Preoperative Immunonutrition and Elective Colorectal Resection Outcomes

Diseases of the Colon and Rectum

Volumn 60, Issue 1, 2017, Pages 68-75

  Thornblade, Lucas W ^a   Varghese, Thomas K ^b   Shi, Xu ^c   Johnson, Eric K ^d   Bastawrous, Amir ^e   Billingham, Richard P ^e   Thirlby, Richard ^f   Fichera, Alessandro ^a   Flum, David R ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d MADIGAN ARMY MEDICAL CENTER   (United States)

^e SWEDISH MEDICAL CENTER   (United States)

^f VIRGINIA MASON MEDICAL CENTER   (United States)

Author keywords

Comparative effectiveness; Immunonutrition; Outcomes; Propensity scores

Indexed keywords

ADULT; ANASTOMOSIS LEAKAGE; CHECKLIST; COHORT ANALYSIS; COLORECTAL SURGERY; COMMUNITY; CONFERENCE PAPER; DEATH; ELECTIVE SURGERY; FEMALE; HOSPITAL; HUMAN; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; NUTRITION; OSTOMY; PATIENT COMPLIANCE; POSTOPERATIVE INFECTION; PREOPERATIVE IMMUNONUTRITION; PROPENSITY SCORE; PROSPECTIVE STUDY; REOPERATION; RURAL POPULATION; SURGEON; TERTIARY CARE CENTER; TREATMENT OUTCOME; ABDOMINAL SURGERY; AGED; ANASTOMOTIC LEAK; COLOSTOMY; COMPARATIVE STUDY; DIETARY SUPPLEMENT; ENTERIC FEEDING; INFECTION; MIDDLE AGED; MORTALITY; POSTOPERATIVE COMPLICATIONS; PREOPERATIVE CARE; PROCEDURES; STATISTICAL MODEL; STATISTICS AND NUMERICAL DATA;

ARGININE;

ADULT; AGED; ANASTOMOTIC LEAK; ARGININE; COHORT STUDIES; COLOSTOMY; DIETARY SUPPLEMENTS; DIGESTIVE SYSTEM SURGICAL PROCEDURES; ELECTIVE SURGICAL PROCEDURES; ENTERAL NUTRITION; FEMALE; HUMANS; INFECTION; LENGTH OF STAY; LOGISTIC MODELS; MALE; MIDDLE AGED; MORTALITY; POSTOPERATIVE COMPLICATIONS; PREOPERATIVE CARE; PROPENSITY SCORE; PROSPECTIVE STUDIES; REOPERATION;

EID: 85006827012     PISSN: 00123706     EISSN: 15300358     Source Type: Journal    
DOI: 10.1097/DCR.0000000000000740     Document Type: Conference Paper

References (59)

1. Cohen ME, Bilimoria KY, Ko CY, Hall BL. Development of an American College of Surgeons National Surgery Quality Improvement Program: morbidity and mortality risk calculator for colorectal surgery. J Am Coll Surg. 2009;208:1009-1016.
2. Kolfschoten NE, Marang-van de Mheen PJ, Wouters MW, et al; Dutch Surgical Colorectal Audit Group. A combined measure of procedural volume and outcome to assess hospital quality of colorectal cancer surgery, a secondary analysis of clinical audit data. PLoS One. 2014;9:e88737.
3. Govaert JA, van Dijk WA, Fiocco M, et al. Nationwide outcomes measurement in colorectal cancer surgery: improving quality and reducing costs. J Am Coll Surg. 2016;222: 19-29.e2.
4. Drover JW, Dhaliwal R, Weitzel L, Wischmeyer PE, Ochoa JB, Heyland DK. Perioperative use of arginine-supplemented diets: a systematic review of the evidence. J Am Coll Surg. 2011;212:385-99, 399.e1.
5. McClave SA, Kozar R, Martindale RG, et al. Summary points and consensus recommendations from the North American Surgical Nutrition Summit. JPEN J Parenter Enteral Nutr. 2013;37(5 suppl):99S-105S.
6. Zhu X, Herrera G, Ochoa JB. Immunosupression and infection after major surgery: a nutritional deficiency. Crit Care Clin. 2010;26:491-500.
7. Morris SM Jr. Arginases and arginine deficiency syndromes. Curr Opin Clin Nutr Metab Care. 2012;15:64-70.
8. Evoy D, Lieberman MD, Fahey TJ 3rd, Daly JM. Immunonutrition: the role of arginine. Nutrition. 1998;14:611-617.
9. Ochoa JB, Makarenkova V. T lymphocytes. Crit Care Med. 2005;33(12 suppl):S510-S513.
10. Zhu X, Pribis JP, Rodriguez PC, et al. The central role of arginine catabolism in T-cell dysfunction and increased susceptibility to infection after physical injury. Ann Surg. 2014;259:171-178.
11. Heyland DK, Novak F, Drover JW, Jain M, Su X, Suchner U. Should immunonutrition become routine in critically ill patients? A systematic review of the evidence. JAMA. 2001;286:944-953.
12. Burden S, Todd C, Hill J, Lal S. Pre-operative nutrition support in patients undergoing gastrointestinal surgery. Cochrane Database Syst Rev. 2012:CD008879. doi: 10.1002/14651858. CD008879.pub2.
13. Sorensen LS, Rasmussen HH, Aardestrup IV, et al. Rapid incorporation of ω-3 fatty acids into colonic tissue after oral supplementation in patients with colorectal cancer: a randomized, placebo-controlled intervention trial. JPEN J Parenter Enteral Nutr. 2014;38:617-624.
14. Wodja TR, Mohammed O, Evans DC. Perioperative nutrition support for surgical patients: aspects and commentary. Curr Surg Rep. 2015; 3:27.
15. Cerantola Y, Hübner M, Grass F, Demartines N, Schäfer M. Immunonutrition in gastrointestinal surgery. Br J Surg. 2011;98:37-48.
16. Braga M, Gianotti L, Nespoli L, Radaelli G, Di Carlo V. Nutritional approach in malnourished surgical patients: a prospective randomized study. Arch Surg. 2002;137:174-180.
17. Braga M, Gianotti L, Radaelli G, et al. Perioperative immunonutrition in patients undergoing cancer surgery: results of a randomized double-blind phase 3 trial. Arch Surg. 1999;134:428-433.
18. Braga M, Gianotti L, Vignali A, Carlo VD. Preoperative oral arginine and n-3 fatty acid supplementation improves the immunometabolic host response and outcome after colorectal resection for cancer. Surgery. 2002;132:805-814.
19. Braga M, Vignali A, Gianotti L, Cestari A, Profili M, Carlo VD. Immune and nutritional effects of early enteral nutrition after major abdominal operations. Eur J Surg. 1996;162:105-112.
20. Casas-Rodera P, Gómez-Candela C, Benítez S, et al. Immunoenhanced enteral nutrition formulas in head and neck cancer surgery: a prospective, randomized clinical trial. Nutr Hosp. 2008;23:105-110.
21. Celik JB, Gezginç K, Ozçelik K, Celik C. The role of immunonutrition in gynecologic oncologic surgery. Eur J Gynaecol Oncol. 2009;30:418-421.
22. Daly JM, Lieberman MD, Goldfine J, et al. Enteral nutrition with supplemental arginine, RNA , and omega-3 fatty acids in patients after operation: immunologic, metabolic, and clinical outcome. Surgery. 1992;112:56-67.
23. Daly JM, Reynolds J, Sigal RK, Shou J, Liberman MD. Effect of dietary protein and amino acids on immune function. Crit Care Med. 1990;18(2 suppl):S86-S93.
24. Daly JM, Weintraub FN, Shou J, Rosato EF, Lucia M. Enteral nutrition during multimodality therapy in upper gastrointestinal cancer patients. Ann Surg. 1995;221:327-338.
25. de Luis DA, Aller R, Izaola O, Cuellar L, Terroba MC. Postsurgery enteral nutrition in head and neck cancer patients. Eur J Clin Nutr. 2002;56:1126-1129.
26. de Luis DA, Izaola O, Cuellar L, Terroba MC, Aller R. Randomized clinical trial with an enteral arginine-enhanced formula in early postsurgical head and neck cancer patients. Eur J Clin Nutr. 2004;58:1505-1508.
27. de Luis DA, Izaola O, Cuellar L, Terroba MC, Martin T, Aller R. Clinical and biochemical outcomes after a randomized trial with a high dose of enteral arginine formula in postsurgical head and neck cancer patients. Eur J Clin Nutr. 2007;61:200-204.
28. Farreras N, Artigas V, Cardona D, Rius X, Trias M, González JA. Effect of early postoperative enteral immunonutrition on wound healing in patients undergoing surgery for gastric cancer. Clin Nutr. 2005;24:55-65.
29. Finco C, Magnanini P, Sarzo G, et al. Prospective randomized study on perioperative enteral immunonutrition in laparoscopic colorectal surgery. Surg Endosc. 2007;21:1175-1179.
30. Gianotti L, Braga M, Nespoli L, Radaelli G, Beneduce A, Di Carlo V. A randomized controlled trial of preoperative oral supplementation with a specialized diet in patients with gastrointestinal cancer. Gastroenterology. 2002;122:1763-1770.
31. Giger U, Büchler M, Farhadi J, et al. Preoperative immunonutrition suppresses perioperative inflammatory response in patients with major abdominal surgery-a randomized controlled pilot study. Ann Surg Oncol. 2007;14:2798-2806.
32. Jiang ZM, Gu ZY, Chen FL, et al. The role of immune enhanced enteral nutrition on plasma amino acid, gut permeability and clinical outcome (a randomized, double blind, controlled, multi-center clinical trial with 120 cases) [in Chinese]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2001;23:515-518.
33. Klek S, Kulig J, Sierzega M, et al. Standard and immunomodulating enteral nutrition in patients after extended gastrointestinal surgery-a prospective, randomized, controlled clinical trial. Clin Nutr. 2008;27:504-512.
34. Klek S, Kulig J, Sierzega M, et al. The impact of immunostimulating nutrition on infectious complications after upper gastrointestinal surgery: a prospective, randomized, clinical trial. Ann Surg. 2008;248:212-220.
35. Lobo DN, Williams RN, Welch NT, et al. Early postoperative jejunostomy feeding with an immune modulating diet in patients undergoing resectional surgery for upper gastrointestinal cancer: a prospective, randomized, controlled, double-blind study. Clin Nutr. 2006;25:716-726.
36. McCarter MD, Gentilini OD, Gomez ME, Daly JM. Preoperative oral supplement with immunonutrients in cancer patients. JPEN J Parenter Enteral Nutr. 1998;22:206-211.
37. Okamoto Y, Okano K, Izuishi K, Usuki H, Wakabayashi H, Suzuki Y. Attenuation of the systemic inflammatory response and infectious complications after gastrectomy with preoperative oral arginine and omega-3 fatty acids supplemented immunonutrition. World J Surg. 2009;33:1815-1821.
38. Riso S, Aluffi P, Brugnani M, Farinetti F, Pia F, D'Andrea F. Postoperative enteral immunonutrition in head and neck cancer patients. Clin Nutr. 2000;19:407-412.
39. Sakurai Y, Masui T, Yoshida I, et al. Randomized clinical trial of the effects of perioperative use of immune-enhancing enteral formula on metabolic and immunological status in patients undergoing esophagectomy. World J Surg. 2007;31:2150-2158.
40. Schilling J, Vranjes N, Fierz W, et al. Clinical outcome and immunology of postoperative arginine, omega-3 fatty acids, and nucleotide-enriched enteral feeding: a randomized prospective comparison with standard enteral and low calorie/low fat i.v. solutions. Nutrition. 1996;12:423-429.
41. Senkal M, Mumme A, Eickhoff U, et al. Early postoperative enteral immunonutrition: clinical outcome and cost-comparison analysis in surgical patients. Crit Care Med. 1997;25:1489-1496.
42. Senkal M, Zumtobel V, Bauer KH, et al. Outcome and costeffectiveness of perioperative enteral immunonutrition in patients undergoing elective upper gastrointestinal tract surgery: a prospective randomized study. Arch Surg. 1999;134:1309-1316.
43. Snyderman CH, Kachman K, Molseed L, et al. Reduced postoperative infections with an immune-enhancing nutritional supplement. Laryngoscope. 1999;109:915-921.
44. Tepaske R, te Velthuis H, Oudemans-van Straaten HM, et al. Glycine does not add to the beneficial effects of perioperative oral immune-enhancing nutrition supplements in highrisk cardiac surgery patients. JPEN J Parenter Enteral Nutr. 2007;31:173-180.
45. Tepaske R, Velthuis H, Oudemans-van Straaten HM, et al. Effect of preoperative oral immune-enhancing nutritional supplement on patients at high risk of infection after cardiac surgery: a randomised placebo-controlled trial. Lancet. 2001;358:696-701.
46. van Bokhorst-De Van Der Schueren MA, Quak JJ, von Blomberg- van der Flier BM, et al. Effect of perioperative nutrition, with and without arginine supplementation, on nutritional status, immune function, postoperative morbidity, and survival in severely malnourished head and neck cancer patients. Am J Clin Nutr. 2001;73:323-332.
47. Wachtler P, Axel Hilger R, König W, Bauer KH, Kemen M, Köller M. Influence of a pre-operative enteral supplement on functional activities of peripheral leukocytes from patients with major surgery. Clin Nutr. 1995;14:275-282.
48. Xu J, Zhong Y, Jing D, Wu Z. Preoperative enteral immunonutrition improves postoperative outcome in patients with gastrointestinal cancer. World J Surg. 2006;30:1284-1289.
49. Hegazi RA, Hustead DS, Evans DC. Preoperative standard oral nutrition supplements vs immunonutrition: results of a systematic review and meta-analysis. J Am Coll Surg. 2014;219:1078-1087.
50. Klek S, Szybinski P, Szczepanek K. Perioperative immunonutrition in surgical cancer patients: a summary of a decade of research. World J Surg. 2014;38:803-812.
51. Aida T, Furukawa K, Suzuki D, et al. Preoperative immunonutrition decreases postoperative complications by modulating prostaglandin E2 production and T-cell differentiation in patients undergoing pancreatoduodenectomy. Surgery. 2014;155:124-133.
52. Barker LA, Gray C, Wilson L, Thomson BN, Shedda S, Crowe TC. Preoperative immunonutrition and its effect on postoperative outcomes in well-nourished and malnourished gastrointestinal surgery patients: a randomised controlled trial. Eur J Clin Nutr. 2013;67:802-807.
53. Fujitani K, Tsujinaka T, Fujita J, et al; Osaka Gastrointestinal Cancer Chemotherapy Study Group. Prospective randomized trial of preoperative enteral immunonutrition followed by elective total gastrectomy for gastric cancer. Br J Surg. 2012;99:621-629.
54. Giger-Pabst U, Lange J, Maurer C, et al. Short-term preoperative supplementation of an immunoenriched diet does not improve clinical outcome in well-nourished patients undergoing abdominal cancer surgery. Nutrition. 2013;29:724-729.
55. Gunerhan Y, Koksal N, Sahin UY, Uzun MA, Ekşioglu-Demiralp E. Effect of preoperative immunonutrition and other nutrition models on cellular immune parameters. World J Gastroenterol. 2009;15:467-472.
56. Horie H, Okada M, Kojima M, Nagai H. Favorable effects of preoperative enteral immunonutrition on a surgical site infection in patients with colorectal cancer without malnutrition. Surg Today. 2006;36:1063-1068.
57. Hübner M, Cerantola Y, Grass F, Bertrand PC, Schäfer M, Demartines N. Preoperative immunonutrition in patients at nutritional risk: results of a double-blinded randomized clinical trial. Eur J Clin Nutr. 2012;66:850-855.
58. Mikagi K, Kawahara R, Kinoshita H, Aoyagi S. Effect of preoperative immunonutrition in patients undergoing hepatectomy; a randomized controlled trial. Kurume Med J. 2011;58:1-8.
59. Drover JW. Immunonutrition: the evidence for its use in elective surgery. Available at: https://www.nestlenutrition-institute.org/ resources/library/Free/conference-proceeding/eras-congress/ Documents/11086-PRPLUS -ERAS%20Proceeding%20HR%20 Professional%20Print-101215%20Final.PDF. Published May 10, 2015. Accessed March 30, 2016.