Structure and function of the kidney in septic shock: A prospective controlled experimental study

American Journal of Respiratory and Critical Care Medicine

Volumn 194, Issue 6, 2016, Pages 692-700

  Maiden, Matthew J ^a,b   Otto, Sophia ^c   Brealey, John K ^c   Finnis, Mark E ^a,b   Chapman, Marianne J ^a,b   Kuchel, Tim R ^d   Nash, Coralie H ^b   Edwards, Jason ^a   Bellomo, Rinaldo ^e  

^a ROYAL ADELAIDE HOSPITAL   (Australia)

^b UNIVERSITY OF ADELAIDE   (Australia)

^c SA Pathology ^*  (Australia)

^d SOUTH AUSTRALIAN HEALTH AND MEDICAL RESEARCH INSTITUTE   (Australia)

^e UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Acute kidney injury; Animal models; Histology; Pathophysiology

Indexed keywords

CREATININE;

ACUTE KIDNEY FAILURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CREATININE CLEARANCE; ELECTRON MICROSCOPY; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTION; EXCRETION FRACTION; EXPERIMENTAL SHEEP; FEMALE; HISTOPATHOLOGY; INTENSIVE CARE; KIDNEY ARTERY; KIDNEY BIOPSY; KIDNEY FUNCTION; KIDNEY HYPERTROPHY; KIDNEY PARENCHYMA; KIDNEY STRUCTURE; MEAN ARTERIAL PRESSURE; NONHUMAN; OLIGURIA; OVINE MODEL; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; SEPTIC SHOCK; SYSTEMIC VASCULAR RESISTANCE; TISSUE PREPARATION; ACUTE KIDNEY INJURY; ANIMAL; BIOPSY; BLOOD PRESSURE; COMPLICATION; DISEASE MODEL; HEART OUTPUT; KIDNEY; KIDNEY CIRCULATION; PATHOLOGY; PATHOPHYSIOLOGY; SHEEP;

ACUTE KIDNEY INJURY; ANIMALS; BIOPSY; BLOOD PRESSURE; CARDIAC OUTPUT; DISEASE MODELS, ANIMAL; FEMALE; KIDNEY; RENAL CIRCULATION; SHEEP; SHOCK, SEPTIC;

EID: 84988938942     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201511-2285OC     Document Type: Article

References (49)

1. Hoste EA, Clermont G, Kersten A, Venkataraman R, Angus DC, De Bacquer D, Kellum JA. RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients: a cohort analysis. Crit Care 2006;10:R73
2. Uchino S, Bellomo R, Goldsmith D, Bates S, Ronco C. An assessment of the RIFLE criteria for acute renal failure in hospitalized patients. Crit Care Med 2006;34:1913-1917
3. Hoste EA, Bagshaw SM, Bellomo R, Cely CM, Colman R, Cruz DN, Edipidis K, Forni LG, Gomersall CD, Govil D, et al. Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study. Intensive Care Med 2015;41:1411-1423
4. Cole L, Bellomo R, Silvester W, Reeves JH. A prospective, multicenter study of the epidemiology, management, and outcome of severe acute renal failure in a "closed" ICU system. Am J Respir Crit Care Med 2000;162:191-196
5. Uchino S, Kellum JA, Bellomo R, Doig GS, Morimatsu H, Morgera S, Schetz M, Tan I, Bouman C, Macedo E, et al.; Beginning and Ending Supportive Therapy for the Kidney (BEST Kidney) Investigators. Acute renal failure in critically ill patients: a multinational, multicenter study. JAMA 2005;294:813-818
6. Bagshaw SM, George C, Bellomo R; ANZICS Database Management Committee. Early acute kidney injury and sepsis: a multicentre evaluation. Crit Care 2008;12:R47
7. Thadhani R, Pascual M, Bonventre JV. Acute renal failure. N Engl J Med 1996;334:1448-1460
8. De Vriese AS. Prevention and treatment of acute renal failure in sepsis. J Am Soc Nephrol 2003;14:792-805
9. Schrier RW, Wang W. Acute renal failure and sepsis. N Engl J Med 2004; 351:159-169
10. Lameire N, Van Biesen W, Vanholder R. Acute renal failure. Lancet 2005;365:417-430
11. Schneider AG, Goodwin MD, Bellomo R. Measurement of kidney perfusion in critically ill patients. Crit Care 2013;17:220
12. Di Giantomasso D, May CN, Bellomo R. Norepinephrine and vital organ blood flow during experimental hyperdynamic sepsis. Intensive Care Med 2003;29:1774-1781
13. Langenberg C, Bellomo R, May C, Wan L, Egi M, Morgera S. Renal blood flow in sepsis. Crit Care 2005;9:R363-R374
14. Langenberg C, Wan L, Egi M, May CN, Bellomo R. Renal blood flow in experimental septic acute renal failure. Kidney Int 2006;69: 1996-2002
15. Langenberg C, Wan L, Egi M, May CN, Bellomo R. Renal blood flow and function during recovery from experimental septic acute kidney injury. Intensive Care Med 2007;33:1614-1618
16. Lieberthal W, Nigam SK. Acute renal failure. II. Experimental models of acute renal failure: imperfect but indispensable. Am J Physiol Renal Physiol 2000;278:F1-F12
17. Guerin C, Girard R, Selli JM, Perdrix JP, Ayzac L; Rhone-Alpes Area Study Group on Acute Renal Failure. Initial versus delayed acute renal failure in the intensive care unit: a multicenter prospective epidemiological study. Am J Respir Crit Care Med 2000;161:872-879
18. Langenberg C, Bagshaw SM, May CN, Bellomo R. The histopathology of septic acute kidney injury: a systematic review. Crit Care 2008;12: R38
19. Langenberg C, Gobe G, Hood S, May CN, Bellomo R. Renal histopathology during experimental septic acute kidney injury and recovery. Crit Care Med 2014;42:e58-e67
20. Chvojka J, Sykora R, Krouzecky A, Radej J, Varnerova V, Karvunidis T, Hes O, Novak I, Radermacher P, Matejovic M. Renal haemodynamic, microcirculatory, metabolic and histopathological responses to peritonitis-induced septic shock in pigs. Crit Care 2008;12:R164
21. Lerolle N, Nochy D, Guérot E, Bruneval P, Fagon J-Y, Diehl J-L, Hill G. Histopathology of septic shock induced acute kidney injury: apoptosis and leukocytic infiltration. Intensive Care Med 2010;36: 471-478
22. Maiden M, Otto S, Brealey J, Chapman M, Nash C, Edwards J, Kuchel T, Bellomo R. Structure and function of the kidney in septic shock-A prospective controlled study [abstract]. Intensive Care Med Exp 2015;3:A838
23. National Health and Medical Research Council (Australia). Australian code of practice for the care and use of animals for scientific purposes. Canberra, Australia: National Health and Medical Research Council; 2004
24. Adams D, McKinley M, Colditz I, Dart C. The sheep [revised 2009 July]. Australian &New Zealand Council for the Care of Animals in Research and Teaching. Fact Sheet A9. Adelaide, South Australia, Australia: University of Adelaide; 2009. Available from: http://www. adelaide.edu.au/ANZCCART/publications/A9-SheepFactSheet.pdf
25. Nawaz M, Shah BH. Renal clearance of endogenous creatinine and urea in sheep during summer and winter. Res Vet Sci 1984;36: 220-224
26. Espinel CH. The FeNa test: use in the differential diagnosis of acute renal failure. JAMA 1976;236:579-581
27. Oberg AL, Mahoney DW. Linear mixed effects models. Methods Mol Biol 2007;404:213-234
28. Brun C, Munck O. Lesions of the kidney in acute renal failure following shock. Lancet 1957;272:603-607
29. Sato T, Kamiyama Y, Jones RT, Cowley RA, Trump BF. Ultrastructural study on kidney cell injury following various types of shock in 26 immediate autopsy patients. Adv Shock Res 1978;1:55-69
30. Hotchkiss RS, Swanson PE, Freeman BD, Tinsley KW, Cobb JP, Matuschak GM, Buchman TG, Karl IE. Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction. Crit Care Med 1999;27:1230-1251
31. Takasu O, Gaut JP, Watanabe E, To K, Fagley RE, Sato B, Jarman S, Efimov IR, Janks DL, Srivastava A, et al. Mechanisms of cardiac and renal dysfunction in patients dying of sepsis. Am J Respir Crit Care Med 2013;187:509-517
32. Schlöndorff D, Banas B. The mesangial cell revisited: no cell is an island. J Am Soc Nephrol 2009;20:1179-1187
33. Weber A, Schwieger IM, Poinsot O, Klohn M, Gaumann DM, Morel DR. Sequential changes in renal oxygen consumption and sodium transport during hyperdynamic sepsis in sheep. Am J Physiol 1992; 262:F965-F971
34. Bagshaw SM, Langenberg C, Wan L, May CN, Bellomo R. A systematic review of urinary findings in experimental septic acute renal failure. Crit Care Med 2007;35:1592-1598
35. Calzavacca P, Evans RG, Bailey M, Bellomo R, May CN. Cortical and medullary tissue perfusion and oxygenation in experimental septic acute kidney injury. Crit Care Med 2015;43:e431-e439
36. Bellomo R, Kellum JA, Pinsky MR. Transvisceral lactate fluxes during early endotoxemia. Chest 1996;110:198-204
37. Heemskerk AE, Huisman E, van Lambalgen AA, van den Bos GC, Hennekes M, Thijs LG, Tangelder GJ. Renal function and oxygen consumption during bacteraemia and endotoxaemia in rats. Nephrol Dial Transplant 1997;12:1586-1594
38. May CN, Ishikawa K, Wan L, Williams J, Wellard RM, Pell GS, Jackson GD, Bellomo R. Renal bioenergetics during early gram-negative mammalian sepsis and angiotensin II infusion. Intensive Care Med 2012;38:886-893
39. Kellum JA, Chawla LS, Keener C, Singbartl K, Palevsky PM, Pike FL, Yealy DM, Huang DT, Angus DC; ProCESS and ProGReSS-AKI Investigators. The effects of alternative resuscitation strategies on acute kidney injury in patients with septic shock. Am J Respir Crit Care Med 2016;193:281-287
40. Linkermann A. Nonapoptotic cell death in acute kidney injury and transplantation. Kidney Int 2016;89:46-57
41. Linkermann A, Green DR. Necroptosis. N Engl J Med 2014;370: 455-465
42. Schurek HJ, Jost U, Baumgärtl H, Bertram H, Heckmann U. Evidence for a preglomerular oxygen diffusion shunt in rat renal cortex. Am J Physiol 1990;259:F910-F915
43. Ljungqvist A. Structure of the arteriole-glomerular units in different zones of the kidney: micro-angiographic and histologic evidence of an extraglomerular medullary circulation. Nephron 1964;1:329-337
44. Takazakura E, Sawabu N, Handa A, Takada A, Shinoda A, Takeuchi J. Intrarenal vascular changes with age and disease. Kidney Int 1972;2: 224-230
45. Casellas D, Mimran A. Shunting in renal microvasculature of the rat: a scanning electron microscopic study of corrosion casts. Anat Rec 1981;201:237-248
46. O'Connor PM, Anderson WP, Kett MM, Evans RG. Renal preglomerular arterial-venous O2 shunting is a structural anti-oxidant defence mechanism of the renal cortex. Clin Exp Pharmacol Physiol 2006;33: 637-641
47. Thurau K, Boylan JW. Acute renal success: the unexpected logic of oliguria in acute renal failure. Am J Med 1976;61:308-315
48. Doi K, Leelahavanichkul A, Yuen PST, Star RA. Animal models of sepsis and sepsis-induced kidney injury. J Clin Invest 2009;119:2868-2878
49. Maiden MJ, Chapman MJ, Torpy DJ, Kuchel TR, Clarke IJ, Nash CH, Fraser JD, Ludbrook GL. Triiodothyronine administration in a model of septic shock: a randomized, blinded, placebo-controlled trial. Crit Care Med 2016;44:1153-1160