Mycobacterium tuberculosis malate synthase structures with fragments reveal a portal for substrate/product exchange

Journal of Biological Chemistry

Volumn 291, Issue 53, 2016, Pages 27421-27432

  Huang, Hsiao Ling ^a   Krieger, Inna V ^a   Parai, Maloy K ^a   Gawandi, Vijay B ^a   Sacchettini, James C ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; HYDROGEN BONDS; POLYCYCLIC AROMATIC HYDROCARBONS;

ADDITIONAL STRUCTURES; BINDING CAPABILITY; COMPARATIVE ANALYSIS; CONFORMATIONAL CHANGE; ENZYME CONFORMATIONS; HIGH THROUGHPUT SCREENING; MYCOBACTERIUM TUBERCULOSIS; STRUCTURAL BIOLOGY;

BINS;

CARBONYL DERIVATIVE; INDOLE DERIVATIVE; MALATE SYNTHASE; METHIONINE; PHENYL DIKETO ACID; REAGENT; UNCLASSIFIED DRUG; MALIC ACID; MALIC ACID DERIVATIVE;

ARTICLE; CATALYSIS; COMPARATIVE STUDY; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME BINDING; ENZYME CONFORMATION; ENZYME STRUCTURE; ENZYME SUBSTRATE; HYDROGEN BOND; IC50; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ANALYSIS; BINDING SITE; CHEMISTRY; ENZYME SPECIFICITY; ENZYMOLOGY; METABOLISM; MOLECULAR MODEL; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CATALYSIS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; MALATE SYNTHASE; MALATES; MODELS, MOLECULAR; MYCOBACTERIUM TUBERCULOSIS; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY;

EID: 85007607694     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M116.750877     Document Type: Article

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