Erythroferrone contributes to hepcidin repression in a mouse model of malarial anemia

Haematologica

Volumn 102, Issue 1, 2017, Pages 60-68

  Latour, Chloé ^a   Wlodarczyk, Myriam F ^b   Jung, Grace ^c   Gineste, Aurélie ^a   Blanchard, Nicolas ^b   Ganz, Tomas ^c   Roth, Marie Paule ^a   Coppin, Hélène ^a   Kautz, Léon ^a  

^a UMR 1220 TCEM (INRA ENITAB)   (France)

^b France   (France)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROFERRONE; GAMMA INTERFERON; HEMOGLOBIN; HEPCIDIN; HORMONE; INTERLEUKIN 6; MESSENGER RNA; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; CTRP15 PROTEIN, MOUSE; CYTOKINE; MUSCLE PROTEIN;

ANEMIA; ANIMAL CELL; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; ERYTHROCYTE COUNT; ERYTHROPOIESIS; GENE EXPRESSION; HEMATOCRIT; HORMONE SYNTHESIS; INFLAMMATION; IRON RESTRICTION; MALARIA; MALE; MEAN CORPUSCULAR VOLUME; METABOLIC INHIBITION; MOUSE; NONHUMAN; PARASITEMIA; PLASMODIUM BERGHEI; ANIMAL; BLOOD; COMPLICATION; DISEASE COURSE; DISEASE MODEL; GENE EXPRESSION REGULATION; GENETICS; KNOCKOUT MOUSE; METABOLISM; PARASITOLOGY; SEVERITY OF ILLNESS INDEX;

ANEMIA; ANIMALS; BIOMARKERS; CYTOKINES; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; ERYTHROPOIESIS; GENE EXPRESSION REGULATION; HEPCIDINS; MALARIA; MALE; MICE; MICE, KNOCKOUT; MUSCLE PROTEINS; PARASITEMIA; PLASMODIUM BERGHEI; RNA, MESSENGER; SEVERITY OF ILLNESS INDEX;

EID: 85008318914     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2016.150227     Document Type: Article

References (44)

1. WHO. World Malaria Report 2015; 2015.
2. Haldar K, Murphy SC, Milner DA, Taylor TE. Malaria: mechanisms of erythrocytic infection and pathological correlates of severe disease. Annu Rev Pathol. 2007;2: 217-249.
3. Deroost K, Pham TT, Opdenakker G, Van den Steen PE. The immunological balance between host and parasite in malaria. FEMS Microbiol Rev. 2016;40(2):208-257.
4. Spottiswoode N, Duffy PE, Drakesmith H. Iron, anemia and hepcidin in malaria. Front Pharmacol. 2014;5:125.
5. Raventos-Suarez C, Pollack S, Nagel RL. Plasmodium falciparum: inhibition of in vitro growth by desferrioxamine. Am J Trop Med Hyg. 1982;31(5):919-922.
6. Fritsch G, Treumer J, Spira DT, Jung A. Plasmodium vinckei: suppression of mouse infections with desferrioxamine B. Exp Parasitol. 1985;60(2):171-174.
7. Ferrer P, Tripathi AK, Clark MA, Hand CC, Rienhoff HY, Jr., Sullivan DJ, Jr. Antimalarial iron chelator, FBS0701, shows asexual and gametocyte Plasmodium falciparum activity and single oral dose cure in a murine malaria model. PLoS One. 2012; 7(5):e37171.
8. Pollack S, Rossan RN, Davidson DE, Escajadillo A. Desferrioxamine suppresses Plasmodium falciparum in Aotus monkeys. Proc Soc Exp Biol Med. 1987;184(2):162-164.
9. Gwamaka M, Kurtis JD, Sorensen BE, et al. Iron deficiency protects against severe Plasmodium falciparum malaria and death in young children. Clin Infect Dis. 2012; 54(8):1137-1144.
10. Kabyemela ER, Fried M, Kurtis JD, Mutabingwa TK, Duffy PE. Decreased susceptibility to Plasmodium falciparum infection in pregnant women with iron deficiency. J Infect Dis. 2008;198(2):163-166.
11. Nyakeriga AM, Troye-Blomberg M, Dorfman JR, et al. Iron deficiency and malaria among children living on the coast of Kenya. J Infect Dis. 2004;190(3):439-447.
12. Sazawal S, Black RE, Ramsan M, et al. Effects of routine prophylactic supplementation with iron and folic acid on admission to hospital and mortality in preschool children in a high malaria transmission setting: community- based, randomised, placebo-controlled trial. Lancet. 2006; 367(9505):133-143.
13. Smith AW, Hendrickse RG, Harrison C, Hayes RJ, Greenwood BM. The effects on malaria of treatment of iron-deficiency anaemia with oral iron in Gambian children. Ann Trop Paediatr. 1989;9(1):17-23.
14. Oppenheimer SJ, Gibson FD, Macfarlane SB, et al. Iron supplementation increases prevalence and effects of malaria: report on clinical studies in Papua New Guinea. Trans R Soc Trop Med Hyg. 1986; 80(4):603-612.
15. Clark MA, Goheen MM, Fulford A, et al. Host iron status and iron supplementation mediate susceptibility to erythrocytic stage Plasmodium falciparum. Nat Commun. 2014;5(4446).
16. Koka S, Foller M, Lamprecht G, et al. Iron deficiency influences the course of malaria in Plasmodium berghei infected mice. Biochem Biophys Res Commun. 2007; 357(3):608-614.
17. Matsuzaki-Moriya C, Tu L, Ishida H, et al. A critical role for phagocytosis in resistance to malaria in iron-deficient mice. Eur J Immunol. 2011;41(5):1365-1375.
18. Ganz T. Hepcidin and iron regulation, 10 years later. Blood. 2011;117(17):4425-4433.
19. Nemeth E, Tuttle MS, Powelson J, et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science. 2004;306(5704):2090-2093.
20. Qiao B, Sugianto P, Fung E, et al. Hepcidininduced endocytosis of ferroportin is dependent on ferroportin ubiquitination. Cell Metab. 2012;15(6):918-924.
21. Ganz T, Nemeth E. Iron metabolism: interactions with normal and disordered erythropoiesis. Cold Spring Harb Perspect Med. 2012;2(5):a011668.
22. Howard CT, McKakpo US, Quakyi IA, et al. Relationship of hepcidin with parasitemia and anemia among patients with uncomplicated Plasmodium falciparum malaria in Ghana. Am J Trop Med Hyg. 2007;77(4): 623-626.
23. de Mast Q, Nadjim B, Reyburn H, Kemna E.H, Amos B, Laarakkers C.M, et al. Assesment of urinary concentrations of hepcidin provides novel insight into disturbances in iron homeostasis during malarial infection. J. Infect. Dis. 2009;199(2):253-262.
24. de Mast Q, Syafruddin D, Keijmel S, et al. Increased serum hepcidin and alterations in blood iron parameters associated with asymptomatic P. falciparum and P. vivax malaria. Haematologica. 2010;95(7):1068-1074.
25. Portugal S, Carret C, Recker M, et al. Hostmediated regulation of superinfection in malaria. Nat Med. 2011;17(6):732-737.
26. Wang HZ, He YX, Yang CJ, Zhou W, Zou CG. Hepcidin is regulated during bloodstage malaria and plays a protective role in malaria infection. J Immunol. 2011; 187(12):6410-6416.
27. Casals-Pascual C, Huang H, Lakhal-Littleton S, et al. Hepcidin demonstrates a biphasic association with anemia in acute Plasmodium falciparum malaria. Haematologica. 2012;97(11):1695-1698.
28. Burte F, Brown BJ, Orimadegun AE, et al. Circulatory hepcidin is associated with the anti-inflammatory response but not with iron or anemic status in childhood malaria. Blood. 2013;121(15):3016-3022.
29. Jonker FA, Calis JC, Phiri K, et al. Low hepcidin levels in severely anemic malawian children with high incidence of infectious diseases and bone marrow iron deficiency. PLoS One. 2013;8(12):e78964.
30. Kautz L, Jung G, Valore EV, Rivella S, Nemeth E, Ganz T. Identification of erythroferrone as an erythroid regulator of iron metabolism. Nat Genet. 2014; 46(7):678-684.
31. Mitchell AJ, Hansen AM, Hee L, et al. Early cytokine production is associated with protection from murine cerebral malaria. Infect Immun. 2005;73(9):5645-5653.
32. Courselaud B, Troadec MB, Fruchon S, et al. Strain and gender modulate hepatic hepcidin 1 and 2 mRNA expression in mice. Blood Cells Mol Dis. 2004;32(2):283-289.
33. Latour C, Kautz L, Besson-Fournier C, et al. Testosterone perturbs systemic iron balance through activation of epidermal growth factor receptor signaling in the liver and repression of hepcidin. Hepatology. 2014;59(2): 683-694.
34. Francis SE, Sullivan DJ, Jr., Goldberg DE. Hemoglobin metabolism in the malaria parasite Plasmodium falciparum. Annu Rev Microbiol. 1997;51:97-123.
35. Young DS. Effect of drugs on Clinical laboratory tests, 4th Ed. 1995;3-361 to 363-364.
36. Weiss G, Goodnough LT. Anemia of chronic disease. N Engl J Med. 2005; 352(10):1011-1023.
37. Tanno T, Bhanu NV, Oneal PA, et al. High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin. Nat Med. 2007;13(9):1096-1101.
38. Tanno T, Porayette P, Sripichai O, et al. Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells. Blood. 2009; 114(1):181-186.
39. Armitage AE, Pinches R, Eddowes LA, Newbold CI, Drakesmith H. Plasmodium falciparum infected erythrocytes induce hepcidin (HAMP) mRNA synthesis by peripheral blood mononuclear cells. Br J Haematol. 2009;147(5):769-771.
40. Besson-Fournier C, Latour C, Kautz L, et al. Induction of activin B by inflammatory stimuliupregulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling. Blood. 2012; 120(2): 431-439
41. Portugal S, Drakesmith H, Mota MM. Superinfection in malaria: Plasmodium shows its iron will. EMBO Rep. 2011; 12(12):1233-1242.
42. Lamikanra AA, Brown D, Potocnik A, Casals-Pascual C, Langhorne J, Roberts DJ. Malarial anemia: of mice and men. Blood. 2007;110(1):18-28.
43. Kautz L, Jung G, Nemeth E, Ganz T. Erythroferrone contributes to recovery from anemia of inflammation. Blood. 2014;124 (16):2569-2574.
44. Kautz L, Jung G, Du X, et al. Erythroferrone contributes to hepcidin suppression and iron overload in a mouse model of beta-thalassemia. Blood. 2015;126(17):2031-2037.