Blood transfusion improves renal oxygenation and renal function in sepsis-induced acute kidney injury in rats

Critical Care

Volumn 20, Issue 1, 2016, Pages

  Zafrani, Lara ^a   Ergin, Bulent ^b   Kapucu, Aysegul ^c   Ince, Can ^b  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c ISTANBUL UNIVERSITY   (Turkey)

Author keywords

Acute kidney injury; Blood transfusion; Endothelial dysfunction; Microcirculation; Renal oxygenation; Sepsis

Indexed keywords

CREATININE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HEMOGLOBIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LACTIC ACID; LIVER ENZYME;

ACUTE KIDNEY FAILURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD TRANSFUSION; CONTROLLED STUDY; CREATININE BLOOD LEVEL; FLUID RESUSCITATION; HEMOGLOBIN BLOOD LEVEL; KIDNEY BLOOD FLOW; KIDNEY BLOOD VESSEL; KIDNEY CIRCULATION; KIDNEY CORTEX; KIDNEY FUNCTION; LACTATE BLOOD LEVEL; LACTIC ACIDOSIS; LIVER FUNCTION; MEAN ARTERIAL PRESSURE; MICROVASCULATURE; NITROSATIVE STRESS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RENAL OXYGENATION; SEPSIS; TISSUE OXYGENATION; ANIMAL; KIDNEY; OXYGEN CONSUMPTION; PATHOPHYSIOLOGY; PHYSIOLOGY; PROCEDURES; RANDOMIZATION; WISTAR RAT;

ACUTE KIDNEY INJURY; ANIMALS; BLOOD TRANSFUSION; KIDNEY; OXYGEN CONSUMPTION; RANDOM ALLOCATION; RATS; RATS, WISTAR; RENAL CIRCULATION; SEPSIS;

EID: 85006766664     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/s13054-016-1581-1     Document Type: Article

References (36)

1. Chertow GM, Burdick E, Honour M, et al. Acute kidney injury, mortality, length of stay, and costs in hospitalized patients. J Am Soc Nephrol. 2005;16:3365-70. doi: 10.1681/ASN.2004090740.
2. Uchino S, Kellum JA, Bellomo R, et al. Acute renal failure in critically ill patients: a multinational, multicenter study. JAMA. 2005;294:813-8. doi: 10.1001/jama.294.7.813.
3. Johannes T, Mik EG, Ince C. Nonresuscitated endotoxemia induces microcirculatory hypoxic areas in the renal cortex in the rat. Shock. 2009;31:97-103. doi: 10.1097/SHK.0b013e31817c02a5.
4. du Cheyron D, Parienti JJ, Fekih-Hassen M, et al. Impact of anemia on outcome in critically ill patients with severe acute renal failure. Intensive Care Med. 2005;31:1529-36. doi: 10.1007/s00134-005-2739-5.
5. Legrand M, Bezemer R, Kandil A, et al. The role of renal hypoperfusion in development of renal microcirculatory dysfunction in endotoxemic rats. Intensive Care Med. 2011;37:1534-42. doi: 10.1007/s00134-011-2267-4.
6. Legrand M, Mik EG, Balestra GM, et al. Fluid resuscitation does not improve renal oxygenation during hemorrhagic shock in rats. Anesthesiology. 2010;112:119-27. doi: 10.1097/ALN.0b013e3181c4a5e2.
7. Sakr Y, Chierego M, Piagnerelli M, et al. Microvascular response to red blood cell transfusion in patients with severe sepsis. Crit Care Med. 2007;35:1639-44. doi: 10.1097/01.CCM.0000269936.73788.32.
8. Creteur J, Neves AP, Vincent JL. Near-infrared spectroscopy technique to evaluate the effects of red blood cell transfusion on tissue oxygenation. Crit Care. 2009;13 Suppl 5:S11. doi: 10.1186/cc8009.
9. Lee HB, Blaufox MD. Blood volume in the rat. J Nucl Med Off Publ Soc Nucl Med. 1985;26:72-6.
10. Vanderkooi JM, Maniara G, Green TJ, Wilson DF. An optical method for measurement of dioxygen concentration based upon quenching of phosphorescence. J Biol Chem. 1987;262:5476-82.
11. Sinaasappel M, Ince C. Calibration of Pd-porphyrin phosphorescence for oxygen concentration measurements in vivo. J Appl Physiol. 1985;81:2297-303.
12. Mik EG, Johannes T, Ince C. Monitoring of renal venous PO2 and kidney oxygen consumption in rats by a near-infrared phosphorescence lifetime technique. Am J Physiol Ren Physiol. 2008;294:F676-81. doi: 10.1152/ajprenal.00569.2007.
13. Inoue RY, Gontijo JA, Franchini KG. Hemodilution mediates hemodynamic changes during acute expansion in unanesthetized rats. Am J Physiol Regul Integr Comp Physiol. 2000;279:R2243-51.
14. Johannes T, Ince C, Klingel K, et al. Iloprost preserves renal oxygenation and restores kidney function in endotoxemia-related acute renal failure in the rat. Crit Care Med. 2009;37:1423-32. doi: 10.1097/CCM.0b013e31819b5f4e.
15. Matejovic M, Radermacher P, Joannidis M. Acute kidney injury in sepsis: is renal blood flow more than just an innocent bystander? Intensive Care Med. 2007;33:1498-500. doi: 10.1007/s00134-007-0735-7.
16. Chvojka J, Sykora R, Krouzecky A, et al. Renal haemodynamic, microcirculatory, metabolic and histopathological responses to peritonitis-induced septic shock in pigs. Crit Care. 2008;12:R164. doi: 10.1186/cc7164.
17. Evans RG, Harrop GK, Ngo JP, et al. Basal renal O2 consumption and the efficiency of O2 utilization for Na+ reabsorption. Am J Physiol Ren Physiol. 2014;306:F551-60. doi: 10.1152/ajprenal.00473.2013.
18. Rosenberger C, Rosen S, Heyman SN. Renal parenchymal oxygenation and hypoxia adaptation in acute kidney injury. Clin Exp Pharmacol Physiol. 2006;33:980-8. doi: 10.1111/j.1440-1681.2006.04472.x.
19. Bonventre JV, Weinberg JM. Recent advances in the pathophysiology of ischemic acute renal failure. J Am Soc Nephrol. 2003;14:2199-210.
20. Coletta C, Modis K, Olah G, et al. Endothelial dysfunction is a potential contributor to multiple organ failure and mortality in aged mice subjected to septic shock: preclinical studies in a murine model of cecal ligation and puncture. Crit Care. 2014;18:511. doi: 10.1186/s13054-014-0511-3.
21. Khan R, Kirschenbaum LA, LaRow C, et al. Augmentation of platelet and endothelial cell eNOS activity decreases sepsis-related neutrophil-endothelial cell interactions. Shock. 2010;33:242-6. doi: 10.1097/SHK.0b013e3181b0f96f.
22. Souza AC, Volpini RA, Shimizu MH, et al. Erythropoietin prevents sepsis-related acute kidney injury in rats by inhibiting NF-kappaB and upregulating endothelial nitric oxide synthase. Am J Physiol Ren Physiol. 2012;302:F1045-54. doi: 10.1152/ajprenal.00148.2011.
23. Hebert PC, Wells G, Blajchman MA, et al. A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group. N Engl J Med. 1999;340:409-17. doi: 10.1056/NEJM199902113400601.
24. Marik PE, Corwin HL. Efficacy of red blood cell transfusion in the critically ill: a systematic review of the literature. Crit Care Med. 2008;36:2667-74. doi: 10.1097/CCM.0b013e3181844677.
25. Vincent J-L, Sakr Y, Sprung C, et al. Are blood transfusions associated with greater mortality rates? Results of the Sepsis Occurrence in Acutely Ill Patients study. Anesthesiology. 2008;108:31-9. doi: 10.1097/01.anes.0000296070.75956.40.
26. Park DW, Chun BC, Kwon SS, et al. Red blood cell transfusions are associated with lower mortality in patients with severe sepsis and septic shock: a propensity-matched analysis. Crit Care Med. 2012;40:3140-5. doi: 10.1097/CCM.0b013e3182657b75.
27. Holst LB, Haase N, Wetterslev J, et al. Lower versus higher hemoglobin threshold for transfusion in septic shock. N Engl J Med. 2014;371:1381-91. doi: 10.1056/NEJMoa1406617.
28. van Bommel J, Siegemund M, Henny CP, Ince C. Heart, kidney, and intestine have different tolerances for anemia. Transl Res J Lab Clin Med. 2008;151:110-7. doi: 10.1016/j.trsl.2007.11.001.
29. Aird WC. Endothelial cell heterogeneity. Cold Spring Harb Perspect Med. 2012;2:a006429. doi: 10.1101/cshperspect.a006429.
30. Yano K, Liaw PC, Mullington JM, et al. Vascular endothelial growth factor is an important determinant of sepsis morbidity and mortality. J Exp Med. 2006;203:1447-58. doi: 10.1084/jem.20060375.
31. Aird WC. Phenotypic heterogeneity of the endothelium: I. Structure, function, and mechanisms. Circ Res. 2007;100:158-73. doi: 10.1161/01.RES.0000255691.76142.4a.
32. Furusu A, Miyazaki M, Abe K, et al. Expression of endothelial and inducible nitric oxide synthase in human glomerulonephritis. Kidney Int. 1998;53:1760-8. doi: 10.1046/j.1523-1755.1998.00907.x.
33. Tsai AG, Cabrales P, Intaglietta M. Microvascular perfusion upon exchange transfusion with stored red blood cells in normovolemic anemic conditions. Transfusion (Paris). 2004;44:1626-34. doi: 10.1111/j.0041-1132.2004.04128.x.
34. Lacroix J, Hébert PC, Fergusson DA, et al. Age of transfused blood in critically ill adults. N Engl J Med. 2015;372:1410-8. doi: 10.1056/NEJMoa1500704.
35. Sennoun N, Montemont C, Gibot S, et al. Comparative effects of early versus delayed use of norepinephrine in resuscitated endotoxic shock. Crit Care Med. 2007;35:1736-40. doi: 10.1097/01.CCM.0000269028.28521.08.
36. Maiden MJ, Otto S, Brealey JK, et al. Structure and function of the kidney in septic shock. A prospective controlled experimental study. Am J Respir Crit Care Med. 2016;194:692-700. doi: 10.1164/rccm.201511-2285OC.