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Volumn 13, Issue , 2017, Pages 139-143

The prefrontal cortex as a critical gate of negative affect and motivation in alcohol use disorder

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; STRESS HORMONE;

EID: 85006802600     PISSN: None     EISSN: 23521546     Source Type: Journal    
DOI: 10.1016/j.cobeha.2016.11.004     Document Type: Review
Times cited : (16)

References (50)
  • 2
    • 77952160762 scopus 로고    scopus 로고
    • Neurobiology of dysregulated motivational systems in drug addiction
    • 2 Edwards, S., Koob, G.F., Neurobiology of dysregulated motivational systems in drug addiction. Future Neurol 5:3 (2010), 393–401.
    • (2010) Future Neurol , vol.5 , Issue.3 , pp. 393-401
    • Edwards, S.1    Koob, G.F.2
  • 3
    • 84889864708 scopus 로고    scopus 로고
    • Traumatic stress reactivity promotes excessive alcohol drinking and alters the balance of prefrontal cortex-amygdala activity
    • 3 Edwards, S., Baynes, B.B., Carmichael, C.Y., Zamora-Martinez, E.R., Barrus, M., Koob, G.F., Gilpin, N.W., Traumatic stress reactivity promotes excessive alcohol drinking and alters the balance of prefrontal cortex-amygdala activity. Transl Psychiatry, 3, 2013, e296.
    • (2013) Transl Psychiatry , vol.3 , pp. e296
    • Edwards, S.1    Baynes, B.B.2    Carmichael, C.Y.3    Zamora-Martinez, E.R.4    Barrus, M.5    Koob, G.F.6    Gilpin, N.W.7
  • 4
    • 84983130306 scopus 로고    scopus 로고
    • The affective dimension of pain as a risk factor for drug and alcohol addiction
    • 4 LeBlanc, D.M., McGinn, M.A., Itoga, C.A., Edwards, S., The affective dimension of pain as a risk factor for drug and alcohol addiction. Alcohol 49:8 (2015), 803–809.
    • (2015) Alcohol , vol.49 , Issue.8 , pp. 803-809
    • LeBlanc, D.M.1    McGinn, M.A.2    Itoga, C.A.3    Edwards, S.4
  • 5
    • 78650274939 scopus 로고    scopus 로고
    • Individual differences in prefrontal cortex function and the transition from drug use to drug dependence
    • A comprehensive and valuable review of prefrontal cortical areas and their afferent and efferent functional connections with respect to drug addiction-related symptomatology.
    • 5•• George, O., Koob, G.F., Individual differences in prefrontal cortex function and the transition from drug use to drug dependence. Neurosci Biobehav Rev 35:2 (2010), 232–247 A comprehensive and valuable review of prefrontal cortical areas and their afferent and efferent functional connections with respect to drug addiction-related symptomatology.
    • (2010) Neurosci Biobehav Rev , vol.35 , Issue.2 , pp. 232-247
    • George, O.1    Koob, G.F.2
  • 6
    • 84904915977 scopus 로고    scopus 로고
    • Alcohol, stress hormones, and the prefrontal cortex: a proposed pathway to the dark side of addiction
    • Describes the manifestation and potentially harmful implications of neuroendocrine tolerance that occurs during the transition from alcohol use to dependence.
    • 6• Lu, Y.L., Richardson, H.N., Alcohol, stress hormones, and the prefrontal cortex: a proposed pathway to the dark side of addiction. Neuroscience 277 (2014), 139–151 Describes the manifestation and potentially harmful implications of neuroendocrine tolerance that occurs during the transition from alcohol use to dependence.
    • (2014) Neuroscience , vol.277 , pp. 139-151
    • Lu, Y.L.1    Richardson, H.N.2
  • 7
    • 84864709870 scopus 로고    scopus 로고
    • Neural regulation of the stress response: the many faces of feedback
    • 7 Myers, B., McKlveen, J.M., Herman, J.P., Neural regulation of the stress response: the many faces of feedback. Cell Mol Neurobiol, 2012.
    • (2012) Cell Mol Neurobiol
    • Myers, B.1    McKlveen, J.M.2    Herman, J.P.3
  • 8
    • 84983126786 scopus 로고    scopus 로고
    • Divergent regulation of distinct glucocorticoid systems in alcohol dependence
    • 8 Edwards, S., Little, H.J., Richardson, H.N., Vendruscolo, L.F., Divergent regulation of distinct glucocorticoid systems in alcohol dependence. Alcohol 49:8 (2015), 811–816.
    • (2015) Alcohol , vol.49 , Issue.8 , pp. 811-816
    • Edwards, S.1    Little, H.J.2    Richardson, H.N.3    Vendruscolo, L.F.4
  • 9
    • 33845615546 scopus 로고    scopus 로고
    • Regional differentiation of the medial prefrontal cortex in regulating adaptive responses to acute emotional stress
    • 9 Radley, J.J., Arias, C.M., Sawchenko, P.E., Regional differentiation of the medial prefrontal cortex in regulating adaptive responses to acute emotional stress. J Neurosci 26:50 (2006), 12967–12976.
    • (2006) J Neurosci , vol.26 , Issue.50 , pp. 12967-12976
    • Radley, J.J.1    Arias, C.M.2    Sawchenko, P.E.3
  • 10
    • 0035889662 scopus 로고    scopus 로고
    • Dendritic reorganization in pyramidal neurons in medial prefrontal cortex after chronic corticosterone administration
    • 10 Wellman, C.L., Dendritic reorganization in pyramidal neurons in medial prefrontal cortex after chronic corticosterone administration. J Neurobiol 49:3 (2001), 245–253.
    • (2001) J Neurobiol , vol.49 , Issue.3 , pp. 245-253
    • Wellman, C.L.1
  • 12
    • 0017819047 scopus 로고
    • Corticosterone concentrations in mice during ethanol drinking and withdrawal
    • 12 Tabakoff, B., Jafee, R.C., Ritzmann, R.F., Corticosterone concentrations in mice during ethanol drinking and withdrawal. J Pharm Pharmacol 30:6 (1978), 371–374.
    • (1978) J Pharm Pharmacol , vol.30 , Issue.6 , pp. 371-374
    • Tabakoff, B.1    Jafee, R.C.2    Ritzmann, R.F.3
  • 13
    • 0025322369 scopus 로고
    • Hypothalamic-pituitary-adrenal axis functioning and cerebrospinal fluid corticotropin releasing hormone and corticotropin levels in alcoholics after recent and long-term abstinence
    • 13 Adinoff, B., Martin, P.R., Bone, G.H., Eckardt, M.J., Roehrich, L., George, D.T., Moss, H.B., Eskay, R., Linnoila, M., Gold, P.W., Hypothalamic-pituitary-adrenal axis functioning and cerebrospinal fluid corticotropin releasing hormone and corticotropin levels in alcoholics after recent and long-term abstinence. Arch Gen Psychiatry 47:4 (1990), 325–330.
    • (1990) Arch Gen Psychiatry , vol.47 , Issue.4 , pp. 325-330
    • Adinoff, B.1    Martin, P.R.2    Bone, G.H.3    Eckardt, M.J.4    Roehrich, L.5    George, D.T.6    Moss, H.B.7    Eskay, R.8    Linnoila, M.9    Gold, P.W.10
  • 14
    • 54049114593 scopus 로고    scopus 로고
    • Selective increases in regional brain glucocorticoid: a novel effect of chronic alcohol
    • Provided a novel neurobiological mechanism of alcohol-induced regulation of brain glucocorticoids relevant to cognition and AUD. Increased brain glucocorticoids were observed in both male and female mice and rats following chronic alcohol administration.
    • 14• Little, H.J., Croft, A.P., O'Callaghan, M.J., Brooks, S.P., Wang, G., Shaw, S.G., Selective increases in regional brain glucocorticoid: a novel effect of chronic alcohol. Neuroscience 156:4 (2008), 1017–1027 Provided a novel neurobiological mechanism of alcohol-induced regulation of brain glucocorticoids relevant to cognition and AUD. Increased brain glucocorticoids were observed in both male and female mice and rats following chronic alcohol administration.
    • (2008) Neuroscience , vol.156 , Issue.4 , pp. 1017-1027
    • Little, H.J.1    Croft, A.P.2    O'Callaghan, M.J.3    Brooks, S.P.4    Wang, G.5    Shaw, S.G.6
  • 15
    • 0030731507 scopus 로고    scopus 로고
    • An initial, three-day-long treatment with alcohol induces a long-lasting phenomenon of selective tolerance in the activity of the rat hypothalamic-pituitary-adrenal axis
    • 15 Lee, S., Rivier, C., An initial, three-day-long treatment with alcohol induces a long-lasting phenomenon of selective tolerance in the activity of the rat hypothalamic-pituitary-adrenal axis. J Neurosci 17:22 (1997), 8856–8866.
    • (1997) J Neurosci , vol.17 , Issue.22 , pp. 8856-8866
    • Lee, S.1    Rivier, C.2
  • 16
    • 69749093901 scopus 로고    scopus 로고
    • Permanent impairment of birth and survival of cortical and hippocampal proliferating cells following excessive drinking during alcohol dependence
    • 16 Richardson, H.N., Chan, S.H., Crawford, E.F., Lee, Y.K., Funk, C.K., Koob, G.F., Mandyam, C.D., Permanent impairment of birth and survival of cortical and hippocampal proliferating cells following excessive drinking during alcohol dependence. Neurobiol Dis 36:1 (2009), 1–10.
    • (2009) Neurobiol Dis , vol.36 , Issue.1 , pp. 1-10
    • Richardson, H.N.1    Chan, S.H.2    Crawford, E.F.3    Lee, Y.K.4    Funk, C.K.5    Koob, G.F.6    Mandyam, C.D.7
  • 17
    • 84899913922 scopus 로고    scopus 로고
    • Operant alcohol self-administration in dependent rats: focus on the vapor model
    • 17 Vendruscolo, L.F., Roberts, A.J., Operant alcohol self-administration in dependent rats: focus on the vapor model. Alcohol 48:3 (2014), 277–286.
    • (2014) Alcohol , vol.48 , Issue.3 , pp. 277-286
    • Vendruscolo, L.F.1    Roberts, A.J.2
  • 20
    • 3042551460 scopus 로고    scopus 로고
    • The glucocorticoid receptor antagonist mifepristone reduces ethanol intake in rats under limited access conditions
    • 20 Koenig, H.N., Olive, M.F., The glucocorticoid receptor antagonist mifepristone reduces ethanol intake in rats under limited access conditions. Psychoneuroendocrinology 29:8 (2004), 999–1003.
    • (2004) Psychoneuroendocrinology , vol.29 , Issue.8 , pp. 999-1003
    • Koenig, H.N.1    Olive, M.F.2
  • 21
    • 84939217669 scopus 로고    scopus 로고
    • Glucocorticoid receptor antagonism decreases alcohol seeking in alcohol-dependent individuals
    • Translational evidence of mifepristone efficacy to reduce excessive drinking in both a preclinical model of severe alcohol use disorder and in alcohol-dependent human subjects.
    • 21•• Vendruscolo, L.F., Estey, D., Goodell, V., Macshane, L.G., Logrip, M.L., Schlosburg, J.E., McGinn, M.A., Zamora-Martinez, E.R., Belanoff, J.K., Hunt, H.J., Sanna, P.P., et al. Glucocorticoid receptor antagonism decreases alcohol seeking in alcohol-dependent individuals. J Clin Invest 125:8 (2015), 3193–3197 Translational evidence of mifepristone efficacy to reduce excessive drinking in both a preclinical model of severe alcohol use disorder and in alcohol-dependent human subjects.
    • (2015) J Clin Invest , vol.125 , Issue.8 , pp. 3193-3197
    • Vendruscolo, L.F.1    Estey, D.2    Goodell, V.3    Macshane, L.G.4    Logrip, M.L.5    Schlosburg, J.E.6    McGinn, M.A.7    Zamora-Martinez, E.R.8    Belanoff, J.K.9    Hunt, H.J.10    Sanna, P.P.11
  • 22
    • 24944442520 scopus 로고    scopus 로고
    • Neurocircuitry in alcoholism: a substrate of disruption and repair
    • 22 Sullivan, E.V., Pfefferbaum, A., Neurocircuitry in alcoholism: a substrate of disruption and repair. Psychopharmacology (Berl) 180:4 (2005), 583–594.
    • (2005) Psychopharmacology (Berl) , vol.180 , Issue.4 , pp. 583-594
    • Sullivan, E.V.1    Pfefferbaum, A.2
  • 23
    • 84866732155 scopus 로고    scopus 로고
    • Chronic alcohol remodels prefrontal neurons and disrupts nmdar-mediated fear extinction encoding
    • Demonstrates the drastic consequences of chronic alcohol exposure on prefrontal function and the development of trauma-related anxiety.
    • 23•• Holmes, A., Fitzgerald, P.J., MacPherson, K.P., DeBrouse, L., Colacicco, G., Flynn, S.M., Masneuf, S., Pleil, K.E., Li, C., Marcinkiewcz, C.A., Kash, T.L., et al. Chronic alcohol remodels prefrontal neurons and disrupts nmdar-mediated fear extinction encoding. Nat Neurosci 15:10 (2012), 1359–1361 Demonstrates the drastic consequences of chronic alcohol exposure on prefrontal function and the development of trauma-related anxiety.
    • (2012) Nat Neurosci , vol.15 , Issue.10 , pp. 1359-1361
    • Holmes, A.1    Fitzgerald, P.J.2    MacPherson, K.P.3    DeBrouse, L.4    Colacicco, G.5    Flynn, S.M.6    Masneuf, S.7    Pleil, K.E.8    Li, C.9    Marcinkiewcz, C.A.10    Kash, T.L.11
  • 24
    • 84861634945 scopus 로고    scopus 로고
    • Chronic alcohol exposure alters behavioral and synaptic plasticity of the rodent prefrontal cortex
    • 24 Kroener, S., Mulholland, P.J., New, N.N., Gass, J.T., Becker, H.C., Chandler, L.J., Chronic alcohol exposure alters behavioral and synaptic plasticity of the rodent prefrontal cortex. PLoS ONE, 7(5), 2012, e37541.
    • (2012) PLoS ONE , vol.7 , Issue.5 , pp. e37541
    • Kroener, S.1    Mulholland, P.J.2    New, N.N.3    Gass, J.T.4    Becker, H.C.5    Chandler, L.J.6
  • 25
    • 0036667834 scopus 로고    scopus 로고
    • Cortisol dysregulation and cognitive impairment in abstinent male alcoholics
    • 25 Errico, A.L., King, A.C., Lovallo, W.R., Parsons, O.A., Cortisol dysregulation and cognitive impairment in abstinent male alcoholics. Alcohol Clin Exp Res 26:8 (2002), 1198–1204.
    • (2002) Alcohol Clin Exp Res , vol.26 , Issue.8 , pp. 1198-1204
    • Errico, A.L.1    King, A.C.2    Lovallo, W.R.3    Parsons, O.A.4
  • 26
    • 78649608571 scopus 로고    scopus 로고
    • The importance of glucocorticoids in alcohol dependence and neurotoxicity
    • 26 Rose, A.K., Shaw, S.G., Prendergast, M.A., Little, H.J., The importance of glucocorticoids in alcohol dependence and neurotoxicity. Alcohol Clin Exp Res 34:12 (2010), 2011–2018.
    • (2010) Alcohol Clin Exp Res , vol.34 , Issue.12 , pp. 2011-2018
    • Rose, A.K.1    Shaw, S.G.2    Prendergast, M.A.3    Little, H.J.4
  • 27
    • 84868103665 scopus 로고    scopus 로고
    • Recruitment of medial prefrontal cortex neurons during alcohol withdrawal predicts cognitive impairment and excessive alcohol drinking
    • 27 George, O., Sanders, C., Freiling, J., Grigoryan, E., Vu, S., Allen, C.D., Crawford, E., Mandyam, C.D., Koob, G.F., Recruitment of medial prefrontal cortex neurons during alcohol withdrawal predicts cognitive impairment and excessive alcohol drinking. Proc Natl Acad Sci U S A 109:44 (2012), 18156–18161.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , Issue.44 , pp. 18156-18161
    • George, O.1    Sanders, C.2    Freiling, J.3    Grigoryan, E.4    Vu, S.5    Allen, C.D.6    Crawford, E.7    Mandyam, C.D.8    Koob, G.F.9
  • 28
    • 57249083987 scopus 로고    scopus 로고
    • Effects of the glucocorticoid antagonist, mifepristone, on the consequences of withdrawal from long term alcohol consumption
    • 28 Jacquot, C., Croft, A.P., Prendergast, M.A., Mulholland, P., Shaw, S.G., Little, H.J., Effects of the glucocorticoid antagonist, mifepristone, on the consequences of withdrawal from long term alcohol consumption. Alcohol Clin Exp Res 32:12 (2008), 2107–2116.
    • (2008) Alcohol Clin Exp Res , vol.32 , Issue.12 , pp. 2107-2116
    • Jacquot, C.1    Croft, A.P.2    Prendergast, M.A.3    Mulholland, P.4    Shaw, S.G.5    Little, H.J.6
  • 29
    • 0037323851 scopus 로고    scopus 로고
    • Ego depletion and self-regulation failure: a resource model of self-control
    • 29 Baumeister, R.F., Ego depletion and self-regulation failure: a resource model of self-control. Alcohol Clin Exp Res 27:2 (2003), 281–284.
    • (2003) Alcohol Clin Exp Res , vol.27 , Issue.2 , pp. 281-284
    • Baumeister, R.F.1
  • 30
    • 84995616656 scopus 로고    scopus 로고
    • Neurobiology of addiction: a neurocircuitry analysis
    • 30 Koob, G.F., Volkow, N.D., Neurobiology of addiction: a neurocircuitry analysis. Lancet Psychiatry 3:8 (2016), 760–773.
    • (2016) Lancet Psychiatry , vol.3 , Issue.8 , pp. 760-773
    • Koob, G.F.1    Volkow, N.D.2
  • 31
    • 84880888671 scopus 로고    scopus 로고
    • Cortical activation of accumbens hyperpolarization-active nmdars mediates aversion-resistant alcohol intake
    • Optogenetic interrogation of the prefrontal circuitry responsible for drinking in the face of adverse consequences.
    • 31•• Seif, T., Chang, S.J., Simms, J.A., Gibb, S.L., Dadgar, J., Chen, B.T., Harvey, B.K., Ron, D., Messing, R.O., Bonci, A., Hopf, F.W., Cortical activation of accumbens hyperpolarization-active nmdars mediates aversion-resistant alcohol intake. Nat Neurosci 16:8 (2013), 1094–1100 Optogenetic interrogation of the prefrontal circuitry responsible for drinking in the face of adverse consequences.
    • (2013) Nat Neurosci , vol.16 , Issue.8 , pp. 1094-1100
    • Seif, T.1    Chang, S.J.2    Simms, J.A.3    Gibb, S.L.4    Dadgar, J.5    Chen, B.T.6    Harvey, B.K.7    Ron, D.8    Messing, R.O.9    Bonci, A.10    Hopf, F.W.11
  • 32
    • 80053510653 scopus 로고    scopus 로고
    • Pain as a global public health priority
    • 32 Goldberg, D.S., McGee, S.J., Pain as a global public health priority. BMC Public Health, 11, 2011, 770.
    • (2011) BMC Public Health , vol.11 , pp. 770
    • Goldberg, D.S.1    McGee, S.J.2
  • 33
    • 85006708749 scopus 로고    scopus 로고
    • Self-report of alcohol use for pain in a multi-ethnic community sample
    • 33 Riley, J.L., King, C., Self-report of alcohol use for pain in a multi-ethnic community sample. J Pain 204 (2009), 423–429.
    • (2009) J Pain , vol.204 , pp. 423-429
    • Riley, J.L.1    King, C.2
  • 34
    • 84855958428 scopus 로고    scopus 로고
    • Development of mechanical hypersensitivity in rats during heroin and ethanol dependence: alleviation by crf(1) receptor antagonism
    • 34 Edwards, S., Vendruscolo, L.F., Schlosburg, J.E., Misra, K.K., Wee, S., Park, P.E., Schulteis, G., Koob, G.F., Development of mechanical hypersensitivity in rats during heroin and ethanol dependence: alleviation by crf(1) receptor antagonism. Neuropharmacology 62:2 (2012), 1142–1151.
    • (2012) Neuropharmacology , vol.62 , Issue.2 , pp. 1142-1151
    • Edwards, S.1    Vendruscolo, L.F.2    Schlosburg, J.E.3    Misra, K.K.4    Wee, S.5    Park, P.E.6    Schulteis, G.7    Koob, G.F.8
  • 35
    • 20044365958 scopus 로고    scopus 로고
    • Pain and use of alcohol to manage pain: prevalence and 3-year outcomes among older problem and non-problem drinkers
    • 35 Brennan, P.L., Schutte, K.K., Moos, R.H., Pain and use of alcohol to manage pain: prevalence and 3-year outcomes among older problem and non-problem drinkers. Addiction 100:6 (2005), 777–786.
    • (2005) Addiction , vol.100 , Issue.6 , pp. 777-786
    • Brennan, P.L.1    Schutte, K.K.2    Moos, R.H.3
  • 36
    • 84867593819 scopus 로고    scopus 로고
    • Alcohol dependence as a chronic pain disorder
    • 36 Egli, M., Koob, G.F., Edwards, S., Alcohol dependence as a chronic pain disorder. Neurosci Biobehav Rev 36:10 (2012), 2179–2192.
    • (2012) Neurosci Biobehav Rev , vol.36 , Issue.10 , pp. 2179-2192
    • Egli, M.1    Koob, G.F.2    Edwards, S.3
  • 37
    • 21744441688 scopus 로고    scopus 로고
    • Pain and emotion interactions in subregions of the cingulate gyrus
    • 37 Vogt, B.A., Pain and emotion interactions in subregions of the cingulate gyrus. Nat Rev Neurosci 6:7 (2005), 533–544.
    • (2005) Nat Rev Neurosci , vol.6 , Issue.7 , pp. 533-544
    • Vogt, B.A.1
  • 39
    • 0034589045 scopus 로고    scopus 로고
    • Concepts of pain mechanisms: the contribution of functional imaging of the human brain
    • 39 Casey, K.L., Concepts of pain mechanisms: the contribution of functional imaging of the human brain. Prog Brain Res 129 (2000), 277–287.
    • (2000) Prog Brain Res , vol.129 , pp. 277-287
    • Casey, K.L.1
  • 41
    • 85027950875 scopus 로고    scopus 로고
    • Saliency, switching, attention and control: a network model of insula function
    • 41 Menon, V., Uddin, L.Q., Saliency, switching, attention and control: a network model of insula function. Brain Struct Funct 214:5–6 (2010), 655–667.
    • (2010) Brain Struct Funct , vol.214 , Issue.5-6 , pp. 655-667
    • Menon, V.1    Uddin, L.Q.2
  • 42
    • 84964720164 scopus 로고    scopus 로고
    • Alcohol dependence and altered engagement of brain networks in risky decisions
    • 42 Zhu, X., Sundby, K., Bjork, J.M., Momenan, R., Alcohol dependence and altered engagement of brain networks in risky decisions. Front Hum Neurosci, 10, 2016, 142.
    • (2016) Front Hum Neurosci , vol.10 , pp. 142
    • Zhu, X.1    Sundby, K.2    Bjork, J.M.3    Momenan, R.4
  • 43
    • 84982899598 scopus 로고    scopus 로고
    • Neural correlates and connectivity underlying stress-related impulse control difficulties in alcoholism
    • 43 Seo, D., Lacadie, C.M., Sinha, R., Neural correlates and connectivity underlying stress-related impulse control difficulties in alcoholism. Alcohol Clin Exp Res 40:9 (2016), 1884–1894.
    • (2016) Alcohol Clin Exp Res , vol.40 , Issue.9 , pp. 1884-1894
    • Seo, D.1    Lacadie, C.M.2    Sinha, R.3
  • 44
    • 84959138547 scopus 로고    scopus 로고
    • Double-blind, 12 month follow-up, placebo-controlled trial of mifepristone on cognition in alcoholics: the mifcog trial protocol
    • 44 Donoghue, K., Rose, A., Coulton, S., Milward, J., Reed, K., Drummond, C., Little, H., Double-blind, 12 month follow-up, placebo-controlled trial of mifepristone on cognition in alcoholics: the mifcog trial protocol. BMC Psychiatry, 16, 2016, 40.
    • (2016) BMC Psychiatry , vol.16 , pp. 40
    • Donoghue, K.1    Rose, A.2    Coulton, S.3    Milward, J.4    Reed, K.5    Drummond, C.6    Little, H.7
  • 45
    • 84871970983 scopus 로고    scopus 로고
    • Role of adrenal glucocorticoid signaling in prefrontal cortex gene expression and acute behavioral responses to ethanol
    • 45 Costin, B.N., Wolen, A.R., Fitting, S., Shelton, K.L., Miles, M.F., Role of adrenal glucocorticoid signaling in prefrontal cortex gene expression and acute behavioral responses to ethanol. Alcohol Clin Exp Res 37:1 (2013), 57–66.
    • (2013) Alcohol Clin Exp Res , vol.37 , Issue.1 , pp. 57-66
    • Costin, B.N.1    Wolen, A.R.2    Fitting, S.3    Shelton, K.L.4    Miles, M.F.5
  • 46
    • 84961900251 scopus 로고    scopus 로고
    • Chronic drinking during adolescence predisposes the adult rat for continued heavy drinking: neurotrophin and behavioral adaptation after long-term, continuous ethanol exposure
    • 46 Fernandez, G.M., Stewart, W.N., Savage, L.M., Chronic drinking during adolescence predisposes the adult rat for continued heavy drinking: neurotrophin and behavioral adaptation after long-term, continuous ethanol exposure. PLOS ONE, 11(3), 2016, e0149987.
    • (2016) PLOS ONE , vol.11 , Issue.3 , pp. e0149987
    • Fernandez, G.M.1    Stewart, W.N.2    Savage, L.M.3
  • 47
    • 84906767459 scopus 로고    scopus 로고
    • Neuroimmune basis of alcoholic brain damage
    • 47 Crews, F.T., Vetreno, R.P., Neuroimmune basis of alcoholic brain damage. Int Rev Neurobiol 118 (2014), 315–357.
    • (2014) Int Rev Neurobiol , vol.118 , pp. 315-357
    • Crews, F.T.1    Vetreno, R.P.2
  • 49
    • 84949535053 scopus 로고    scopus 로고
    • Alcohol-induced dysregulation of stress-related circuitry: the search for novel targets and implications for interventions across the sexes
    • This review sets the stage for future investigations into sex as a highly relevant variable at the intersection of stress and AUD treatment.
    • 49•• Retson, T.A., Sterling, R.C., Van Bockstaele, E.J., Alcohol-induced dysregulation of stress-related circuitry: the search for novel targets and implications for interventions across the sexes. Prog Neuropsychopharmacol Biol Psychiatry 65 (2016), 252–259 This review sets the stage for future investigations into sex as a highly relevant variable at the intersection of stress and AUD treatment.
    • (2016) Prog Neuropsychopharmacol Biol Psychiatry , vol.65 , pp. 252-259
    • Retson, T.A.1    Sterling, R.C.2    Van Bockstaele, E.J.3
  • 50
    • 84924453121 scopus 로고    scopus 로고
    • Females uniquely vulnerable to alcohol-induced neurotoxicity show altered glucocorticoid signaling
    • 50 Wilhelm, C.J., Hashimoto, J.G., Roberts, M.L., Bloom, S.H., Beard, D.K., Wiren, K.M., Females uniquely vulnerable to alcohol-induced neurotoxicity show altered glucocorticoid signaling. Brain Res 1601 (2015), 102–116.
    • (2015) Brain Res , vol.1601 , pp. 102-116
    • Wilhelm, C.J.1    Hashimoto, J.G.2    Roberts, M.L.3    Bloom, S.H.4    Beard, D.K.5    Wiren, K.M.6


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