메뉴 건너뛰기




Volumn 40, Issue 1, 2017, Pages 54-62

Metformin is associated with higher relative abundance of mucin-degrading akkermansia muciniphila and several short-chain fatty acid-producing microbiota in the gut

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; METFORMIN; MUCIN; SHORT CHAIN FATTY ACID; ANTIDIABETIC AGENT; RNA 16S; VOLATILE FATTY ACID;

EID: 85008192260     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc16-1324     Document Type: Article
Times cited : (550)

References (40)
  • 1
    • 84878465280 scopus 로고    scopus 로고
    • Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity
    • Everard A, Belzer C, Geurts L, et al. Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. Proc Natl Acad Sci U S A 2013;110:9066-9071
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 9066-9071
    • Everard, A.1    Belzer, C.2    Geurts, L.3
  • 2
    • 84867074831 scopus 로고    scopus 로고
    • A metagenome-wide association study of gut microbiota in type 2 diabetes
    • Qin J, Li Y, Cai Z, et al. A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature 2012;490:55-60
    • (2012) Nature , vol.490 , pp. 55-60
    • Qin, J.1    Li, Y.2    Cai, Z.3
  • 3
    • 84878709716 scopus 로고    scopus 로고
    • Gut metagenome in European women with normal, impaired and diabetic glucose control
    • Karlsson FH, Tremaroli V, Nookaew I, et al. Gut metagenome in European women with normal, impaired and diabetic glucose control. Nature 2013;498:99-103
    • (2013) Nature , vol.498 , pp. 99-103
    • Karlsson, F.H.1    Tremaroli, V.2    Nookaew, I.3
  • 4
    • 77949393654 scopus 로고    scopus 로고
    • Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults
    • Larsen N, Vogensen FK, van den Berg FWJ, et al. Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults. PLoS One 2010;5:e9085
    • (2010) PLoS One , vol.5 , pp. e9085
    • Larsen, N.1    Vogensen, F.K.2    Van Den Berg, F.W.J.3
  • 5
    • 84883181684 scopus 로고    scopus 로고
    • Human gut microbiota changes reveal the progression of glucose intolerance
    • Zhang X, Shen D, Fang Z, et al. Human gut microbiota changes reveal the progression of glucose intolerance. PLoS One 2013;8:e71108
    • (2013) PLoS One , vol.8 , pp. e71108
    • Zhang, X.1    Shen, D.2    Fang, Z.3
  • 6
    • 84949772416 scopus 로고    scopus 로고
    • Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota
    • MetaHIT consortium
    • Forslund K, Hildebrand F, Nielsen T, et al.; MetaHIT consortium. Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota. Nature 2015;528: 262-266
    • (2015) Nature , vol.528 , pp. 262-266
    • Forslund, K.1    Hildebrand, F.2    Nielsen, T.3
  • 7
    • 84905757105 scopus 로고    scopus 로고
    • Metformin-mode of action and clinical implications for diabetes and cancer
    • Pernicova I, Korbonits M. Metformin-mode of action and clinical implications for diabetes and cancer. Nat Rev Endocrinol 2014;10:143-156
    • (2014) Nat Rev Endocrinol , vol.10 , pp. 143-156
    • Pernicova, I.1    Korbonits, M.2
  • 8
    • 78851470539 scopus 로고    scopus 로고
    • Effect of metformin on cardiovascular events and mortality: A meta-analysis of randomized clinical trials
    • Lamanna C, Monami M, Marchionni N, Mannucci E. Effect of metformin on cardiovascular events and mortality: A meta-analysis of randomized clinical trials. Diabetes ObesMetab 2011;13:221-228
    • (2011) Diabetes ObesMetab , vol.13 , pp. 221-228
    • Lamanna, C.1    Monami, M.2    Marchionni, N.3    Mannucci, E.4
  • 9
    • 84947209464 scopus 로고    scopus 로고
    • Repurposing metformin: An old drug with new tricks in its binding pockets
    • Pryor R, Cabreiro F. Repurposing metformin: an old drug with new tricks in its binding pockets. Biochem J 2015;471:307-322
    • (2015) Biochem J , vol.471 , pp. 307-322
    • Pryor, R.1    Cabreiro, F.2
  • 10
    • 84881614717 scopus 로고    scopus 로고
    • Molecular mechanism of action of metformin: Old or new insights?
    • Rena G, Pearson ER, Sakamoto K. Molecular mechanism of action of metformin: old or new insights? Diabetologia 2013;56:1898-1906
    • (2013) Diabetologia , vol.56 , pp. 1898-1906
    • Rena, G.1    Pearson, E.R.2    Sakamoto, K.3
  • 11
    • 84907021154 scopus 로고    scopus 로고
    • Effect of metformin on metabolic improvement and gut microbiota
    • Lee H, Ko G. Effect of metformin on metabolic improvement and gut microbiota. Appl Environ Microbiol 2014;80:5935-5943
    • (2014) Appl Environ Microbiol , vol.80 , pp. 5935-5943
    • Lee, H.1    Ko, G.2
  • 12
    • 84897960120 scopus 로고    scopus 로고
    • An increase in the Akkermansia spp. Population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice
    • Shin N-RR, Lee J-CC, Lee H-YY, et al. An increase in the Akkermansia spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice. Gut 2014;63:727-735
    • (2014) Gut , vol.63 , pp. 727-735
    • N-Rr, S.1    J-Cc, L.2    H-Yy, L.3
  • 13
    • 84942133352 scopus 로고    scopus 로고
    • Modulation of gut microbiota by berberine and metformin during the treatment of high-fat diet-induced obesity in rats
    • Zhang X, Zhao Y, Xu J, et al. Modulation of gut microbiota by berberine and metformin during the treatment of high-fat diet-induced obesity in rats. Sci Rep 2015;5:14405
    • (2015) Sci Rep , vol.5 , pp. 14405
    • Zhang, X.1    Zhao, Y.2    Xu, J.3
  • 14
    • 0021362746 scopus 로고
    • Lack of effect of intravenous metformin on plasma concentrations of glucose, insulin, C-peptide, glucagon and growth hormone in non-diabetic subjects
    • Bonora E, Cigolini M, Bosello O, et al. Lack of effect of intravenous metformin on plasma concentrations of glucose, insulin, C-peptide, glucagon and growth hormone in non-diabetic subjects. Curr Med Res Opin 1984;9:47-51
    • (1984) Curr Med Res Opin , vol.9 , pp. 47-51
    • Bonora, E.1    Cigolini, M.2    Bosello, O.3
  • 15
    • 84962094356 scopus 로고    scopus 로고
    • The primary glucose-lowering effect of metformin resides in the gut, not the circulation: Results from short-term pharmacokinetic and 12-week dose-ranging studies
    • Buse JB, DeFronzo RA, Rosenstock J, et al. The primary glucose-lowering effect of metformin resides in the gut, not the circulation: Results from short-term pharmacokinetic and 12-week dose-ranging studies. Diabetes Care 2016;39:198-205
    • (2016) Diabetes Care , vol.39 , pp. 198-205
    • Buse, J.B.1    DeFronzo, R.A.2    Rosenstock, J.3
  • 17
    • 84903759811 scopus 로고    scopus 로고
    • Novel gut-based pharmacology of metformin in patients with type 2 diabetes mellitus
    • Napolitano A, Miller S, Nicholls AW, et al. Novel gut-based pharmacology of metformin in patients with type 2 diabetes mellitus. PLoS One 2014;9:e100778
    • (2014) PLoS One , vol.9 , pp. e100778
    • Napolitano, A.1    Miller, S.2    Nicholls, A.W.3
  • 18
    • 84924187224 scopus 로고    scopus 로고
    • The gut microbiota of Colombians differs from that of Americans, Europeans and Asians
    • Escobar JS, Klotz B, Valdes BE, Agudelo GM. The gut microbiota of Colombians differs from that of Americans, Europeans and Asians. BMC Microbiol 2014;14:311
    • (2014) BMC Microbiol , vol.14 , pp. 311
    • Escobar, J.S.1    Klotz, B.2    Valdes, B.E.3    Agudelo, G.M.4
  • 19
    • 84884251320 scopus 로고    scopus 로고
    • Development of a dual-index sequencing strategy and curation pipeline for analyzing amplicon sequence data on the MiSeq Illumina sequencing platform
    • KozichJJ,WestcottSL,BaxterNT,Highlander SK, Schloss PD. Development of a dual-index sequencing strategy and curation pipeline for analyzing amplicon sequence data on the MiSeq Illumina sequencing platform. Appl Environ Microbiol 2013;79:5112-5120
    • (2013) Appl Environ Microbiol , vol.79 , pp. 5112-5120
    • Kozich, J.J.1    Westcott, S.L.2    Baxter, N.T.3    Highlander, S.K.4    Schloss, P.D.5
  • 20
    • 72949107142 scopus 로고    scopus 로고
    • Introducing mothur: Open-source, platformindependent, community-supported software for describing and comparing microbial communities
    • Schloss PD, Westcott SL, Ryabin T, et al. Introducing mothur: open-source, platformindependent, community-supported software for describing and comparing microbial communities. Appl Environ Microbiol 2009;75:7537-7541
    • (2009) Appl Environ Microbiol , vol.75 , pp. 7537-7541
    • Schloss, P.D.1    Westcott, S.L.2    Ryabin, T.3
  • 21
    • 84965039431 scopus 로고    scopus 로고
    • R Development Core Team. Vienna, Austria, R Foundation for Statistical Computing
    • R Development Core Team. R: A Language and Environment for Statistical Computing. Vienna, Austria, R Foundation for Statistical Computing, 2012
    • (2012) R: A Language and Environment for Statistical Computing
  • 23
    • 84865082160 scopus 로고    scopus 로고
    • Associating microbiome composition with environmental covariates using generalized UniFrac distances
    • Chen J, Bittinger K, Charlson ES, et al. Associating microbiome composition with environmental covariates using generalized UniFrac distances. Bioinformatics 2012;28:2106-2113
    • (2012) Bioinformatics , vol.28 , pp. 2106-2113
    • Chen, J.1    Bittinger, K.2    Charlson, E.S.3
  • 24
    • 79959383523 scopus 로고    scopus 로고
    • Metagenomic biomarker discovery and explanation
    • Segata N, Izard J, Waldron L, et al. Metagenomic biomarker discovery and explanation. Genome Biol 2011;12:R60
    • (2011) Genome Biol , vol.12 , pp. R60
    • Segata, N.1    Izard, J.2    Waldron, L.3
  • 26
    • 80053618114 scopus 로고    scopus 로고
    • Linking long-term dietary patterns with gut microbial enterotypes
    • Wu GD, Chen J, Hoffmann C, et al. Linking long-term dietary patterns with gut microbial enterotypes. Science 2011;334:105-108
    • (2011) Science , vol.334 , pp. 105-108
    • Wu, G.D.1    Chen, J.2    Hoffmann, C.3
  • 27
    • 0034058528 scopus 로고    scopus 로고
    • Vancomycin-resistant enterococcal infections
    • Murray BE. Vancomycin-resistant enterococcal infections. N Engl J Med 2000;342:710-721
    • (2000) N Engl J Med , vol.342 , pp. 710-721
    • Murray, B.E.1
  • 28
    • 84875738351 scopus 로고    scopus 로고
    • Metformin retards aging in C. Elegans by altering microbial folate and methionine metabolism
    • Cabreiro F, Au C, Leung KY, et al. Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 2013; 153:228-239
    • (2013) Cell , vol.153 , pp. 228-239
    • Cabreiro, F.1    Au, C.2    Leung, K.Y.3
  • 29
    • 78951476273 scopus 로고    scopus 로고
    • Metformin regulates the incretin receptor axis via a pathway dependent on peroxisome proliferator-activated receptor-A in mice
    • Maida A, Lamont BJ, Cao X, Drucker DJ. Metformin regulates the incretin receptor axis via a pathway dependent on peroxisome proliferator-activated receptor-A in mice. Diabetologia 2011;54:339-349
    • (2011) Diabetologia , vol.54 , pp. 339-349
    • Maida, A.1    Lamont, B.J.2    Cao, X.3    Drucker, D.J.4
  • 30
    • 0035097211 scopus 로고    scopus 로고
    • Effect of metformin on glucagon-like peptide 1 (GLP-1) and leptin levels in obese nondiabetic subjects
    • Mannucci E, Ognibene A, Cremasco F, et al. Effect of metformin on glucagon-like peptide 1 (GLP-1) and leptin levels in obese nondiabetic subjects. Diabetes Care 2001;24:489-494
    • (2001) Diabetes Care , vol.24 , pp. 489-494
    • Mannucci, E.1    Ognibene, A.2    Cremasco, F.3
  • 31
    • 84991053856 scopus 로고    scopus 로고
    • Intestinal crosstalk between bile acids and microbiota and its impact on host metabolism
    • Wahlström A, Sayin SI, Marschall H-U, Bäckhed F. Intestinal crosstalk between bile acids and microbiota and its impact on host metabolism. Cell Metab 2016;24:41-50
    • (2016) Cell Metab , vol.24 , pp. 41-50
    • Wahlström, A.1    Sayin, S.I.2    Marschall, H.-U.3    Bäckhed, F.4
  • 32
    • 78650609691 scopus 로고    scopus 로고
    • Genome analysis of Bifidobacterium bifidumPRL2010 reveals metabolic pathways for host-derived glycan foraging
    • Turroni F, Bottacini F, Foroni E, et al. Genome analysis of Bifidobacterium bifidumPRL2010 reveals metabolic pathways for host-derived glycan foraging. Proc Natl Acad SciUSA2010;107:19514-19519
    • (2010) Proc Natl Acad SciUSA , vol.107 , pp. 19514-19519
    • Turroni, F.1    Bottacini, F.2    Foroni, E.3
  • 33
    • 47249135018 scopus 로고    scopus 로고
    • Sutterella parvirubra sp. nov. and Megamonas funiformis sp. nov., isolated from human faeces
    • Sakon H, Nagai F, Morotomi M, Tanaka R. Sutterella parvirubra sp. nov. and Megamonas funiformis sp. nov., isolated from human faeces. Int J Syst Evol Microbiol 2008;58:970-975
    • (2008) Int J Syst Evol Microbiol , vol.58 , pp. 970-975
    • Sakon, H.1    Nagai, F.2    Morotomi, M.3    Tanaka, R.4
  • 34
    • 79251584066 scopus 로고    scopus 로고
    • Bifidobacteria can protect from enteropathogenic infection through production of acetate
    • Fukuda S, Toh H, Hase K, et al. Bifidobacteria can protect from enteropathogenic infection through production of acetate. Nature 2011; 469:543-547
    • (2011) Nature , vol.469 , pp. 543-547
    • Fukuda, S.1    Toh, H.2    Hase, K.3
  • 35
    • 84987915653 scopus 로고    scopus 로고
    • Consumption of a Bifidobacterium bifidum strain for 4 weeks modulates dominant intestinal bacterial taxa and fecal butyrate in healthy adults
    • Gargari G, Taverniti V, Balzaretti S, et al. Consumption of a Bifidobacterium bifidum strain for 4 weeks modulates dominant intestinal bacterial taxa and fecal butyrate in healthy adults. Appl Environ Microbiol 2016;82:5850-5859
    • (2016) Appl Environ Microbiol , vol.82 , pp. 5850-5859
    • Gargari, G.1    Taverniti, V.2    Balzaretti, S.3
  • 37
    • 84892814749 scopus 로고    scopus 로고
    • Microbiota-generated metabolites promote metabolic benefits via gutbrain neural circuits
    • De Vadder F, Kovatcheva-Datchary P, Goncalves D, et al. Microbiota-generated metabolites promote metabolic benefits via gutbrain neural circuits. Cell 2014;156:84-96
    • (2014) Cell , vol.156 , pp. 84-96
    • De Vadder, F.1    Kovatcheva-Datchary, P.2    Goncalves, D.3
  • 38
    • 84929502588 scopus 로고    scopus 로고
    • Crosstalk between microbiota-derived short-chain fatty acids and intestinal epithelial HIF augments tissue barrier function
    • Kelly CJ, Zheng L, Campbell EL, et al. Crosstalk between microbiota-derived short-chain fatty acids and intestinal epithelial HIF augments tissue barrier function. Cell HostMicrobe 2015;17:662-671
    • (2015) Cell HostMicrobe , vol.17 , pp. 662-671
    • Kelly, C.J.1    Zheng, L.2    Campbell, E.L.3
  • 39
    • 84904048875 scopus 로고    scopus 로고
    • A decrease of the butyrate-producing species Roseburia hominis and Faecalibacterium prausnitzii defines dysbiosis in patients with ulcerative colitis
    • Machiels K, Joossens M, Sabino J, et al. A decrease of the butyrate-producing species Roseburia hominis and Faecalibacterium prausnitzii defines dysbiosis in patients with ulcerative colitis. Gut 2014;63:1275-1283
    • (2014) Gut , vol.63 , pp. 1275-1283
    • Machiels, K.1    Joossens, M.2    Sabino, J.3
  • 40
    • 70349488325 scopus 로고    scopus 로고
    • Low counts of Faecalibacterium prausnitzii in colitis microbiota
    • Sokol H, Seksik P, Furet JP, et al. Low counts of Faecalibacterium prausnitzii in colitis microbiota. Inflamm Bowel Dis 2009;15:1183-1189
    • (2009) Inflamm Bowel Dis , vol.15 , pp. 1183-1189
    • Sokol, H.1    Seksik, P.2    Furet, J.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.