Neuroprotective effects of endurance exercise against neuroinflammation in MPTP-induced Parkinson's disease mice

Brain Research

Volumn 1655, Issue , 2017, Pages 186-193

  Jang, Yongchul ^a,d   Koo, Jung Hoon ^a   Kwon, Insu ^d   Kang, Eun Bum ^a   Um, Hyun Seob ^b   Soya, Hideaki ^c   Lee, Youngil ^d   Cho, Joon Yong ^a  

^a Korea National Sport University   (South Korea)

^b Konyang University   (South Korea)

^c UNIVERSITY OF TSUKUBA   (Japan)

^d UNIVERSITY OF WEST FLORIDA   (United States)

Author keywords

Endurance exercise; Parkinson's disease; Toll like receptor 2; Tyrosine hydroxylase; synuclein

Indexed keywords

ALPHA SYNUCLEIN; I KAPPA B KINASE ALPHA; INTERLEUKIN 1BETA; LAMIN B; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR 2; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; TYROSINE 3 MONOOXYGENASE; CYTOKINE; SNCA PROTEIN, MOUSE; TLR2 PROTEIN, MOUSE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL DEATH; CONTROLLED STUDY; CORPUS STRIATUM; ENDURANCE TRAINING; ENZYME PHOSPHORYLATION; MALE; MOTOR COORDINATION; MOTOR DYSFUNCTION; MOUSE; MPTP-INDUCED PARKINSONISM; NERVOUS SYSTEM INFLAMMATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROGNOSIS; YOUNG ADULT; ANIMAL; APOPTOSIS; C57BL MOUSE; ENDURANCE; IMMUNOLOGY; IMMUNOMODULATION; KINESIOTHERAPY; METABOLISM; MOTOR ACTIVITY; MPTP POISONING; PATHOLOGY; PHYSIOLOGY; RANDOMIZATION; ROTAROD TEST; RUNNING; SEDENTARY LIFESTYLE; SUBSTANTIA NIGRA PARS COMPACTA;

ALPHA-SYNUCLEIN; ANIMALS; APOPTOSIS; CORPUS STRIATUM; CYTOKINES; EXERCISE THERAPY; MALE; MICE, INBRED C57BL; MOTOR ACTIVITY; MPTP POISONING; NEUROIMMUNOMODULATION; NEUROPROTECTION; PARS COMPACTA; PHYSICAL ENDURANCE; RANDOM ALLOCATION; ROTAROD PERFORMANCE TEST; RUNNING; SEDENTARY LIFESTYLE; TOLL-LIKE RECEPTOR 2; TYROSINE 3-MONOOXYGENASE;

EID: 85006931144     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2016.10.029     Document Type: Article

References (37)

1. Al-Jarrah, M., Obaidat, H., Bataineh, Z., Walton, L., Al-Khateeb, A., Endurance exercise training protects against the upregulation of nitric oxide in the striatum of MPTP/probenecid mouse model of Parkinson's disease. NeuroRehabilitation 32 (2013), 141–147.
2. Allen, N.E., Moloney, N., van Vliet, V., Canning, C.G., The rationale for exercise in the management of pain in Parkinson's Disease. J. Park. Dis., 2015.
3. Beraud, D., Maguire-Zeiss, K.A., Misfolded alpha-synuclein and Toll-like receptors: therapeutic targets for Parkinson's disease. Park. Relat. Disord. 18:Suppl 1 (2012), S17–S20.
4. Bezard, E., Yue, Z., Kirik, D., Spillantini, M.G., Animal models of Parkinson's disease: limits and relevance to neuroprotection studies. Mov. Disord. 28 (2013), 61–70.
5. Cho, H.S., Shin, M.S., Song, W., Jun, T.W., Lim, B.V., Kim, Y.P., Kim, C.J., Treadmill exercise alleviates short-term memory impairment in 6-hydroxydopamine-induced Parkinson's rats. J. Exerc Rehabil. 9 (2013), 354–361.
6. Codolo, G., Plotegher, N., Pozzobon, T., Brucale, M., Tessari, I., Bubacco, L., de Bernard, M., Triggering of inflammasome by aggregated alpha-synuclein, an inflammatory response in synucleinopathies. PLoS One, 8, 2013, e55375.
7. Dimatelis, J.J., Hendricks, S., Hsieh, J., Vlok, N.M., Bugarith, K., Daniels, W.M., Russell, V.A., Exercise partly reverses the effect of maternal separation on hippocampal proteins in 6-hydroxydopamine-lesioned rat brain. Exp. Physiol. 98 (2013), 233–244.
8. Drouin-Ouellet, J., Gibrat, C., Bousquet, M., Calon, F., Kriz, J., Cicchetti, F., The role of the MYD88-dependent pathway in MPTP-induced brain dopaminergic degeneration. J. Neuroinflamm., 8, 2011, 137.
9. Eikelenboom, P., Veerhuis, R., Scheper, W., Rozemuller, A.J., van Gool, W.A., Hoozemans, J.J., The significance of neuroinflammation in understanding Alzheimer's disease. J. Neural Transm. 113 (2006), 1685–1695.
10. Ferreiro, D.U., Komives, E.A., Molecular mechanisms of system control of NF-kappaB signaling by IkappaBalpha. Biochemistry 49 (2010), 1560–1567.
11. Fisher, B.E., Wu, A.D., Salem, G.J., Song, J., Lin, C.H., Yip, J., Cen, S., Gordon, J., Jakowec, M., Petzinger, G., The effect of exercise training in improving motor performance and corticomotor excitability in people with early Parkinson's disease. Arch. Phys. Med Rehabil. 89 (2008), 1221–1229.
12. Flynn, M.G., McFarlin, B.K., Markofski, M.M., The anti-inflammatory actions of exercise training. Am. J. Lifestyle Med. 1 (2007), 220–235.
13. Gasparini, C., Feldmann, M., NF-kappaB as a target for modulating inflammatory responses. Curr. Pharm. Des. 18 (2012), 5735–5745.
14. Guillot, T.S., Asress, S.A., Richardson, J.R., Glass, J.D., Miller, G.W., Treadmill gait analysis does not detect motor deficits in animal models of Parkinson's disease or amyotrophic lateral sclerosis. J. Mot. Behav. 40 (2008), 568–577.
15. Hanke, M.L., Kielian, T., Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential. Clin. Sci. (Lond.) 121 (2011), 367–387.
16. Hayward, J.H., Lee, S.J., A decade of research on TLR2 discovering its pivotal role in glial activation and neuroinflammation in neurodegenerative diseases. Exp. Neurobiol. 23 (2014), 138–147.
17. Hensley, K., Abdel-Moaty, H., Hunter, J., Mhatre, M., Mou, S., Nguyen, K., Potapova, T., Pye, Q.N., Qi, M., Rice, H., Stewart, C., Stroukoff, K., West, M., Primary glia expressing the G93A-SOD1 mutation present a neuroinflammatory phenotype and provide a cellular system for studies of glial inflammation. J. Neuroinflamm., 3, 2006, 2.
18. Kim, C., Ho, D.H., Suk, J.E., You, S., Michael, S., Kang, J., Joong Lee, S., Masliah, E., Hwang, D., Lee, H.J., Lee, S.J., Neuron-released oligomeric alpha-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia. Nat. Commun., 4, 2013, 1562.
19. Kohman, R.A., DeYoung, E.K., Bhattacharya, T.K., Peterson, L.N., Rhodes, J.S., Wheel running attenuates microglia proliferation and increases expression of a proneurogenic phenotype in the hippocampus of aged mice. Brain Behav. Immun. 26 (2012), 803–810.
20. Lim, K.L., Dawson, V.L., Dawson, T.M., The cast of molecular characters in Parkinson's disease: felons, conspirators, and suspects. Ann. NY Acad. Sci. 991 (2003), 80–92.
21. Marxreiter, F., Ettle, B., May, V.E., Esmer, H., Patrick, C., Kragh, C.L., Klucken, J., Winner, B., Riess, O., Winkler, J., Masliah, E., Nuber, S., Glial A30P alpha-synuclein pathology segregates neurogenesis from anxiety-related behavior in conditional transgenic mice. Neurobiol. Dis. 59 (2013), 38–51.
22. Montgomery, S.L., Bowers, W.J., Tumor necrosis factor-alpha and the roles it plays in homeostatic and degenerative processes within the central nervous system, J Neuroimmune Pharmacol. 7, 2012, 42-59.
23. Moore, D.J., West, A.B., Dawson, V.L., Dawson, T.M., Molecular pathophysiology of Parkinson's disease. Annu Rev. Neurosci. 28 (2005), 57–87.
24. Petzinger, G.M., Fisher, B.E., McEwen, S., Beeler, J.A., Walsh, J.P., Jakowec, M.W., Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease. Lancet Neurol. 12 (2013), 716–726.
25. Petzinger, G.M., Walsh, J.P., Akopian, G., Hogg, E., Abernathy, A., Arevalo, P., Turnquist, P., Vuckovic, M., Fisher, B.E., Togasaki, D.M., Jakowec, M.W., Effects of treadmill exercise on dopaminergic transmission in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse model of basal ganglia injury. J. Neurosci. 27 (2007), 5291–5300.
26. Prajapati, P., Sripada, L., Singh, K., Bhatelia, K., Singh, R., Singh, R.,TNF-alpha regulates miRNA targeting mitochondrial complex-I and induces cell death in dopaminergic cells, Biochim Biophys Actab. 3, 2015, 451-461.
27. Ridgel, A.L., Vitek, J.L., Alberts, J.L., Forced, not voluntary, exercise improves motor function in Parkinson's disease patients. Neurorehabil Neural Repair 23 (2009), 600–608.
28. Saiki, S., The association of Parkinson's disease pathogenesis with inflammation. Rinsho Shinkeigaku. 54 (2014), 1125–1127.
29. Smith, B.A., Goldberg, N.R., Meshul, C.K., Effects of treadmill exercise on behavioral recovery and neural changes in the substantia nigra and striatum of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse. Brain Res. 1386 (2011), 70–80.
30. Spielman, L.J., Little, J.P., Klegeris, A., Physical activity and exercise attenuate neuroinflammation in neurological diseases. Brain Res. Bull. 125 (2016), 19–29.
31. Spillantini, M.G., Goedert, M., The alpha-synucleinopathies: parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. Ann. NY Acad. Sci. 920 (2000), 16–27.
32. Spillantini, M.G., Schmidt, M.L., Lee, V.M., Trojanowski, J.Q., Jakes, R., Goedert, M., Alpha-synuclein in Lewy bodies. Nature 388 (1997), 839–840.
33. Sung, Y.H., Kim, S.C., Hong, H.P., Park, C.Y., Shin, M.S., Kim, C.J., Seo, J.H., Kim, D.Y., Kim, D.J., Cho, H.J., Treadmill exercise ameliorates dopaminergic neuronal loss through suppressing microglial activation in Parkinson's disease mice. Life Sci. 91 (2012), 1309–1316.
34. Thomas, B., Beal, M.F., Parkinson's disease. Hum. Mol. Genet. 16 (2007), R183–R194.
35. Tuon, T., Valvassori, S.S., Lopes-Borges, J., Luciano, T., Trom, C.B., Silva, L.A., Quevedo, J., Souza, C.T., Lira, F.S., Pinho, R.A., Physical training exerts neuroprotective effects in the regulation of neurochemical factors in an animal model of Parkinson's disease. Neuroscience 227 (2012), 305–312.
36. Um, H.S., Kang, E.B., Koo, J.H., Kim, H.T., Jin, L., Kim, E.J., Yang, C.H., An, G.Y., Cho, I.H., Cho, J.Y., Treadmill exercise represses neuronal cell death in an aged transgenic mouse model of Alzheimer's disease. Neurosci. Res. 69 (2011), 161–173.
37. Yoon, M.C., Shin, M.S., Kim, T.S., Kim, B.K., Ko, I.G., Sung, Y.H., Kim, S.E., Lee, H.H., Kim, Y.P., Kim, C.J., Treadmill exercise suppresses nigrostriatal dopaminergic neuronal loss in 6-hydroxydopamine-induced Parkinson's rats. Neurosci. Lett. 423 (2007), 12–17.