Cortisol stress reactivity across psychiatric disorders: A systematic review and meta-analysis

Psychoneuroendocrinology

Volumn 77, Issue , 2017, Pages 25-36

  Zorn, Jelle V ^a   Schür, Remmelt R ^a   Boks, Marco P ^a   Kahn, René S ^a   Joëls, Marian ^a,b   Vinkers, Christiaan H ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

Acute stress; AUC; Psychiatry; Psychosocial stress; Trier social stress test

Indexed keywords

HYDROCORTISONE;

ANXIETY DISORDER; CORTISOL STRESS REACTIVITY; DISEASE ASSOCIATION; DRUG USE; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYDROCORTISONE RELEASE; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MAJOR DEPRESSION; MENTAL DISEASE; MENTAL STRESS; PANIC; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; REVIEW; SCHIZOPHRENIA; SEX DIFFERENCE; SOCIAL PHOBIA; STRESS ASSESSMENT; SYSTEMATIC REVIEW; CHEMISTRY; HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS HYPOPHYSIS SYSTEM; META ANALYSIS; PATHOPHYSIOLOGY; SALIVA;

HUMANS; HYDROCORTISONE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MENTAL DISORDERS; PITUITARY-ADRENAL SYSTEM; SALIVA; STRESS, PSYCHOLOGICAL;

EID: 85006952396     PISSN: 03064530     EISSN: 18733360     Source Type: Journal    
DOI: 10.1016/j.psyneuen.2016.11.036     Document Type: Review

References (60)

1. Agnew-Blais, J., Danese, A., Childhood maltreatment and unfavourable clinical outcomes in bipolar disorder: a systematic review and meta-analysis. Lancet Psychiatry 3 (2016), 342–349.
2. Ahrens, T., Deuschle, M., Krumm, B., van der Pompe, G., den Boer, J.A., Lederbogen, F., Pituitary-adrenal and sympathetic nervous system responses to stress in women remitted from recurrent major depression. Psychosom. Med. 70 (2008), 461–467.
3. Bagley, S.L., Weaver, T.L., Buchanan, T.W., Sex differences in physiological and affective responses to stress in remitted depression. Physiol. Behav. 104 (2011), 180–186.
4. Booij, S.H., Bouma, E.M.C., De Jonge, P., Ormel, J., Oldehinkel, A.J., Chronicity of depressive problems and the cortisol response to psychosocial stress in adolescents: the TRAILS study. Psychoneuroendocrinology 38 (2013), 659–666.
5. Borenstein, M., Hedges, L., Higgins, J.R.H., Comprehensive Meta- Analysis Version 2. 2005.
6. Brenner, K., St-Hilaire, A., Liu, A., Laplante, D.P., King, S., Cortisol response and coping style predict quality of life in schizophrenia. Schizophr. Res. 128 (2011), 23–29.
7. Ciufolini, S., Dazzan, P., Kempton, M.J., Pariante, C., Mondelli, V., HPA axis response to social stress is attenuated in schizophrenia but normal in depression: evidence from a meta-analysis of existing studies. Neurosci. Biobehav. Rev. 47 (2014), 359–368.
8. Cohrs, S., Röher, C., Jordan, W., Meier, A., Huether, G., Wuttke, W., Rüther, E., Rodenbeck, A., The atypical antipsychotics olanzapine and quetiapine, but not haloperidol, reduce ACTH and cortisol secretion in healthy subjects. Psychopharmacology (Berl.) 185 (2006), 11–18.
9. Dietz, L.J., Stoyak, S., Melhem, N., Porta, G., Matthews, K.A., Walker Payne, M., Brent, D.A., Cortisol response to social stress in parentally bereaved youth. Biol. Psychiatry 73 (2013), 379–387.
10. Egger, M., Smith, G.D., Schneider, M., Minder, C., Bias in meta-analysis detected by a simple, graphical test. BMJ 315 (1997), 629–634.
11. Elzinga, B.M., Schmahl, C.G., Vermetten, E., van Dyck, R., Bremner, J.D., Higher cortisol levels following exposure to traumatic reminders in abuse-related PTSD. Neuropsychopharmacology 28 (2003), 1656–1665.
12. Foley, P., Kirschbaum, C., Human hypothalamus–pituitary–adrenal axis responses to acute psychosocial stress in laboratory settings. Neurosci. Biobehav. Rev. 35 (2010), 91–96.
13. Höhne, N., Poidinger, M., Merz, F., Pfister, H., Brückl, T., Zimmermann, P., Uhr, M., Holsboer, F., Ising, M., FKBP5 genotype-dependent DNA methylation and mRNA regulation after psychosocial stress in remitted depression and healthy controls. Int. J. Neuropsychopharmacol., 13(18), 2014.
14. Handa, R.J., Weiser, M.J., Gonadal steroid hormones and the hypothalamo-pituitary-adrenal axis. Front. Neuroendocrinol. 35 (2014), 197–220.
15. Harkness, K.L., Stewart, J.G., Wynne-Edwards, K.E., Cortisol reactivity to social stress in adolescents: role of depression severity and child maltreatment. Psychoneuroendocrinology 36 (2011), 173–181.
16. Heim, C., Newport, D.J., Heit, S., Graham, Y.P., Wilcox, M., Bonsall, R., Miller, A.H., Nemeroff, C.B., Pituitary-adrenal and autonomic responses to stress in women after sexual and physical abuse in childhood. JAMA 284 (2000), 592–597.
17. Heim, C., Newport, D.J., Mletzko, T., Miller, A.H., Nemeroff, C.B., The link between childhood trauma and depression: insights from HPA axis studies in humans. Psychoneuroendocrinology 33 (2008), 693–710.
18. Hellhammer, D., Hero, T., Gerhards, F., Hellhammer, J., Neuropattern: a new translational tool to detect and treat stress pathology I. Strategical consideration. Stress 15 (2012), 479–487.
19. Higgins, J.P., Thompson, S.G., Deeks, J.J., Altman, D.G., Measuring inconsistency in meta-analyses. BMJ 327 (2003), 557–560.
20. Holtzman, C.W., Trotman, H.D., Goulding, S.M., Ryan, A.T., MacDonald, A.N., Shapiro, D.I., Brasfield, J.L., Walker, E.F., Stress and neurodevelopmental processes in the emergence of psychosis. Neuroscience 249 (2013), 172–191.
21. Houtepen, L.C., Boks, M.P., Kahn, R.S., Joëls, M., Vinkers, C.H., Antipsychotic use is associated with a blunted cortisol stress response: a study in euthymic bipolar disorder patients and their unaffected siblings. Eur. Neuropsychopharmacol. 25:2015 (2015), 77–84.
22. Houtepen, L.C., Vinkers, C.H., Carrillo-Roa, T., Hiemstra, M., van Lier, P.A., Meeus, W., Branje, S., Heim, C.M., Nemeroff, C.B., Mill, J., Schalkwyk, L.C., Creyghton, M.P., Kahn, R.S., Joëls, M., Binder, E.B., Boks, M.P., Genome-wide DNA methylation levels and altered cortisol stress reactivity following childhood trauma in humans. Nat. Commun., 21, 2016, 10967.
23. Jansen, L.M., Gispen-de Wied, C.C., Gademan, P.J., De Jonge, R.C., van der Linden, J.A., Kahn, R.S., Blunted cortisol response to a psychosocial stressor in schizophrenia. Schizophr. Res. 33 (1998), 87–94.
24. Jansen, L.M., Gispen-de Wied, C.C., Kahn, R.S., Selective impairments in the stress response in schizophrenic patients. Psychopharmacology (Berl.) 149 (2000), 319–325.
25. Juster, R.P., Raymond, C., Desrochers, A.B., Bourdon, O., Durand, N., Wan, N., Pruessner, J.C., Lupien, S.J., Sex hormones adjust sex-specific reactive and diurnal cortisol profiles. Psychoneuroendocrinology, 63, 2016.
26. Kendler, K.S., Karkowski, L.M., Prescott, C.A., Causal relationship between stressful life events and the onset of major depression. Am. J. Psychiatry 156 (1999), 837–841.
27. Kirschbaum, C., Pirke, K.M., Hellhammer, D.H., The ‘Trier Social Stress Test’–a tool for investigating psychobiological stress responses in a laboratory setting. Neuropsychobiology 28 (1993), 76–81.
28. Kirschbaum, C., Kudielka, B.M., Gaab, J., Schommer, N.C., Hellhammer, D.H., Impact of gender, menstrual cycle phase, and oral contraceptives on the activity of the hypothalamus-pituitary-adrenal axis. Psychosom. Med. 61 (1999), 154–162.
29. Klimes-Dougan, B., Eberly, L.E., Westlund Schreiner, M., Kurkiewicz, P., Houri, A., Schlesinger, A., Thomas, K.M., Mueller, B.A., Lim, K.O., Cullen, K.R., Multilevel assessment of the neurobiological threat system in depressed adolescents: interplay between the limbic system and hypothalamic-pituitary-adrenal axis. Dev. Psychopathol. 26 (2014), 1321–1335.
30. Klumbies, E., Braeuer, D., Hoyer, J., Kirschbaum, C., The reaction to social stress in social phobia: discordance between physiological and subjective parameters. PLoS One, 25(9), 2014.
31. Krämer, M., Seefeldt, W.L., Heinrichs, N., Tuschen-Caffier, B., Schmitz, J., Wolf, O.T., Blechert, J., Subjective, autonomic, and endocrine reactivity during social stress in children with social phobia. J. Abnorm. Child Psychol. 40 (2012), 95–104.
32. Kudielka, B.M., Buske-Kirschbaum, A., Hellhammer, D.H., Kirschbaum, C., HPA axis responses to laboratory psychosocial stress in healthy elderly adults, younger adults, and children: impact of age and gender. Psychoneuroendocrinology 29 (2004), 83–98.
33. Lange, C., Zschucke, E., Ising, M., Uhr, M., Bermpohl, F., Adli, M., Evidence for a normal HPA axis response to psychosocial stress in patients remitted from depression. Psychoneuroendocrinology 38 (2013), 2729–2736.
34. Lennartsson, A.K., Kushnir, M.M., Bergquist, J., Billig, H., Jonsdottir, I.H., Sex steroid levels temporarily increase in response to acute psychosocial stress in healthy men and women. Int. J. Psychophysiol. 84 (2012), 246–253.
35. Lupien, S.J., McEwen, B.S., Gunnar, M.R., Heim, C., Effects of stress throughout the lifespan on the brain, behavior and cognition. Nat. Rev. Neurosci. 10 (2009), 434–454.
36. Manthey, L., Leeds, C., Giltay, E.J., van Veen, T., Vreeburg, S.A., Penninx, B.W., Zitman, F.G., Antidepressant use and salivary cortisol in depressive and anxiety disorders. Eur. Neuropsychopharmacol. 21 (2011), 691–699.
37. Mazurka, R., Wynne-Edwards, K.E., Harkness, K.L., Stressful life events prior to depression onset and the cortisol response to stress in youth with first onset versus recurrent depression. J. Abnorm. Child Psychol. 44 (2016), 1173–1184.
38. McEwen, B.S., Protection and damage from acute and chronic stress: allostasis and allostatic overload and relevance to the pathophysiology of psychiatric disorders. Ann. N. Y. Acad. Sci. 1032 (2004), 1–7.
39. Moreno-Peral, P., Conejo-Cerón, S., Motrico, E., Rodríguez-Morejón, A., Fernández, A., García-Campayo, J., Roca, M., Serrano-Blanco, A., Rubio-Valera, M., Bellón, J.Á., Risk factors for the onset of panic and generalised anxiety disorders in the general adult population: a systematic review of cohort studies. J. Affect. Disord. 168 (2014), 337–348.
40. Morris, M.C., Rao, U., Cortisol response to psychosocial stress during a depressive episode and remission. Stress 17 (2014), 51–58.
41. Morris, M.C., Ciesla, J.A., Garber, J., A prospective study of stress autonomy versus stress sensitization in adolescents at varied risk for depression. J. Abnorm. Psychol. 119 (2010), 341–354.
42. Morris, M.C., Rao, U., Wang, L., Garber, J., Cortisol reactivity to experimentally manipulated psychosocial stress in young adults at varied risk for depression. Depress. Anxiety 31 (2014), 44–52.
43. Petrowski, K., Wintermann, G.B., Schaarschmidt, M., Bornstein, S.R., Kirschbaum, C., Blunted salivary and plasma cortisol response in patients with panic disorder under psychosocial stress. Int. J. Psychophysiol. 88 (2013), 35–39.
44. Pierrehumbert, B., Torrisi, R., Glatz, N., Dimitrova, N., Heinrichs, M., Halfon, O., The influence of attachment on perceived stress and cortisol response to acute stress in women sexually abused in childhood or adolescence. Psychoneuroendocrinology 34 (2009), 924–938.
45. Pinna, K.L., Johnson, D.M., Delahanty, D.L., PTSD, comorbid depression, and the cortisol waking response in victims of intimate partner violence: preliminary evidence. Anxiety Stress Coping 27 (2014), 253–269.
46. Pruessner, J.C., Kirschbaum, C., Meinlschmid, G., Hellhammer, D.H., Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change. Psychoneuroendocrinology 28 (2003), 916–993.
47. Roelofs, K., van Peer, J., Berretty, E., Jong Pd, Spinhoven, P., Elzinga, B.M., Hypothalamus–Pituitary–Adrenal axis hyperresponsiveness is associated with increased social avoidance behavior in social phobia. Biol. Psychiatry 65 (2009), 336–343.
48. Schmidt-Reinwald, A., Pruessner, J.C., Hellhammer, D.H., Federenko, I., Rohleder, N., Schürmeyer, T.H., Kirschbaum, C., The cortisol response to awakening in relation to different challenge tests and a 12-hour cortisol rhythm. Life Sci. 64 (1999), 1653–1660.
49. Stephens, M.A., Mahon, P.B., McCaul, M.E., Wand, G.S., Hypothalamic-pituitary-adrenal axis response to acute psychosocial stress: effects of biological sex and circulating sex hormones. Psychoneuroendocrinology 66 (2016), 47–55.
50. Stewart, J.G., Mazurka, R., Bond, L., Wynne-Edwards, K.E., Harkness, K.L., Rumination and impaired cortisol recovery following a social stressor in adolescent depression. J. Abnorm. Child Psychol. 41 (2013), 1015–1026.
51. Taylor, C.B., Conrad, A., Wilhelm, F.H., Strachowski, D., Khaylis, A., Neri, E., Giese-Davis, J., Roth, W.T., Cooke, J.P., Kraemer, H., Spiegel, D., Does improving mood in depressed patients alter factors that may affect cardiovascular disease risk?. J. Psychiatr. Res. 43 (2009), 1246–1252.
52. Uhart, M., McCaul, M.E., Oswald, L.M., Choi, L., Wand, G.S., GABRA6 gene polymorphism and an attenuated stress response. Mol. Psychiatry 9 (2004), 998–1006.
53. Van West, D., Claes, S., Sulon, J., Deboutte, D., Hypothalamic-pituitary-adrenal reactivity in prepubertal children with social phobia. J. Affect. Disord. 111 (2008), 281–290.
54. Van Zuiden, M., Geuze, E., Willemen, H.L.D.M., Vermetten, E., Maas, M., Heijnen, C.J., Kavelaars, A., Pre-existing high glucocorticoid receptor number predicting development of posttraumatic stress symptoms after military deployment. Am. J. Psychiatry 168 (2011), 89–96.
55. Weinstein, A.A., Deuster, P.A., Francis, J.L., Bonsall, R.W., Tracy, R.P., Kop, W.J., Neurohormonal and inflammatory hyper-responsiveness to acute mental stress in depression. Biol. Psychol. 84 (2010), 228–234.
56. Wintermann, G.B., Kirschbaum, C., Petrowski, K., Predisposition or side effect of the duration: the reactivity of the HPA-axis under psychosocial stress in panic disorder. Int. J. Psychophysiol. 107 (2016), 9–15.
57. Woods, S.W., Calculation of CPZ Equivalents. 2005 www.scottwilliamwoods.com/files/Equivtext.doc (Assessed 26.06.2016).
58. Yoon, K.L., Joormann, J., Stress reactivity in social anxiety disorder with and without comorbid depression. J. Abnorm. Psychol. 121 (2012), 250–255.
59. Young, E.A., Abelson, J.L., Cameron, O.G., Effect of comorbid anxiety disorders on the hypothalamic-pituitary-adrenal axis response to a social stressor in major depression. Biol. Psychiatry 56 (2004), 113–120.
60. Zaba, M., Kirmeier, T., Ionescu, I.A., Wollweber, B., Buell, D.R., Gall-Kleebach, D.J., Schubert, C.F., Novak, B., Huber, C., Köhler, K., Holsboer, F., Pütz, B., Müller-Myhsok, B., Höhne, N., Uhr, M., Ising, M., Herrmann, L., Schmidt, U., Identification and characterization of HPA-axis reactivity endophenotypes in a cohort of female PTSD patients. Psychoneuroendocrinology 55 (2015), 102–115.