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Volumn 101, Issue 1, 2017, Pages 81-88

Daratumumab, Elotuzumab, and the Development of Therapeutic Monoclonal Antibodies in Multiple Myeloma

Author keywords

[No Author keywords available]

Indexed keywords

CD38 MONOCLONAL ANTIBODY; DARATUMUMAB; ELOTUZUMAB; INDATUXIMAB RAVTANSINE; MONOCLONAL ANTIBODY; PROGRAMMED DEATH 1 RECEPTOR; SILTUXIMAB; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; DEXAMETHASONE; LENALIDOMIDE; THALIDOMIDE;

EID: 85006676577     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1002/cpt.550     Document Type: Article
Times cited : (32)

References (66)
  • 1
    • 42449114035 scopus 로고    scopus 로고
    • Multiple myeloma
    • Kyle, R.A. & Rajkumar, S.V. Multiple myeloma. Blood 111, 2962–2972 (2008).
    • (2008) Blood , vol.111 , pp. 2962-2972
    • Kyle, R.A.1    Rajkumar, S.V.2
  • 4
    • 41949130070 scopus 로고    scopus 로고
    • Improved survival in multiple myeloma and the impact of novel therapies
    • Kumar, S.K. et al. Improved survival in multiple myeloma and the impact of novel therapies. Blood 111, 2516–2520 (2008).
    • (2008) Blood , vol.111 , pp. 2516-2520
    • Kumar, S.K.1
  • 6
    • 1842368507 scopus 로고    scopus 로고
    • IDEC-C2B8 (Rituximab) anti-CD20 monoclonal antibody therapy in patients with relapsed low-grade non-Hodgkin's lymphoma
    • Maloney, D.G. et al. IDEC-C2B8 (Rituximab) anti-CD20 monoclonal antibody therapy in patients with relapsed low-grade non-Hodgkin's lymphoma. Blood 90, 2188–2195 (1997).
    • (1997) Blood , vol.90 , pp. 2188-2195
    • Maloney, D.G.1
  • 7
    • 0345337254 scopus 로고    scopus 로고
    • Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: half of patients respond to a four-dose treatment program
    • McLaughlin, P. et al. Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: half of patients respond to a four-dose treatment program. J. Clin. Oncol. 16, 2825–2833 (1998).
    • (1998) J. Clin. Oncol. , vol.16 , pp. 2825-2833
    • McLaughlin, P.1
  • 8
    • 0037165261 scopus 로고    scopus 로고
    • CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma
    • Coiffier, B. et al. CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma. N. Engl. J. Med. 346, 235–242 (2002).
    • (2002) N. Engl. J. Med. , vol.346 , pp. 235-242
    • Coiffier, B.1
  • 9
    • 33745982067 scopus 로고    scopus 로고
    • Rituximab-CHOP versus CHOP alone or with maintenance rituximab in older patients with diffuse large B-cell lymphoma
    • Habermann, T.M. et al. Rituximab-CHOP versus CHOP alone or with maintenance rituximab in older patients with diffuse large B-cell lymphoma. J. Clin. Oncol. 24, 3121–3127 (2006).
    • (2006) J. Clin. Oncol. , vol.24 , pp. 3121-3127
    • Habermann, T.M.1
  • 10
    • 84988449072 scopus 로고    scopus 로고
    • Rituximab in B-lineage adult acute lymphoblastic leukemia
    • Maury, S. et al. Rituximab in B-lineage adult acute lymphoblastic leukemia. N. Engl. J. Med. 375, 1044–1053 (2016).
    • (2016) N. Engl. J. Med. , vol.375 , pp. 1044-1053
    • Maury, S.1
  • 11
    • 84862903106 scopus 로고    scopus 로고
    • Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
    • Brahmer, J.R. et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N. Engl. J. Med. 366, 2455–2465 (2012).
    • (2012) N. Engl. J. Med. , vol.366 , pp. 2455-2465
    • Brahmer, J.R.1
  • 12
    • 0035869407 scopus 로고    scopus 로고
    • Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
    • Slamon, D.J. et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N. Engl. J. Med. 344, 783–792 (2001).
    • (2001) N. Engl. J. Med. , vol.344 , pp. 783-792
    • Slamon, D.J.1
  • 13
    • 78650303860 scopus 로고    scopus 로고
    • Bortezomib with thalidomide plus dexamethasone compared with thalidomide plus dexamethasone as induction therapy before, and consolidation therapy after, double autologous stem-cell transplantation in newly diagnosed multiple myeloma: a randomised phase 3 study
    • Cavo, M. et al. Bortezomib with thalidomide plus dexamethasone compared with thalidomide plus dexamethasone as induction therapy before, and consolidation therapy after, double autologous stem-cell transplantation in newly diagnosed multiple myeloma: a randomised phase 3 study. Lancet 376, 2075–2085 (2010).
    • (2010) Lancet , vol.376 , pp. 2075-2085
    • Cavo, M.1
  • 14
    • 84954253780 scopus 로고    scopus 로고
    • Bortezomib, lenalidomide and dexamethasone vs. lenalidomide and dexamethasone in patients (pts) with previously untreated multiple myeloma without an intent for immediate autologous stem cell transplant (ASCT): results of the randomized phase III trial SWOG S0777
    • Durie, B. et al. Bortezomib, lenalidomide and dexamethasone vs. lenalidomide and dexamethasone in patients (pts) with previously untreated multiple myeloma without an intent for immediate autologous stem cell transplant (ASCT): results of the randomized phase III trial SWOG S0777. Blood 126, 25 (2015).
    • (2015) Blood , vol.126 , pp. 25
    • Durie, B.1
  • 15
    • 84907007989 scopus 로고    scopus 로고
    • Autologous transplantation and maintenance therapy in multiple myeloma
    • Palumbo, A. et al. Autologous transplantation and maintenance therapy in multiple myeloma. N. Engl. J. Med. 371, 895–905 (2014).
    • (2014) N. Engl. J. Med. , vol.371 , pp. 895-905
    • Palumbo, A.1
  • 16
    • 84948807402 scopus 로고    scopus 로고
    • Chemotherapy plus lenalidomide versus autologous transplantation, followed by lenalidomide plus prednisone versus lenalidomide maintenance, in patients with multiple myeloma: a randomised, multicentre, phase 3 trial
    • Gay, F. et al. Chemotherapy plus lenalidomide versus autologous transplantation, followed by lenalidomide plus prednisone versus lenalidomide maintenance, in patients with multiple myeloma: a randomised, multicentre, phase 3 trial. Lancet Oncol. 16, 1617–1629 (2015).
    • (2015) Lancet Oncol. , vol.16 , pp. 1617-1629
    • Gay, F.1
  • 17
    • 84969429674 scopus 로고    scopus 로고
    • Autologous transplantation for multiple myeloma in the era of new drugs: a phase III study of the Intergroupe Francophone Du Myelome (IFM/DFCI 2009 Trial)
    • Attal, M. et al. Autologous transplantation for multiple myeloma in the era of new drugs: a phase III study of the Intergroupe Francophone Du Myelome (IFM/DFCI 2009 Trial). Blood 126, 391 (2015).
    • (2015) Blood , vol.126 , pp. 391
    • Attal, M.1
  • 18
    • 85011796267 scopus 로고    scopus 로고
    • Upfront autologous stem cell transplantation (ASCT) versus novel agent-based therapy for multiple myeloma (MM): a randomized phase 3 study of the European Myeloma Network (EMN02/HO95 MM trial)
    • abstract
    • Cavo, M. et al. Upfront autologous stem cell transplantation (ASCT) versus novel agent-based therapy for multiple myeloma (MM): a randomized phase 3 study of the European Myeloma Network (EMN02/HO95 MM trial). J. Clin. Oncol. 34(suppl.), abstract 8000 (2016).
    • (2016) J. Clin. Oncol. , vol.34 , pp. 8000
    • Cavo, M.1
  • 19
    • 84860709392 scopus 로고    scopus 로고
    • Lenalidomide maintenance after stem-cell transplantation for multiple myeloma
    • Attal, M. et al. Lenalidomide maintenance after stem-cell transplantation for multiple myeloma. N. Engl. J. Med. 366, 1782–1791 (2012).
    • (2012) N. Engl. J. Med. , vol.366 , pp. 1782-1791
    • Attal, M.1
  • 20
    • 84860741191 scopus 로고    scopus 로고
    • Lenalidomide after stem-cell transplantation for multiple myeloma
    • McCarthy, P.L. et al. Lenalidomide after stem-cell transplantation for multiple myeloma. N. Engl. J. Med. 366, 1770–1781 (2012).
    • (2012) N. Engl. J. Med. , vol.366 , pp. 1770-1781
    • McCarthy, P.L.1
  • 21
    • 84860744403 scopus 로고    scopus 로고
    • Continuous lenalidomide treatment for newly diagnosed multiple myeloma
    • Palumbo, A. et al. Continuous lenalidomide treatment for newly diagnosed multiple myeloma. N. Engl. J. Med. 366, 1759–1769 (2012).
    • (2012) N. Engl. J. Med. , vol.366 , pp. 1759-1769
    • Palumbo, A.1
  • 22
    • 84907012637 scopus 로고    scopus 로고
    • Lenalidomide and dexamethasone in transplant-ineligible patients with myeloma
    • Benboubker, L. et al. Lenalidomide and dexamethasone in transplant-ineligible patients with myeloma. N. Engl. J. Med. 371, 906–917 (2014).
    • (2014) N. Engl. J. Med. , vol.371 , pp. 906-917
    • Benboubker, L.1
  • 23
    • 84895786240 scopus 로고    scopus 로고
    • Consolidation and maintenance therapy with lenalidomide, bortezomib and dexamethasone (RVD) in high-risk myeloma patients
    • Nooka, A.K. et al. Consolidation and maintenance therapy with lenalidomide, bortezomib and dexamethasone (RVD) in high-risk myeloma patients. Leukemia 28, 690–693 (2014).
    • (2014) Leukemia , vol.28 , pp. 690-693
    • Nooka, A.K.1
  • 24
    • 84958074272 scopus 로고    scopus 로고
    • Management of relapsed multiple myeloma: recommendations of the International Myeloma Working Group
    • Laubach, J. et al. Management of relapsed multiple myeloma: recommendations of the International Myeloma Working Group. Leukemia 30, 1005–1017 (2016).
    • (2016) Leukemia , vol.30 , pp. 1005-1017
    • Laubach, J.1
  • 25
    • 34548539381 scopus 로고    scopus 로고
    • Randomized phase III study of pegylated liposomal doxorubicin plus bortezomib compared with bortezomib alone in relapsed or refractory multiple myeloma: combination therapy improves time to progression
    • Orlowski, R.Z. et al. Randomized phase III study of pegylated liposomal doxorubicin plus bortezomib compared with bortezomib alone in relapsed or refractory multiple myeloma: combination therapy improves time to progression. J. Clin. Oncol. 25, 3892–3901 (2007).
    • (2007) J. Clin. Oncol. , vol.25 , pp. 3892-3901
    • Orlowski, R.Z.1
  • 26
    • 84908133944 scopus 로고    scopus 로고
    • Panobinostat plus bortezomib and dexamethasone versus placebo plus bortezomib and dexamethasone in patients with relapsed or relapsed and refractory multiple myeloma: a multicentre, randomised, double-blind phase 3 trial
    • San-Miguel, J.F. et al. Panobinostat plus bortezomib and dexamethasone versus placebo plus bortezomib and dexamethasone in patients with relapsed or relapsed and refractory multiple myeloma: a multicentre, randomised, double-blind phase 3 trial. Lancet Oncol. 15, 1195–1206 (2014).
    • (2014) Lancet Oncol. , vol.15 , pp. 1195-1206
    • San-Miguel, J.F.1
  • 27
    • 84920599743 scopus 로고    scopus 로고
    • Carfilzomib, lenalidomide, and dexamethasone for relapsed multiple myeloma
    • Stewart, A.K. et al. Carfilzomib, lenalidomide, and dexamethasone for relapsed multiple myeloma. N. Engl. J. Med. 372, 142–152 (2015).
    • (2015) N. Engl. J. Med. , vol.372 , pp. 142-152
    • Stewart, A.K.1
  • 28
    • 84964931441 scopus 로고    scopus 로고
    • Oral ixazomib, lenalidomide, and dexamethasone for multiple myeloma
    • Moreau, P. et al. Oral ixazomib, lenalidomide, and dexamethasone for multiple myeloma. N. Engl. J. Med. 374, 1621–1634 (2016).
    • (2016) N. Engl. J. Med. , vol.374 , pp. 1621-1634
    • Moreau, P.1
  • 29
    • 79251570884 scopus 로고    scopus 로고
    • Daratumumab, a novel therapeutic human CD38 monoclonal antibody, induces killing of multiple myeloma and other hematological tumors
    • de Weers, M. et al. Daratumumab, a novel therapeutic human CD38 monoclonal antibody, induces killing of multiple myeloma and other hematological tumors. J. Immunol. 186, 1840–1848 (2011).
    • (2011) J. Immunol. , vol.186 , pp. 1840-1848
    • de Weers, M.1
  • 30
    • 84866534949 scopus 로고    scopus 로고
    • Crosstalk between human IgG isotypes and murine effector cells
    • Overdijk, M.B. et al. Crosstalk between human IgG isotypes and murine effector cells. J. Immunol. 189, 3430–3438 (2012).
    • (2012) J. Immunol. , vol.189 , pp. 3430-3438
    • Overdijk, M.B.1
  • 31
    • 84979519854 scopus 로고    scopus 로고
    • Daratumumab depletes CD38+ immune regulatory cells, promotes T-cell expansion, and skews T-cell repertoire in multiple myeloma
    • Krejcik, J. et al. Daratumumab depletes CD38+ immune regulatory cells, promotes T-cell expansion, and skews T-cell repertoire in multiple myeloma. Blood 128, 384–394 (2016).
    • (2016) Blood , vol.128 , pp. 384-394
    • Krejcik, J.1
  • 32
    • 52049104695 scopus 로고    scopus 로고
    • CS1, a potential new therapeutic antibody target for the treatment of multiple myeloma
    • Hsi, E.D. et al. CS1, a potential new therapeutic antibody target for the treatment of multiple myeloma. Clin. Cancer Res. 14, 2775–2784 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , pp. 2775-2784
    • Hsi, E.D.1
  • 33
    • 51649083849 scopus 로고    scopus 로고
    • Anti-CS1 humanized monoclonal antibody HuLuc63 inhibits myeloma cell adhesion and induces antibody-dependent cellular cytotoxicity in the bone marrow milieu
    • Tai, Y.T. et al. Anti-CS1 humanized monoclonal antibody HuLuc63 inhibits myeloma cell adhesion and induces antibody-dependent cellular cytotoxicity in the bone marrow milieu. Blood 112, 1329–1337 (2008).
    • (2008) Blood , vol.112 , pp. 1329-1337
    • Tai, Y.T.1
  • 34
    • 84890429971 scopus 로고    scopus 로고
    • Elotuzumab directly enhances NK cell cytotoxicity against myeloma via CS1 ligation: evidence for augmented NK cell function complementing ADCC
    • Collins, S.M. et al. Elotuzumab directly enhances NK cell cytotoxicity against myeloma via CS1 ligation: evidence for augmented NK cell function complementing ADCC. Cancer Immunol. Immunother. 62, 1841–1849 (2013).
    • (2013) Cancer Immunol. Immunother. , vol.62 , pp. 1841-1849
    • Collins, S.M.1
  • 35
    • 84942436321 scopus 로고    scopus 로고
    • Targeting CD38 with daratumumab monotherapy in multiple myeloma
    • Lokhorst, H.M. et al. Targeting CD38 with daratumumab monotherapy in multiple myeloma. N. Engl. J. Med. 373, 1207–1219 (2015).
    • (2015) N. Engl. J. Med. , vol.373 , pp. 1207-1219
    • Lokhorst, H.M.1
  • 36
    • 84953325096 scopus 로고    scopus 로고
    • Daratumumab monotherapy in patients with treatment-refractory multiple myeloma (SIRIUS): an open-label, randomised, phase 2 trial
    • Lonial, S. et al. Daratumumab monotherapy in patients with treatment-refractory multiple myeloma (SIRIUS): an open-label, randomised, phase 2 trial. Lancet 387, 1551–1560 (2016).
    • (2016) Lancet , vol.387 , pp. 1551-1560
    • Lonial, S.1
  • 37
    • 84990242886 scopus 로고    scopus 로고
    • Phase 1/2 study of daratumumab, lenalidomide, and dexamethasone for relapsed multiple myeloma
    • Plesner, T. et al. Phase 1/2 study of daratumumab, lenalidomide, and dexamethasone for relapsed multiple myeloma. Blood 128, 1821–1828 (2016).
    • (2016) Blood , vol.128 , pp. 1821-1828
    • Plesner, T.1
  • 38
    • 84990046018 scopus 로고    scopus 로고
    • Daratumumab, lenalidomide, and dexamethasone for multiple myeloma
    • Dimopoulos, M.A. et al. Daratumumab, lenalidomide, and dexamethasone for multiple myeloma. N. Engl. J. Med. 375, 1319–1331 (2016).
    • (2016) N. Engl. J. Med. , vol.375 , pp. 1319-1331
    • Dimopoulos, M.A.1
  • 39
    • 84984680198 scopus 로고    scopus 로고
    • Daratumumab, bortezomib, and dexamethasone for multiple myeloma
    • Palumbo, A. et al. Daratumumab, bortezomib, and dexamethasone for multiple myeloma. N. Engl. J. Med. 375, 754–766 (2016).
    • (2016) N. Engl. J. Med. , vol.375 , pp. 754-766
    • Palumbo, A.1
  • 40
    • 84864118302 scopus 로고    scopus 로고
    • A phase 1, multicenter, open-label, dose escalation study of elotuzumab in patients with advanced multiple myeloma
    • Zonder, J.A. et al. A phase 1, multicenter, open-label, dose escalation study of elotuzumab in patients with advanced multiple myeloma. Blood 120, 552–559 (2012).
    • (2012) Blood , vol.120 , pp. 552-559
    • Zonder, J.A.1
  • 41
    • 84863919927 scopus 로고    scopus 로고
    • Elotuzumab in combination with lenalidomide and low-dose dexamethasone in relapsed or refractory multiple myeloma
    • Lonial, S. et al. Elotuzumab in combination with lenalidomide and low-dose dexamethasone in relapsed or refractory multiple myeloma. J. Clin. Oncol. 30, 1953–1959 (2012).
    • (2012) J. Clin. Oncol. , vol.30 , pp. 1953-1959
    • Lonial, S.1
  • 42
    • 84862672400 scopus 로고    scopus 로고
    • Phase I trial of anti-CS1 monoclonal antibody elotuzumab in combination with bortezomib in the treatment of relapsed/refractory multiple myeloma
    • Jakubowiak, A.J. et al. Phase I trial of anti-CS1 monoclonal antibody elotuzumab in combination with bortezomib in the treatment of relapsed/refractory multiple myeloma. J. Clin. Oncol. 30, 1960–1965 (2012).
    • (2012) J. Clin. Oncol. , vol.30 , pp. 1960-1965
    • Jakubowiak, A.J.1
  • 43
    • 84964968270 scopus 로고    scopus 로고
    • Elotuzumab in combination with lenalidomide and dexamethasone in patients with relapsed multiple myeloma: final phase 2 results from the randomised, open-label, phase 1b-2 dose-escalation study
    • Richardson, P.G. et al. Elotuzumab in combination with lenalidomide and dexamethasone in patients with relapsed multiple myeloma: final phase 2 results from the randomised, open-label, phase 1b-2 dose-escalation study. Lancet Haematol. 2, e516–e527 (2015).
    • (2015) Lancet Haematol. , vol.2 , pp. e516-e527
    • Richardson, P.G.1
  • 44
    • 84933569079 scopus 로고    scopus 로고
    • Elotuzumab therapy for relapsed or refractory multiple myeloma
    • Lonial, S. et al. Elotuzumab therapy for relapsed or refractory multiple myeloma. N. Engl. J. Med. 373, 621–631 (2015).
    • (2015) N. Engl. J. Med. , vol.373 , pp. 621-631
    • Lonial, S.1
  • 45
    • 84991616656 scopus 로고    scopus 로고
    • Eloquent-2 update: a phase 3, randomized, open-label study of elotuzumab in combination with lenalidomide/dexamethasone in patients with relapsed/refractory multiple myeloma – 3-year safety and efficacy follow-up
    • abstract
    • Dimopoulos, M.A. et al. Eloquent-2 update: a phase 3, randomized, open-label study of elotuzumab in combination with lenalidomide/dexamethasone in patients with relapsed/refractory multiple myeloma – 3-year safety and efficacy follow-up. Blood 126, abstract 28 (2015).
    • (2015) Blood , vol.126 , pp. 28
    • Dimopoulos, M.A.1
  • 46
    • 84969776462 scopus 로고    scopus 로고
    • Interference of daratumumab in monitoring multiple myeloma patients using serum immunofixation electrophoresis can be abrogated using the daratumumab IFE reflex assay (DIRA)
    • van de Donk, N.W. et al. Interference of daratumumab in monitoring multiple myeloma patients using serum immunofixation electrophoresis can be abrogated using the daratumumab IFE reflex assay (DIRA). Clin. Chem. Lab. Med. 54, 1105–1109 (2016).
    • (2016) Clin. Chem. Lab. Med. , vol.54 , pp. 1105-1109
    • van de Donk, N.W.1
  • 47
    • 84969835048 scopus 로고    scopus 로고
    • Monitoring multiple myeloma patients treated with daratumumab: teasing out monoclonal antibody interference
    • McCudden, C. et al. Monitoring multiple myeloma patients treated with daratumumab: teasing out monoclonal antibody interference. Clin. Chem. Lab. Med. 54, 1095–1104 (2016).
    • (2016) Clin. Chem. Lab. Med. , vol.54 , pp. 1095-1104
    • McCudden, C.1
  • 48
    • 84992034885 scopus 로고    scopus 로고
    • Investigation into the interference of the monoclonal antibody daratumumab on the free light chain assay
    • Rosenberg, A.S., Bainbridge, S., Pahwa, R. & Jialal, I. Investigation into the interference of the monoclonal antibody daratumumab on the free light chain assay. Clin. Biochem. 49, 1202–1204 (2016).
    • (2016) Clin. Biochem. , vol.49 , pp. 1202-1204
    • Rosenberg, A.S.1    Bainbridge, S.2    Pahwa, R.3    Jialal, I.4
  • 49
    • 0027497231 scopus 로고
    • A single protein immunologically identified as CD38 displays NAD+ glycohydrolase, ADP-ribosyl cyclase and cyclic ADP-ribose hydrolase activities at the outer surface of human erythrocytes
    • Zocchi, E. et al. A single protein immunologically identified as CD38 displays NAD+ glycohydrolase, ADP-ribosyl cyclase and cyclic ADP-ribose hydrolase activities at the outer surface of human erythrocytes. Biochem. Biophys. Res. Commun. 196, 1459–1465 (1993).
    • (1993) Biochem. Biophys. Res. Commun. , vol.196 , pp. 1459-1465
    • Zocchi, E.1
  • 50
    • 84931577511 scopus 로고    scopus 로고
    • Resolving the daratumumab interference with blood compatibility testing
    • Chapuy, C.I. et al. Resolving the daratumumab interference with blood compatibility testing. Transfusion 55(6 Pt 2), 1545–1554 (2015).
    • (2015) Transfusion , vol.55 , Issue.6 , pp. 1545-1554
    • Chapuy, C.I.1
  • 51
    • 84989937428 scopus 로고    scopus 로고
    • Improvement in renal function and its impact on survival in patients with newly diagnosed multiple myeloma
    • Gonsalves, W.I. et al. Improvement in renal function and its impact on survival in patients with newly diagnosed multiple myeloma. Blood Cancer J. 5, e296 (2015).
    • (2015) Blood Cancer J. , vol.5
    • Gonsalves, W.I.1
  • 52
    • 84958940565 scopus 로고    scopus 로고
    • Pharmacokinetics and safety of elotuzumab combined with lenalidomide and dexamethasone in patients with multiple myeloma and various levels of renal impairment: results of a phase Ib study
    • Berdeja, J. et al. Pharmacokinetics and safety of elotuzumab combined with lenalidomide and dexamethasone in patients with multiple myeloma and various levels of renal impairment: results of a phase Ib study. Clin. Lymphoma Myeloma Leuk. 16, 129–138 (2016).
    • (2016) Clin. Lymphoma Myeloma Leuk. , vol.16 , pp. 129-138
    • Berdeja, J.1
  • 53
    • 84911112328 scopus 로고    scopus 로고
    • A phase I trial of SAR650984, a CD38 monoclonal antibody, in relapsed or refractory multiple myeloma
    • &, abstract
    • Martin, T.G., Hsu, K., Strickland, S.A., Glenn, M.J., Mikhael, J. & Charpentier, E. A phase I trial of SAR650984, a CD38 monoclonal antibody, in relapsed or refractory multiple myeloma. J. Clin. Oncol. 32 (suppl.), abstract 8532 (2014).
    • (2014) J. Clin. Oncol. , vol.32 , pp. 8532
    • Martin, T.G.1    Hsu, K.2    Strickland, S.A.3    Glenn, M.J.4    Mikhael, J.5    Charpentier, E.6
  • 54
    • 84992739324 scopus 로고    scopus 로고
    • A phase Ib dose-escalation trial of SAR650984 (anti-CD-38 mAb) in combination with lenalidomide and dexamethasone in relapsed/refractory multiple myeloma
    • abstract
    • Martin, T.G. III et al. A phase Ib dose-escalation trial of SAR650984 (anti-CD-38 mAb) in combination with lenalidomide and dexamethasone in relapsed/refractory multiple myeloma. J. Clin. Oncol. 32 Suppl, abstract 8512 (2014).
    • (2014) J. Clin. Oncol. , vol.32 , pp. 8512
    • Martin, T.G.1
  • 55
    • 85006307498 scopus 로고    scopus 로고
    • MOR202 alone and in combination with pomalidomide or lenalidomide in relapsed or refractory multiple myeloma: data from clinically relevant cohorts from a phase I/IIa study
    • abstract
    • Raab, M.S. et al. MOR202 alone and in combination with pomalidomide or lenalidomide in relapsed or refractory multiple myeloma: data from clinically relevant cohorts from a phase I/IIa study. J. Clin. Oncol. 34 (suppl.), abstract 8012 (2016).
    • (2016) J. Clin. Oncol. , vol.34 , pp. 8012
    • Raab, M.S.1
  • 56
    • 0030041147 scopus 로고    scopus 로고
    • Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-kappa B
    • Chauhan, D. et al. Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-kappa B. Blood 87, 1104–1112 (1996).
    • (1996) Blood , vol.87 , pp. 1104-1112
    • Chauhan, D.1
  • 57
    • 0034353524 scopus 로고    scopus 로고
    • The interleukin-6 receptor alpha-chain (CD126) is expressed by neoplastic but not normal plasma cells
    • Rawstron, A.C. et al. The interleukin-6 receptor alpha-chain (CD126) is expressed by neoplastic but not normal plasma cells. Blood 96, 3880–3886 (2000).
    • (2000) Blood , vol.96 , pp. 3880-3886
    • Rawstron, A.C.1
  • 58
    • 84903642514 scopus 로고    scopus 로고
    • Phase 2 randomized study of bortezomib-melphalan-prednisone with or without siltuximab (anti-IL-6) in multiple myeloma
    • San-Miguel, J. et al. Phase 2 randomized study of bortezomib-melphalan-prednisone with or without siltuximab (anti-IL-6) in multiple myeloma. Blood 123, 4136–4142 (2014).
    • (2014) Blood , vol.123 , pp. 4136-4142
    • San-Miguel, J.1
  • 59
    • 85018193822 scopus 로고    scopus 로고
    • Siltuximab (CNTO 328) with lenalidomide, bortezomib and dexamethasone in newly-diagnosed, previously untreated multiple myeloma: an open-label phase I trial
    • Shah, J.J. et al. Siltuximab (CNTO 328) with lenalidomide, bortezomib and dexamethasone in newly-diagnosed, previously untreated multiple myeloma: an open-label phase I trial. Blood Cancer J. 6, e396 (2016).
    • (2016) Blood Cancer J. , vol.6
    • Shah, J.J.1
  • 60
    • 67449119398 scopus 로고    scopus 로고
    • The monoclonal antibody nBT062 conjugated to cytotoxic maytansinoids has selective cytotoxicity against CD138-positive multiple myeloma cells in vitro and in vivo
    • Ikeda, H. et al. The monoclonal antibody nBT062 conjugated to cytotoxic maytansinoids has selective cytotoxicity against CD138-positive multiple myeloma cells in vitro and in vivo. Clin. Cancer Res. 15, 4028–4037 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , pp. 4028-4037
    • Ikeda, H.1
  • 61
    • 84879588054 scopus 로고    scopus 로고
    • BT062, an antibody-drug conjugate directed against CD138, given weekly for 3 weeks in each 4 week cycle: safety and further evidence of clinical activity
    • Heffner, L.T. et al. BT062, an antibody-drug conjugate directed against CD138, given weekly for 3 weeks in each 4 week cycle: safety and further evidence of clinical activity. Blood 120, 4042 (2012).
    • (2012) Blood , vol.120 , pp. 4042
    • Heffner, L.T.1
  • 62
    • 84937795971 scopus 로고    scopus 로고
    • Indatuximab ravtansine (BT062) in combination with lenalidomide and low-dose dexamethasone in patients with relapsed and/or refractory multiple myeloma: clinical activity in patients already exposed to lenalidomide and bortezomib
    • Kelly, K.R. et al. Indatuximab ravtansine (BT062) in combination with lenalidomide and low-dose dexamethasone in patients with relapsed and/or refractory multiple myeloma: clinical activity in patients already exposed to lenalidomide and bortezomib. Blood 124, 4736 (2014).
    • (2014) Blood , vol.124 , pp. 4736
    • Kelly, K.R.1
  • 63
    • 84945586394 scopus 로고    scopus 로고
    • Lenalidomide enhances immune checkpoint blockade-induced immune response in multiple myeloma
    • Görgün, G. et al. Lenalidomide enhances immune checkpoint blockade-induced immune response in multiple myeloma. Clin. Cancer Res. 21, 4607–4618 (2015).
    • (2015) Clin. Cancer Res. , vol.21 , pp. 4607-4618
    • Görgün, G.1
  • 64
    • 84930577478 scopus 로고    scopus 로고
    • Targeting PD1-PDL1 immune checkpoint in plasmacytoid dendritic cell interactions with T cells, natural killer cells and multiple myeloma cells
    • Ray, A. et al. Targeting PD1-PDL1 immune checkpoint in plasmacytoid dendritic cell interactions with T cells, natural killer cells and multiple myeloma cells. Leukemia 29, 1441–1444 (2015).
    • (2015) Leukemia , vol.29 , pp. 1441-1444
    • Ray, A.1
  • 65
    • 85007202056 scopus 로고    scopus 로고
    • Pembrolizumab in combination with lenalidomide and low-dose dexamethasone for relapsed/refractory multiple myeloma (RRMM): final efficacy and safety analysis
    • abstract
    • Mateos, M-V. et al. Pembrolizumab in combination with lenalidomide and low-dose dexamethasone for relapsed/refractory multiple myeloma (RRMM): final efficacy and safety analysis. J. Clin. Oncol. 34 (suppl.), abstract 8010 (2016).
    • (2016) J. Clin. Oncol. , vol.34 , pp. 8010
    • Mateos, M.-V.1
  • 66
    • 84955473366 scopus 로고    scopus 로고
    • A phase II study of anti PD-1 antibody pembrolizumab, pomalidomide and dexamethasone in patients with relapsed/refractory multiple myeloma (RRMM)
    • Badros, A.Z. et al. A phase II study of anti PD-1 antibody pembrolizumab, pomalidomide and dexamethasone in patients with relapsed/refractory multiple myeloma (RRMM). Blood 126, 506 (2015).
    • (2015) Blood , vol.126 , pp. 506
    • Badros, A.Z.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.