection against hydrogen peroxide-induced cytotoxicity in PC12 cells by scutellarin. Life Sci 74: 2959-2973, 2004.
6. Zhang GH, Wang Q, Chen JJ, Zhang XM, Tam SC and Zheng YT: The anti-HIV-1 effect of scutellarin. Biochem Biophys Res Commun 334: 812-816, 2005.
7. Pan Z, Zhao W, Zhang X, Wang B, Wang J, Sun X, Liu X, Feng S, Yang B and Lu Y: Scutellarin alleviates interstitial fibrosis and cardiac dysfunction of infarct rats by inhibiting TGFβ1 expression and activation of p38-MAPK and ERK1/2. Br J Pharmacol 162: 688-700, 2011.
8. Li H, Huang D, Gao Z, Lv Y, Zhang L, Cui H and Zheng J: Scutellarin inhibits cell migration by regulating production of αvβ6 integrin and E-cadherin in human tongue cancer cells. Oncol Rep 24: 1153-1160, 2010.
9. Chan JY, Tan BK and Lee SC: Scutellarin sensitizes drug-evoked colon cancer cell apoptosis through enhanced caspase-6 activation. Anticancer Res 29: 3043-3047, 2009.
10. Korsmeyer SJ: BCL-2 gene family and the regulation of programmed cell death. Cancer Res 59 (Suppl 7): 1693S-1700S, 1999.
11. Miyashita T, Krajewski S, Krajewska M, Wang HG, Lin HK, Liebermann DA, Hoffman B and Reed JC: Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene 9: 1799-1805, 1994.
12. Harris SL and Levine AJ: The p53 pathway: Positive and negative feedback loops. Oncogene 24: 2899-2908, 2005.
13. Müller M, Wilder S, Bannasch D, Israeli D, Lehlbach K, Li-Weber M, Friedman SL, Galle PR, Stremmel W, Oren M and Krammer PH: p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs. J Exp Med 188: 2033-2045, 1998.
14. Boyle P and Ferlay J: Cancer incidence and mortality in Europe, 2004. Ann Oncol 16: 481-488, 2005.
15. Schrag D, Cramer LD, Bach PB and Begg CB: Age and adjuvant chemotherapy use after surgery for stage III colon cancer. J Natl Cancer Inst 93: 850-857, 2001.
16. Feng Y, Zhang S, Tu J, Cao Z, Pan Y, Shang B, Liu R, Bao M, Guo P and Zhou Q: Novel function of scutellarin in inhibiting cell proliferation and inducing cell apoptosis of human Burkitt lymphoma Namalwa cells. Leuk Lymphoma 53: 2456-2464, 2012.
17. Li H, Fan H, Wang Z, Zheng J and Cao W: Potentiation of scutellarin on human tongue carcinoma xenograft by low-intensity ultrasound. PLoS One 8: e59473, 2013.
18. Ling YH, Liebes L, Jiang JD, Holland JF, Elliott PJ, Adams J, Muggia FM and Perez-Soler R: Mechanisms of proteasome inhibitor PS-341-induced G(2)-M-phase arrest and apoptosis in human non-small cell lung cancer cell lines. Clin Cancer Res 9: 1145-1154, 2003.
19. Barlev NA, Liu L, Chehab NH, Mansfield K, Harris KG, Halazonetis TD and Berger SL: Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases. Mol Cell 8: 1243-1254, 2001.
20. Yin XM, Oltvai ZN, Veis-Novack DJ, Linette GP and Korsmeyer SJ: Bcl-2 gene family and the regulation of programmed cell death. Cold Spring Harb Symp Quant Biol 59: 387-393, 1994.
21. Swanton E, Savory P, Cosulich S, Clarke P and Woodman P: Bcl-2 regulates a caspase-3/caspase-2 apoptotic cascade in cytosolic extracts. Oncogene 18: 1781-1787, 1999.
22. Drygin D, O'Brien SE, Hannan RD, McArthur GA and Von Hoff DD: Targeting the nucleolus for cancer-specific activation of p53. Drug Discov Today 19: 259-265, 2014.