Transmissible gastroenteritis virus does not suppress IFN-β induction but is sensitive to IFN in IPEC-J2 cells

Veterinary Microbiology

Volumn 199, Issue , 2017, Pages 128-134

  Zhu, Liqi ^a   Yang, Xing ^a   Mou, Chunxiao ^a   Yang, Qian ^a  

^a NANJING AGRICULTURAL UNIVERSITY   (China)

Author keywords

IFN; Intestinal epithelial cells; ISGs; TGEV

Indexed keywords

BETA INTERFERON; INTERFERON; IMMUNOLOGIC FACTOR; INTERFERON RECEPTOR; POLYINOSINIC POLYCYTIDYLIC ACID;

ANIMAL CELL; ANIMAL CELL CULTURE; ANTIVIRAL ACTIVITY; ARTICLE; CYTOKINE PRODUCTION; GENE ACTIVATION; IMMUNE RESPONSE; INTESTINE EPITHELIUM CELL; NONHUMAN; PIGLET; RECEPTOR UPREGULATION; TRANSMISSIBLE GASTROENTERITIS VIRUS; VIRUS INFECTION; VIRUS REPLICATION; ANIMAL; CELL LINE; DRUG EFFECTS; EPITHELIUM CELL; GENE EXPRESSION REGULATION; GENE INACTIVATION; GENETICS; HOST PATHOGEN INTERACTION; IMMUNOLOGY; PIG; TRANSMISSIBLE GASTROENTERITIS OF SWINE; VIROLOGY;

ANIMALS; CELL LINE; EPITHELIAL CELLS; GASTROENTERITIS, TRANSMISSIBLE, OF SWINE; GENE EXPRESSION REGULATION; GENE KNOCKOUT TECHNIQUES; HOST-PATHOGEN INTERACTIONS; IMMUNOLOGIC FACTORS; INTERFERON TYPE I; INTERFERON-BETA; POLY I-C; RECEPTORS, INTERFERON; SWINE; TRANSMISSIBLE GASTROENTERITIS VIRUS; VIRUS REPLICATION;

EID: 85008600396     PISSN: 03781135     EISSN: 18732542     Source Type: Journal    
DOI: 10.1016/j.vetmic.2016.12.031     Document Type: Article

References (31)

1. Arpaia, N., Barton, G.M., Toll-like receptors: key players in antiviral immunity. Curr. Opin. Virol. 1 (2011), 447–454.
2. Becares, M., Pascual-Iglesias, A., Nogales, A., Sola, I., Enjuanes, L., Zuniga, S., Mutagenesis of coronavirus nsp14 reveals its potential role in modulation of the innate immune response. J. Virol. 90 (2016), 5399–5414.
3. Bouvet, M., Imbert, I., Subissi, L., Gluais, L., Canard, B., Decroly, E., RNA 3′-end mismatch excision by the severe acute respiratory syndrome coronavirus nonstructural protein nsp10/nsp14 exoribonuclease complex. Proc. Natl. Acad. Sci. U. S. A. 109 (2012), 9372–9377.
4. Brosnahan, A.J., Brown, D.R., Porcine IPEC-J2 intestinal epithelial cells in microbiological investigations. Vet. Microbiol. 156 (2012), 229–237.
5. Cao, L., Ge, X., Gao, Y., Herrler, G., Ren, Y., Ren, X., Li, G., Porcine epidemic diarrhea virus inhibits dsRNA-induced interferon-beta production in porcine intestinal epithelial cells by blockade of the RIG-I-mediated pathway. Virol. J., 12, 2015, 127.
6. Chawla-Sarkar, M., Lindner, D.J., Liu, Y.F., Williams, B.R., Sen, G.C., Silverman, R.H., Borden, E.C., Apoptosis and interferons: role of interferon-stimulated genes as mediators of apoptosis. Apoptosis 8 (2003), 237–249.
7. Cruz, J.L., Sola, I., Becares, M., Alberca, B., Plana, J., Enjuanes, L., Zuniga, S., Coronavirus gene 7 counteracts host defenses and modulates virus virulence. PLoS Pathog., 7, 2011, e1002090.
8. Cruz, J.L., Becares, M., Sola, I., Oliveros, J.C., Enjuanes, L., Zuniga, S., Alphacoronavirus protein 7 modulates host innate immune response. J. Virol. 87 (2013), 9754–9767.
9. Cruz, J.L., Becares, M., Sola, I., Oliveros, J.C., Enjuanes, L., Zuniga, S., Alphacoronavirus protein 7 modulates host innate immune response. J. Virol. 87 (2013), 9754–9767.
10. Dixit, E., Boulant, S., Zhang, Y., Lee, A.S., Odendall, C., Shum, B., Hacohen, N., Chen, Z.J., Whelan, S.P., Fransen, M., Nibert, M.L., Superti-Furga, G., Kagan, J.C., Peroxisomes are signaling platforms for antiviral innate immunity. Cell 141 (2010), 668–681.
11. Enjuanes, L., Smerdou, C., Castilla, J., Anton, I.M., Torres, J.M., Sola, I., Golvano, J., Sanchez, J.M., Pintado, B., Development of protection against coronavirus induced diseases. A review. Adv. Exp. Med. Biol. 380 (1995), 197–211.
12. Fung, T.S., Liu, D.X., Coronavirus infection, ER stress, apoptosis and innate immunity. Front. Microbiol., 5, 2014, 296.
13. Katze, M.G., He, Y., Gale, M.J., Viruses and interferon: a fight for supremacy. Nat. Rev. Immunol. 2 (2002), 675–687.
14. Katze, M.G., Fornek, J.L., Palermo, R.E., Walters, K.A., Korth, M.J., Innate immune modulation by RNA viruses: emerging insights from functional genomics. Nat. Rev. Immunol. 8 (2008), 644–654.
15. Kindler, E., Thiel, V., To sense or not to sense viral RNA—essentials of coronavirus innate immune evasion. Curr. Opin. Microbiol. 20 (2014), 69–75.
16. Loo, Y.M., Gale, M.J., Immune signaling by RIG-I-like receptors. Immunity 34 (2011), 680–692.
17. Lundin, A., Dijkman, R., Bergström, T., Kann, N., Adamiak, B., Hannoun, C., Kindler, E., Jónsdóttir, H.R., Muth, D., Kint, J., Targeting membrane-bound viral RNA synthesis reveals potent inhibition of diverse coronaviruses including the middle East respiratory syndrome virus. PLoS Pathog. 10 (2014), 1178–1191.
18. Marquez-Jurado, S., Nogales, A., Zuniga, S., Enjuanes, L., Almazan, F., Identification of a gamma interferon-activated inhibitor of translation-like RNA motif at the 3′ end of the transmissible gastroenteritis coronavirus genome modulating innate immune response. mBio, 6, 2015, e00105.
19. McNab, F., Mayer-Barber, K., Sher, A., Wack, A., O'Garra, A., Type I interferons in infectious disease. Nat. Rev. Immunol. 15 (2015), 87–103.
20. Mcclurkin, A.W., Studies on transmissible gastroenteritis of swine. I. The isolation and identification of a cytopathogenic virus of transmissible gastroenteritis in primary swine kidney cell cultures. Can. J. Compar. Med. Vet. Sci. 29 (1965), 46–53.
21. Narayanan, K., Ramirez, S.I., Lokugamage, K.G., Makino, S., Coronavirus nonstructural protein 1: common and distinct functions in the regulation of host and viral gene expression. Virus Res. 202 (2015), 89–100.
22. Sadler, A.J., Williams, B.R., Interferon-inducible antiviral effectors. Nat. Rev. Immunol. 8 (2008), 559–568.
23. Shi, C.S., Qi, H.Y., Boularan, C., Huang, N.N., Abu-Asab, M., Shelhamer, J.H., Kehrl, J.H., SARS-coronavirus open reading frame-9b suppresses innate immunity by targeting mitochondria and the MAVS/TRAF3/TRAF6 signalosome. J. Immunol. 193 (2014), 3080–3089.
24. Snijder, E.J., van der Meer, Y., Zevenhoven-Dobbe, J., Onderwater, J.J., van der Meulen, J., Koerten, H.K., Mommaas, A.M., Ultrastructure and origin of membrane vesicles associated with the severe acute respiratory syndrome coronavirus replication complex. J. Virol. 80 (2006), 5927–5940.
25. Totura, A.L., Baric, R.S., SARS coronavirus pathogenesis: host innate immune responses and viral antagonism of interferon. Curr. Opin. Virol. 2 (2012), 264–275.
26. Vergauwen, H., The IPEC-J2 Cell Line. 2015, Springer International Publishing.
27. Wang, D., Fang, L., Shi, Y., Zhang, H., Gao, L., Peng, G., Chen, H., Li, K., Xiao, S., Porcine epidemic diarrhea virus 3C-like protease regulates its interferon antagonism by cleaving NEMO. J. Virol. 90 (2016), 2090–2101.
28. Weingartl, H.M., Derbyshire, J.B., Antiviral activity against transmissible gastroenteritis virus, and cytotoxicity, of natural porcine interferons alpha and beta. Can. J. Vet. Res. 55 (1991), 143–149.
29. Wong, M.T., Chen, S.S., Emerging roles of interferon-stimulated genes in the innate immune response to hepatitis C virus infection. Cell. Mol. Immunol. 13 (2016), 11–35.
30. Zust, R., Cervantesbarragan, L., Habjan, M., Maier, R., Neuman, B.W., Ziebuhr, J., Szretter, K.J., Baker, S.C., Barchet, W., Diamond, M.S., Ribose 2′-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5. Nat. Immunol. 12 (2011), 137–143.
31. Zust, R., Cervantes-Barragan, L., Habjan, M., Maier, R., Neuman, B.W., Ziebuhr, J., Szretter, K.J., Baker, S.C., Barchet, W., Diamond, M.S., Siddell, S.G., Ludewig, B., Thiel, V., Ribose 2′-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5. Nat. Immunol. 12 (2011), 137–143.