메뉴 건너뛰기




Volumn 8, Issue 12, 2013, Pages

Low hepcidin levels in severely anemic Malawian children with high incidence of infectious diseases and bone marrow iron deficiency

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; ERYTHROPOIETIN; FERRITIN; HEPCIDIN; INTERLEUKIN 6; TRANSFERRIN RECEPTOR; IRON;

EID: 84891960858     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0078964     Document Type: Article
Times cited : (38)

References (40)
  • 1
    • 51849108672 scopus 로고    scopus 로고
    • WHO (2005) Worldwide prevalence of anaemia 1993-2005. Available: www.who.int/entity/wormcontrol/documents/joint-statements/en/ ppc-unicef-finalreport.pdf
    • (2005) Worldwide Prevalence of Anaemia 1993-2005
  • 2
    • 0035256562 scopus 로고    scopus 로고
    • Iron-deficiency anemia: Reexamining the nature and magnitude of the public health problem. Summary: Implications for research and programs
    • Stoltzfus RJ (2001) Iron-deficiency anemia: reexamining the nature and magnitude of the public health problem. Summary: implications for research and programs. J Nutr 131: 697S-700S.
    • (2001) J Nutr , vol.131
    • Stoltzfus, R.J.1
  • 5
    • 30444459334 scopus 로고    scopus 로고
    • Effects of routine prophylactic supplementation with iron and folic acid on admission to hospital and mortality in preschool children in a high malaria transmission setting: Community-based, randomised, placebo-controlled trial
    • DOI 10.1016/S0140-6736(06)67962-2, PII S0140673606679622
    • Sazawal S, Black RE, Ramsan M, Chwaya HM, Stoltzfus RJ, et al (2006) Effects of routine prophylactic supplementation with iron and folic acid on admission to hospital and mortality in preschool children in a high malaria transmission setting: community-based, randomised, placebo-controlled trial. Lancet 367: 133-143. S0140-6736(06)67962-2 [pii];10.1016/S0140-6736(06)67962-2 [doi]. (Pubitemid 43077129)
    • (2006) Lancet , vol.367 , Issue.9505 , pp. 133-143
    • Sazawal, S.1    Black, R.E.2    Ramsan, M.3    Chwaya, H.M.4    Stoltzfus, R.J.5    Dutta, A.6    Dhingra, U.7    Kabole, I.8    Deb, S.9    Othman, M.K.10    Kabole, F.M.11
  • 8
    • 0035896642 scopus 로고    scopus 로고
    • Hepcidin, a urinary antimicrobial peptide synthesized in the liver
    • 10.1074/jbc.M008922200 [doi]; M008922200 [pii]
    • Park CH, Valore EV, Waring AJ, Ganz T (2001) Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem 276: 7806-7810. 10.1074/jbc.M008922200 [doi];M008922200 [pii].
    • (2001) J Biol Chem , vol.276 , pp. 7806-7810
    • Park, C.H.1    Valore, E.V.2    Waring, A.J.3    Ganz, T.4
  • 10
    • 0035896581 scopus 로고    scopus 로고
    • A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload
    • 10.1074/jbc.M008923200 [doi]; M008923200 [pii]
    • Pigeon C, Ilyin G, Courselaud B, Leroyer P, Turlin B, et al (2001) A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem 276: 7811- 7819. 10.1074/jbc.M008923200 [doi];M008923200 [pii].
    • (2001) J Biol Chem , vol.276 , pp. 7811-7819
    • Pigeon, C.1    Ilyin, G.2    Courselaud, B.3    Leroyer, P.4    Turlin, B.5
  • 11
    • 23944502314 scopus 로고    scopus 로고
    • Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS
    • DOI 10.1182/blood-2005-03-1159
    • Kemna E, Pickkers P, Nemeth E, van der Hoeven H, Swinkels D (2005) Timecourse analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS. Blood 106: 1864-1866. 2005-03-1159 [pii];10.1182/blood- 2005-03-1159 [doi]. (Pubitemid 41208606)
    • (2005) Blood , vol.106 , Issue.5 , pp. 1864-1866
    • Kemna, E.1    Pickkers, P.2    Nemeth, E.3    Van Der Hoeven, H.4    Swinkels, D.5
  • 12
    • 82755195789 scopus 로고    scopus 로고
    • Hepcidin in human iron disorders: Diagnostic implications
    • clinchem. 2009. 140053 [pii];10.1373/clinchem.2009. 140053 [doi]
    • Kroot JJ, Tjalsma H, Fleming RE, Swinkels DW (2011) Hepcidin in human iron disorders: diagnostic implications. Clin Chem 57: 1650-1669. clinchem. 2009.140053 [pii];10.1373/clinchem.2009.140053 [doi].
    • (2011) Clin Chem , vol.57 , pp. 1650-1669
    • Kroot, J.J.1    Tjalsma, H.2    Fleming, R.E.3    Swinkels, D.W.4
  • 13
    • 0038662619 scopus 로고    scopus 로고
    • Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein
    • DOI 10.1182/blood-2002-10-3235
    • Nemeth E, Valore EV, Territo M, Schiller G, Lichtenstein A, et al (2003) Hepcidin, a putative mediator of anemia of inflammation, is a type II acutephase protein. Blood 101: 2461-2463. 10.1182/blood-2002-10-3235 [doi];2002- 10-3235 [pii]. (Pubitemid 36857598)
    • (2003) Blood , vol.101 , Issue.7 , pp. 2461-2463
    • Nemeth, E.1    Valore, E.V.2    Territo, M.3    Schiller, G.4    Lichtenstein, A.5    Ganz, T.6
  • 14
    • 77954249308 scopus 로고    scopus 로고
    • Two to tango: Regulation of Mammalian iron metabolism
    • S0092- 8674(10) 00718-X [pii];10.1016/j.cell.2010. 06.028 [doi]
    • Hentze MW, Muckenthaler MU, Galy B, Camaschella C (2010) Two to tango: regulation of Mammalian iron metabolism. Cell 142: 24-38. S0092- 8674(10)00718-X [pii];10.1016/j.cell.2010.06.028 [doi].
    • (2010) Cell , vol.142 , pp. 24-38
    • Hentze, M.W.1    Muckenthaler, M.U.2    Galy, B.3    Camaschella, C.4
  • 15
    • 79953757053 scopus 로고    scopus 로고
    • Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice
    • 10.1002/hep.24178 [doi]
    • Ramos E, Kautz L, Rodriguez R, Hansen M, Gabayan V, et al (2011) Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice. Hepatology 53: 1333-1341. 10.1002/hep.24178 [doi].
    • (2011) Hepatology , vol.53 , pp. 1333-1341
    • Ramos, E.1    Kautz, L.2    Rodriguez, R.3    Hansen, M.4    Gabayan, V.5
  • 16
    • 84856292277 scopus 로고    scopus 로고
    • Iron overload in human disease
    • 10.1056/NEJMra1004967 [doi]
    • Fleming RE, Ponka P (2012) Iron overload in human disease. N Engl J Med 366: 348-359. 10.1056/NEJMra1004967 [doi].
    • (2012) N Engl J Med , vol.366 , pp. 348-359
    • Fleming, R.E.1    Ponka, P.2
  • 17
    • 84857617139 scopus 로고    scopus 로고
    • Hepcidin is the major predictor of erythrocyte iron incorporation in anemic African children
    • blood-2011-11-391219 [pii];10.1182/blood-2011-11-391219 [doi]
    • Prentice AM, Doherty CP, Abrams SA, Cox SE, Atkinson SH, et al (2012) Hepcidin is the major predictor of erythrocyte iron incorporation in anemic African children. Blood. blood-2011-11-391219 [pii];10.1182/blood-2011-11-391219 [doi].
    • (2012) Blood
    • Prentice, A.M.1    Doherty, C.P.2    Abrams, S.A.3    Cox, S.E.4    Atkinson, S.H.5
  • 18
    • 66149153847 scopus 로고    scopus 로고
    • Mild increases in serum hepcidin and interleukin-6 concentrations impair iron incorporation in haemoglobin during an experimental human malaria infection
    • BJH7664 [pii];10.1111/j.1365-2141. 2009.07664.x [doi]
    • de Mast Q., van Dongen-Lases EC, Swinkels DW, Nieman AE, Roestenberg M, et al (2009) Mild increases in serum hepcidin and interleukin-6 concentrations impair iron incorporation in haemoglobin during an experimental human malaria infection. Br J Haematol 145: 657-664. BJH7664 [pii];10.1111/j.1365-2141.2009. 07664.x [doi].
    • (2009) Br J Haematol , vol.145 , pp. 657-664
    • De Mast, Q.1    Van Dongen-Lases, E.C.2    Swinkels, D.W.3    Nieman, A.E.4    Roestenberg, M.5
  • 19
    • 58849136770 scopus 로고    scopus 로고
    • Assessment of urinary concentrations of hepcidin provides novel insight into disturbances in iron homeostasis during malarial infection
    • 10.1086/595790 [doi]
    • de Mast Q., Nadjm B, Reyburn H, Kemna EH, Amos B, et al (2009) Assessment of urinary concentrations of hepcidin provides novel insight into disturbances in iron homeostasis during malarial infection. J Infect Dis 199: 253-262. 10.1086/595790 [doi].
    • (2009) J Infect Dis , vol.199 , pp. 253-262
    • De Mast, Q.1    Nadjm, B.2    Reyburn, H.3    Kemna, E.H.4    Amos, B.5
  • 21
    • 73449123426 scopus 로고    scopus 로고
    • New cut-off values for ferritin and soluble transferrin receptor for the assessment of iron deficiency in children in a high infection pressure area
    • 62/12/1103 [pii];10.1136/jcp. 2009. 066498 [doi]
    • Phiri KS, Calis JC, Siyasiya A, Bates I, Brabin B, et al (2009) New cut-off values for ferritin and soluble transferrin receptor for the assessment of iron deficiency in children in a high infection pressure area. J Clin Pathol 62: 1103-1106. 62/12/1103 [pii];10.1136/jcp.2009.066498 [doi].
    • (2009) J Clin Pathol , vol.62 , pp. 1103-1106
    • Phiri, K.S.1    Calis, J.C.2    Siyasiya, A.3    Bates, I.4    Brabin, B.5
  • 22
    • 72249092796 scopus 로고
    • The quantitative estimation of total iron stores in human bone marrow
    • 10.1172/JCI104793 [doi]
    • Gale, Torrance J, Bothwell T (1963) The quantitative estimation of total iron stores in human bone marrow. J Clin Invest 42: 1076-1082. 10.1172/JCI104793 [doi].
    • (1963) J Clin Invest , vol.42 , pp. 1076-1082
    • Gale Torrance, J.1    Bothwell, T.2
  • 24
    • 77957735568 scopus 로고    scopus 로고
    • Immunochemical and mass-spectrometry-based serum hepcidin assays for iron metabolism disorders
    • clinchem. 2010 149187 [pii];10.1373/clinchem.2010.149187 [doi]
    • Kroot JJ, Laarakkers CM, Geurts-Moespot AJ, Grebenchtchikov N, Pickkers P, et al (2010) Immunochemical and Mass-Spectrometry-Based Serum Hepcidin Assays for Iron Metabolism Disorders. Clin Chem. clinchem.2010.149187 [pii];10.1373/clinchem.2010.149187 [doi].
    • (2010) Clin Chem
    • Kroot, J.J.1    Laarakkers, C.M.2    Geurts-Moespot, A.J.3    Grebenchtchikov, N.4    Pickkers, P.5
  • 25
    • 50549094991 scopus 로고    scopus 로고
    • Advances in quantitative hepcidin measurements by time-of-flight mass spectrometry
    • 10.1371/journal.pone. 0002706 [doi]
    • Swinkels DW, Girelli D, Laarakkers C, Kroot J, Campostrini N, et al (2008) Advances in quantitative hepcidin measurements by time-of-flight mass spectrometry. PLoS One 3: e2706. 10.1371/journal.pone.0002706 [doi].
    • (2008) PLoS One , vol.3
    • Swinkels, D.W.1    Girelli, D.2    Laarakkers, C.3    Kroot, J.4    Campostrini, N.5
  • 26
    • 0020035215 scopus 로고
    • Perspectives in iron metabolism
    • Finch CA, Huebers H (1982) Perspectives in iron metabolism. N Engl J Med 306: 1520-1528. 10.1056/NEJM198206243062504 [doi]. (Pubitemid 12123933)
    • (1982) New England Journal of Medicine , vol.306 , Issue.25 , pp. 1520-1528
    • Finch, C.A.1    Huebers, H.2
  • 28
    • 38549097359 scopus 로고    scopus 로고
    • second edition of the World Health Organization
    • WHO (2004) Assessing the iron status of populations, second edition of the World Health Organization. Available: http://www.who.int/nutrition/ publications/micronutrients/anaemia-iron-deficiency/9789241596107/en/index.html
    • (2004) Assessing the Iron Status of Populations
  • 29
    • 0030976033 scopus 로고    scopus 로고
    • Serum transferrin receptor and its ratio to serum ferritin in the diagnosis of iron deficiency
    • Punnonen K, Irjala K, Rajamaki A (1997) Serum transferrin receptor and its ratio to serum ferritin in the diagnosis of iron deficiency. Blood 89: 1052-1057. (Pubitemid 27121300)
    • (1997) Blood , vol.89 , Issue.3 , pp. 1052-1057
    • Punnonen, K.1    Irjala, K.2    Rajamaki, A.3
  • 31
    • 79959517566 scopus 로고    scopus 로고
    • Serum hepcidin: Reference ranges and biochemical correlates in the general population
    • blood-2011-02-337907 [pii];10.1182/blood-2011-02-337907 [doi]
    • Galesloot TE, Vermeulen SH, Geurts-Moespot AJ, Klaver SM, Kroot JJ, et al (2011) Serum hepcidin: reference ranges and biochemical correlates in the general population. Blood 117: e218-e225. blood-2011-02-337907 [pii];10.1182/blood-2011-02-337907 [doi].
    • (2011) Blood , vol.117
    • Galesloot, T.E.1    Vermeulen, S.H.2    Geurts-Moespot, A.J.3    Klaver, S.M.4    Kroot, J.J.5
  • 32
    • 84866243889 scopus 로고    scopus 로고
    • Hepcidin expression in the liver of mice with implanted tumour reacts to iron deficiency, inflammation and erythropoietin administration
    • FB2011A0035 [pii]
    • Vokurka M, Krijt J, Vavrova J, Necas E (2011) Hepcidin expression in the liver of mice with implanted tumour reacts to iron deficiency, inflammation and erythropoietin administration. Folia Biol (Praha) 57: 248-254. FB2011A0035 [pii].
    • (2011) Folia Biol (Praha) , vol.57 , pp. 248-254
    • Vokurka, M.1    Krijt, J.2    Vavrova, J.3    Necas, E.4
  • 33
    • 58149181388 scopus 로고    scopus 로고
    • An insight into the relationships between hepcidin, anemia, infections and inflammatory cytokines in pediatric refugees: A cross-sectional study
    • 10.1371/journal.pone. 0004030 [doi]
    • Cherian S, Forbes DA, Cook AG, Sanfilippo FM, Kemna EH, et al (2008) An insight into the relationships between hepcidin, anemia, infections and inflammatory cytokines in pediatric refugees: a cross-sectional study. PLoS One 3: e4030. 10.1371/journal.pone.0004030 [doi].
    • (2008) PLoS One , vol.3
    • Cherian, S.1    Forbes, D.A.2    Cook, A.G.3    Sanfilippo, F.M.4    Kemna, E.H.5
  • 34
    • 84874547339 scopus 로고    scopus 로고
    • Iron status and systemic inflammation, but not gut inflammation, strongly predict genderspecific concentrations of serum hepcidin in infants in rural Kenya
    • 10.1371/journal.pone. 0057513 [doi];PONE-D-12-35305 [pii]
    • Jaeggi T, Moretti D, Kvalsvig J, Holding PA, Tjalsma H, et al (2013) Iron status and systemic inflammation, but not gut inflammation, strongly predict genderspecific concentrations of serum hepcidin in infants in rural Kenya. PLoS One 8: e57513. 10.1371/journal.pone.0057513 [doi];PONE-D-12-35305 [pii].
    • (2013) PLoS One , vol.8
    • Jaeggi, T.1    Moretti, D.2    Kvalsvig, J.3    Holding, P.A.4    Tjalsma, H.5
  • 35
    • 67651043722 scopus 로고    scopus 로고
    • Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells
    • blood-2008-12-195503 [pii];10.1182/blood-2008-12-195503 [doi]
    • Tanno T, Porayette P, Sripichai O, Noh SJ, Byrnes C, et al (2009) Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells. Blood 114: 181-186. blood-2008-12-195503 [pii];10.1182/blood-2008-12-195503 [doi].
    • (2009) Blood , vol.114 , pp. 181-186
    • Tanno, T.1    Porayette, P.2    Sripichai, O.3    Noh, S.J.4    Byrnes, C.5
  • 36
    • 47049116150 scopus 로고    scopus 로고
    • Erythropoietin mediates hepcidin expression in hepatocytes through EPOR signaling and regulation of C/EBPalpha
    • blood-2007-08-106195 [pii];10.1182/blood-2007-08-106195 [doi]
    • Pinto JP, Ribeiro S, Pontes H, Thowfeequ S, Tosh D, et al (2008) Erythropoietin mediates hepcidin expression in hepatocytes through EPOR signaling and regulation of C/EBPalpha. Blood 111: 5727-5733. blood-2007-08-106195 [pii];10.1182/blood-2007-08-106195 [doi].
    • (2008) Blood , vol.111 , pp. 5727-5733
    • Pinto, J.P.1    Ribeiro, S.2    Pontes, H.3    Thowfeequ, S.4    Tosh, D.5
  • 37
    • 78651272558 scopus 로고    scopus 로고
    • Afebrile Plasmodium falciparum parasitemia decreases absorption of fortification iron but does not affect systemic iron utilization: A double stable-isotope study in young Beninese women
    • ajcn. 2010. 30051 [pii];10.3945/ajcn.2010.30051 [doi]
    • Cercamondi CI, Egli IM, Ahouandjinou E, Dossa R, Zeder C, et al (2010) Afebrile Plasmodium falciparum parasitemia decreases absorption of fortification iron but does not affect systemic iron utilization: a double stable-isotope study in young Beninese women. Am J Clin Nutr 92: 1385-1392. ajcn.2010.30051 [pii];10.3945/ajcn.2010.30051 [doi].
    • (2010) Am J Clin Nutr , vol.92 , pp. 1385-1392
    • Cercamondi, C.I.1    Egli, I.M.2    Ahouandjinou, E.3    Dossa, R.4    Zeder, C.5
  • 38
    • 4944264570 scopus 로고    scopus 로고
    • How should stainable iron in bone marrow films be assessed?
    • DOI 10.1136/jcp.2003.015834
    • Hughes DA, Stuart-Smith SE, Bain BJ (2004) How should stainable iron in bone marrow films be assessed? J Clin Pathol 57: 1038-1040. 10.1136/jcp.2003. 015834 [doi];57/10/1038 [pii]. (Pubitemid 39331352)
    • (2004) Journal of Clinical Pathology , vol.57 , Issue.10 , pp. 1038-1040
    • Hughes, D.A.1    Stuart-Smith, S.E.2    Bain, B.J.3
  • 39
    • 79958143306 scopus 로고    scopus 로고
    • Hostmediated regulation of superinfection in malaria
    • nm.2368 [pii];10.1038/nm.2368 [doi]
    • Portugal S, Carret C, Recker M, Armitage AE, Goncalves LA, et al (2011) Hostmediated regulation of superinfection in malaria. Nat Med 17: 732-737. nm.2368 [pii];10.1038/nm.2368 [doi].
    • (2011) Nat Med , vol.17 , pp. 732-737
    • Portugal, S.1    Carret, C.2    Recker, M.3    Armitage, A.E.4    Goncalves, L.A.5
  • 40
    • 84865089856 scopus 로고    scopus 로고
    • Iron status predicts malaria risk in Malawian preschool children
    • 10.1371/journal.pone. 0042670 [doi];PONE-D-12-08731 [pii]
    • Jonker FA, Calis JC, van Hensbroek MB, Phiri K, Geskus RB, et al (2012) Iron status predicts malaria risk in Malawian preschool children. PLoS One 7: e42670. 10.1371/journal.pone.0042670 [doi];PONE-D-12-08731 [pii].
    • (2012) PLoS One , vol.7
    • Jonker, F.A.1    Calis, J.C.2    Van Hensbroek, M.B.3    Phiri, K.4    Geskus, R.B.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.