Mechanisms of diminished attention to eyes in Autism

American Journal of Psychiatry

Volumn 174, Issue 1, 2017, Pages 26-35

  Moriuchi, Jennifer M ^a   Klin, Ami ^a   Jones, Warren ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; ASSOCIATION; AUTISM; AVERSION; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; EYE FIXATION; EYE TRACKING; GAZE; HUMAN; LATENT PERIOD; PRESCHOOL CHILD; PRIORITY JOURNAL; SACCADIC EYE MOVEMENT; VISUAL ATTENTION; VISUAL STIMULATION; ATTENTION; AUTISM SPECTRUM DISORDER; EMOTION; EYE; FACIAL EXPRESSION; FEMALE; HUMAN RELATION; MALE; PATHOPHYSIOLOGY; PHYSIOLOGY; PSYCHOLOGY; REACTION TIME; REFERENCE VALUE; VISION;

ATTENTION; AUTISM SPECTRUM DISORDER; CHILD, PRESCHOOL; CUES; EMOTIONS; EYE; FACIAL EXPRESSION; FEMALE; FIXATION, OCULAR; HUMANS; INTERPERSONAL RELATIONS; MALE; REACTION TIME; REFERENCE VALUES; SACCADES; VISUAL PERCEPTION;

EID: 85008507488     PISSN: 0002953X     EISSN: 15357228     Source Type: Journal    
DOI: 10.1176/appi.ajp.2016.15091222     Document Type: Article

References (47)

1. Robins D, Fein D, Barton M: The Modified Checklist for Autism in Toddlers (M-CHAT). Storrs, University of Connecticut, 1999
2. Lord C, Rutter M, DiLavore PC, et al: Autism Diagnostic Observation Schedule. Los Angeles, Western Psychological Services, 2002
3. Jones W, Klin A: Attention to eyes is present but in decline in 2-6-month-old infants later diagnosed with autism. Nature 2013; 504: 427-431
4. Pelphrey KA, Sasson NJ, Reznick JS, et al: Visual scanning of faces in autism. J Autism Dev Disord 2002; 32:249-261
5. Yoder P, Stone WL, Walden T, et al: Predicting social impairment and ASD diagnosis in younger siblings of children with autism spectrum disorder. J Autism Dev Disord 2009; 39:1381-1391
6. Hutt C, Ounsted C: The biological significance of gaze aversion with particular reference to the syndrome of infantile autism. Behav Sci 1966; 11:346-356
7. KliemannD, Dziobek I, Hatri A, et al: Atypical reflexive gaze patterns on emotional faces in autism spectrum disorders. J Neurosci 2010; 30:12281-12287
8. Senju A, Johnson MH: Atypical eye contact in autism: models, mechanisms, and development. Neurosci Biobehav Rev 2009; 33: 1204-1214
9. Cohen IL, Vietze PM, Sudhalter V, et al: Parent-child dyadic gaze patterns in fragile X males and in non-fragile X males with autistic disorder. J Child Psychol Psychiatry 1989; 30:845-856
10. Tanaka JW, Sung A: The "eye avoidance" hypothesis of autism face processing. J Autism Dev Disord 2016; 46:1538-1552.
11. Tottenham N, Hertzig ME, Gillespie-Lynch K, et al: Elevated amygdala response to faces and gaze aversion in autism spectrum disorder. Soc Cogn Affect Neurosci 2014; 9:106-117.
12. Klin A, Jones W, Schultz R, et al: Defining and quantifying the social phenotype in autism. Am J Psychiatry 2002; 159:895-908
13. Kylliäinen A, Hietanen JK: Skin conductance responses to another person's gaze in children with autism. J Autism Dev Disord 2006; 36: 517-525
14. Kaartinen M, Puura K, Mäkelä T, et al: Autonomic arousal to direct gaze correlates with social impairments among children with ASD. J Autism Dev Disord 2012; 42:1917-1927
15. Kleinhans NM, Richards T, Weaver K, et al: Association between amygdala response to emotional faces and social anxiety in autism spectrum disorders. Neuropsychologia 2010; 48:3665-3670
16. Dalton KM, Nacewicz BM, Johnstone T, et al: Gaze fixation and the neural circuitry of face processing in autism. Nat Neurosci 2005; 8: 519-526
17. Corden B, Chilvers R, Skuse D: Avoidance of emotionally arousing stimuli predicts social-perceptual impairment in Asperger's syndrome. Neuropsychologia 2008; 46:137-147
18. Joseph RM, Ehrman K, McNally R, et al: Affective response to eye contact and face recognition ability in children with ASD. J Int Neuropsychol Soc 2008; 14:947-955
19. Pierce K, Müller RA,AmbroseJ, et al: Face processing occurs outside the fusiform "face area" in autism: evidence from functional MRI. Brain 2001; 124:2059-2073
20. Pelphrey KA, Shultz S, Hudac CM, et al: Research review: constraining heterogeneity: The social brain and its development in autism spectrum disorder. J Child Psychol Psychiatry 2011; 52: 631-644
21. Pelphrey KA, Morris JP, McCarthy G: Neural basis of eye gaze processing deficits in autism. Brain 2005; 128:1038-1048
22. Kampe KKW, Frith CD, Dolan RJ, et al: Reward value of attractiveness and gaze. Nature 2001; 413:589-602
23. Davies MS, Dapretto M, Sigman M, et al: Neural bases of gaze and emotion processing in children with autism spectrum disorders. Brain Behav 2011; 1:1-11
24. Nummenmaa L, Calder AJ: Neural mechanisms of social attention. Trends Cogn Sci 2009; 13:135-143
25. Parkes SL, Balleine BW: Incentive memory: evidence the basolateral amygdala encodes and the insular cortex retrieves outcome values to guide choice between goal-directed actions. J Neurosci 2013; 33: 8753-8763
26. Holland PC, GallagherM:Amygdala-frontal interactions and reward expectancy. Curr Opin Neurobiol 2004; 14:148-155
27. Zamzow RM, Christ SE, Saklayen SS, et al: Effect of propranolol on facial scanning in autism spectrum disorder: A preliminary investigation. J Clin Exp Neuropsychol 2014; 36:431-445
28. Golan O, Ashwin E, Granader Y, et al: Enhancing emotion recognition in children with autism spectrum conditions: an intervention using animated vehicles with real emotional faces. J Autism Dev Disord 2010; 40:269-279
29. Rutter M, LeCouter A, Lord C: Autism Diagnostic Interview-Revised. Los Angeles, Western Psychological Services, 2003
30. Mullen EM: Mullen Scales of Early Learning: AGS Edition. Circle Pines, Minn, American Guidance Service, 1995
31. Senju A, Tojo Y, Dairoku H, et al: Reflexive orienting in response to eye gaze and an arrow in children with and without autism. J Child Psychol Psychiatry 2004; 45:445-458
32. Chawarska K, Klin A, Volkmar F: Automatic attention cueing through eyemovementin 2-year-old children with autism. ChildDev 2003; 74:1108-1122
33. Stone M: Cross-validatory choice and assessment of statistical predictions. J R Stat Soc B 1974; 36:111-147
34. Pflugshaupt T, Mosimann UP, von Wartburg R, et al: Hypervigilanceavoidance pattern in spider phobia. J Anxiety Disord 2005; 19: 105-116
35. Silverman BW: Density Estimation for Statistics and Data Analysis. London, Chapman and Hall, 1986
36. Jones W, Carr K, Klin A: Absence of preferential looking to the eyes of approaching adults predicts level of social disability in 2-year-old toddlers with autism spectrum disorder. Arch Gen Psychiatry 2008; 65:946-954
37. Landry R, Bryson SE: Impaired disengagement of attention in young children with autism. J Child Psychol Psychiatry 2004; 45:1115-1122
38. Shultz S, Klin A, Jones W: Inhibition of eye blinking reveals subjective perceptions of stimulus salience. Proc NatlAcadSciUSA2011; 108:21270-21275
39. Nation K, Penny S: Sensitivity to eye gaze in autism: Is it normal? Is it automatic? Is it social? Dev Psychopathol 2008; 20:79-97
40. Mundy P, Sullivan L, Mastergeorge AM: A parallel and distributedprocessing model of joint attention, social cognition, and autism. Autism Res 2009; 2:2-21
41. Baron-Cohen S, Campbell R, Karmiloff-Smith A, et al: Are children with autism blind to the mentalistic significance of the eyes? Br J Dev Psychol 1995; 13:379-398
42. Robison JE:LookMein the Eye:MyLifeWithAsperger's.NewYork, Crown Publishing Group, 2007
43. van Steensel FJ, Bögels SM, Perrin S: Anxiety disorders in children and adolescents with autistic spectrum disorders: A meta-analysis. Clin Child Fam Psychol Rev 2011; 14:302-317
44. White SW, Oswald D, Ollendick T, et al: Anxiety in children and adolescents with autism spectrum disorders. Clin Psychol Rev 2009; 29:216-229
45. Davidson RJ, Ekman P, Saron CD, et al: Approach-withdrawal and cerebral asymmetry: emotional expression and brain physiology, I. J Pers Soc Psychol 1990; 58:330-341
46. Kylliäinen A, Wallace S, CoutancheMN, et al: Affective-motivational brain responses to direct gaze in children with autism spectrum disorder. J Child Psychol Psychiatry 2012; 53:790-797
47. Mundy P: Annotation: The neural basis of social impairments in autism: The role of the dorsal medial-frontal cortex and anterior cingulate system. J Child Psychol Psychiatry 2003; 44: 793-809