Evaluation of high-sensitivity cardiac Troponin i levels in patients with suspected acute coronary syndrome

JAMA Cardiology

Volumn 1, Issue 4, 2016, Pages 405-412

  Carlton, Edward ^a   Greenslade, Jaimi ^b,c,d   Cullen, Louise ^b,c,d   Body, Richard ^e   Than, Martin ^e,f   Pickering, John W ^f,g   Aldous, Sally ^f   Carley, Simon ^e   Hammett, Christopher ^b   Kendall, Jason ^a   Keevil, Brian ^e   Lord, Sarah ^h   Parsonage, William ^b   Greaves, Kim ⁱ  

^a SOUTHMEAD HOSPITAL   (United Kingdom)

^b ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

^c UNIVERSITY OF QUEENSLAND   (Australia)

^d QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

^e MANCHESTER UNIVERSITY NHS FOUNDATION TRUST   (United Kingdom)

^f CHRISTCHURCH HOSPITAL   (New Zealand)

^g UNIVERSITY OF OTAGO   (New Zealand)

^h UNIVERSITY OF NOTRE DAME   (Australia)

ⁱ UNIVERSITY OF THE SUNSHINE COAST   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

TROPONIN I;

ACUTE HEART INFARCTION; ADULT; AGED; ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; ELECTROCARDIOGRAPHY; FEMALE; FOLLOW UP; HIGH SENSITIVITY TROPONIN I ASSAY; HOSPITAL DISCHARGE; HUMAN; IMMUNOASSAY; IMMUNOASSAY ANALYZER; LIMIT OF DETECTION; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; PREDICTIVE VALUE; PROTEIN BLOOD LEVEL; SENSITIVITY AND SPECIFICITY; THORAX PAIN; ACUTE CORONARY SYNDROME; AUSTRALIA; BLOOD; COMPLICATION; ENGLAND; HEART INFARCTION; META ANALYSIS; NEW ZEALAND; PROSPECTIVE STUDY;

ACUTE CORONARY SYNDROME; ADULT; AGED; AUSTRALIA; CHEST PAIN; COHORT STUDIES; ENGLAND; FEMALE; HUMANS; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; NEW ZEALAND; PROSPECTIVE STUDIES; SENSITIVITY AND SPECIFICITY; TROPONIN I;

EID: 85008445512     PISSN: 23806583     EISSN: 23806591     Source Type: Journal    
DOI: 10.1001/jamacardio.2016.1309     Document Type: Article

References (19)

1. Niska R, Bhuiya F, Xu J. National Hospital Ambulatory Medical Care Survey: 2007 emergency department summary. Natl Health Stat Report. 2010;26(26):1-31.
2. Amsterdam EA, Wenger NK, Brindis RG, et al; American College of Cardiology; American Heart Association Task Force on Practice Guidelines; Society for Cardiovascular Angiography and Interventions; Society of Thoracic Surgeons; American Association for Clinical Chemistry. 2014 AHA/ACC Guideline for the Management of Patients with Non-ST-Elevation Acute Coronary Syndromes: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2014;64 (24):e139-e228.
3. Thokala P, Goodacre SW, Collinson PO, et al. Cost-effectiveness of presentation versus delayed troponin testing for acute myocardial infarction. Heart. 2012;98(20):1498-1503.
4. Bandstein N, Ljung R, Johansson M, Holzmann MJ. Undetectable high-sensitivity cardiac troponin T level in the emergency department and risk of myocardial infarction. J Am Coll Cardiol. 2014;63 (23):2569-2578.
5. Shah ASV, Anand A, Sandoval Y, et al; High-STEACS investigators. High-sensitivity cardiac troponin I at presentation in patients with suspected acute coronary syndromes: A cohort study. Lancet. 2015;386(10012):2481-2488.
6. Zhelev Z, Hyde C, Youngman E, et al. Diagnostic accuracy of single baseline measurement of Elecsys troponin T high-sensitive assay for diagnosis of acutemyocardial infarction in emergency department: Systematic review and meta-analysis. BMJ. 2015;350:h15.
7. Than M, HerbertM, Flaws D, et al. What is an acceptable risk of major adverse cardiac event in chest pain patients soon after discharge from the emergency department?. a clinical survey. Int J Cardiol. 2013;166(3):752-754.
8. Than M, Cullen L, Aldous S, et al. 2-Hour accelerated diagnostic protocol to assess patients with chest pain symptoms using contemporary troponins as the only biomarker: The ADAPT trial. J Am Coll Cardiol. 2012;59(23):2091-2098.
9. Carlton EW, Cullen L, Than M, Gamble J, Khattab A, Greaves K. A novel diagnostic protocol to identify patients suitable for discharge after a single high-sensitivity troponin. Heart. 2015;101(13): 1041-1046.
10. Body R, Cook G, Burrows G, Carley S, Lewis PS. Can emergency physicians "rule in" and "rule out" acutemyocardial infarction with clinical judgement?. Emerg Med J. 2014;31(11):872-876.
11. Body R, Lewis PS, Carley S, Burrows G, Haves B, Cook G. Chest pain: If it hurts a lot, is heart attack more likely?. Eur J Emerg Med. 2016;23(2):89-94.
12. Cullen L, Than M, Brown AFT, et al. Comprehensive standardized data definitions for acute coronary syndrome research in emergency departments in Australasia. Emerg Med Australas. 2010;22(1):35-55.
13. Kavsak PA, MacRae AR, Yerna MJ, Jaffe AS. Analytic and clinical utility of a next-generation, highly sensitive cardiac troponin I assay for early detection ofmyocardial injury. Clin Chem. 2009;55 (3):573-577.
14. Thygesen K, Alpert JS, Jaffe AS, et al; Joint ESC/ACCF/AHA/WHF Task Force for Universal Definition ofMyocardial Infarction; Authors/Task Force Members Chairpersons; Biomarker Subcommittee; ECG Subcommittee; Imaging Subcommittee; Classification Subcommittee; Intervention Subcommittee; Trials & Registries Subcommittee; Trials & Registries Subcommittee; Trials & Registries Subcommittee; Trials & Registries Subcommittee; ESC Committee for Practice Guidelines (CPG); Document Reviewers. Third universal definition ofmyocardial infarction. J Am Coll Cardiol. 2012;60(16):1581-1598.
15. Body R, Carley S, McDowell G, et al. Rapid exclusion of acutemyocardial infarction in patients with undetectable troponin using a high-sensitivity assay. J Am Coll Cardiol. 2011;58(13):1332-1339.
16. Rubini Giménez M, Hoeller R, Reichlin T, et al. Rapid rule out of acutemyocardial infarction using undetectable levels of high-sensitivity cardiac troponin. Int J Cardiol. 2013;168(4):3896-3901.
17. Body R, Burrows G, Carley S, et al. High-sensitivity cardiac troponin T concentrations below the limit of detection to exclude acute myocardial infarction: A prospective evaluation. Clin Chem. 2015;61(7):983-989.
18. NICE: National Institute of Health Excellence. Myocardial infarction (acute): Early rule-out using high-sensitivity troponin tests (Elecsys Troponin T high-sensitive, ARCHITECT STAT high sensitive troponin-I and AccuTnI+3 assays): NICE diagnostics guidance [DC15]. http://www.nice.org.uk/guidance /dg15. Published October 2014. Accessed April 5, 2016.
19. Apple FS, Jaffe AS, Collinson P, et al; International Federation of Clinical Chemistry (IFCC) Task Force on Clinical Applications of Cardiac Bio-Markers. IFCC educational materials on selected analytical and clinical applications of high sensitivity cardiac troponin assays. Clin Biochem. 2015;48(4-5):201-203.