One shot to rule out: Does the limit of detection of a high-sensitivity troponin assay hit the mark?

Clinical Chemistry

Volumn 63, Issue 1, 2017, Pages 21-23

  Body, Richard ^a,b,c   Reynard, Charles ^b  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b NATIONAL HEALTH SERVICE   (United Kingdom)

^c MANCHESTER METROPOLITAN UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; TROPONIN; BIOLOGICAL MARKER; TROPONIN I; TROPONIN T;

ACUTE CORONARY SYNDROME; ACUTE HEART INFARCTION; DIAGNOSTIC TEST ACCURACY STUDY; EDITORIAL; ELECTROCARDIOGRAM; HEART DISEASE; HEART INFARCTION; HUMAN; LIMIT OF DETECTION; PREDICTION; PREDICTIVE VALUE; RANDOMIZED CONTROLLED TRIAL (TOPIC); SECONDARY ANALYSIS; SENSITIVITY AND SPECIFICITY; BIOASSAY; BLOOD; PROCEDURES;

BIOLOGICAL ASSAY; BIOMARKERS; HUMANS; LIMIT OF DETECTION; MYOCARDIAL INFARCTION; TROPONIN I; TROPONIN T;

EID: 85008428554     PISSN: 00099147     EISSN: 15308561     Source Type: Journal    
DOI: 10.1373/clinchem.2016.266460     Document Type: Editorial

References (12)

1. Body R, Carley S, McDowell G, Jaffe AS, France M, Cruickshank K, et al. Rapid exclusion of acute myocardial infarction in patients with undetectable troponin using a highsensitivity assay. J Am Coll Cardiol 2011;58:1332-9.
2. Bandstein N, Ljung R, Johansson M, Holzmann MJ. Undetectable high sensitivity troponin T level in the Emergency Department and risk of myocardial infarction. J Am Coll Cardiol 2014;63:2569-78.
3. Body R, Burrows G, Carley S, Cullen L, Than M, Jaffe AS, et al. High-sensitivity cardiac troponin t concentrations below the limit of detection to exclude acute myocardial infarction: a prospective evaluation. Clin Chem 2015;61:983-9.
4. Body R, Carley SD, Burrows G, Mackway-Jones K. The Manchester Acute Coronary Syndromes (MACS) decision rule to reduce unnecessary admissions for cardiac chest pain: derivation and external validation [Abstract]. Acad Emerg Med 2012;19:744.
5. Carlton E, Kendall J, Khattab A, Greaves K. Low concentrations of high-sensitivity troponin T at presentation to the Emergency Department. Clin Chem 2017;63:431-2.
6. Shortt C, Ma J, Clayton N, Sherbino J, Whitlock R, Pare G, et al. Rule-in and rule-out of myocardial infarctionusing cardiac troponin and glycemic biomarkersinpatientswith symptoms suggestive of acute coronary syndrome. Clin Chem 2017;63:403-14.
7. Shah A S V, Anand A, Sandoval Y, Lee KK, Smith SW, Adamson PD, et al. High-sensitivity cardiactroponinIatpresentationinpatients with suspected acutecoronary syndrome: a cohort study. Lancet. 2015;386:2481-8.
8. Carlton E, Greenslade J, Cullen L, Body R, Than M, Pickering JW, et al. Evaluation of high-sensitivity cardiac troponin I levels in patients with suspected acute coronary syndrome. JAMA Cardiol 2016;1:405.
9. Neumann JT, Sorensen NA, Ojeda F, Schwemer T, Lehmacher J, Gonner S, et al. Immediate rule-outofacute myocardial infarction using electrocardiogram and baseline high-sensitivity troponin I. Clin Chem 2017;63:394-402.
10. Sandoval Y, Smith SW, Shah A, Anand A, Chapman AR, Love SA, et al. Rapid rule-out of acute myocardial injury using a single high-sensitivity cardiac troponin I measurement. Clin Chem 2017;63:369-76.
11. Mueller C, Giannitsis E, Christ M, Ordóñez-Llanos J, De Filippi C, McCord J, et al. Multicenter evaluation of a 0-hour/1-hour algorithm in the diagnosis of myocardial infarction with high-sensitivity cardiac troponin T. Ann Emerg Med 2016;68:76-87.
12. Body R, Carlton E, Sperrin M, Lewis PS, Burrows G, Carley S, et al. Troponin-only Manchester Acute Coronary Syndromes (T-MACS) decision aid: single biomarker rederivation and external validation in three cohorts. Emerg Med J 2016 Aug. 26; emermed-2016-205983.