Polysialic acid blocks mononuclear phagocyte reactivity, inhibits complement activation, and protects from vascular damage in the retina

EMBO Molecular Medicine

Volumn 9, Issue 2, 2017, Pages 154-166

  Karlstetter, Marcus ^a,b   Kopatz, Jens ^c   Aslanidis, Alexander ^a   Shahraz, Anahita ^c   Caramoy, Albert ^a   Linnartz Gerlach, Bettina ^c   Lin, Yuchen ^d   Lückoff, Anika ^a   Fauser, Sascha ^a   Düker, Katharina ^c   Claude, Janine ^c   Wang, Yiner ^c   Ackermann, Johannes ^c   Schmidt, Tobias ^c   Hornung, Veit ^c,e   Skerka, Christine ^d   Langmann, Thomas ^a   Neumann, Harald ^c  

^a UNIVERSITY OF COLOGNE   (Germany)

^b BAYER PHARMA AG   (Germany)

^c UNIVERSITY HOSPITAL BONN   (Germany)

^d HANS KNÖLL INSTITUTE   (Germany)

^e UNIVERSITY OF MUNICH   (Germany)

Author keywords

age related macular degeneration; complement; microglia; polysialic acid; SIGLEC

Indexed keywords

LECTIN RECEPTOR; POLYSIALIC ACID; PROTEIN SIGLEC11; SUPEROXIDE; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; VASCULOTROPIN A; IMMUNOLOGIC FACTOR; LECTIN; MEMBRANE PROTEIN; SIALIC ACID DERIVATIVE; SIGLEC11 PROTEIN, HUMAN;

AGE RELATED MACULAR DEGENERATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL INJURY; COMPLEMENT ALTERNATIVE PATHWAY; COMPLEMENT DEPENDENT CYTOTOXICITY; COMPLEMENT INHIBITION; COMPLEX FORMATION; CONTROLLED STUDY; IMMUNOREACTIVITY; INNATE IMMUNITY; LASER; LOW DRUG DOSE; MACROPHAGE; MICROGLIA; MONONUCLEAR PHAGOCYTE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PHAGOCYTOSIS; POLYMERIZATION; PROPHYLAXIS; PROTEIN EXPRESSION; RETINA INJURY; ANIMAL; CHOROIDAL NEOVASCULARIZATION; COMPLEMENT ACTIVATION; DRUG EFFECTS; GENETICS; HUMAN; IMMUNOLOGY; INJURIES; METABOLISM; PHAGOCYTE; RETINA; SCID MOUSE; TRANSGENIC MOUSE;

ANIMALS; CHOROIDAL NEOVASCULARIZATION; COMPLEMENT ACTIVATION; HUMANS; IMMUNOLOGIC FACTORS; LASERS; LECTINS; MEMBRANE PROTEINS; MICE, SCID; MICE, TRANSGENIC; PHAGOCYTES; RETINA; SIALIC ACIDS;

EID: 85007049661     PISSN: 17574676     EISSN: 17574684     Source Type: Journal    
DOI: 10.15252/emmm.201606627     Document Type: Article

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