Mycophenolate mofetil prevents high-fat diet–induced hypertension and renal glomerular injury in dahl SS rats

Physiological Reports

Volumn 1, Issue 6, 2013, Pages 1-11

  Spradley, Frank T ^a,b   De Miguel, Carmen ^a   Hobbs, Janet ^a   Pollock, David M ^a   Pollock, Jennifer S ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

Author keywords

Dahl salt sensitive rat; Glomerulus; High fat diet; Hypertension; SS 13BN rat T lymphocytes

Indexed keywords

ADIPOCYTOKINE; CREATININE; FATTY ACID; HIGH DENSITY LIPOPROTEIN; LEPTIN; LOW DENSITY LIPOPROTEIN; MYCOPHENOLATE MOFETIL; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

ALBUMINURIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD3+ T LYMPHOCYTE; COLORIMETRY; CONTROLLED STUDY; DAHL SALT SENSITIVE RAT; ENZYME LINKED IMMUNOSORBENT ASSAY; EPIDIDYMIS FAT; GLOMERULAR STRUCTURE; GLOMERULOSCLEROSIS; HEART RATE; HEMODYNAMICS; HYPERTENSION; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY INJURY; LIPID DIET; LYMPHOCYTIC INFILTRATION; MEAN ARTERIAL PRESSURE; METABOLIC PARAMETERS; NONHUMAN; PERIRENAL FAT; PLASMA RENIN ACTIVITY; PROTEINURIA; RADIOIMMUNOASSAY; RAT; SCORING SYSTEM; TELEMETRY;

EID: 85008881418     PISSN: None     EISSN: 2051817X     Source Type: Journal    
DOI: 10.1002/phy2.137     Document Type: Article

References (49)

1. Agapitov, A. V., M. L. Correia, C. A. Sinkey, and W. G. Haynes. 2008. Dissociation between sympathetic nerve traffic and sympathetically mediated vascular tone in normotensive human obesity. Hypertension 52: 687–695.
2. Allison, C., and E. M. Eugui. 2000. Mycophenolate mofetil and its mechanisms of action. Immunopharmacology 47: 85–118.
3. Allock, G., M. Hukkanen, J. M. Polak, J. S. Pollock, and D. M. Pollock. 1999. Increased nitric oxide synthase-3 expression in kidneys of deoxycorticosterone acetate-salt hypertensive rats. JASN 10: 2283–2289.
4. Appel, L. J., E. D. Frohlich, J. E. Hall, T. A. Pearson, R. L. Sacco, D. R. Seals, et al. 2011. The importance of population-wide sodium reduction as a means to prevent cardiovascular disease and stroke: a call to action from the American Heart Association. Circulation 123: 1138–1143.
5. Beyer, A. M., G. Raffai, B. Weinberg, K. Fredrich, and J. H. Lombard. 2012. Dahl salt-sensitive rats are protected against vascular defects related to diet-induced obesity. Hypertension 60: 404–410.
6. Bjorntorp, P., H. Bergman, and E. Varnauskas. 1969. Plasma free fatty acid turnover rate in obesity. Acta Med. Scand. 185: 351–356.
7. Boesen, E. I., D. L. Williams, J. S. Pollock, and D. M. Pollock. 2010. Immunosuppression with mycophenolate mofetil attenuates the development of hypertension and albuminuria in deoxycorticosterone acetate-salt hypertensive rats. Clin. Exp. Pharmacol. Physiol. 37: 1016–1022.
8. Butani, L., M. S. Polinsky, B. A. Kaiser, and H. J. Baluarte. 2002. Dietary protein intake significantly affects the serum creatinine concentration. Kidney Int. 61: 1907.
9. do Carmo, J. M., L. S. Tallam, J. V. Roberts, E. L. Brandon, J. Biglane, A. A. da Silva, et al. 2009. Impact of obesity on renal structure and function in the presence and absence of hypertension: Evidence from melanocortin-4 receptor-deficient mice. Am. J. Physiol. 297: R803–R812.
10. Cohn, R., A. Mirkovich, B. Dunlap, P. Burton, S. H. Chiu, E. M. Eugui, et al. 1999. Mycophenolic acid increases apoptosis, lysosomes and lipid droplets in human lymphoid and monocytic cell lines. Transplantation 68: 411–418.
11. Cowley, A. W. Jr, R. J. Roman, M. L. Kaldunski, P. Dumas, J. G. Dickhout, A. S. Greene, et al. 2001. Brown Norway chromosome 13 confers protection from high salt to consomic Dahl S rat. Hypertension 37: 456–461.
12. Dahl, L. K., M. Heine, and K. Thompson. 1974. Genetic influence of the kidneys on blood pressure. Evidence from chronic renal homografts in rats with opposite predispositions to hypertension. Circ. Res. 40: 94–101.
13. Dahly-Vernon, A. J., M. Sharma, E. T. McCarthy, V. J. Savin, S. R. Ledbetter, and R. J. Roman. 2005. Transforming growth factor-beta, 20-HETE interaction, and glomerular injury in Dahl salt-sensitive rats. Hypertension 45: 643–648.
14. De Miguel, C., S. Das, H. Lund, and D. L. Mattson. 2010. T lymphocytes mediate hypertension and kidney damage in Dahl salt-sensitive rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 298: R1136–R1142.
15. De Miguel, C., C. Guo, H. Lund, D. Feng, and D. L. Mattson. 2011a. Infiltrating T lymphocytes in the kidney increase oxidative stress and participate in the development of hypertension and renal disease. Am. J. Physiol. Renal Physiol. 300: F734–F742.
16. De Miguel, C., H. Lund, and D. L. Mattson. 2011b. High dietary protein exacerbates hypertension and renal damage in Dahl SS rats by increasing infiltrating immune cells in the kidney. Hypertension 57: 269–274.
17. Dobrian, A. D., M. J. Davies, R. L. Prewitt, and T. J. Lauterio. 2000. Development of hypertension in a rat model of diet-induced obesity. Hypertension 35: 1009–1015.
18. Dobrian, A. D., M. J. Davies, S. D. Schriver, T. J. Lauterio, and R. L. Prewitt. 2001. Oxidative stress in a rat model of obesity-induced hypertension. Hypertension 37: 554–560.
19. Egan, B. M., N. J. Schork, and A. B. Weder. 1989. Regional hemodynamic abnormalities in overweight men. Focus on alpha-adrenergic vascular responses. Am. J. Hypertens. 2: 428–434.
20. Elmarakby, A. A., E. D. Loomis, J. S. Pollock, and D. M. Pollock. 2005. NADPH oxidase inhibition attenuates oxidative stress but not hypertension produced by chronic ET-1. Hypertension 45: 283–287.
21. Grim, C., F. C. Luft, J. Z. Miller, R. J. Rose, J. C. Christian, and M. H. Weinberger. 1980. An approach to the evaluation of genetic influences on factors that regulate arterial blood pressure in man. Hypertension 2: I34–I42.
22. Hall, J. E., M. W. Brands, W. N. Dixon, and M. J. Smith Jr. 1993. Obesity-induced hypertension. Renal function and systemic hemodynamics. Hypertension 22: 292–299.
23. Ishimitsu, T., Y. Uehara, A. Numabe, H. Tsukada, Y. Ogawa, J. Iwai, et al. 1992. Interferon gamma attenuates hypertensive renal injury in salt-sensitive Dahl rats. Hypertension 19: 804–808.
24. Ishimitsu, T., Y. Uehara, A. Numabe, H. Tsukada, Y. Ogawa, and S. Yagi. 1994. Antihypertensive effect of interleukin-2 in salt-sensitive Dahl rats. Hypertension 23: 68–73.
25. Iwashita, S., M. Tanida, N. Terui, Y. Ootsuka, M. Shu, D. Kang, et al. 2002. Direct measurement of renal sympathetic nervous activity in high-fat diet-related hypertensive rats. Life Sci. 71: 537–546.
26. Jiao, S., T. G. Cole, R. T. Kitchens, B. Pfleger, and G. Schonfeld. 1990. Genetic heterogeneity of lipoproteins in inbred strains of mice: analysis by gel-permeation chromatography. Metabolism 39: 155–160.
27. Johnson, R. J., K. L. Gordon, C. Giachelli, T. Kurth, M. M. Skelton, and A. W. Cowley Jr. 2000. Tubulointerstitial injury and loss of nitric oxide synthases parallel the development of hypertension in the Dahl-SS rat. J. Hypertens. 18: 1497–1505.
28. Kotchen, T. A., C. E. Grim, J. M. Kotchen, S. Krishnaswami, H. Yang, R. G. Hoffmann, et al. 2008. Altered relationship of blood pressure to adiposity in hypertension. Am. J. Hypertens. 21: 284–289.
29. Li, Z., M. J. Soloski, and A. M. Diehl. 2005. Dietary factors alter hepatic innate immune system in mice with nonalcoholic fatty liver disease. Hepatology 42: 880–885.
30. Lim, K., S. L. Burke, and G. A. Head. 2013. Obesity-related hypertension and the role of insulin and leptin in high-fat-fed rabbits. Hypertension 61: 628–634.
31. Lin, L., W. E. Phillips, and R. D. Manning Jr 2009. Intrarenal angiotensin II is associated with inflammation, renal damage and dysfunction in Dahl salt-sensitive hypertension. J. Am. Soc. Hypertens. 3: 306–314.
32. Ma, X., J. Hua, A. R. Mohamood, A. R. Hamad, R. Ravi, and Z. Li. 2007. A high-fat diet and regulatory T cells influence susceptibility to endotoxin-induced liver injury. Hepatology 46: 1519–1529.
33. Ma, L. J., B. A. Corsa, J. Zhou, H. Yang, H. Li, Y. W. Tang, et al. 2011. Angiotensin type 1 receptor modulates macrophage polarization and renal injury in obesity. Am. J. Physiol. Renal Physiol. 300: F1203–F1213.
34. Mattson, D. L., C. J. Meister, and M. L. Marcelle. 2005. Dietary protein source determines the degree of hypertension and renal disease in the Dahl salt-sensitive rat. Hypertension 45: 736–741.
35. Mattson, D. L., L. James, E. A. Berdan, and C. J. Meister. 2006. Immune suppression attenuates hypertension and renal disease in the Dahl salt-sensitive rat. Hypertension 48: 149–156.
36. Molony, D. A., and J. C. Craig. 2009. Evidence-based nephrology. Wiley-Blackwell, Oxford, U. K., Hoboken, NJ.
37. Mori, T., A. Polichnowski, P. Glocka, M. Kaldunski, Y. Ohsaki, M. Liang, et al. 2008. High perfusion pressure accelerates renal injury in salt-sensitive hypertension. J. Am. Soc. Nephrol. 1 9: 1472–1482.
38. Nagae, A., M. Fujita, H. Kawarazaki, H. Matsui, K. Ando, and T. Fujita. 2009. Effect of high fat loading in Dahl salt-sensitive rats. Clin. Exp. Hypertens. 31: 451–461.
39. Nishiyama, A., Y. Masanori, H. Hitomi, S. Kagami, S. Kondo, A. Miyatake, et al. 2004. The SOD mimetic tempol ameliorates glomerular injury and reduces mitogen-activated protein kinase activity in Dahl salt-sensitive rats. J. Am. Soc. Nephrol. 1 5: 306–315.
40. Okosun, I. S., J. M. Boltri, V. A. Hepburn, M. P. Eriksen, and M. Davis-Smith. 2006. Regional fat localizations and racial/ ethnic variations in odds of hypertension in at-risk American adults. J. Hum. Hypertens. 20: 362–371.
41. Pausova, Z., L. Sedova, J. Berube, P. Hamet, J. Tremblay, M. Dumont, et al. 2003. Segment of rat chromosome 20 regulates diet-induced augmentations in adiposity, glucose intolerance, and blood pressure. Hypertension 41: 1047–1055.
42. Raij, L., S. Azar, and W. Keane. 1984. Mesangial immune injury, hypertension, and progressive glomerular damage in Dahl rats. Kidney Int. 26: 137–143.
43. Raij, L., S. Azar, and W. F. Keane. 1985. Role of hypertension in progressive glomerular immune injury. Hypertension 7: 398–404.
44. Schneider, M. P., J. C. Sullivan, P. F. Wach, E. I. Boesen, T. Yamamoto, T. Fukai, et al. 2010. Protective role of extracellular superoxide dismutase in renal ischemia/ reperfusion injury. Kidney Int. 78: 374–381.
45. Siegel, A. K., P. Kossmehl, M. Planert, A. Schulz, M. Wehland, M. Stoll, et al. 2004. Genetic linkage of albuminuria and renal injury in Dahl salt-sensitive rats on a high-salt diet: comparison with spontaneously hypertensive rats. Physiol. Genomics 18: 218–225.
46. Strodthoff, D., A. M. Lundberg, H. E. Agardh, D. F. Ketelhuth, G. Paulsson-Berne, P. Arner, et al. 2013. Lack of invariant natural killer T cells affects lipid metabolism in adipose tissue of diet-induced obese mice. Arterioscler. Thromb. Vasc. Biol. 3 3: 1189–1196.
47. Umpierrez, G. E., D. Smiley, G. Robalino, L. Peng, A. E. Kitabchi, B. Khan, et al. 2009. Intravenous intralipid-induced blood pressure elevation and endothelial dysfunction in obese African-Americans with type 2 diabetes. J. Clin. Endocrinol. Metab. 94: 609–614.
48. Weinberger, M. H. 1996. Salt sensitivity of blood pressure in humans. Hypertension 27: 481–490.
49. Wu, H., S. Ghosh, X. D. Perrard, L. Feng, G. E. Garcia, J. L. Perrard, et al. 2007. T-cell accumulation and regulated on activation, normal T cell expressed and secreted upregulation in adipose tissue in obesity. Circulation 115: 1029–1038.