Effects of genistein on secretion of extracellular matrix components and transforming growth factor beta in high-glucose-cultured rat mesangial cells

Journal of Artificial Organs

Volumn 12, Issue 4, 2009, Pages 242-246

  Yuan, Wei Jie ^a   Jia, Feng Yu ^b   Meng, Jian Zhong ^b  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b GENERAL HOSPITAL OF NORTHERN THEATER COMMAND   (China)

Author keywords

Extracellular matrix components; Genistein; High glucose; TGF ; Uremia patients with diabetes

Indexed keywords

COLLAGEN TYPE 4; FIBRONECTIN; GENISTEIN; MESSENGER RNA; TRANSFORMING GROWTH FACTOR BETA; GLUCOSE; PROTEIN KINASE INHIBITOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; EXTRACELLULAR MATRIX; GENE EXPRESSION; GENE OVEREXPRESSION; MESANGIUM CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; PROTEIN SYNTHESIS INHIBITION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPRAGUE DAWLEY RAT; ANIMAL; BIOSYNTHESIS; CELL PROLIFERATION; DIABETIC NEPHROPATHY; DRUG EFFECT; FLOW CYTOMETRY; METABOLISM; SECRETION; TOXICITY TESTING;

ANIMALS; CELL PROLIFERATION; CELLS, CULTURED; COLLAGEN TYPE IV; DIABETIC NEPHROPATHIES; EXTRACELLULAR MATRIX; FIBRONECTINS; FLOW CYTOMETRY; GENISTEIN; GLUCOSE; MESANGIAL CELLS; PROTEIN KINASE INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TOXICITY TESTS; TRANSFORMING GROWTH FACTOR BETA;

EID: 77949896132     PISSN: 14347229     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10047-009-0479-y     Document Type: Article

References (20)

1. Cortes P, Zhao X, Riser BL. Role of glomerular mechanical strain in the pathogenesis of diabetic nephropathy. Kidney Int 1997;51(1): 57-68
2. Cosio FG. Effects of high glucose concentrations on human mesangial cell proliferation. J Am Soc Nephrol 1995;5(8):1600-1609
3. Weber C, Negrescu E, Erl W, Pietsch A, Frankenberger M, Ziegler-Heitbrock HW, Siess W, Weber PC. Inhibitors of protein tyrosine kinase suppress TNF-stimulated induction of endothelial cell adhesion molecules. J Immunol 1995;155:445-451
4. Motojima M, Kakuchi J, Yoshioka T. Association of TGF-β signaling in angiotensin -induced PAI-1 mRNA upregulation in mesangial cells: role of PKC. Biochim Biophys Acta 1999; 1449(3):217-226
5. Neugarten J, Acharya A, Lei J. Selective estrogen receptor modulators suppress mesangial cell collagen synthesis. Am J Physiol Renal Physiol 2000;279(2):F309-318
6. Sharma K, Deelman L, Madesh M, Kurz B, Ciccone E, Siva S, Hu T, Zhu Y, Wang L, Henning R, Ma X, Hajnoczky G. Involvement of transforming growth factor-β in regulation of calcium transients in diabetic vascular smooth muscle cells. Am J Physiol Renal Physiol 2003;285:F1258-F1270
7. Sharma K, Ziyadeh FN. Hyperglycemia and diabetic kidney disease: the case for transforming growth factor-β as a key mediator. Diabetes 1995;44:1139-1146
8. Ziyadeh FN, Hoffman BB, Han DC, Iglesias-de la Cruz MC, Hong SW, Isono M, Chen S, McGowan TA, Sharma K. Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-β antibody in db/db diabetic mice. Proc Natl Acad Sci USA 2000;97:8015-8020
9. Ziyadeh FN, Sharma K, Ericksen M, Wolf G. Stimulation of collagen gene expression and protein synthesis in murine mesangial cells by high glucose is mediated by activation of transforming growth factor-β. J Clin Invest 1994;93:536-542
10. Hoffman BB, Sharma K, Zhu Y, Ziyadeh FN. Transcriptional activation of transforming growth factor-β1 in mesangial cell culture by high glucose concentration. Kidney Int 1998;54: 1107-1116
11. Ziyadeh FN, Hoffman BB, Han DC, Iglesias-de la Cruz MC, Hong SW, Isono M, Chen S, McGowan TA, Sharma K. Longterm prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-β antibody in db/db diabetic mice. Proc Natl Acad Sci USA 2000;97:8015-8020
12. Wolf G, Ziyadeh FN. Molecular mechanisms of diabetic renal hypertrophy. Kidney Int 1999;56:393-405 (Pubitemid 29353136)
13. Jibani MM, Bloodworth LL, Foden E, Griffiths KD, Galpin OP. Predominantly vegetarian diet in patients with incipient and early clinical diabetic nephropathy: early effects on albumin excretion rate and nutritional status. Diabetes Med 1991;8:949-953
14. Yu Z, Tang Y, Hu D, Li J. Inhibitory effect of genistein on mouse colon cancer MC-26 cells involved TGF-β1/Smad pathway. Biochem Biophys Res Commun 2005;333(3):827-832
15. Chen AC, Donovan SM. Genistein at a concentration present in soy infant formula inhibits Caco-2BBe cell proliferation by causing G2/M cell cycle arrest. J Nutr 2004;134:1303-1308
16. Jayagopal V, Albertazzi P, Kilpatrick ES, Howarth EM, Jennings PE, Hepburn DA, Atkin SL. Benefi cial effects of soy phytoestrogen intake in postmenopausal women with type 2 diabetes. Diabetes Care 2002;25:1709-1714
17. Mezei O, Banz WJ, Steger RW, Peluso MR, Winters TA, Shay N. Soy isofl avones exert antidiabetic and hypolipidemic effects through the PPAR pathways in obese Zucker rats and murine RAW 264.7 cells. J Nutr 2003;133(5):1238-1243
18. Chang PC, Chen TH, Chang CJ, Hou CC, Chan P, Lee HM. Advanced glycosylation end products induce inducible nitric oxide synthase (iNOS) expression via a p38 MAPK-dependent pathway. Kidney Int 2004;65(5):1664-1675
19. Neugarten J, Medve I, Lei J, Silbiger SR. Estradiol suppresses mesangial cell type I collagen synthesis via activation of the MAP kinase cascade. Am J Physiol Renal Physiol 1999;277: 875-881
20. Kuiper GGJM, Lemmen JG, Carlsson B, Corton JC, Safe SH, Saag VT, Burg BV, Gustafsson J. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor β. Endocrinology 1998;139:4252-4263