Integrating GWAS and Co-expression Network Data Identifies Bone Mineral Density Genes SPTBN1 and MARK3 and an Osteoblast Functional Module

Cell Systems

Volumn 4, Issue 1, 2017, Pages 46-59.e4

  Calabrese, Gina M ^a   Mesner, Larry D ^a   Stains, Joseph P ^b   Tommasini, Steven M ^c   Horowitz, Mark C ^c   Rosen, Clifford J ^d   Farber, Charles R ^a,e  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d Maine Medical Center Research Institute   (United States)

^e UNIVERSITY OF VIRGINIA   (United States)

Author keywords

BMD; bone fragility; bone mineral density; co expression network; fracture; genetics; genome wide association study; GWAS; osteoporosis; systems genetics

Indexed keywords

MARK3 PROTEIN; MEMBRANE PROTEIN; SPTBN1 PROTEIN; UNCLASSIFIED DRUG; MARK3 PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE; SPECTRIN; SPTBN1 PROTEIN, HUMAN; TRANSCRIPTOME;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE DENSITY; CELL FUNCTION; CHROMOSOME 2P; CONTROLLED STUDY; CORTICAL BONE; GENE; GENE CONSTRUCT; GENE EXPRESSION; GENE IDENTIFICATION; GENE LOCUS; GENE MAPPING; GENOME-WIDE ASSOCIATION STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; OSTEOBLAST; PREDICTION; PRIORITY JOURNAL; TRANSCRIPTOMICS; ANIMAL; BONE; C57BL MOUSE; CHROMOSOMAL MAPPING; FRAGILITY FRACTURE; GENETIC PREDISPOSITION; GENETICS; KNOCKOUT MOUSE; METABOLISM; OSTEOPOROSIS; PATHOPHYSIOLOGY; PHENOTYPE; PHYSIOLOGY; PROCEDURES; SINGLE NUCLEOTIDE POLYMORPHISM;

ANIMALS; BONE AND BONES; BONE DENSITY; CHROMOSOME MAPPING; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OSTEOBLASTS; OSTEOPOROSIS; OSTEOPOROTIC FRACTURES; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN-SERINE-THREONINE KINASES; SPECTRIN; TRANSCRIPTOME;

EID: 85006746732     PISSN: 24054712     EISSN: 24054720     Source Type: Journal    
DOI: 10.1016/j.cels.2016.10.014     Document Type: Article

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