메뉴 건너뛰기




Volumn 24, Issue 1, 2009, Pages 47-53

A new immunomodulatory therapy for severe sepsis: Ulinastatin plus thymosin α 1

Author keywords

APACHE II; Clinical trial; Immunomodulatory therapy; Sepsis; Thymosin 1; Ulinastatin

Indexed keywords

CYTOKINE; PLACEBO; THYMOSIN ALPHA1; ULINASTATIN;

EID: 58349089304     PISSN: 08850666     EISSN: 15251489     Source Type: Journal    
DOI: 10.1177/0885066608326970     Document Type: Article
Times cited : (35)

References (50)
  • 1
    • 0026710191 scopus 로고
    • Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. the ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine
    • Bone RC, Balk RA, Cerra FB, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest. 1992 ; 101: 1644-1655.
    • (1992) Chest , vol.101 , pp. 1644-1655
    • Bone, R.C.1    Balk, R.A.2    Cerra, F.B.3
  • 2
    • 3242775982 scopus 로고    scopus 로고
    • Surviving Sepsis Campaign guidelines for the management of severe sepsis and septic shock
    • for the Surviving Sepsis Campaign Management Guidelines Committee.
    • Dellinger RP, Carlet JM, Masur H., et al. for the Surviving Sepsis Campaign Management Guidelines Committee. Surviving Sepsis Campaign guidelines for the management of severe sepsis and septic shock. Crit Care Med. 2004 ; 32: 858-873.
    • (2004) Crit Care Med. , vol.32 , pp. 858-873
    • Dellinger, R.P.1    Carlet, J.M.2    Masur, H.3
  • 3
    • 0037451929 scopus 로고    scopus 로고
    • The epidemiology of sepsis in the United States from 1979 through 2000
    • Martin GS, Mannino DM, Eaton S., Moss M. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med. 2003 ; 348: 1546-1554.
    • (2003) N Engl J Med. , vol.348 , pp. 1546-1554
    • Martin, G.S.1    Mannino, D.M.2    Eaton, S.3    Moss, M.4
  • 5
    • 0034958947 scopus 로고    scopus 로고
    • Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated cost of care
    • Angus DC, Linde-Zwirble WT, Lidicker J., Clermont G., Carcillo J., Pinsky MR Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated cost of care. Crit Care Med. 2001 ; 29: 1303-1310.
    • (2001) Crit Care Med , vol.29 , pp. 1303-1310
    • Angus, D.C.1    Linde-Zwirble, W.T.2    Lidicker, J.3    Clermont, G.4    Carcillo, J.5    Pinsky, M.R.6
  • 6
    • 17344372114 scopus 로고    scopus 로고
    • The dynamics of disease progression in sepsis: Markov modeling describing the natural history and the likely impact of effective antisepsis agents
    • Rangel-Frausto MS, Pittet D., Hwang T., Woolson RF, Wenzel RP The dynamics of disease progression in sepsis: Markov modeling describing the natural history and the likely impact of effective antisepsis agents. Clin Infec Dis. 1998 ; 27: 185-190.
    • (1998) Clin Infec Dis , vol.27 , pp. 185-190
    • Rangel-Frausto, M.S.1    Pittet, D.2    Hwang, T.3    Woolson, R.F.4    Wenzel, R.P.5
  • 8
    • 0036213966 scopus 로고    scopus 로고
    • Epidemiology of sepsis and infection in ICU patients from an international multicentre cohort study
    • Alberti C., Brun-Buisson C., Burchardi H., et al. Epidemiology of sepsis and infection in ICU patients from an international multicentre cohort study. Intensive Care Med. 2002 ; 28: 108-121.
    • (2002) Intensive Care Med , vol.28 , pp. 108-121
    • Alberti, C.1    Brun-Buisson, C.2    Burchardi, H.3
  • 9
    • 0032993780 scopus 로고    scopus 로고
    • Antibiotic prophylaxis for the prevention of bacterial infections in cirrhotic patients with gastrointestinal bleeding: A meta-analysis
    • Bernard B., Grange JD, Khac EN, Amiot X., Opolon P., Poynard T. Antibiotic prophylaxis for the prevention of bacterial infections in cirrhotic patients with gastrointestinal bleeding: a meta-analysis. Hepatology. 1999 ; 29: 1655-1661.
    • (1999) Hepatology , vol.29 , pp. 1655-1661
    • Bernard, B.1    Grange, J.D.2    Khac, E.N.3    Amiot, X.4    Opolon, P.5    Poynard, T.6
  • 10
    • 0035158312 scopus 로고    scopus 로고
    • Prophylactic antibiotic administration reduces sepsis and mortality in acute necrotizing pancreatitis: A meta-analysis
    • Sharma VK, Howden CW Prophylactic antibiotic administration reduces sepsis and mortality in acute necrotizing pancreatitis: a meta-analysis. Pancreas. 2001 ; 22: 28-31.
    • (2001) Pancreas , vol.22 , pp. 28-31
    • Sharma, V.K.1    Howden, C.W.2
  • 11
    • 0035829852 scopus 로고    scopus 로고
    • Intensive insulin therapy in the critically ill patients
    • van den Berghe G., Wouters P., Weekers F., et al. Intensive insulin therapy in the critically ill patients. N Engl J Med. 2001 ; 345: 1359-1367.
    • (2001) N Engl J Med , vol.345 , pp. 1359-1367
    • Van Den Berghe, G.1    Wouters, P.2    Weekers, F.3
  • 12
    • 0141537234 scopus 로고    scopus 로고
    • Effects of selective decontamination of digestive tract on mortality and acquisition of resistant bacteria in intensive care: A randomised controlled trial
    • de Jonge E., Schultz MJ, Spanjaard L., et al. Effects of selective decontamination of digestive tract on mortality and acquisition of resistant bacteria in intensive care: a randomised controlled trial. Lancet. 2003 ; 362: 1011-1016.
    • (2003) Lancet , vol.362 , pp. 1011-1016
    • De Jonge, E.1    Schultz, M.J.2    Spanjaard, L.3
  • 13
    • 0141501475 scopus 로고    scopus 로고
    • Haemophilus influenzae oral whole cell vaccination for preventing acute exacerbations of chronic bronchitis
    • Foxwell AR, Cripps AW, Dear KBG. Haemophilus influenzae oral whole cell vaccination for preventing acute exacerbations of chronic bronchitis. Cochrane Database Syst Rev. 2004 ; 3: CD001958.
    • (2004) Cochrane Database Syst Rev. , vol.3 , pp. 001958
    • Foxwell, A.R.1    Cripps, A.W.2    Dear, K.B.G.3
  • 15
    • 0026689978 scopus 로고
    • Prophylaxis of infection with intravenous immunoglobulins plus antibiotic for patients at risk for sepsis undergoing surgery for colorectal cancer: Results of a randomized, multicenter clinical trial
    • Cafiero F., Gipponi M., Bonalumi U., et al. Prophylaxis of infection with intravenous immunoglobulins plus antibiotic for patients at risk for sepsis undergoing surgery for colorectal cancer: results of a randomized, multicenter clinical trial. Surgery. 1992 ; 112: 24-31.
    • (1992) Surgery , vol.112 , pp. 24-31
    • Cafiero, F.1    Gipponi, M.2    Bonalumi, U.3
  • 16
    • 0033981124 scopus 로고    scopus 로고
    • Prevention of infection in multiple trauma patients by high-dose intravenous immunoglobulins
    • Douzinas EE, Pitaridis MT, Louris G., et al. Prevention of infection in multiple trauma patients by high-dose intravenous immunoglobulins. Crit Care Med. 2000 ; 28: 254-255.
    • (2000) Crit Care Med , vol.28 , pp. 254-255
    • Douzinas, E.E.1    Pitaridis, M.T.2    Louris, G.3
  • 17
    • 4344618571 scopus 로고    scopus 로고
    • Corticosteroids for severe sepsis and septic shock: A systematic review and meta-analysis
    • Annane D., Bellissant E., Bollaert P., et al. Corticosteroids for severe sepsis and septic shock: a systematic review and meta-analysis. BMJ. 2004 ; 329: 480.
    • (2004) BMJ , vol.329 , pp. 480
    • Annane, D.1    Bellissant, E.2    Bollaert, P.3
  • 18
    • 8044246571 scopus 로고    scopus 로고
    • The effects of ibuprofen on the physiology and survival of patients with sepsis. the Ibuprofen in Sepsis Study Group
    • Bernard GR, Wheeler AP, Russell JA, et al. The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group. N Engl J Med. 1997 ; 336: 912-918.
    • (1997) N Engl J Med. , vol.336 , pp. 912-918
    • Bernard, G.R.1    Wheeler, A.P.2    Russell, J.A.3
  • 19
    • 0038482456 scopus 로고    scopus 로고
    • Much stuff as dreams are made on: Mediator-directed therapy in sepsis
    • Marshall JC Much stuff as dreams are made on: mediator-directed therapy in sepsis. Nat Rev Drug Discov. 2003 ; 2: 391-405.
    • (2003) Nat Rev Drug Discov , vol.2 , pp. 391-405
    • Marshall, J.C.1
  • 20
    • 0024791433 scopus 로고
    • Radioimmunological quantitation of the urinary trypsin inhibitor in normal blood and urine
    • Jonsson BM, Ohlsson K., Rosengren M. Radioimmunological quantitation of the urinary trypsin inhibitor in normal blood and urine. Biol Chem Hoppe Seyler. 1989 ; 370: 1157-1161.
    • (1989) Biol Chem Hoppe Seyler , vol.370 , pp. 1157-1161
    • Jonsson, B.M.1    Ohlsson, K.2    Rosengren, M.3
  • 21
    • 0034117744 scopus 로고    scopus 로고
    • Antiviral therapy of HBV- and HCV-induced liver cirrhosis
    • Zavaglia C., Airoldi A., Pinzello G. Antiviral therapy of HBV- and HCV-induced liver cirrhosis. J Clin Gastroenterol. 2000 ; 30: 234-241.
    • (2000) J Clin Gastroenterol , vol.30 , pp. 234-241
    • Zavaglia, C.1    Airoldi, A.2    Pinzello, G.3
  • 22
    • 0030060762 scopus 로고    scopus 로고
    • The effects of ulinastatin, a human protease inhibitor, on the transfusion-induced increase of plasma polymolphonuclear granulocyte elastase
    • Nishiyama T., Aibiki M., Hanaoka K. The effects of ulinastatin, a human protease inhibitor, on the transfusion-induced increase of plasma polymolphonuclear granulocyte elastase. Anesth Analg. 1996 ; 82: 108-112.
    • (1996) Anesth Analg , vol.82 , pp. 108-112
    • Nishiyama, T.1    Aibiki, M.2    Hanaoka, K.3
  • 23
    • 0021332228 scopus 로고
    • Effects of urinary trypsin inhibitor on pancreatic enzyme and experimental acute pancreatitis
    • Ohnishi H., Kosuzume H., Ashida Y., Kato K., Honjo I. Effects of urinary trypsin inhibitor on pancreatic enzyme and experimental acute pancreatitis. Dig Dis Sci. 1984 ; 29: 26-32.
    • (1984) Dig Dis Sci , vol.29 , pp. 26-32
    • Ohnishi, H.1    Kosuzume, H.2    Ashida, Y.3    Kato, K.4    Honjo, I.5
  • 24
    • 32944479858 scopus 로고    scopus 로고
    • Immunomodulatory function of orally administered thymosin alpha1
    • Chen XM, Jiang HL, Zhou LF, et al. Immunomodulatory function of orally administered thymosin alpha1. J Zhejiang Univ Sci B. 2005 ; 6: 873-876.
    • (2005) J Zhejiang Univ Sci B , vol.6 , pp. 873-876
    • Chen, X.M.1    Jiang, H.L.2    Zhou, L.F.3
  • 25
    • 0034813422 scopus 로고    scopus 로고
    • The combined treatment of interferon alpha-2a and thymosin alpha 1 for chronic hepatitis C: The 48 weeks end of treatment results
    • Kullavanuaya P., Treeprasertsuk S., Thong-Ngam D., Chaermthai K., Gonlachanvit S., Suwanagool P. The combined treatment of interferon alpha-2a and thymosin alpha 1 for chronic hepatitis C: the 48 weeks end of treatment results. J Med Assoc Thai. 2001 ; 84 (suppl 1). S462 - S468.
    • (2001) J Med Assoc Thai. , vol.84 , Issue.1
    • Kullavanuaya, P.1    Treeprasertsuk, S.2    Thong-Ngam, D.3    Chaermthai, K.4    Gonlachanvit, S.5    Suwanagool, P.6
  • 26
    • 0034982919 scopus 로고    scopus 로고
    • In vitro effect of thymosin-alpha1 and interferon-alpha on Th1 and Th2 cytokine synthesis in patients with chronic hepatitis C
    • Andreone P., Cursaro C., Gramenzi A., et al. In vitro effect of thymosin-alpha1 and interferon-alpha on Th1 and Th2 cytokine synthesis in patients with chronic hepatitis C. J Viral Hepat. 2001 ; 8: 194-201.
    • (2001) J Viral Hepat , vol.8 , pp. 194-201
    • Andreone, P.1    Cursaro, C.2    Gramenzi, A.3
  • 27
    • 0034535749 scopus 로고    scopus 로고
    • Thymosin alpha 1 in the treatment of cancer: From basic research to clinical application
    • Garaci E., Pica F., Rasi G., Favalli C. Thymosin alpha 1 in the treatment of cancer: from basic research to clinical application. Int J Immunopharmacol. 2000 ; 22: 1067-1076.
    • (2000) Int J Immunopharmacol , vol.22 , pp. 1067-1076
    • Garaci, E.1    Pica, F.2    Rasi, G.3    Favalli, C.4
  • 28
    • 0038082975 scopus 로고    scopus 로고
    • Long-term outcomes of thymosin-alpha 1 and interferon alpha-2b combination therapy in patients with hepatitis B e antigen (HBeAg) negative chronic hepatitis B
    • Saruc M., Ozden N., Turkel N., et al. Long-term outcomes of thymosin-alpha 1 and interferon alpha-2b combination therapy in patients with hepatitis B e antigen (HBeAg) negative chronic hepatitis B. J Pharm Sci. 2003 ; 92: 1386-1395.
    • (2003) J Pharm Sci , vol.92 , pp. 1386-1395
    • Saruc, M.1    Ozden, N.2    Turkel, N.3
  • 29
    • 0035174029 scopus 로고    scopus 로고
    • Do the effects of a protease inhibitor, ulinastatin, on elastase release by blood transfusion depend on interleukin 6?
    • Nishiyama T., Hanaoka K. Do the effects of a protease inhibitor, ulinastatin, on elastase release by blood transfusion depend on interleukin 6? Crit Care Med. 2001 ; 29: 2106-2110.
    • (2001) Crit Care Med , vol.29 , pp. 2106-2110
    • Nishiyama, T.1    Hanaoka, K.2
  • 30
    • 33645506889 scopus 로고    scopus 로고
    • Correlations between plasma levels of polymorphonuclear leukocyte elastase and coagulation and fibrinolysis parameters in patients undergoing major abdominal surgery
    • Nishiyama T., Yokoyama T., Hanaoka K. Correlations between plasma levels of polymorphonuclear leukocyte elastase and coagulation and fibrinolysis parameters in patients undergoing major abdominal surgery. Anesth Res. 1996 ; 32: 369-372.
    • (1996) Anesth Res , vol.32 , pp. 369-372
    • Nishiyama, T.1    Yokoyama, T.2    Hanaoka, K.3
  • 31
    • 9144265427 scopus 로고    scopus 로고
    • Role of interleukin 6 in myocardial dysfunction of meningococcal septic shock
    • Pathan N., Hemingway CA, Alizadeh AA, et al. Role of interleukin 6 in myocardial dysfunction of meningococcal septic shock. Lancet. 2004 ; 363: 203-209.
    • (2004) Lancet , vol.363 , pp. 203-209
    • Pathan, N.1    Hemingway, C.A.2    Alizadeh, A.A.3
  • 32
    • 0346157331 scopus 로고    scopus 로고
    • TIR domain-containing adaptors define the specificity of TLR signaling
    • Yamamoto M., Takeda K., Akira S. TIR domain-containing adaptors define the specificity of TLR signaling. Mol Immunol. 2004 ; 40: 861-868.
    • (2004) Mol Immunol , vol.40 , pp. 861-868
    • Yamamoto, M.1    Takeda, K.2    Akira, S.3
  • 33
    • 3442893287 scopus 로고    scopus 로고
    • The role of peptidoglycan recognition in innate immunity
    • Girardin SE, Philpott DJ The role of peptidoglycan recognition in innate immunity. Eur J Immunol. 2004 ; 34: 1777-1782.
    • (2004) Eur J Immunol , vol.34 , pp. 1777-1782
    • Girardin, S.E.1    Philpott, D.J.2
  • 34
    • 0348048803 scopus 로고    scopus 로고
    • Peptidoglycan recognition proteins (PGRPs)
    • Dziarski R. Peptidoglycan recognition proteins (PGRPs). Mol Immunol. 2004 ; 40: 877-886.
    • (2004) Mol Immunol , vol.40 , pp. 877-886
    • Dziarski, R.1
  • 35
    • 0035158312 scopus 로고    scopus 로고
    • Prophylactic antibiotic administration reduces sepsis and mortality in acute necrotizing pancreatitis: A meta-analysis
    • Sharma VK, Howden CW Prophylactic antibiotic administration reduces sepsis and mortality in acute necrotizing pancreatitis: a meta-analysis. Pancreas. 2001 ; 22: 28-31.
    • (2001) Pancreas , vol.22 , pp. 28-31
    • Sharma, V.K.1    Howden, C.W.2
  • 36
    • 0036724929 scopus 로고    scopus 로고
    • HMGB1 B box increases the permeability of Caco-2 enterocytic monolayers and impairs intestinal barrier function in mice
    • Sappington P., Yang R., Yang H., Tracey KJ, Delude RL, Fink MP HMGB1 B box increases the permeability of Caco-2 enterocytic monolayers and impairs intestinal barrier function in mice. Gastroenterology. 2002 ; 123: 790-702.
    • (2002) Gastroenterology , vol.123 , pp. 790-702
    • Sappington, P.1    Yang, R.2    Yang, H.3    Tracey, K.J.4    Delude, R.L.5    Fink, M.P.6
  • 37
    • 0345447585 scopus 로고    scopus 로고
    • Proinflammatory cytokines disrupt epithelial barrier function by apoptosis independent mechanisms
    • Bruewer M., Luegering A., Kucharzik T., et al. Proinflammatory cytokines disrupt epithelial barrier function by apoptosis independent mechanisms. J Immun. 2003 ; 171: 6164-6172.
    • (2003) J Immun , vol.171 , pp. 6164-6172
    • Bruewer, M.1    Luegering, A.2    Kucharzik, T.3
  • 38
    • 0038690407 scopus 로고    scopus 로고
    • Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis: A randomized controlled trial
    • Abraham E., Reinhart K., Opal S., et al. OPTIMIST Trial Study Group. Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis: a randomized controlled trial. JAMA. 2003 ; 290: 238-247.
    • (2003) JAMA , vol.290 , pp. 238-247
    • Abraham, E.1    Reinhart, K.2    Opal, S.3    Trial Study Group, O.4
  • 39
    • 0038115187 scopus 로고    scopus 로고
    • Aggravation of endotoxin-induced disseminated intravascular coagulation and cytokine activation in heterozygous protein-C-deficient mice
    • Levi M., Dorffler-Melly J., Reitsma P., et al. Aggravation of endotoxin-induced disseminated intravascular coagulation and cytokine activation in heterozygous protein-C-deficient mice. Blood. 2003 ; 101: 4823-4827.
    • (2003) Blood , vol.101 , pp. 4823-4827
    • Levi, M.1    Dorffler-Melly, J.2    Reitsma, P.3
  • 40
    • 4344618571 scopus 로고    scopus 로고
    • Corticosteroids for severe sepsis and septic shock: A systematic review and meta-analysis
    • Annane D., Bellissant E., Bollaert PE, Briegel J., Keh D., Kupfer Y. Corticosteroids for severe sepsis and septic shock: a systematic review and meta-analysis. BMJ. 2004 ; 329: 480.
    • (2004) BMJ , vol.329 , pp. 480
    • Annane, D.1    Bellissant, E.2    Bollaert, P.E.3    Briegel, J.4    Keh, D.5    Kupfer, Y.6
  • 41
    • 3042858950 scopus 로고    scopus 로고
    • Meta-analysis: The effect of steroids on survival and shock during sepsis depends on the dose
    • Minneci PC, Deans KJ, Banks SM, Eichacker PQ, Natanson C. Meta-analysis: the effect of steroids on survival and shock during sepsis depends on the dose. Intern Med. 2004 ; 141: 47-56.
    • (2004) Intern Med , vol.141 , pp. 47-56
    • Minneci, P.C.1    Deans, K.J.2    Banks, S.M.3    Eichacker, P.Q.4    Natanson, C.5
  • 42
    • 0026016470 scopus 로고
    • Treatment of gram-negative bacteremia and septic shock with HA-1A human monoclonal antibody against endotoxin. a randomized, double-blind,placebo- controlled trial. the HA-1A Sepsis Study Group
    • Ziegler EJ, Fisher CJ, Sprung CL, et al. Treatment of gram-negative bacteremia and septic shock with HA-1A human monoclonal antibody against endotoxin. A randomized, double-blind,placebo-controlled trial. The HA-1A Sepsis Study Group. N Engl J Med. 1991 ; 324: 429-436.
    • (1991) N Engl J Med. , vol.324 , pp. 429-436
    • Ziegler, E.J.1    Fisher, C.J.2    Sprung, C.L.3
  • 43
    • 0025997952 scopus 로고
    • Randomized, double-blind phase II study of anti-endotoxin antibody (E5) as adjuvant therapy in humans with serious gram-negative infections
    • Greenberg RN, Wilson KM, Kunz AY, Wedel NI, Gorelick KJ Randomized, double-blind phase II study of anti-endotoxin antibody (E5) as adjuvant therapy in humans with serious gram-negative infections. Prog Clin Biol Res. 1991 ; 367: 179-186.
    • (1991) Prog Clin Biol Res , vol.367 , pp. 179-186
    • Greenberg, R.N.1    Wilson, K.M.2    Kunz, A.Y.3    Wedel, N.I.4    Gorelick, K.J.5
  • 44
    • 0027396598 scopus 로고
    • Assessment of ability of murine and human anti-lipid a monoclonal antibodies to bind and neutralize lipopolysaccharide
    • Warren HS, Amato SF, Fitting C., et al. Assessment of ability of murine and human anti-lipid A monoclonal antibodies to bind and neutralize lipopolysaccharide. J Exp Med. 1993 ; 177: 89-97.
    • (1993) J Exp Med , vol.177 , pp. 89-97
    • Warren, H.S.1    Amato, S.F.2    Fitting, C.3
  • 45
    • 0027487144 scopus 로고
    • Increase in the plasma concentration of reduced glutathione observed in rats with liver damage induced by lipopolysaccharide/D-galactosamine: Effects of ulinastatin, a urinary trypsin inhibitor
    • Okabe H., Irita K., Kurosawa K., et al. Increase in the plasma concentration of reduced glutathione observed in rats with liver damage induced by lipopolysaccharide/D-galactosamine: effects of ulinastatin, a urinary trypsin inhibitor. Circ Shock. 1993 ; 41: 268-272.
    • (1993) Circ Shock , vol.41 , pp. 268-272
    • Okabe, H.1    Irita, K.2    Kurosawa, K.3
  • 46
    • 0037026527 scopus 로고    scopus 로고
    • Protective role of phospholipid oxidation products in endotoxin-induced tissue damage
    • Bochkov VN, Kadl A., Huber J., Gruber F., Binder BR, Leitinger N. Protective role of phospholipid oxidation products in endotoxin-induced tissue damage. Nature. 2002 ; 419: 77-81.
    • (2002) Nature , vol.419 , pp. 77-81
    • Bochkov, V.N.1    Kadl, A.2    Huber, J.3    Gruber, F.4    Binder, B.R.5    Leitinger, N.6
  • 47
    • 0030056373 scopus 로고    scopus 로고
    • Epinephrine inhibits tumor necrosis factor-alpha and potentiates interleukin-10 production during human endotoxemia
    • van der Poll T., Coyle SM, Barbosa K., Braxton CC, Lowry SF Epinephrine inhibits tumor necrosis factor-alpha and potentiates interleukin-10 production during human endotoxemia. J Clin Invest. 1996 ; 97: 713-719.
    • (1996) J Clin Invest , vol.97 , pp. 713-719
    • Van Der Poll, T.1    Coyle, S.M.2    Barbosa, K.3    Braxton, C.C.4    Lowry, S.F.5
  • 48
    • 0042744797 scopus 로고    scopus 로고
    • C-reactive protein: A critical update
    • Pepys MB, Hirschfield GM C-reactive protein: a critical update. J Clin Invest. 2003 ; 111: 1805-1812.
    • (2003) J Clin Invest , vol.111 , pp. 1805-1812
    • Pepys, M.B.1    Hirschfield, G.M.2
  • 49
    • 0033545342 scopus 로고    scopus 로고
    • Acute phase proteins and other systemic responses to inflammation
    • Gabay C., Kushner I. Acute phase proteins and other systemic responses to inflammation. N Engl J Med. 1999 ; 340: 448-454.
    • (1999) N Engl J Med , vol.340 , pp. 448-454
    • Gabay, C.1    Kushner, I.2
  • 50
    • 34247463353 scopus 로고    scopus 로고
    • Clinical trial with a new immunomodulatory strategy: Treatment of severe sepsis with ulinastatin and maipuxin
    • The Cooperative Group of immunomodulatory Therapy of Sepsis
    • The Cooperative Group of immunomodulatory Therapy of Sepsis, Lin HY Clinical trial with a new immunomodulatory strategy: treatment of severe sepsis with ulinastatin and maipuxin. Zhonghua Yi Xue Za Zhi. 2007 ; 87: 451-457.
    • (2007) Zhonghua Yi Xue Za Zhi. , vol.87 , pp. 451-457


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.