Atypical reflexive gaze patterns on emotional faces in autism spectrum disorders

Journal of Neuroscience

Volumn 30, Issue 37, 2010, Pages 12281-12287

  Kliemann, Dorit ^a,b   Dziobek, Isabel ^a   Hatri, Alexander ^a   Steimke, Rosa ^a,c   Heekeren, Hauke R ^a,b  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b MAX PLANCK INSTITUTE FOR HUMAN DEVELOPMENT   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; AUTISM; AVOIDANCE BEHAVIOR; CLINICAL ARTICLE; CONTROLLED STUDY; EMOTIONALITY; EYE MOVEMENT; EYE TRACKING; FEMALE; GAZE; HUMAN; MALE; PRIORITY JOURNAL; VISUAL STIMULATION; CHILD; CHILD DEVELOPMENT DISORDERS, PERVASIVE; EYE FIXATION; FACIES; MIDDLE AGED; NEUROPSYCHOLOGICAL TEST; OCULAR MOTILITY DISORDERS; PATHOPHYSIOLOGY; PHYSIOLOGY; PSYCHOLOGY; SOCIAL BEHAVIOR DISORDERS; YOUNG ADULT;

ADULT; CHILD; CHILD DEVELOPMENT DISORDERS, PERVASIVE; EYE MOVEMENTS; FACIES; FEMALE; FIXATION, OCULAR; HUMANS; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; OCULAR MOTILITY DISORDERS; SOCIAL BEHAVIOR DISORDERS; YOUNG ADULT;

EID: 77956859727     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0688-10.2010     Document Type: Article

References (45)

1. Adolphs R, Tranel D, Damasio AR (1998) The human amygdala in social judgment. Nature 393:470-474.
2. Adolphs R, Gosselin F, Buchanan TW, Tranel D, Schyns P, Damasio AR (2005) A mechanism for impaired fear recognition after amygdala damage. Nature 433:68-72.
3. American Psychiatric Association (1994) Diagnostic and statistical manual of mental disorders, Ed 4. Washington, DC: American Psychiatric Press.
4. Anders S, Eippert F, Weiskopf N, Veit R (2008) The human amygdala is sensitive to the valence of pictures and sounds irrespective of arousal: an fMRI study. Soc Cogn Affect Neurosci 3:233-243.
5. Asghar AU, Chiu YC, Hallam G, Liu S, Mole H, Wright H, YoungAW (2008) An amygdala response to fearful faces with covered eyes. Neuropsychologia 46:2364-2370.
6. Ball T, Rahm B, Eickhoff SB, Schulze-Bonhage A, Speck O, Mutschler I (2007) Response properties of human amygdala subregions: evidence based on functional MRI combined with probabilistic anatomical maps. PLoS ONE 2:e307.
7. Baron-Cohen S, Ring HA, Bullmore ET, Wheelwright S, Ashwin C, Williams SC (2000) The amygdala theory of autism. Neurosci Biobehav Rev 24:355-364.
8. Baron-Cohen S, Wheelwright S, Hill J, Raste Y, Plumb I (2001a) The "Reading the Mind in the Eyes" Test revised version: a study with normal adults, and adults with Asperger syndrome or high-functioning autism. J Child Psychol Psychiatry 42:241-251.
9. Baron-Cohen S, Wheelwright S, Skinner R, Martin J, Clubley E (2001b) The autism-spectrum quotient (AQ): evidence from Asperger syndrome/ high-functioning autism, males and females, scientists and mathematicians. J Autism Dev Disord 31:5-17.
10. Bölte S, Poustka F (2001) Factor structure of the Autism Diagnostic Interview-Revised (ADI-R): a study of dimensional versus categorical classification of autistic disorders. Z Kinder Jugendpsychiatr Psychother 29:221-229.
11. Dalton KM, Nacewicz BM, Johnstone T, Schaefer HS, Gernsbacher MA, Goldsmith HH, Alexander AL, Davidson RJ (2005) Gaze fixation and the neural circuitry of face processing in autism. Nat Neurosci 8:519-526.
12. Gamer M, Büchel C (2009) Amygdala activation predicts gaze toward fearful eyes. J Neurosci 29:9123-9126.
13. Gamer M, Zurowski B, Büchel C (2010) Different amygdala subregions mediate valence-related and attentional effects of oxytocin in humans. Proc Natl Acad Sci U S A 107:9400-9405.
14. Gillberg C, Gillberg C, Råstam M, Wentz E (2001) The Asperger Syndrome (and High-Functioning Autism) Diagnostic Interview (ASDI): a preliminary study of a new structured clinical interview. Autism 5:57-66.
15. Goeleven E, De Raedt R, Leyman L, Verschuere B (2008) The Karolinska directed emotional faces: a validation study. Cogn Emotion 22:1094-1118.
16. Goldberg MC, Lasker AG, Zee DS, Garth E, Tien A, Landa RJ (2002) Deficits in the initiation of eye movements in the absence of a visual target in adolescents with high functioning autism. Neuropsychologia 40:2039-2049.
17. Hadjikhani N, Hoge R, Snyder J, de Gelder B (2008) Pointing with the eyes: the role of gaze in communicating danger. Brain Cogn 68:1-8.
18. Hurlemann R, Rehme AK, Diessel M, Kukolja J, Maier W, Walter H, Cohen MX (2008) Segregating intra-amygdalar responses to dynamic facial emotion with cytoarchitectonic maximum probability maps. J Neurosci Methods 172:13-20.
19. Hutt C, Ounsted C (1966) Biological Significance of Gaze Aversion with Particular Reference to Syndrome of Infantile Autism. Behavioral Science 11:346-356.
20. Joseph RM, Ehrman K, McNally R, Keehn B (2008) Affective response to eye contact and face recognition ability in children with ASD. J Int Neuropsychol Soc 14:947-955.
21. Klin A, Jones W, Schultz R, Volkmar F, Cohen D (2002) Visual fixation patterns during viewing of naturalistic social situations as predictors of social competence in individuals with autism. Arch Gen Psychiatry 59:809-816.
22. Kylliäinen A, Hietanen JK (2006) Skin conductance responses to another person's gaze in children with autism. J Autism Dev Disord 36:517-525.
23. LeDoux JE, Iwata J, Cicchetti P, Reis DJ (1988) Different projections of the central amygdaloid nucleus mediate autonomic and behavioral correlates of conditioned fear. J Neurosci 8:2517-2529.
24. Leekam SR, Hunnisett E, Moore C (1998) Targets and cues: gaze-following in children with autism. J Child Psychol Psychiatry 39:951-962.
25. Lehrl S, Triebig G, Fischer B (1995) Multiple choice vocabulary test MWT as a valid and short test to estimate premorbid intelligence. Acta Neurol Scand 91:335-345.
26. Lord C, Rutter M, Le Couteur A (1994) Autism diagnostic interview-revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. J Autism Dev Disord 24:659-685.
27. Luna B, Doll SK, Hegedus SJ, Minshew NJ, Sweeney JA (2007) Maturation of executive function in autism. Biol Psychiatry 61:474-481.
28. Lundqvist D, Flykt A, Öhmann A (1998) The Karolinska directed emotional faces - KDEF, CD-ROM from Department of Clinical Neuroscience, Psychology section, Karoliska Institutet.
29. Minshew NJ, Luna B, Sweeney JA (1999) Oculomotor evidence for neocortical systems but not cerebellar dysfunction in autism. Neurology 52:917-922.
30. Morris JS, Frith CD, Perrett DI, Rowland D, Young AW, Calder AJ, Dolan RJ (1996) A differential neural response in the human amygdala to fearful and happy facial expressions. Nature 383:812-815.
31. Nation K, Penny S (2008) Sensitivity to eye gaze in autism: is it normal? Is it automatic? Is it social? Dev Psychopathol 20:79-97.
32. Neumann D, Spezio ML, Piven J, Adolphs R (2006) Looking you in the mouth: abnormal gaze in autism resulting from impaired top-down modulation of visual attention. Soc Cogn Affect Neurosci 1:194-202.
33. Nowinski CV, Minshew NJ, Luna B, Takarae Y, Sweeney JA (2005) Oculomotor studies of cerebellar function in autism. Psychiatry Res 137:11-19.
34. Pelphrey KA, Sasson NJ, Reznick JS, Paul G, Goldman BD, Piven J (2002) Visual scanning of faces in autism. J Autism Dev Disord 32:249-261.
35. Pessoa L, Japee S, Ungerleider LG (2005a) Visual awareness and the detection of fearful faces. Emotion 5:243-247.
36. Pessoa L, Padmala S, Morland T (2005b) Fate of unattended fearful faces in the amygdala is determined by both attentional resources and cognitive modulation. Neuroimage 28:249-255.
37. Phelps EA, Delgado MR, Nearing KI, LeDoux JE (2004) Extinction learning in humans: role of the amygdala and vmPFC. Neuron 43:897-905.
38. Richer JM, Coss RG (1976) Gaze aversion in autistic and normal children. Acta Psychiatr Scand 53:193-210.
39. Schultz RT (2005) Developmental deficits in social perception in autism: the role of the amygdala and fusiform face area. Int J Dev Neurosci 23:125-141.
40. Senju A, Johnson MH (2009) Atypical eye contact in autism: models, mechanisms and development. Neurosci Biobehav Rev 33:1204-1214.
41. Seymour B, O'Doherty JP, Koltzenburg M, Wiech K, Frackowiak R, Friston K, Dolan R (2005) Opponent appetitive-aversive neural processes underlie predictive learning of pain relief. Nat Neurosci 8:1234-1240.
42. Smith ML, Cottrell GW, Gosselin F, Schyns PG (2005) Transmitting and decoding facial expressions. Psychol Sci 16:184-189.
43. Spezio ML, Adolphs R, Hurley RS, Piven J (2007a) Analysis of face gaze in autism using "Bubbles." Neuropsychologia 45:144-151.
44. Spezio ML, Huang PY, Castelli F, Adolphs R (2007b) Amygdala damage impairs eye contact during conversations with real people. J Neurosci 27:3994-3997.
45. Thakkar KN, Polli FE, Joseph RM, Tuch DS, Hadjikhani N, Barton JJ, Manoach DS (2008) Response monitoring, repetitive behaviour and anterior cingulate abnormalities in autism spectrum disorders (ASD). Brain 131:2464-2478.