The proteomic profile of whole and glandular saliva in healthy pain-free subjects

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Jasim, Hajer ^a,b   Olausson, Patrik ^c   Hedenberg Magnusson, Britt ^a,b   Ernberg, Malin ^a   Ghafouri, Bijar ^c  

^a Scandinavian Center for Orofacial Neurosciences (SCON)   (Sweden)

^b Folktandvården Stockholm AB ^*  (Sweden)

^c LINKÖPING UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

SALIVA PROTEIN;

ADULT; COMPARATIVE STUDY; FEMALE; HUMAN; MALE; METABOLISM; NORMAL HUMAN; PROCEDURES; PROTEOMICS; SALIVA; SALIVARY GLAND; SPECIMEN HANDLING; TWO DIMENSIONAL GEL ELECTROPHORESIS; YOUNG ADULT;

ADULT; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; FEMALE; HEALTHY VOLUNTEERS; HUMANS; MALE; PROTEOMICS; SALIVA; SALIVARY GLANDS; SALIVARY PROTEINS AND PEPTIDES; SPECIMEN HANDLING; YOUNG ADULT;

EID: 85006265319     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep39073     Document Type: Article

References (46)

1. Hu, S., Loo, J. A., Wong, D. T. Human saliva proteome analysis. Annals of the New York Academy of Sciences 1098, 323-329, doi: 10.1196/annals.1384.015 (2007).
2. Dodds, M., Roland, S., Edgar, M., Thornhill, M. Saliva A review of its role in maintaining oral health and preventing dental disease. Bdj Team 2, 15123, doi: 10.1038/bdjteam.2015.123 (2015).
3. Fabian, T. K., Hermann, P., Beck, A., Fejerdy, P., Fabian, G. Salivary defense proteins: their network and role in innate and acquired oral immunity. International journal of molecular sciences 13, 4295-4320, doi: 10.3390/ijms13044295 (2012).
4. Fischer, H. P., Eich, W., Russell, I. J. A possible role for saliva as a diagnostic fluid in patients with chronic pain. Seminars in arthritis and rheumatism 27, 348-359 (1998).
5. Levine, J. D., Goetzl, E. J., Basbaum, A. I. Contribution of the nervous system to the pathophysiology of rheumatoid arthritis and other polyarthritides. Rheumatic diseases clinics of North America 13, 369-383 (1987).
6. Ernberg, M., Hedenberg-Magnusson, B., Alstergren, P., Kopp, S. The level of serotonin in the superficial masseter muscle in relation to local pain and allodynia. Life sciences 65, 313-325 (1999).
7. Castrillon, E. E., et al. Interstitial glutamate concentration is elevated in the masseter muscle of myofascial temporomandibular disorder patients. Journal of orofacial pain 24, 350-360 (2010).
8. Olausson, P., et al. Protein alterations in women with chronic widespread pain-An explorative proteomic study of the trapezius muscle. Scientific reports 5, 11894, doi: 10.1038/srep11894 (2015).
9. Gerdle, B., Ghafouri, B., Ernberg, M., Larsson, B. Chronic musculoskeletal pain: review of mechanisms and biochemical biomarkers as assessed by the microdialysis technique. Journal of pain research 7, 313-326, doi: 10.2147/jpr.s59144 (2014).
10. Hu, S., Loo, J. A., Wong, D. T. Human saliva proteome analysis and disease biomarker discovery. Expert review of proteomics 4, 531-538, doi: 10.1586/14789450.4.4.531 (2007).
11. Lee, Y. H., Wong, D. T. Saliva: an emerging biofluid for early detection of diseases. American journal of dentistry 22, 241-248 (2009).
12. Pfaffe, T., Cooper-White, J., Beyerlein, P., Kostner, K., Punyadeera, C. Diagnostic potential of saliva: current state and future applications. Clinical chemistry 57, 675-687, doi: 10.1373/clinchem.2010.153767 (2011).
13. Liu, J., Duan, Y. Saliva: a potential media for disease diagnostics and monitoring. Oral oncology 48, 569-577, doi: 10.1016/j. oraloncology.2012.01.021 (2012).
14. Messana, I., Inzitari, R., Fanali, C., Cabras, T., Castagnola, M. Facts and artifacts in proteomics of body fluids. What proteomics of saliva is telling us? Journal of separation science 31, 1948-1963, doi: 10.1002/jssc.200800100 (2008).
15. Al Kawas, S., Rahim, Z. H., Ferguson, D. B. Potential uses of human salivary protein and peptide analysis in the diagnosis of disease. Archives of oral biology 57, 1-9, doi: 10.1016/j.archoralbio.2011.06.013 (2012).
16. Wu, S., et al. Quantitative analysis of human salivary gland-derived intact proteome using top-down mass spectrometry. Proteomics 14, 1211-1222, doi: 10.1002/pmic.201300378 (2014).
17. Walz, A., et al. Proteome analysis of glandular parotid and submandibular-sublingual saliva in comparison to whole human saliva by two-dimensional gel electrophoresis. Proteomics 6, 1631-1639, doi: 10.1002/pmic.200500125 (2006).
18. de Almeida Pdel, V., Gregio, A. M., Machado, M. A., de Lima, A. A., Azevedo, L. R. Saliva composition and functions: a comprehensive review. The journal of contemporary dental practice 9, 72-80 (2008).
19. Castagnola, M., et al. The human salivary proteome: a critical overview of the results obtained by different proteomic platforms. Expert review of proteomics 9, 33-46, doi: 10.1586/epr.11.77 (2012).
20. Schiffman, E., et al. Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) for Clinical and Research Applications: recommendations of the International RDC/TMD Consortium Network and Orofacial Pain Special Interest Groupdagger. Journal of oral, facial pain and headache 28, 6-27, doi: 10.11607/jop.1151 (2014).
21. Kroenke, K., Spitzer, R. L., Williams, J. B. The PHQ-9: validity of a brief depression severity measure. Journal of general internal medicine 16, 606-613 (2001).
22. Kroenke, K., Spitzer, R. L., Williams, J. B. The PHQ-15: validity of a new measure for evaluating the severity of somatic symptoms. Psychosomatic medicine 64, 258-266 (2002).
23. Lowe, B., et al. Validation and standardization of the Generalized Anxiety Disorder Screener (GAD-7) in the general population. Medical care 46, 266-274, doi: 10.1097/MLR.0b013e318160d093 (2008).
24. Nordin, M., Nordin, S. Psychometric evaluation and normative data of the Swedish version of the 10-item perceived stress scale. Scandinavian journal of psychology 54, 502-507, doi: 10.1111/sjop.12071 (2013).
25. Ohrbach, R., Larsson, P., List, T. The jaw functional limitation scale: development, reliability, and validity of 8-item and 20-item versions. Journal of orofacial pain 22, 219-230 (2008).
26. Shannon, I. L., Prigmore, J. R., Chauncey, H. H. Modified Carlson-Crittenden device for the collection of parotid fluid. Journal of dental research 41, 778-783 (1962).
27. Lashley, K. S. Reflex secretion of the human parotid gland. Journal of Experimental Psychology 1, 461-493, doi: doi.org/10.1037/h0073282 (1916).
28. Gorg, A., et al. The current state of two-dimensional electrophoresis with immobilized pH gradients. Electrophoresis 21, 1037-1053, doi: 10.1002/(sici)1522-2683(20000401)21:6 3.0.co;2-v (2000).
29. Ghafouri, B., Tagesson, C., Lindahl, M. Mapping of proteins in human saliva using two-dimensional gel electrophoresis and peptide mass fingerprinting. Proteomics 3, 1003-1015, doi: 10.1002/pmic.200300426 (2003).
30. Shevchenko, A., Wilm, M., Vorm, O., Mann, M. Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. Analytical chemistry 68, 850-858 (1996).
31. Swain, M., Ross, N. W. A silver stain protocol for proteins yielding high resolution and transparent background in sodium dodecyl sulfate-polyacrylamide gels. Electrophoresis 16, 948-951 (1995).
32. Eriksson, L., et al. Multi-and megavariate data analysis. Part I-II, Basic principles and applications 2nd edn (Umetrics AB, 2006).
33. Wheelock, A. M., Wheelock, C. E. Trials and tribulations of 'omics data analysis: assessing quality of SIMCA-based multivariate models using examples from pulmonary medicine. Molecular bioSystems 9, 2589-2596, doi: 10.1039/c3mb70194h (2013).
34. Rabilloud, T., Lelong, C. Two-dimensional gel electrophoresis in proteomics: a tutorial. Journal of proteomics 74, 1829-1841, doi: 10.1016/j.jprot.2011.05.040 (2011).
35. Fleissig, Y., et al. Comparative proteomic analysis of human oral fluids according to gender and age. Oral diseases 16, 831-838, doi: 10.1111/j.1601-0825.2010.01696.x (2010).
36. Golatowski, C., et al. Comparative evaluation of saliva collection methods for proteome analysis. Clinica chimica acta; international journal of clinical chemistry 419, 42-46, doi: 10.1016/j.cca.2013.01.013 (2013).
37. Topkas, E., Keith, P., Dimeski, G., Cooper-White, J., Punyadeera, C. Evaluation of saliva collection devices for the analysis of proteins. Clinica chimica acta; international journal of clinical chemistry 413, 1066-1070, doi: 10.1016/j.cca.2012.02.020 (2012).
38. Baum, B. J. Evaluation of stimulated parotid saliva flow rate in different age groups. Journal of dental research 60, 1292-1296 (1981).
39. Helmerhorst, E. J., Oppenheim, F. G. Saliva: a dynamic proteome. Journal of dental research 86, 680-693 (2007).
40. Denny, P., et al. The proteomes of human parotid and submandibular/sublingual gland salivas collected as the ductal secretions. Journal of proteome research 7, 1994-2006, doi: 10.1021/pr700764j (2008).
41. Frejerskov, O., Nyvad, B., Kidd, E. Dental caries: the disease and its clinical management 3rd edn (John Wiley Sons, 2015).
42. Zalewska, A., Zwierz, K., Zolkowski, K., Gindzienski, A. Structure and biosynthesis of human salivary mucins. Acta biochimica Polonica 47, 1067-1079 (2000).
43. Pedersen, A. M., Bardow, A., Jensen, S. B., Nauntofte, B. Saliva and gastrointestinal functions of taste, mastication, swallowing and digestion. Oral diseases 8, 117-129 (2002).
44. Murphy, L. C., Tsuyuki, D., Myal, Y., Shiu, R. P. Isolation and sequencing of a cDNA clone for a prolactin-inducible protein (PIP). Regulation of PIP gene expression in the human breast cancer cell line, T-47D. The Journal of biological chemistry 262, 15236-15241 (1987).
45. Mirels, L., Hand, A. R., Branin, H. J. Expression of gross cystic disease fluid protein-15/Prolactin-inducible protein in rat salivary glands. The journal of histochemistry and cytochemistry: official journal of the Histochemistry Society 46, 1061-1071 (1998).
46. Hu, S., et al. Differentially expressed protein markers in human submandibular and sublingual secretions. International journal of oncology 25, 1423-1430 (2004).