Association of NKG2D gene variants with susceptibility and severity of rheumatoid arthritis

Clinical and Experimental Immunology

Volumn 187, Issue 3, 2017, Pages 369-375

  Mariaselvam, C M ^a,b   Tamouza, R ^b   Krishnamoorthy, R ^b   Charron, D ^b   Misra, D P ^b   Jain, V K ^b   Negi, V S ^b  

^a JAWAHARLAL INSTITUTE OF POSTGRADUATE MEDICAL EDUCATION AND RESEARCH   (India)

^b SAINT LOUIS HOSPITAL   (France)

Author keywords

haplotypes; MHC class I related chain A; NKG2D receptor; rheumatoid arthritis; single nucleotide polymorphism

Indexed keywords

METHOTREXATE; NATURAL KILLER CELL RECEPTOR; NATURAL KILLER CELL RECEPTOR NKG2A17; NATURAL KILLER CELL RECEPTOR NKG2D; NATURAL KILLER CELL RECEPTOR NKG2D10; NATURAL KILLER CELL RECEPTOR NKG2D11; NATURAL KILLER CELL RECEPTOR NKG2D12; NATURAL KILLER CELL RECEPTOR NKG2D3; NATURAL KILLER CELL RECEPTOR NKG2D4; NATURAL KILLER CELL RECEPTOR NKG2D7; NATURAL KILLER CELL RECEPTOR NKG2D9; UNCLASSIFIED DRUG; KLRK1 PROTEIN, HUMAN; LECTIN; NATURAL KILLER CELL LECTIN LIKE RECEPTOR SUBFAMILY K;

ADULT; AGED; ARTICLE; CASE CONTROL STUDY; CHROMOSOME 12; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE SEVERITY; DNA POLYMORPHISM; FEMALE; GENE FREQUENCY; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; LINKAGE ANALYSIS; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SINGLE NUCLEOTIDE POLYMORPHISM; TREATMENT RESPONSE; ADOLESCENT; ALLELE; GENETIC PREDISPOSITION; GENETICS; MIDDLE AGED; ODDS RATIO; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; ALLELES; ARTHRITIS, RHEUMATOID; CASE-CONTROL STUDIES; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HUMANS; LECTINS, C-TYPE; MALE; MIDDLE AGED; NK CELL LECTIN-LIKE RECEPTOR SUBFAMILY K; ODDS RATIO; POLYMORPHISM, SINGLE NUCLEOTIDE; YOUNG ADULT;

EID: 85007173678     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/cei.12891     Document Type: Article

References (27)

1. Scott DL, Wolfe F, Huizinga TW. Rheumatoid arthritis. Lancet 2010; 376:1094–108.
2. McInnes IB, Schett G. The pathogenesis of rheumatoid arthritis. N Engl J Med 2011; 365:2205–19.
3. Jacob N, Jacob CO. Genetics of rheumatoid arthritis: an impressionist perspective. Rheum Dis Clin North Am 2012; 38:243–57.
4. Butler NS, Harty JT. A ‘memorable’ NK cell discovery. Cell Res 2009; 19:277–8.
5. Yen JH, Moore BE, Nakajima T et al. Major histocompatibility complex class I-recognizing receptors are disease risk genes in rheumatoid arthritis. J Exp Med 2001; 193:1159–67.
6. Majorczyk E, Pawlik A, Luszczek W et al. Associations of killer cell immunoglobulin-like receptor genes with complications of rheumatoid arthritis. Genes Immun 2007; 8:678–83.
7. Yen JH, Lin CH, Tsai WC et al. Killer cell immunoglobulin-like receptor gene's repertoire in rheumatoid arthritis. Scand J Rheumatol 2006; 35:124–7.
8. Ramirez-De los Santos S, Sanchez-Hernandez PE, Munoz-Valle JF et al. Associations of killer cell immunoglobulin- like receptor genes with rheumatoid arthritis. Dis Markers 2012; 33:201–6.
9. Nazari M, Mahmoudi M, Rahmani F et al. Association of killer cell immunoglobulin-like receptor genes in iranian patients with rheumatoid arthritis. PLOS ONE 2015; 10:e0143757.
10. Prakash S, Alam S, Bharadwaj U et al. Associations of killer cell immunoglobulin like receptors with rheumatoid arthritis among North Indian population. Hum Immunol 2014; 75:802–7.
11. Velarde-de la Cruz EE, Sanchez-Hernandez PE, Munoz-Valle JF et al. KIR2DL2 and KIR2DS2 as genetic markers to the methotrexate response in rheumatoid arthritis patients. Immunopharmacol Immunotoxicol 2016; 38:303–9.
12. Majorczyk E, Pawlik A, Gendosz D, Kusnierczyk P. Presence of the full-length KIR2DS4 gene reduces the chance of rheumatoid arthritis patients to respond to methotrexate treatment. BMC Musculoskelet Disord 2014; 15:256.
13. Zafirova B, Wensveen FM, Gulin M, Polic B. Regulation of immune cell function and differentiation by the NKG2D receptor. Cell Mol Life Sci 2011; 68:3519–29.
14. Achour Y, Kammoun A, Ben Hamad M et al. Association study of MICA gene polymorphisms with rheumatoid arthritis susceptibility in south Tunisian population. Int J Immunogenet 2014; 41:486–92.
15. Caillat-Zucman S. How NKG2D ligands trigger autoimmunity? Hum Immunol 2006; 67:204–7.
16. Groh V, Bruhl A, El-Gabalawy H, Nelson JL, Spies T. Stimulation of T cell autoreactivity by anomalous expression of NKG2D and its MIC ligands in rheumatoid arthritis. Proc Natl Acad Sci USA 2003; 100:9452–7.
17. Groh V, Smythe K, Dai Z, Spies T. Fas-ligand-mediated paracrine T cell regulation by the receptor NKG2D in tumor immunity. Nat Immunol 2006; 7:755–62.
18. Park KS, Park JH, Song YW. Inhibitory NKG2A and activating NKG2D and NKG2C natural killer cell receptor genes: susceptibility for rheumatoid arthritis. Tissue Antigens 2008; 72:342–6.
19. Aletaha D, Neogi T, Silman AJ et al. Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum 2010; 62:2569–81.
20. van Gestel AM, Prevoo ML, van't Hof MA et al. Development and validation of the European League Against Rheumatism response criteria for rheumatoid arthritis. Comparison with the preliminary American College of Rheumatology and the World Health Organization/International League Against Rheumatism Criteria. Arthritis Rheum 1996; 39:34–40.
21. Hayashi T, Imai K, Morishita Y et al. Identification of the NKG2D haplotypes associated with natural cytotoxic activity of peripheral blood lymphocytes and cancer immunosurveillance. Cancer Res 2006; 66:563–70.
22. The CaTS Power Calculator. Available at: http://csg.sph.umich.edu/abecasis/cats/index.html (accessed 4 October 2016).
23. Ogasawara K, Hamerman JA, Ehrlich LR et al. NKG2D blockade prevents autoimmune diabetes in NOD mice. Immunity 2004; 20:757–67.
24. La Scaleia R, Stoppacciaro A, Oliva S et al. NKG2D/Ligand dysregulation and functional alteration of innate immunity cell populations in pediatric IBD. Inflamm Bowel Dis 2012; 18:1910–22.
25. Kjellev S, Haase C, Lundsgaard D et al. Inhibition of NKG2D receptor function by antibody therapy attenuates transfer-induced colitis in SCID mice. Eur J Immunol 2007; 37:1397–406.
26. Kabalak G, Thomas RM, Martin J et al. Association of an NKG2D gene variant with systemic lupus erythematosus in two populations. Hum Immunol 2010; 71:74–8.
27. Piotrowski P, Lianeri M, Olesinska M, Jagodzinski PP. Prevalence of the NKG2D Thr72Ala polymorphism in patients with systemic lupus erythematosus. Mol Biol Rep 2012; 39:1343–7.