The association of Parkinson's disease pathogenesis with inflammation

Clinical Neurology

Volumn 54, Issue 12, 2014, Pages 1125-1127

  Saiki, Shinji ^a  

^a JUNTENDO UNIVERSITY   (Japan)

Author keywords

Biomarker; Inflammatory cytokines; Microglia; Parkinson's disease

Indexed keywords

ALPHA SYNUCLEIN; APOLIPOPROTEIN A1; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE;

CONFERENCE PAPER; DISEASE ASSOCIATION; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PARKINSON DISEASE; PATHOGENESIS; ANIMAL; DISEASE COURSE; HUMAN; INFLAMMATION; MICROGLIA; PHYSIOLOGY; RAT;

ANIMALS; CYTOKINES; DISEASE PROGRESSION; HUMANS; INFLAMMATION; MICROGLIA; PARKINSON DISEASE; RATS;

EID: 84919711632     PISSN: 0009918X     EISSN: None     Source Type: Journal    
DOI: 10.5692/clinicalneurol.54.1125     Document Type: Conference Paper

References (10)

1. Zhang W, Wang T, Pei Z, et al. Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease. FASEB J 2005;19:533-542.
2. Hunter RL, Dragicevic N, Seifert K. Inflammation induces mitochondrial dysfunction and dopaminergic neurodegeneration in the nigrostriatal system. J Neurochem 2007;100:1375-1386.
3. Chahine LM, Stern MB, Chen-Plotkin A, et al. Blood-based biomarkers for Parkinson's disease. Parkinsonism Relat Disord 2014;20(Suppl 1):S99-S103.
4. Glass CK, Saijo K, Winner B, et al. Mechanisms underlying inflammation in neurodegeneration. Cell 2010;140:918-934.
5. Ferrari CC, Tarelli R. Parkinson's disease and systemic inflammation. Parkinsons Dis 2011;2011:436813.
6. Gerhard A, Pavese N, Hotton G, et al. In vivo imaging of microglial activation with [11C] (R)-PK11195 PET in idiopathic Parkinson's disease. Neurobiol Dis 2006;21:404-412.
7. Chahine LM, Qiang J, Ashbridge E, et al. Clinical and biochemical differences in patients having Parkinson disease with vs without GBA mutations. JAMA Neurol 2013;70:852-858.
8. Chen H, Zhang SM, Hernán MA, et al. Nonsteroidal antiinflammatory drugs and the risk of Parkinson disease. Arch Neurol 2003;60:1059-1064.
9. Chen H, Jacobs E, Schwarzschild MA, et al. Nonsteroidal antiinflammatory drug use and the risk for Parkinson's disease. Ann Neurol 2005;58:963-967.
10. Wu DC, Jackson-Lewis V, Vila M, et al. Blockade of microglial activation is neuro protective in the 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine mouse model of Parkinson disease. J Neurosci 2002;22:1763-1771.