Metal dependence and branched RNA cocrystal structures of the RNA lariat debranching enzyme Dbr1

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 51, 2016, Pages 14727-14732

  Clark, Nathaniel E ^a   Katolik, Adam ^b   Roberts, Kenneth M ^c   Taylor, Alexander B ^a   Holloway, Stephen P ^a   Schuermann, Jonathan P ^d   Montemayor, Eric J ^e   Stevens, Scott W ^f   Fitzpatrick, Paul F ^a   Damha, Masad J ^b   Hart, P John ^a,g  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b MCGILL UNIVERSITY   (Canada)

^c UNIVERSITY OF SOUTH CAROLINA AIKEN   (United States)

^d Department of Obstetrics Gynecology   (United States)

^e UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^f UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^g SOUTH TEXAS VETERANS HEALTH CARE SYSTEM   (United States)

Author keywords

Dbr1; Enzyme kinetics; Intron lariat; RNA debranching; X ray crystallography

Indexed keywords

APOENZYME; CALCIUM ION; ENZYME; ENZYME DBR1; FERROUS ION; INTRON LARIAT; MANGANESE; MESSENGER RNA; MICROBIAL ENZYME; MICRORNA; SMALL NUCLEOLAR RNA; UNCLASSIFIED DRUG; ZINC ION; IRON; LARIAT DEBRANCHING ENZYME; PEPTIDE; PROTOZOAL PROTEIN; RNA; RNA POLYMERASE; RNA PRECURSOR; RNA, CIRCULAR; ZINC;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DIFFRACTION; ENTAMOEBA HISTOLYTICA; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME STRUCTURE; HIGH THROUGHPUT SCREENING; HYDROLYSIS; INTRON; IRON ABSORPTION; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; RNA DEGRADATION; RNA SPLICING; STOICHIOMETRY; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY; CATALYSIS; CHEMISTRY; CRYSTALLIZATION; ENZYMOLOGY; KINETICS; MUTATION; PROCEDURES; X RAY;

CATALYSIS; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; ENTAMOEBA HISTOLYTICA; HYDROLYSIS; INTRONS; IRON; KINETICS; MASS SPECTROMETRY; MUTATION; PEPTIDES; PROTOZOAN PROTEINS; RNA; RNA NUCLEOTIDYLTRANSFERASES; RNA PRECURSORS; RNA SPLICING; X-RAYS; ZINC;

EID: 85006340413     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1612729114     Document Type: Article

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