A novel STAT3 inhibitor HO-3867 induces cell apoptosis by reactive oxygen species-dependent endoplasmic reticulum stress in human pancreatic cancer cells

Anti-Cancer Drugs

Volumn 28, Issue 4, 2017, Pages 392-400

  Hu, Yan ^a   Zhao, Chengguang ^a   Zheng, Hailun ^a   Lu, Kongqin ^a   Shi, Dengjian ^a   Liu, Zhiguo ^a   Dai, Xuanxuan ^a   Zhang, Yi ^a   Zhang, Xiuhua ^a   Hu, Wanle ^a   Liang, Guang ^a  

^a WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

endoplasmic reticulum stress; HO 3867; pancreatic cancer; reactive oxygen species; signal transducer and activator of transcription 3

Indexed keywords

ACETYLCYSTEINE; ANTINEOPLASTIC AGENT; HO 3867; MITOGEN ACTIVATED PROTEIN KINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROCASPASE 3; PROTEIN BAX; PROTEIN BCL 2; PROTEIN INHIBITOR; REACTIVE OXYGEN METABOLITE; STAT3 PROTEIN; UNCLASSIFIED DRUG; (3,5-BIS((4-FLUOROPHENYL)METHYLIDENE)-1-((1-HYDROXY-2,2,5,5-TETRAMETHYL-2,5-DIHYDRO-1H-PYRROL-3-YL)METHYL)PIPERIDIN-4-ONE); PIPERIDONE DERIVATIVE; STAT3 PROTEIN, HUMAN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG MECHANISM; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; HUMAN; HUMAN CELL; PANCREAS CANCER; PANCREATIC CANCER CELL LINE; PRIORITY JOURNAL; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; MAPK SIGNALING; METABOLISM; PANCREAS TUMOR; PATHOLOGY; TUMOR CELL LINE;

APOPTOSIS; CELL LINE, TUMOR; ENDOPLASMIC RETICULUM STRESS; HUMANS; MAP KINASE SIGNALING SYSTEM; PANCREATIC NEOPLASMS; PIPERIDONES; REACTIVE OXYGEN SPECIES; STAT3 TRANSCRIPTION FACTOR;

EID: 85008670913     PISSN: 09594973     EISSN: 14735741     Source Type: Journal    
DOI: 10.1097/CAD.0000000000000470     Document Type: Article

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