Dietary low-fat soy milk powder retards diabetic nephropathy progression via inhibition of renal fibrosis and renal inflammation

Molecular Nutrition and Food Research

Volumn 61, Issue 3, 2017, Pages

  Jheng, Huei Fen ^a   Hirotsuka, Motohiko ^a   Goto, Tsuyoshi ^a   Shibata, Masayuki ^a,b   Matsumura, Yasuki ^a   Kawada, Teruo ^a  

^a KYOTO UNIVERSITY   (Japan)

^b FUJI OIL HOLDINGS INC   (Japan)

Author keywords

Diabetic nephropathy; Epithelial mesenchymal transition; Macrophage infiltration; Renal fibrosis; Soybean

Indexed keywords

ADMINISTRATION AND DOSAGE; ALBUMINURIA; ANIMAL; COMPLICATION; DIABETIC NEPHROPATHY; DIET THERAPY; DRUG EFFECTS; EXPERIMENTAL DIABETES MELLITUS; FAT INTAKE; FIBROSIS; KIDNEY; MOUSE; NEPHRITIS; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOLOGY; PATHOPHYSIOLOGY; PHARMACOLOGY; POWDER; SOYBEAN MILK;

ALBUMINURIA; ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; DIABETIC NEPHROPATHIES; DIETARY FATS; FIBROSIS; KIDNEY; MICE; NEPHRITIS; POWDERS; SOY MILK;

EID: 85006323921     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201600461     Document Type: Article

References (45)

1. Brosius, F. C., Alpers, C. E., Bottinger, E. P., Breyer, M. D. et al., Mouse models of diabetic nephropathy. J. Am. Soc. Nephrol. 2009, 20, 2503–2512.
2. Mason, R. M., Wahab, N. A., Extracellular matrix metabolism in diabetic nephropathy. J. Am. Soc. Nephrol. 2003, 14, 1358–1373.
3. Simonson, M. S., Phenotypic transitions and fibrosis in diabetic nephropathy. Kidney Int. 2007, 71, 846–854.
4. Wada, T., Furuichi, K., Sakai, N., Iwata, Y. et al., Upregulation of monocyte chemoattractant protein-1 in tubulointerstitial lesions of human diabetic nephropathy. Kidney Int. 2000, 58, 1492–1499.
5. Nguyen, D., Ping, F., Mu, W., Hill, P. et al., Macrophage accumulation in human progressive diabetic nephropathy. Nephrology 2006, 11, 226–231.
6. Chow, F., Ozols, E., Nikolic-Paterson, D. J., Atkins, R. C., Tesch, G. H., Macrophages in mouse type 2 diabetic nephropathy: correlation with diabetic state and progressive renal injury. Kidney Int. 2004, 65, 116–128.
7. Jheng, H. F., Tsai, P. J., Chuang, Y. L., Shen, Y. T. et al., Albumin stimulates renal tubular inflammation through an HSP70-TLR4 axis in mice with early diabetic nephropathy. Dis. Model. Mech. 2015, 8, 1311–1321.
8. Wang, Z., Wei, M., Wang, M., Chen, L. et al., Inhibition of macrophage migration inhibitory factor reduces diabetic nephropathy in type II diabetes mice. Inflammation 2014, 37, 2020–2029.
9. Saito, T., Yoshida, K., Matsumoto, K., Saeki, K. et al., Inflammatory cytokines induce a reduction in E-cadherin expression and morphological changes in MDCK cells. Res. Vet. Sci. 2014, 96, 288–291.
10. Zhang, Y., Ma, K. L., Liu, J., Wu, Y. et al., Inflammatory stress exacerbates lipid accumulation and podocyte injuries in diabetic nephropathy. Acta Diabetol. 2015, 52, 1045–1056.
11. Pan, B., Liu, G., Jiang, Z., Zheng, D., Regulation of renal fibrosis by macrophage polarization. Cell. Physiol. Biochem. 2015, 35, 1062–1069.
12. Stephenson, T. J., Setchell, K. D., Kendall, C. W., Jenkins, D. J. et al., Effect of soy protein-rich diet on renal function in young adults with insulin-dependent diabetes mellitus. Clin. Nephrol. 2005, 64, 1–11.
13. Teixeira, S. R., Tappenden, K. A., Carson, L., Jones, R. et al., Isolated soy protein consumption reduces urinary albumin excretion and improves the serum lipid profile in men with type 2 diabetes mellitus and nephropathy. J. Nutr. 2004, 134, 1874–1880.
14. Kim, M. J., Lim, Y., Protective effect of short-term genistein supplementation on the early stage in diabetes-induced renal damage. Mediators Inflamm. 2013, 2013, 510212.
15. Elmarakby, A. A., Ibrahim, A. S., Faulkner, J., Mozaffari, M. S. et al., Tyrosine kinase inhibitor, genistein, reduces renal inflammation and injury in streptozotocin-induced diabetic mice. Vascul. Pharmacol. 2011, 55, 149–156.
16. Yang, H. Y., Wu, L. Y., Yeh, W. J., Chen, J. R., Beneficial effects of β-conglycinin on renal function and nephrin expression in early streptozotocin-induced diabetic nephropathy rats. Br. J. Nutr. 2014, 111, 78–85.
17. Molitch, M. E., DeFronzo, R. A., Franz, M. J., Keane, W. F. et al., Nephropathy in diabetes. Diabetes Care 2004, 27 (Suppl 1), S79–S83.
18. Ruggenenti, P., Remuzzi, G., Nephropathy of type 1 and type 2 diabetes: diverse pathophysiology, same treatment? Nephrol. Dial. Transplant. 2000, 15, 1900–1902.
19. Miner, J. H., Focusing on the glomerular slit diaphragm: podocin enters the picture. Am. J. Pathol. 2002, 160, 3–5.
20. Gekle, M., Renal tubule albumin transport. Annu. Rev. Physiol. 2005, 67, 573–594.
21. Tojo, A., Kinugasa, S., Mechanisms of glomerular albumin filtration and tubular reabsorption. Int. J. Nephrol. 2012, 2012, 481520.
22. Christensen, E. I., Birn, H., Megalin and cubilin: synergistic endocytic receptors in renal proximal tubule. Am. J. Physiol. Renal Physiol. 2001, 280, F562–F573.
23. Tojo, A., Onozato, M. L., Ha, H., Kurihara, H. et al., Reduced albumin reabsorption in the proximal tubule of early-stage diabetic rats. Histochem. Cell Biol. 2001, 116, 269–276.
24. Batsford, S., Duermueller, U., Seemayer, C., Mueller, C. et al., Protein level expression of Toll-like receptors 2, 4 and 9 in renal disease. Nephrol. Dial. Transplant. 2011, 26, 1413–1416.
25. Devaraj, S., Tobias, P., Kasinath, B. S., Ramsamooj, R. et al., Knockout of toll-like receptor-2 attenuates both the proinflammatory state of diabetes and incipient diabetic nephropathy. Arterioscler. Thromb. Vasc. Biol. 2011, 31, 1796–1804.
26. Kiyici, S., Erturk, E., Budak, F., Ersoy, C. et al., Serum monocyte chemoattractant protein-1 and monocyte adhesion molecules in type 1 diabetic patients with nephropathy. Arch. Med. Res. 2006, 37, 998–1003.
27. Morii, T., Fujita, H., Narita, T., Shimotomai, T. et al., Association of monocyte chemoattractant protein-1 with renal tubular damage in diabetic nephropathy. J. Diabetes Complications 2003, 17, 11–15.
28. Mauer, S. M., Steffes, M. W., Ellis, E. N., Sutherland, D. E. et al., Structural-functional relationships in diabetic nephropathy. J. Clin. Invest. 1984, 74, 1143–1155.
29. Fioretto, P., Mauer, M., Histopathology of diabetic nephropathy. Semin. Nephrol. 2007, 27, 195–207.
30. Wynn, T. A., Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases. J. Clin. Invest. 2007, 117, 524–529.
31. Duffield, J. S., Macrophages and immunologic inflammation of the kidney. Semin. Nephrol. 2010, 30, 234–254.
32. Chow, F. Y., Nikolic-Paterson, D. J., Ma, F. Y., Ozols, E. et al., Monocyte chemoattractant protein-1-induced tissue inflammation is critical for the development of renal injury but not type 2 diabetes in obese db/db mice. Diabetologia 2007, 50, 471–480.
33. LeBleu, V. S., Taduri, G., O'Connell, J., Teng, Y. et al., Origin and function of myofibroblasts in kidney fibrosis. Nat. Med. 2013, 19, 1047–1053.
34. Strutz, F., Zeisberg, M., Renal fibroblasts and myofibroblasts in chronic kidney disease. J. Am. Soc. Nephrol. 2006, 17, 2992–2998.
35. Kalluri, R., Neilson, E. G., Epithelial-mesenchymal transition and its implications for fibrosis. J. Clin. Invest. 2003, 112, 1776–1784.
36. Marsenic, O., Glucose control by the kidney: an emerging target in diabetes. Am. J. Kidney Dis. 2009, 53, 875–883.
37. Triplitt, C. L., Understanding the kidneys' role in blood glucose regulation. Am. J. Manag. Care 2012, 18, S11–16.
38. Dan, K., Fujita, H., Seto, Y., Kato, R., Relation between stable glycated hemoglobin A1C and plasma glucose levels in diabetes-model mice. Exp. Anim. 1997, 46, 135–140.
39. King, A. J., The use of animal models in diabetes research. Br. J. Pharmacol. 2012, 166, 877–894.
40. Tachibana, N., Yamashita, Y., Nagata, M., Wanezaki, S. et al., Soy β-conglycinin improves glucose uptake in skeletal muscle and ameliorates hepatic insulin resistance in Goto-Kakizaki rats. Nutr. Res. 2014, 34, 160–167.
41. Yuan, W. J., Jia, F. Y., Meng, J. Z., Effects of genistein on secretion of extracellular matrix components and transforming growth factor beta in high-glucose-cultured rat mesangial cells. J. Artif. Organs 2009, 12, 242–246.
42. Li, W., Huang, D., Gao, A., Yang, X., Stachyose increases absorption and hepatoprotective effect of tea polyphenols in high fructose-fed mice. Mol. Nutr. Food Res. 2016, 60, 502–510.
43. Uehara, M., Ohta, A., Sakai, K., Suzuki, K. et al., Dietary fructooligosaccharides modify intestinal bioavailability of a single dose of genistein and daidzein and affect their urinary excretion and kinetics in blood of rats. J. Nutr. 2001, 131, 787–795.
44. Jia, S., Zhang, S., Yuan, H., Chen, N., Lunasin inhibits cell proliferation via apoptosis and reduces the production of proinflammatory cytokines in cultured rheumatoid arthritis synovial fibroblasts. Biomed. Res. Int. 2015, 2015, 346839.
45. Kang, J. H., Han, I. H., Sung, M. K., Yoo, H. et al., Soybean saponin inhibits tumor cell metastasis by modulating expressions of MMP-2, MMP-9 and TIMP- 2. Cancer Lett. 2008, 261, 84–92.