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Volumn 69, Issue 1, 2017, Pages 77-85

Combined Treatment With Chondroitin Sulfate and Glucosamine Sulfate Shows No Superiority Over Placebo for Reduction of Joint Pain and Functional Impairment in Patients With Knee Osteoarthritis: A Six-Month Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Author keywords

[No Author keywords available]

Indexed keywords

CHONDROITIN SULFATE; GLUCOSAMINE SULFATE; PARACETAMOL; PLACEBO; GLUCOSAMINE;

EID: 85007279690     PISSN: 23265191     EISSN: 23265205     Source Type: Journal    
DOI: 10.1002/art.39819     Document Type: Article
Times cited : (94)

References (40)
  • 1
    • 0035138098 scopus 로고    scopus 로고
    • Knee pain and osteoarthritis in older adults: a review of community burden and current use of primary health care [review]
    • Peat G, McCarney R, Croft P. Knee pain and osteoarthritis in older adults: a review of community burden and current use of primary health care [review]. Ann Rheum Dis 2001;60:91–7.
    • (2001) Ann Rheum Dis , vol.60 , pp. 91-97
    • Peat, G.1    McCarney, R.2    Croft, P.3
  • 2
    • 84859773681 scopus 로고    scopus 로고
    • American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee
    • Hochberg MC, Altman RD, April KT, Benkhalti M, Guyatt G, McGowan J, et al. American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee. Arthritis Care Res (Hoboken) 2012;64:465–74.
    • (2012) Arthritis Care Res (Hoboken) , vol.64 , pp. 465-474
    • Hochberg, M.C.1    Altman, R.D.2    April, K.T.3    Benkhalti, M.4    Guyatt, G.5    McGowan, J.6
  • 5
    • 84919631358 scopus 로고    scopus 로고
    • An algorithm recommendation for the management of knee osteoarthritis in Europe and internationally: a report from a task force of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO)
    • Bruyère O, Cooper C, Pelletier JP, Branco J, Luisa Brandi M, Guillemin F, et al. An algorithm recommendation for the management of knee osteoarthritis in Europe and internationally: a report from a task force of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). Semin Arthritis Rheum 2014;44:253–63.
    • (2014) Semin Arthritis Rheum , vol.44 , pp. 253-263
    • Bruyère, O.1    Cooper, C.2    Pelletier, J.P.3    Branco, J.4    Luisa Brandi, M.5    Guillemin, F.6
  • 6
    • 33847016418 scopus 로고    scopus 로고
    • Glucosamine sulfate in the treatment of knee osteoarthritis symptoms: a randomized, double-blind, placebo-controlled study using acetaminophen as a side comparator
    • Herrero-Beaumont G, Ivorra JA, del Carmen Trabado M, Blanco FJ, Benito P, Martín-Mola E, et al. Glucosamine sulfate in the treatment of knee osteoarthritis symptoms: a randomized, double-blind, placebo-controlled study using acetaminophen as a side comparator. Arthritis Rheum 2007;56:555–67.
    • (2007) Arthritis Rheum , vol.56 , pp. 555-567
    • Herrero-Beaumont, G.1    Ivorra, J.A.2    del Carmen Trabado, M.3    Blanco, F.J.4    Benito, P.5    Martín-Mola, E.6
  • 7
    • 84954371655 scopus 로고    scopus 로고
    • Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib
    • Hochberg MC, Martel-Pelletier J, Monfort J, Möller I, Castillo JR, Arden N, et al. Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib. Ann Rheum Dis 2016;75:37–44.
    • (2016) Ann Rheum Dis , vol.75 , pp. 37-44
    • Hochberg, M.C.1    Martel-Pelletier, J.2    Monfort, J.3    Möller, I.4    Castillo, J.R.5    Arden, N.6
  • 8
    • 33344461287 scopus 로고    scopus 로고
    • Glucosamine, chondroitin sulfate and the two in combination for painful knee osteoarthritis
    • Clegg DO, Reda DJ, Harris CL, Klein MA, O'Dell JR, Hooper MM, et al. Glucosamine, chondroitin sulfate and the two in combination for painful knee osteoarthritis. N Engl J Med 2006;354:795–808.
    • (2006) N Engl J Med , vol.354 , pp. 795-808
    • Clegg, D.O.1    Reda, D.J.2    Harris, C.L.3    Klein, M.A.4    O'Dell, J.R.5    Hooper, M.M.6
  • 10
    • 84912119164 scopus 로고    scopus 로고
    • Risk of bias and brand explain the observed inconsistency in trials on glucosamine for symptomatic relief of osteoarthritis: a meta-analysis of placebo-controlled trials
    • Eriksen P, Bartels EM, Altman RD, Bliddal H, Juhl C, Christensen R. Risk of bias and brand explain the observed inconsistency in trials on glucosamine for symptomatic relief of osteoarthritis: a meta-analysis of placebo-controlled trials. Arthritis Care Res (Hoboken) 2014;66:1844–55.
    • (2014) Arthritis Care Res (Hoboken) , vol.66 , pp. 1844-1855
    • Eriksen, P.1    Bartels, E.M.2    Altman, R.D.3    Bliddal, H.4    Juhl, C.5    Christensen, R.6
  • 11
    • 84940103785 scopus 로고    scopus 로고
    • Is chondroitin sulfate plus glucosamine superior to placebo in the treatment of knee osteoarthritis? [letter]
    • Zeng C, Wei J, Lei GH. Is chondroitin sulfate plus glucosamine superior to placebo in the treatment of knee osteoarthritis? [letter]. Ann Rheum Dis 2015;74:e37.
    • (2015) Ann Rheum Dis , vol.74
    • Zeng, C.1    Wei, J.2    Lei, G.H.3
  • 12
    • 84926618656 scopus 로고    scopus 로고
    • Does MOVES move the needle? [letter]
    • Meyer R. Does MOVES move the needle? [letter]. Ann Rheum Dis 2015;74:e35.
    • (2015) Ann Rheum Dis , vol.74
    • Meyer, R.1
  • 13
    • 56049109217 scopus 로고    scopus 로고
    • The placebo effect and its determinants in osteoarthritis: meta-analysis of randomised controlled trials
    • Zhang W, Robertson J, Jones AC, Dieppe PA, Doherty M. The placebo effect and its determinants in osteoarthritis: meta-analysis of randomised controlled trials. Ann Rheum Dis 2008;67:1716–23.
    • (2008) Ann Rheum Dis , vol.67 , pp. 1716-1723
    • Zhang, W.1    Robertson, J.2    Jones, A.C.3    Dieppe, P.A.4    Doherty, M.5
  • 15
    • 84960241534 scopus 로고    scopus 로고
    • Recommendations for an update of the 2010 European regulatory guideline on clinical investigation of medicinal products used in the treatment of osteoarthritis and reflections about related clinically relevant outcomes: expert consensus statement
    • Reginster JY, Reiter-Niesert S, Bruyère O, Berenbaum F, Brandi ML, Branco J, et al. Recommendations for an update of the 2010 European regulatory guideline on clinical investigation of medicinal products used in the treatment of osteoarthritis and reflections about related clinically relevant outcomes: expert consensus statement. Osteoarthritis Cartilage 2015;23:2086–93.
    • (2015) Osteoarthritis Cartilage , vol.23 , pp. 2086-2093
    • Reginster, J.Y.1    Reiter-Niesert, S.2    Bruyère, O.3    Berenbaum, F.4    Brandi, M.L.5    Branco, J.6
  • 16
    • 0022465236 scopus 로고
    • Development of criteria for the classification and reporting of osteoarthritis: classification of osteoarthritis of the knee
    • Altman R, Asch E, Bloch D, Bole G, Borenstein D, Brandt K, et al. Development of criteria for the classification and reporting of osteoarthritis: classification of osteoarthritis of the knee. Arthritis Rheum 1986;29:1039–49.
    • (1986) Arthritis Rheum , vol.29 , pp. 1039-1049
    • Altman, R.1    Asch, E.2    Bloch, D.3    Bole, G.4    Borenstein, D.5    Brandt, K.6
  • 17
    • 62949246527 scopus 로고
    • Radiological assessment of osteo-arthrosis
    • Kellgren JH, Lawrence JS. Radiological assessment of osteo-arthrosis. Ann Rheum Dis 1957;16:494–502.
    • (1957) Ann Rheum Dis , vol.16 , pp. 494-502
    • Kellgren, J.H.1    Lawrence, J.S.2
  • 18
    • 0024268463 scopus 로고
    • Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee
    • Bellamy N, Buchanan WW, Goldsmith CH, Campbell J, Stitt LW. Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. J Rheumatol 1988;15:1833–40.
    • (1988) J Rheumatol , vol.15 , pp. 1833-1840
    • Bellamy, N.1    Buchanan, W.W.2    Goldsmith, C.H.3    Campbell, J.4    Stitt, L.W.5
  • 19
    • 2342652256 scopus 로고    scopus 로고
    • OMERACT-OARSI initiative: Osteoarthritis Research Society International set of responder criteria for osteoarthritis clinical trials revisited. Osteoarthritis
    • Pham T, van der Heijde D, Altman RD, Anderson JJ, Bellamy N, Hochberg M, et al. OMERACT-OARSI initiative: Osteoarthritis Research Society International set of responder criteria for osteoarthritis clinical trials revisited. Osteoarthritis Cartilage 2004;12:389–99.
    • (2004) Cartilage , vol.12 , pp. 389-399
    • Pham, T.1    van der Heijde, D.2    Altman, R.D.3    Anderson, J.J.4    Bellamy, N.5    Hochberg, M.6
  • 21
    • 85007310730 scopus 로고    scopus 로고
    • Guideline on data monitoring committee. July 27, 2005
    • European Medicines Agency Committee for Medicinal Products for Human Use. Guideline on data monitoring committee. July 27, 2005. URL: http://osp.od.nih.gov/sites/default/files/resources/WC500003635.pdf.
  • 22
    • 0024832356 scopus 로고
    • Practical problems in interim analyses, with particular regard to estimation
    • Pocock SJ, Hughes MD. Practical problems in interim analyses, with particular regard to estimation. Control Clin Trials 1989;10 Suppl:209S–21S.
    • (1989) Control Clin Trials , vol.10 , pp. 209S-221S
    • Pocock, S.J.1    Hughes, M.D.2
  • 23
    • 84958104663 scopus 로고    scopus 로고
    • Effects of glucosamine sulfate on the use of rescue non-steroidal anti-inflammatory drugs in knee osteoarthritis: results from the Pharmaco-Epidemiology of GonArthroSis (PEGASus) study
    • Rovati LC, Girolami F, D'Amato M, Giacovelli G. Effects of glucosamine sulfate on the use of rescue non-steroidal anti-inflammatory drugs in knee osteoarthritis: results from the Pharmaco-Epidemiology of GonArthroSis (PEGASus) study. Semin Arthritis Rheum 2016;45 Suppl:S34–41.
    • (2016) Semin Arthritis Rheum , vol.45 , pp. S34-41
    • Rovati, L.C.1    Girolami, F.2    D'Amato, M.3    Giacovelli, G.4
  • 24
    • 84896421136 scopus 로고    scopus 로고
    • Chondroitin and glucosamine in the management of osteoarthritis: an update [review]
    • Henrotin Y, Lambert C. Chondroitin and glucosamine in the management of osteoarthritis: an update [review]. Curr Rheumatol Rep 2013;15:361.
    • (2013) Curr Rheumatol Rep , vol.15 , pp. 361
    • Henrotin, Y.1    Lambert, C.2
  • 25
    • 84922383392 scopus 로고    scopus 로고
    • First-line analysis of the effects of treatment on progression of structural changes in knee osteoarthritis over 24 months: data from the osteoarthritis initiative progression cohort
    • Martel-Pelletier J, Roubille C, Abram F, Hochberg MC, Dorais M, Delorme P, et al. First-line analysis of the effects of treatment on progression of structural changes in knee osteoarthritis over 24 months: data from the osteoarthritis initiative progression cohort. Ann Rheum Dis 2015;74:547–56.
    • (2015) Ann Rheum Dis , vol.74 , pp. 547-556
    • Martel-Pelletier, J.1    Roubille, C.2    Abram, F.3    Hochberg, M.C.4    Dorais, M.5    Delorme, P.6
  • 26
    • 84926454571 scopus 로고    scopus 로고
    • Glucosamine and chondroitin for knee osteoarthritis: a double-blind randomized placebo-controlled clinical trial evaluating single and combination regimens
    • Fransen M, Agaliotis M, Nairn L, Votrubec M, Bridgett L, Su S, et al. Glucosamine and chondroitin for knee osteoarthritis: a double-blind randomized placebo-controlled clinical trial evaluating single and combination regimens. Ann Rheum Dis 2015;74:851–8.
    • (2015) Ann Rheum Dis , vol.74 , pp. 851-858
    • Fransen, M.1    Agaliotis, M.2    Nairn, L.3    Votrubec, M.4    Bridgett, L.5    Su, S.6
  • 27
    • 77957342022 scopus 로고    scopus 로고
    • Effects of glucosamine, chondroitin, or placebo in patients with osteoarthritis of hip or knee: network meta-analysis
    • Wandel S, Jüni P, Tendal B, Nüesch E, Villiger PM, Welton NJ, et al. Effects of glucosamine, chondroitin, or placebo in patients with osteoarthritis of hip or knee: network meta-analysis. BMJ 2010;341:c4675.
    • (2010) BMJ , vol.341 , pp. c4675
    • Wandel, S.1    Jüni, P.2    Tendal, B.3    Nüesch, E.4    Villiger, P.M.5    Welton, N.J.6
  • 28
    • 77955444703 scopus 로고    scopus 로고
    • Clinical efficacy and safety of glucosamine, chondroitin sulphate, their combination, celecoxib or placebo taken to treat osteoarthritis of the knee: 2-year results from GAIT
    • Sawitzke AD, Shi H, Finco MF, Dunlop DD, Harris CL, Singer NG, et al. Clinical efficacy and safety of glucosamine, chondroitin sulphate, their combination, celecoxib or placebo taken to treat osteoarthritis of the knee: 2-year results from GAIT. Ann Rheum Dis 2010;69:1459–64.
    • (2010) Ann Rheum Dis , vol.69 , pp. 1459-1464
    • Sawitzke, A.D.1    Shi, H.2    Finco, M.F.3    Dunlop, D.D.4    Harris, C.L.5    Singer, N.G.6
  • 29
    • 54949121728 scopus 로고    scopus 로고
    • The effect of glucosamine and/or chondroitin sulfate on the progression of knee osteoarthritis: a report from the glucosamine/chondroitin arthritis intervention trial
    • Sawitzke AD, Shi H, Finco MF, Dunlop DD, Bingham CO III, Harris CL, et al. The effect of glucosamine and/or chondroitin sulfate on the progression of knee osteoarthritis: a report from the glucosamine/chondroitin arthritis intervention trial. Arthritis Rheum 2008;58:3183–91.
    • (2008) Arthritis Rheum , vol.58 , pp. 3183-3191
    • Sawitzke, A.D.1    Shi, H.2    Finco, M.F.3    Dunlop, D.D.4    Bingham, C.O.I.I.I.5    Harris, C.L.6
  • 30
    • 84923621642 scopus 로고    scopus 로고
    • Effects of glucosamine and chondroitin supplementation on knee osteoarthritis: an analysis with marginal structural models
    • Yang S, Eaton CB, McAlindon TE, Lapane KL. Effects of glucosamine and chondroitin supplementation on knee osteoarthritis: an analysis with marginal structural models. Arthritis Rheumatol 2015;67:714–23.
    • (2015) Arthritis Rheumatol , vol.67 , pp. 714-723
    • Yang, S.1    Eaton, C.B.2    McAlindon, T.E.3    Lapane, K.L.4
  • 31
    • 34547446740 scopus 로고    scopus 로고
    • The efficacy of glucosamine sulfate in osteoarthritis: financial and nonfinancial conflict of interest [editorial]
    • Reginster JY. The efficacy of glucosamine sulfate in osteoarthritis: financial and nonfinancial conflict of interest [editorial]. Arthritis Rheum 2007;56:2105–10.
    • (2007) Arthritis Rheum , vol.56 , pp. 2105-2110
    • Reginster, J.Y.1
  • 32
    • 78649342425 scopus 로고    scopus 로고
    • Glucosamine sulfate for knee osteoarthritis: science and evidence-based use
    • Roman-Blas JA, Castañeda S, Largo R, Herrero-Beaumont G. Glucosamine sulfate for knee osteoarthritis: science and evidence-based use. Therapy 2010;7:591–604.
    • (2010) Therapy , vol.7 , pp. 591-604
    • Roman-Blas, J.A.1    Castañeda, S.2    Largo, R.3    Herrero-Beaumont, G.4
  • 33
    • 84898865454 scopus 로고    scopus 로고
    • Absorption, distribution and mechanism of action of SYSADOAS
    • Du Souich P. Absorption, distribution and mechanism of action of SYSADOAS. Pharmacol Ther 2014;142:362–74.
    • (2014) Pharmacol Ther , vol.142 , pp. 362-374
    • Du Souich, P.1
  • 34
    • 84922377576 scopus 로고    scopus 로고
    • Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis
    • Bannuru RR, Schmid CH, Kent DM, Vaysbrot EE, Wong JB, McAlindon TE. Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis. Ann Intern Med 2015;162:46–54.
    • (2015) Ann Intern Med , vol.162 , pp. 46-54
    • Bannuru, R.R.1    Schmid, C.H.2    Kent, D.M.3    Vaysbrot, E.E.4    Wong, J.B.5    McAlindon, T.E.6
  • 36
    • 70349237213 scopus 로고    scopus 로고
    • The “placebo” response in osteoarthritis and its implications for clinical practice
    • Doherty M, Dieppe P. The “placebo” response in osteoarthritis and its implications for clinical practice. Osteoarthritis Cartilage 2009;17:1255–62.
    • (2009) Osteoarthritis Cartilage , vol.17 , pp. 1255-1262
    • Doherty, M.1    Dieppe, P.2
  • 37
    • 84940531679 scopus 로고    scopus 로고
    • Placebos for knee osteoarthritis: reaffirmation of “needle is better than pill
    • Zhang W, Zou K, Doherty M. Placebos for knee osteoarthritis: reaffirmation of “needle is better than pill.” Ann Intern Med 2015;163:392–3.
    • (2015) Ann Intern Med , vol.163 , pp. 392-393
    • Zhang, W.1    Zou, K.2    Doherty, M.3
  • 38
    • 79955954713 scopus 로고    scopus 로고
    • Therapeutic trajectory following intra-articular hyaluronic acid injection in knee osteoarthritis: meta-analysis
    • Bannuru RR, Natov NS, Dasi UR, Schmid CH, McAlindon TE. Therapeutic trajectory following intra-articular hyaluronic acid injection in knee osteoarthritis: meta-analysis. Osteoarthritis Cartilage 2011;19:611–9.
    • (2011) Osteoarthritis Cartilage , vol.19 , pp. 611-619
    • Bannuru, R.R.1    Natov, N.S.2    Dasi, U.R.3    Schmid, C.H.4    McAlindon, T.E.5
  • 39
    • 76549129482 scopus 로고    scopus 로고
    • The human pharmacokinetics of oral ingestion of glucosamine and chondroitin sulfate taken separately or in combination
    • Jackson CG, Plaas AH, Sandy JD, Hua C, Kim-Rolands S, Barnhill JG, et al. The human pharmacokinetics of oral ingestion of glucosamine and chondroitin sulfate taken separately or in combination. Osteoarthritis Cartilage 2010;18:297–302.
    • (2010) Osteoarthritis Cartilage , vol.18 , pp. 297-302
    • Jackson, C.G.1    Plaas, A.H.2    Sandy, J.D.3    Hua, C.4    Kim-Rolands, S.5    Barnhill, J.G.6
  • 40
    • 84871919556 scopus 로고    scopus 로고
    • Equivalence of a single dose (1200 mg) compared to a three-time a day dose (400 mg) of chondroitin 4&6 sulfate in patients with knee osteoarthritis: results of a randomized double blind placebo controlled study
    • Zegels B, Crozes P, Uebelhart D, Bruyère O, Reginster JY. Equivalence of a single dose (1200 mg) compared to a three-time a day dose (400 mg) of chondroitin 4&6 sulfate in patients with knee osteoarthritis: results of a randomized double blind placebo controlled study. Osteoarthritis Cartilage 2013;21:22–7.
    • (2013) Osteoarthritis Cartilage , vol.21 , pp. 22-27
    • Zegels, B.1    Crozes, P.2    Uebelhart, D.3    Bruyère, O.4    Reginster, J.Y.5


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