CK2 inhibitor CX-4945 destabilizes NOTCH1 and synergizes with JQ1 against human t-acute lymphoblastic leukemic cells

Haematologica

Volumn 102, Issue 1, 2017, Pages e17-e21

  Lian, Haiwei ^a,b,c   Li, Dun ^b   Zhou, Yun ^b,c   Landesman Bollag, Esther ^b   Zhang, Guanglan ^d   Anderson, Nicole M ^b   Tang, Kevin Charles ^b   Roderick, Justine E ^e   Kelliher, Michelle A ^e   Seldin, David C ^b   Fu, Hui ^a   Feng, Hui ^b  

^a WUHAN UNIVERSITY   (China)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

^d BOSTON UNIVERSITY   (United States)

^e UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 CHLOROPHENYL) 2,3,9 TRIMETHYL 6H THIENO[3,2 F][1,2,4]TRIAZOLO[4,3 A][1,4]DIAZEPINE 6 ACETIC ACID TERT BUTYL ESTER; MYC PROTEIN; NOTCH1 RECEPTOR; SILMITASERTIB; (+)-JQ1 COMPOUND; 5-(3-CHLOROPHENYLAMINO)BENZO(C)(2,6)NAPHTHYRIDINE-8-CARBOXYLIC ACID; AZEPINE DERIVATIVE; CASEIN KINASE II; NAPHTHYRIDINE DERIVATIVE; NOTCH1 PROTEIN, HUMAN; TRIAZOLE DERIVATIVE; TUMOR PROTEIN;

CELL SIGNALING ASSAY; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; DRUG POTENTIATION; HUMAN; HUMAN CELL; LETTER; MRNA EXPRESSION ASSAY; ONCOGENE C MYC; PHOSPHORYLATION; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; T CELL LYMPHOBLASTIC LEUKEMIA CELL; ACUTE LYMPHOBLASTIC LEUKEMIA; AGONISTS; ANTAGONISTS AND INHIBITORS; FEMALE; GENETICS; IMMUNOLOGY; MALE; METABOLISM; PATHOLOGY; PROTEIN STABILITY; TUMOR CELL LINE;

AZEPINES; CASEIN KINASE II; CELL LINE, TUMOR; DRUG SYNERGISM; FEMALE; HUMANS; MALE; NAPHTHYRIDINES; NEOPLASM PROTEINS; PRECURSOR T-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROTEIN STABILITY; RECEPTOR, NOTCH1; TRIAZOLES;

EID: 85008388782     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2016.154013     Document Type: Letter

References (15)

1. Ko RH, Ji L, Barnette P, et al. Outcome of patients treated for relapsed or refractory acute lymphoblastic leukemia: a Therapeutic Advances in Childhood Leukemia Consortium study. J Clin Oncol. 2010;28(4):648-654.
2. Marks DI, Paietta EM, Moorman AV, et al. T-cell acute lymphoblastic leukemia in adults: clinical features, immunophenotype, cytogenetics, and outcome from the large randomized prospective trial (UKALL XII/ECOG 2993). Blood. 2009;114(25):5136-5145.
3. Palomero T, Ferrando A. Oncogenic NOTCH1 control of MYC and PI3K: challenges and opportunities for anti-NOTCH1 therapy in Tcell acute lymphoblastic leukemias and lymphomas. Clin Cancer Res. 2008;14(17):5314-5317.
4. Roderick JE, Tesell J, Shultz LD, et al. c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells. Blood. 2014;123(7):1040-1050.
5. Ranganathan P, Vasquez-Del Carpio R, Kaplan FM, et al. Hierarchical phosphorylation within the ankyrin repeat domain defines a phosphoregulatory loop that regulates Notch transcriptional activity. J Biol Chem. 2011;286(33):28844-28857.
6. Buontempo F, Orsini E, Martins LR, et al. Cytotoxic activity of the casein kinase 2 inhibitor CX-4945 against T-cell acute lymphoblastic leukemia: targeting the unfolded protein response signaling. Leukemia. 2014;28(3):543-553.
7. Zhang S, Long H, Yang YL, et al. Inhibition of CK2alpha down-regulates Notch1 signalling in lung cancer cells. J Cell Mol Med. 2013;17(7):854-862.
8. Silva A, Yunes JA, Cardoso BA, et al. PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability. J Clin Invest. 2008;118(11):3762-3774.
9. Van Vlierberghe P, Ambesi-Impiombato A, De Keersmaecker K, et al. Prognostic relevance of integrated genetic profiling in adult T-cell acute lymphoblastic leukemia. Blood. 2013;122(1):74-82.
10. Di Maira G, Salvi M, Arrigoni G, et al. Protein kinase CK2 phosphorylates and upregulates Akt/PKB. Cell Death Differ. 2005;12(6):668-677.
11. Park HS, Jun do Y, Han CR, Woo HJ, Kim YH. Proteasome inhibitor MG132-induced apoptosis via ER stress-mediated apoptotic pathway and its potentiation by protein tyrosine kinase p56lck in human Jurkat T cells. Biochem Pharmacol. 2011;82(9):1110-1125.
12. Chastagner P, Israël A, Brou C. AIP4/Itch regulates Notch receptor degradation in the absence of ligand. PloS One. 2008;3(7):e2735.
13. O'Neil J, Grim J, Strack P, et al. FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors. J Exp Med. 2007;204(8):1813-1824.
14. Hart LS, Cunningham JT, Datta T, et al. ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth. J Clin Invest. 2012;122(12):4621-4634.
15. Knoechel B, Roderick JE, Williamson KE, et al. An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia. Nat Genet. 2014;46(4):364-370.