-
3
-
-
77952994052
-
Metastatic colorectal cancer: from improved survival to potential cure
-
Gallagher DJ, Kemeny N. Metastatic colorectal cancer: from improved survival to potential cure. Oncology 2010;78:237-48.
-
(2010)
Oncology
, vol.78
, pp. 237-248
-
-
Gallagher, D.J.1
Kemeny, N.2
-
4
-
-
77954801079
-
Improved survival with ipilimumab in patients with metastatic melanoma
-
Hodi FS, O'Day SJ, McDermott DF, et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 2010;363:711-23.
-
(2010)
N Engl J Med
, vol.363
, pp. 711-723
-
-
Hodi, F.S.1
O'Day, S.J.2
McDermott, D.F.3
-
5
-
-
84995740118
-
Impact of the immune system and immunotherapy in colorectal cancer
-
Markman JL, Shiao SL. Impact of the immune system and immunotherapy in colorectal cancer. J Gastrointest Oncol 2015;6:208-23.
-
(2015)
J Gastrointest Oncol
, vol.6
, pp. 208-223
-
-
Markman, J.L.1
Shiao, S.L.2
-
8
-
-
78650574270
-
Therapeutic cancer vaccines: are we there yet?
-
Klebanoff CA, Acquavella N, Yu Z, et al. Therapeutic cancer vaccines: are we there yet? Immunol Rev 2011;239:27-44.
-
(2011)
Immunol Rev
, vol.239
, pp. 27-44
-
-
Klebanoff, C.A.1
Acquavella, N.2
Yu, Z.3
-
9
-
-
0033985949
-
Adjuvant active specific immunotherapy for stage II and III colon cancer with an autologous tumor cell vaccine: Eastern Cooperative Oncology Group Study E5283
-
Harris JE, Ryan L, Hoover HC, et al. Adjuvant active specific immunotherapy for stage II and III colon cancer with an autologous tumor cell vaccine: Eastern Cooperative Oncology Group Study E5283. J Clin Oncol 2000;18:148-57.
-
(2000)
J Clin Oncol
, vol.18
, pp. 148-157
-
-
Harris, J.E.1
Ryan, L.2
Hoover, H.C.3
-
10
-
-
0141576738
-
Vaccination with irradiated, autologous melanoma cells engineered to secrete granulocyte-macrophage colony-stimulating factor by adenoviral-mediated gene transfer augments antitumor immunity in patients with metastatic melanoma
-
Soiffer R, Hodi FS, Haluska F, et al. Vaccination with irradiated, autologous melanoma cells engineered to secrete granulocyte-macrophage colony-stimulating factor by adenoviral-mediated gene transfer augments antitumor immunity in patients with metastatic melanoma. J Clin Oncol 2003;21:3343-50.
-
(2003)
J Clin Oncol
, vol.21
, pp. 3343-3350
-
-
Soiffer, R.1
Hodi, F.S.2
Haluska, F.3
-
11
-
-
0037441842
-
Vaccination with irradiated autologous tumor cells engineered to secrete granulocyte-macrophage colony-stimulating factor augments antitumor immunity in some patients with metastatic non-small-cell lung carcinoma
-
Salgia R, Lynch T, Skarin A, et al. Vaccination with irradiated autologous tumor cells engineered to secrete granulocyte-macrophage colony-stimulating factor augments antitumor immunity in some patients with metastatic non-small-cell lung carcinoma. J Clin Oncol 2003;21:624-30.
-
(2003)
J Clin Oncol
, vol.21
, pp. 624-630
-
-
Salgia, R.1
Lynch, T.2
Skarin, A.3
-
12
-
-
84918783663
-
A safety and feasibility study of an allogeneic colon cancer cell vaccine administered with a granulocyte-macrophage colony stimulating factor-producing bystander cell line in patients with metastatic colorectal cancer
-
Zheng L, Edil BH, Soares KC, et al. A safety and feasibility study of an allogeneic colon cancer cell vaccine administered with a granulocyte-macrophage colony stimulating factor-producing bystander cell line in patients with metastatic colorectal cancer. Ann Surg Oncol 2014;21:3931-7.
-
(2014)
Ann Surg Oncol
, vol.21
, pp. 3931-3937
-
-
Zheng, L.1
Edil, B.H.2
Soares, K.C.3
-
13
-
-
0025763446
-
In vitro and clinical characterisation of a Newcastle disease virusmodified autologous tumour cell vaccine for treatment of colorectal cancer patients
-
Liebrich W, Schlag P, Manasterski M, et al. In vitro and clinical characterisation of a Newcastle disease virusmodified autologous tumour cell vaccine for treatment of colorectal cancer patients. Eur J Cancer 1991;27:703-10.
-
(1991)
Eur J Cancer
, vol.27
, pp. 703-710
-
-
Liebrich, W.1
Schlag, P.2
Manasterski, M.3
-
14
-
-
0026744022
-
Active specific immunotherapy with Newcastle-disease-virus-modified autologous tumor cells following resection of liver metastases in colorectal cancer. First evaluation of clinical response of a phase II-trial
-
Schlag P, Manasterski M, Gerneth T, et al. Active specific immunotherapy with Newcastle-disease-virus-modified autologous tumor cells following resection of liver metastases in colorectal cancer. First evaluation of clinical response of a phase II-trial. Cancer Immunol Immunother 1992;35:325-30.
-
(1992)
Cancer Immunol Immunother
, vol.35
, pp. 325-330
-
-
Schlag, P.1
Manasterski, M.2
Gerneth, T.3
-
15
-
-
54849420913
-
Efficiency of adjuvant active specific immunization with Newcastle disease virus modified tumor cells in colorectal cancer patients following resection of liver metastases: results of a prospective randomized trial
-
Schulze T, Kemmner W, Weitz J, et al. Efficiency of adjuvant active specific immunization with Newcastle disease virus modified tumor cells in colorectal cancer patients following resection of liver metastases: results of a prospective randomized trial. Cancer Immunol Immunother 2009;58:61-9.
-
(2009)
Cancer Immunol Immunother
, vol.58
, pp. 61-69
-
-
Schulze, T.1
Kemmner, W.2
Weitz, J.3
-
16
-
-
84986888531
-
Peptide Vaccine Therapy in Colorectal Cancer
-
Bartnik A, Nirmal AJ, Yang SY. Peptide Vaccine Therapy in Colorectal Cancer. Vaccines 2012;1:1-16.
-
(2012)
Vaccines
, vol.1
, pp. 1-16
-
-
Bartnik, A.1
Nirmal, A.J.2
Yang, S.Y.3
-
17
-
-
77950508445
-
EphA2-derived peptide vaccine with amphiphilic poly(gammaglutamic acid) nanoparticles elicits an anti-tumor effect against mouse liver tumor
-
Yamaguchi S, Tatsumi T, Takehara T, et al. EphA2-derived peptide vaccine with amphiphilic poly(gammaglutamic acid) nanoparticles elicits an anti-tumor effect against mouse liver tumor. Cancer Immunol Immunother 2010;59:759-67.
-
(2010)
Cancer Immunol Immunother
, vol.59
, pp. 759-767
-
-
Yamaguchi, S.1
Tatsumi, T.2
Takehara, T.3
-
18
-
-
0035992254
-
Active specific immunotherapy with a beta-human chorionic gonadotropin peptide vaccine in patients with metastatic colorectal cancer: antibody response is associated with improved survival
-
Moulton HM, Yoshihara PH, Mason DH, et al. Active specific immunotherapy with a beta-human chorionic gonadotropin peptide vaccine in patients with metastatic colorectal cancer: antibody response is associated with improved survival. Clin Cancer Res 2002;8:2044-51.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 2044-2051
-
-
Moulton, H.M.1
Yoshihara, P.H.2
Mason, D.H.3
-
19
-
-
84894483952
-
Phase I trial of a recombinant yeast-CEA vaccine (GI-6207) in adults with metastatic CEA-expressing carcinoma
-
Bilusic M, Heery CR, Arlen PM, et al. Phase I trial of a recombinant yeast-CEA vaccine (GI-6207) in adults with metastatic CEA-expressing carcinoma. Cancer Immunol Immunother 2014;63:225-34.
-
(2014)
Cancer Immunol Immunother
, vol.63
, pp. 225-234
-
-
Bilusic, M.1
Heery, C.R.2
Arlen, P.M.3
-
20
-
-
0035679233
-
Induction of cellular immune responses to tumor cells and peptides in colorectal cancer patients by vaccination with SART3 peptides
-
Miyagi Y, Imai N, Sasatomi T, et al. Induction of cellular immune responses to tumor cells and peptides in colorectal cancer patients by vaccination with SART3 peptides. Clin Cancer Res 2001;7:3950-62.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 3950-3962
-
-
Miyagi, Y.1
Imai, N.2
Sasatomi, T.3
-
21
-
-
61349184597
-
Induction of p53-specific immunity by a p53 synthetic long peptide vaccine in patients treated for metastatic colorectal cancer
-
Speetjens FM, Kuppen PJK, Welters MJP, et al. Induction of p53-specific immunity by a p53 synthetic long peptide vaccine in patients treated for metastatic colorectal cancer. Clin Cancer Res 2009;15:1086-95.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 1086-1095
-
-
Speetjens, F.M.1
Kuppen, P.J.K.2
Welters, M.J.P.3
-
22
-
-
84872705290
-
MUC1 vaccine for individuals with advanced adenoma of the colon: a cancer immunoprevention feasibility study
-
Kimura T, McKolanis JR, Dzubinski LA, et al. MUC1 vaccine for individuals with advanced adenoma of the colon: a cancer immunoprevention feasibility study. Cancer Prev Res (Phila) 2013;6:18-26.
-
(2013)
Cancer Prev Res (Phila)
, vol.6
, pp. 18-26
-
-
Kimura, T.1
McKolanis, J.R.2
Dzubinski, L.A.3
-
23
-
-
20044366918
-
A potent immunogenic general cancer vaccine that targets survivin, an inhibitor of apoptosis proteins
-
Idenoue S, Hirohashi Y, Torigoe T, et al. A potent immunogenic general cancer vaccine that targets survivin, an inhibitor of apoptosis proteins. Clin Cancer Res 2005;11:1474-82.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 1474-1482
-
-
Idenoue, S.1
Hirohashi, Y.2
Torigoe, T.3
-
24
-
-
78751603860
-
Phase I clinical trial of a novel peptide vaccine in combination with UFT/LV for metastatic colorectal cancer
-
Okuno K, Sugiura F, Hida JI, et al. Phase I clinical trial of a novel peptide vaccine in combination with UFT/LV for metastatic colorectal cancer. Exp Ther Med 2011;2:73-9.
-
(2011)
Exp Ther Med
, vol.2
, pp. 73-79
-
-
Okuno, K.1
Sugiura, F.2
Hida, J.I.3
-
25
-
-
84899960635
-
A phase II study of five peptides combination with oxaliplatinbased chemotherapy as a first-line therapy for advanced colorectal cancer (FXV study)
-
Hazama S, Nakamura Y, Tanaka H, et al. A phase II study of five peptides combination with oxaliplatinbased chemotherapy as a first-line therapy for advanced colorectal cancer (FXV study). J Transl Med 2014;12:108.
-
(2014)
J Transl Med
, vol.12
, pp. 108
-
-
Hazama, S.1
Nakamura, Y.2
Tanaka, H.3
-
26
-
-
85006211658
-
A phase I/II trial of the multipeptide cancer vaccine IMA910 in patients with advanced colorectal cancer (CRC)
-
Mayer F, Mayer-Mokler A, Nowara E, et al. A phase I/II trial of the multipeptide cancer vaccine IMA910 in patients with advanced colorectal cancer (CRC). J Clin Oncol 2012;30:abstr 555.
-
(2012)
J Clin Oncol
, vol.30
-
-
Mayer, F.1
Mayer-Mokler, A.2
Nowara, E.3
-
27
-
-
84880721353
-
Dendritic-cell-based therapeutic cancer vaccines
-
Palucka K, Banchereau J. Dendritic-cell-based therapeutic cancer vaccines. Immunity 2013;39:38-48.
-
(2013)
Immunity
, vol.39
, pp. 38-48
-
-
Palucka, K.1
Banchereau, J.2
-
28
-
-
0030048724
-
Peptidepulsed dendritic cells induce antigen-specific CTLmediated protective tumor immunity
-
Celluzzi CM, Mayordomo JI, Storkus WJ, et al. Peptidepulsed dendritic cells induce antigen-specific CTLmediated protective tumor immunity. J Exp Med 1996;183:283-7.
-
(1996)
J Exp Med
, vol.183
, pp. 283-287
-
-
Celluzzi, C.M.1
Mayordomo, J.I.2
Storkus, W.J.3
-
29
-
-
0031941423
-
Vaccination of melanoma patients with peptide-or tumorlysate-pulsed dendritic cells
-
Nestle FO, Alijagic S, Gilliet M, et al. Vaccination of melanoma patients with peptide-or tumorlysate-pulsed dendritic cells. Nat Med 1998;4:328-32.
-
(1998)
Nat Med
, vol.4
, pp. 328-332
-
-
Nestle, F.O.1
Alijagic, S.2
Gilliet, M.3
-
30
-
-
0034606349
-
Cross-priming of naive CD8 T cells against melanoma antigens using dendritic cells loaded with killed allogeneic melanoma cells
-
Berard F, Blanco P, Davoust J, et al. Cross-priming of naive CD8 T cells against melanoma antigens using dendritic cells loaded with killed allogeneic melanoma cells. J Exp Med 2000;192:1535-44.
-
(2000)
J Exp Med
, vol.192
, pp. 1535-1544
-
-
Berard, F.1
Blanco, P.2
Davoust, J.3
-
31
-
-
0034670002
-
Induction of antitumor immunity by vaccination of dendritic cells transfected with MUC1 RNA
-
Koido S, Kashiwaba M, Chen D, et al. Induction of antitumor immunity by vaccination of dendritic cells transfected with MUC1 RNA. J Immunol 2000;165:5713-9.
-
(2000)
J Immunol
, vol.165
, pp. 5713-5719
-
-
Koido, S.1
Kashiwaba, M.2
Chen, D.3
-
32
-
-
0030904482
-
Induction of antitumor activity by immunization with fusions of dendritic and carcinoma cells
-
Gong J, Chen D, Kashiwaba M, et al. Induction of antitumor activity by immunization with fusions of dendritic and carcinoma cells. Nat Med 1997;3:558-61.
-
(1997)
Nat Med
, vol.3
, pp. 558-561
-
-
Gong, J.1
Chen, D.2
Kashiwaba, M.3
-
33
-
-
0036170543
-
Adenovirus-mediated CD40 ligand gene-engineered dendritic cells elicit enhanced CD8(+) cytotoxic T-cell activation and antitumor immunity
-
Liu Y, Zhang X, Zhang W, et al. Adenovirus-mediated CD40 ligand gene-engineered dendritic cells elicit enhanced CD8(+) cytotoxic T-cell activation and antitumor immunity. Cancer Gene Ther 2002;9:202-8.
-
(2002)
Cancer Gene Ther
, vol.9
, pp. 202-208
-
-
Liu, Y.1
Zhang, X.2
Zhang, W.3
-
34
-
-
0033017065
-
A Phase I study of active immunotherapy with carcinoembryonic antigen peptide (CAP-1)-pulsed, autologous human cultured dendritic cells in patients with metastatic malignancies expressing carcinoembryonic antigen
-
Morse MA, Deng Y, Coleman D, et al. A Phase I study of active immunotherapy with carcinoembryonic antigen peptide (CAP-1)-pulsed, autologous human cultured dendritic cells in patients with metastatic malignancies expressing carcinoembryonic antigen. Clin Cancer Res 1999;5:1331-8.
-
(1999)
Clin Cancer Res
, vol.5
, pp. 1331-1338
-
-
Morse, M.A.1
Deng, Y.2
Coleman, D.3
-
35
-
-
0035902607
-
Altered peptide ligand vaccination with Flt3 ligand expanded dendritic cells for tumor immunotherapy
-
Fong L, Hou Y, Rivas A, et al. Altered peptide ligand vaccination with Flt3 ligand expanded dendritic cells for tumor immunotherapy. Proc Natl Acad Sci U S A 2001;98:8809-14.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 8809-8814
-
-
Fong, L.1
Hou, Y.2
Rivas, A.3
-
36
-
-
0036124550
-
Immunotherapy of solid cancer using dendritic cells pulsed with the HLAA24-restricted peptide of carcinoembryonic antigen
-
Itoh T, Ueda Y, Kawashima I, et al. Immunotherapy of solid cancer using dendritic cells pulsed with the HLAA24-restricted peptide of carcinoembryonic antigen. Cancer Immunol Immunother 2002;51:99-106.
-
(2002)
Cancer Immunol Immunother
, vol.51
, pp. 99-106
-
-
Itoh, T.1
Ueda, Y.2
Kawashima, I.3
-
37
-
-
33646863192
-
Vaccination of colorectal cancer patients with CEA-loaded dendritic cells: antigen-specific T cell responses in DTH skin tests
-
Lesterhuis WJ, de Vries IJM, Schuurhuis DH, et al. Vaccination of colorectal cancer patients with CEA-loaded dendritic cells: antigen-specific T cell responses in DTH skin tests. Ann Oncol 2006;17:974-80.
-
(2006)
Ann Oncol
, vol.17
, pp. 974-980
-
-
Lesterhuis, W.J.1
de Vries, I.J.M.2
Schuurhuis, D.H.3
-
38
-
-
85006185930
-
Phase II randomized trial of autologous tumor lysate dendritic cell vaccine (ADC) plus best supportive care (BSC) compared with BSC, in pre-treated advanced colorectal cancer patients
-
Maurel J, Caballero-Baños M, Mila J, et al. Phase II randomized trial of autologous tumor lysate dendritic cell vaccine (ADC) plus best supportive care (BSC) compared with BSC, in pre-treated advanced colorectal cancer patients. J Clin Oncol 2015;33:abstr 3048.
-
(2015)
J Clin Oncol
, vol.33
-
-
Maurel, J.1
Caballero-Baños, M.2
Mila, J.3
-
39
-
-
20044364936
-
Phase I study of sequential vaccinations with fowlpox-CEA(6D)-TRICOM alone and sequentially with vaccinia-CEA(6D)-TRICOM, with and without granulocyte-macrophage colonystimulating factor, in patients with carcinoembryonic antigenexpressing carcinomas
-
Marshall JL, Gulley JL, Arlen PM, et al. Phase I study of sequential vaccinations with fowlpox-CEA(6D)-TRICOM alone and sequentially with vaccinia-CEA(6D)-TRICOM, with and without granulocyte-macrophage colonystimulating factor, in patients with carcinoembryonic antigenexpressing carcinomas. J Clin Oncol 2005;23:720-31.
-
(2005)
J Clin Oncol
, vol.23
, pp. 720-731
-
-
Marshall, J.L.1
Gulley, J.L.2
Arlen, P.M.3
-
40
-
-
51049083164
-
Combination chemotherapy and ALVAC-CEA/B7.1 vaccine in patients with metastatic colorectal cancer
-
Kaufman HL, Lenz HJ, Marshall J, et al. Combination chemotherapy and ALVAC-CEA/B7.1 vaccine in patients with metastatic colorectal cancer. Clin Cancer Res 2008;14:4843-9.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 4843-4849
-
-
Kaufman, H.L.1
Lenz, H.J.2
Marshall, J.3
-
41
-
-
0034075941
-
T cell suppression as a mechanism for tolerance to MUC1 antigen in MUC1 transgenic mice
-
Chen D, Koido S, Li Y, et al. T cell suppression as a mechanism for tolerance to MUC1 antigen in MUC1 transgenic mice. Breast Cancer Res Treat 2000;60:107-15.
-
(2000)
Breast Cancer Res Treat
, vol.60
, pp. 107-115
-
-
Chen, D.1
Koido, S.2
Li, Y.3
-
42
-
-
33846194189
-
MUC1-specific immune therapy generates a strong anti-tumor response in a MUC1-tolerant colon cancer model
-
Mukherjee P, Pathangey LB, Bradley JB, et al. MUC1-specific immune therapy generates a strong anti-tumor response in a MUC1-tolerant colon cancer model. Vaccine 2007;25:1607-18.
-
(2007)
Vaccine
, vol.25
, pp. 1607-1618
-
-
Mukherjee, P.1
Pathangey, L.B.2
Bradley, J.B.3
-
43
-
-
46849089908
-
Guanylyl cyclase C-induced immunotherapeutic responses opposing tumor metastases without autoimmunity
-
Snook AE, Stafford BJ, Li P, et al. Guanylyl cyclase C-induced immunotherapeutic responses opposing tumor metastases without autoimmunity. J Natl Cancer Inst 2008;100:950-61.
-
(2008)
J Natl Cancer Inst
, vol.100
, pp. 950-961
-
-
Snook, A.E.1
Stafford, B.J.2
Li, P.3
-
44
-
-
84939209351
-
Involvement of IL17A, IL17F and IL23R Polymorphisms in Colorectal Cancer Therapy
-
Omrane I, Medimegh I, Baroudi O, et al. Involvement of IL17A, IL17F and IL23R Polymorphisms in Colorectal Cancer Therapy. PLoS One 2015;10:e0128911.
-
(2015)
PLoS One
, vol.10
-
-
Omrane, I.1
Medimegh, I.2
Baroudi, O.3
-
45
-
-
84976316817
-
A first-inhuman dose escalation study of PEGylated recombinant human IL-10 (AM0010) in advanced solid tumors
-
Infante JR, Naing A, Papadopoulos KP, et al. A first-inhuman dose escalation study of PEGylated recombinant human IL-10 (AM0010) in advanced solid tumors. J Clin Oncol 2015;33:abstr 3017.
-
(2015)
J Clin Oncol
, vol.33
-
-
Infante, J.R.1
Naing, A.2
Papadopoulos, K.P.3
-
46
-
-
84926089064
-
MGN1703, an immunomodulator and toll-like receptor 9 (TLR-9) agonist: from bench to bedside
-
Wittig B, Schmidt M, Scheithauer W, et al. MGN1703, an immunomodulator and toll-like receptor 9 (TLR-9) agonist: from bench to bedside. Crit Rev Oncol Hematol 2015;94:31-44.
-
(2015)
Crit Rev Oncol Hematol
, vol.94
, pp. 31-44
-
-
Wittig, B.1
Schmidt, M.2
Scheithauer, W.3
-
47
-
-
43749102276
-
Immune surveillance: a balance between protumor and antitumor immunity
-
Ostrand-Rosenberg S. Immune surveillance: a balance between protumor and antitumor immunity. Curr Opin Genet Dev 2008;18:11-8.
-
(2008)
Curr Opin Genet Dev
, vol.18
, pp. 11-18
-
-
Ostrand-Rosenberg, S.1
-
48
-
-
79959634861
-
Pattern recognition receptors and the innate immune response to viral infection
-
Thompson MR, Kaminski JJ, Kurt-Jones EA, et al. Pattern recognition receptors and the innate immune response to viral infection. Viruses 2011;3:920-40.
-
(2011)
Viruses
, vol.3
, pp. 920-940
-
-
Thompson, M.R.1
Kaminski, J.J.2
Kurt-Jones, E.A.3
-
49
-
-
84863981516
-
Study of the expression of toll-like receptors in different histological types of colorectal polyps and their relationship with colorectal cancer
-
Eiró N, González L, González LO, et al. Study of the expression of toll-like receptors in different histological types of colorectal polyps and their relationship with colorectal cancer. J Clin Immunol 2012;32:848-54.
-
(2012)
J Clin Immunol
, vol.32
, pp. 848-854
-
-
Eiró, N.1
González, L.2
González, L.O.3
-
50
-
-
79960110662
-
Randomized phase III trial of paclitaxel/carboplatin with or without PF-3512676 (Toll-like receptor 9 agonist) as first-line treatment for advanced non-small-cell lung cancer
-
Hirsh V, Paz-Ares L, Boyer M, et al. Randomized phase III trial of paclitaxel/carboplatin with or without PF-3512676 (Toll-like receptor 9 agonist) as first-line treatment for advanced non-small-cell lung cancer. J Clin Oncol 2011;29:2667-74.
-
(2011)
J Clin Oncol
, vol.29
, pp. 2667-2674
-
-
Hirsh, V.1
Paz-Ares, L.2
Boyer, M.3
-
51
-
-
84884819741
-
Phase Ib trial of the Toll-like receptor 9 agonist IMO-2055 in combination with 5-fluorouracil, cisplatin, and cetuximab as first-line palliative treatment in patients with recurrent/metastatic squamous cell carcinoma of the head and neck
-
Machiels JP, Kaminsky MC, Keller U, et al. Phase Ib trial of the Toll-like receptor 9 agonist IMO-2055 in combination with 5-fluorouracil, cisplatin, and cetuximab as first-line palliative treatment in patients with recurrent/metastatic squamous cell carcinoma of the head and neck. Invest New Drugs 2013;31:1207-16.
-
(2013)
Invest New Drugs
, vol.31
, pp. 1207-1216
-
-
Machiels, J.P.1
Kaminsky, M.C.2
Keller, U.3
-
52
-
-
84925447071
-
Phase I clinical study of the toll-like receptor 9 agonist MGN1703 in patients with metastatic solid tumours
-
Weihrauch MR, Richly H, von Bergwelt-Baildon MS, et al. Phase I clinical study of the toll-like receptor 9 agonist MGN1703 in patients with metastatic solid tumours. Eur J Cancer 2015;51:146-56.
-
(2015)
Eur J Cancer
, vol.51
, pp. 146-156
-
-
Weihrauch, M.R.1
Richly, H.2
von Bergwelt-Baildon, M.S.3
-
53
-
-
84902676837
-
Maintenance treatment with the immunomodulator MGN1703, a Tolllike receptor 9 (TLR9) agonist, in patients with metastatic colorectal carcinoma and disease control after chemotherapy: a randomised, double-blind, placebo-controlled trial
-
Schmoll HJ, Wittig B, Arnold D, et al. Maintenance treatment with the immunomodulator MGN1703, a Tolllike receptor 9 (TLR9) agonist, in patients with metastatic colorectal carcinoma and disease control after chemotherapy: a randomised, double-blind, placebo-controlled trial. J Cancer Res Clin Oncol 2014;140:1615-24.
-
(2014)
J Cancer Res Clin Oncol
, vol.140
, pp. 1615-1624
-
-
Schmoll, H.J.1
Wittig, B.2
Arnold, D.3
-
54
-
-
85006210326
-
A subgroup with improved overall survival from the phase 2 IMPACT study: Maintenance therapy of metastatic colorectal cancer patients with the TLR-9 agonist MGN1703
-
Riera-Knorrenschild J, Arnold D, Kopp HG, et al. A subgroup with improved overall survival from the phase 2 IMPACT study: Maintenance therapy of metastatic colorectal cancer patients with the TLR-9 agonist MGN1703. J Clin Oncol 2015;33:abstr 3049.
-
(2015)
J Clin Oncol
, vol.33
-
-
Riera-Knorrenschild, J.1
Arnold, D.2
Kopp, H.G.3
-
55
-
-
84858758766
-
Adoptive immunotherapy for cancer: harnessing the T cell response
-
Restifo NP, Dudley ME, Rosenberg SA. Adoptive immunotherapy for cancer: harnessing the T cell response. Nat Rev Immunol 2012;12:269-81.
-
(2012)
Nat Rev Immunol
, vol.12
, pp. 269-281
-
-
Restifo, N.P.1
Dudley, M.E.2
Rosenberg, S.A.3
-
56
-
-
79960299888
-
Durable Complete Responses in Heavily Pretreated Patients with Metastatic Melanoma Using T-Cell Transfer Immunotherapy
-
Rosenberg SA, Yang JC, Sherry RM, et al. Durable Complete Responses in Heavily Pretreated Patients with Metastatic Melanoma Using T-Cell Transfer Immunotherapy. Clin Cancer Res 2011;17:4550-7.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 4550-4557
-
-
Rosenberg, S.A.1
Yang, J.C.2
Sherry, R.M.3
-
57
-
-
79952304769
-
Tumor regression in patients with metastatic synovial cell sarcoma and melanoma using genetically engineered lymphocytes reactive with NY-ESO-1
-
Robbins PF, Morgan RA, Feldman SA, et al. Tumor regression in patients with metastatic synovial cell sarcoma and melanoma using genetically engineered lymphocytes reactive with NY-ESO-1. J Clin Oncol 2011;29:917-24.
-
(2011)
J Clin Oncol
, vol.29
, pp. 917-924
-
-
Robbins, P.F.1
Morgan, R.A.2
Feldman, S.A.3
-
58
-
-
84876325876
-
Chimeric antigen receptor-modified T cells for acute lymphoid leukemia
-
Grupp SA, Kalos M, Barrett D, et al. Chimeric antigen receptor-modified T cells for acute lymphoid leukemia. N Engl J Med 2013;368:1509-18.
-
(2013)
N Engl J Med
, vol.368
, pp. 1509-1518
-
-
Grupp, S.A.1
Kalos, M.2
Barrett, D.3
-
59
-
-
79952187823
-
T cells targeting carcinoembryonic antigen can mediate regression of metastatic colorectal cancer but induce severe transient colitis
-
Parkhurst MR, Yang JC, Langan RC, et al. T cells targeting carcinoembryonic antigen can mediate regression of metastatic colorectal cancer but induce severe transient colitis. Mol Ther 2011;19:620-6.
-
(2011)
Mol Ther
, vol.19
, pp. 620-626
-
-
Parkhurst, M.R.1
Yang, J.C.2
Langan, R.C.3
-
60
-
-
77950475517
-
Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2
-
Morgan RA, Yang JC, Kitano M, et al. Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2. Mol Ther 2010;18:843-51.
-
(2010)
Mol Ther
, vol.18
, pp. 843-851
-
-
Morgan, R.A.1
Yang, J.C.2
Kitano, M.3
-
61
-
-
84939566085
-
Phase I/II study of adjuvant immunotherapy with sentinel lymph node T lymphocytes in patients with colorectal cancer
-
Zhen YH, Liu XH, Yang Y, et al. Phase I/II study of adjuvant immunotherapy with sentinel lymph node T lymphocytes in patients with colorectal cancer. Cancer Immunol Immunother 2015;64:1083-93.
-
(2015)
Cancer Immunol Immunother
, vol.64
, pp. 1083-1093
-
-
Zhen, Y.H.1
Liu, X.H.2
Yang, Y.3
-
62
-
-
84894569887
-
Management of locally advanced and metastatic colon cancer in elderly patients
-
Kurniali PC, Hrinczenko B, Al-Janadi A. Management of locally advanced and metastatic colon cancer in elderly patients. World J Gastroenterol 2014;20:1910-22.
-
(2014)
World J Gastroenterol
, vol.20
, pp. 1910-1922
-
-
Kurniali, P.C.1
Hrinczenko, B.2
Al-Janadi, A.3
-
63
-
-
63849088630
-
Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer
-
Van Cutsem E, Köhne CH, Hitre E, et al. Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N Engl J Med 2009;360:1408-17.
-
(2009)
N Engl J Med
, vol.360
, pp. 1408-1417
-
-
Van Cutsem, E.1
Köhne, C.H.2
Hitre, E.3
-
64
-
-
34548289390
-
FDA drug approval summary: panitumumab (Vectibix)
-
Giusti RM, Shastri KA, Cohen MH, et al. FDA drug approval summary: panitumumab (Vectibix). Oncologist 2007;12:577-83.
-
(2007)
Oncologist
, vol.12
, pp. 577-583
-
-
Giusti, R.M.1
Shastri, K.A.2
Cohen, M.H.3
-
65
-
-
34147190880
-
FDA drug approval summary: bevacizumab plus FOLFOX4 as second-line treatment of colorectal cancer
-
Cohen MH, Gootenberg J, Keegan P, et al. FDA drug approval summary: bevacizumab plus FOLFOX4 as second-line treatment of colorectal cancer. Oncologist 2007;12:356-61.
-
(2007)
Oncologist
, vol.12
, pp. 356-361
-
-
Cohen, M.H.1
Gootenberg, J.2
Keegan, P.3
-
66
-
-
84863011440
-
Aflibercept in the treatment of metastatic colorectal cancer
-
Wang TF, Lockhart AC. Aflibercept in the treatment of metastatic colorectal cancer. Clin Med Insights Oncol 2012;6:19-30.
-
(2012)
Clin Med Insights Oncol
, vol.6
, pp. 19-30
-
-
Wang, T.F.1
Lockhart, A.C.2
-
67
-
-
84872921660
-
Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial
-
Grothey A, Van Cutsem E, Sobrero A, et al. Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial. Lancet 2013;381:303-12.
-
(2013)
Lancet
, vol.381
, pp. 303-312
-
-
Grothey, A.1
Van Cutsem, E.2
Sobrero, A.3
-
68
-
-
79953151458
-
Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion
-
Schreiber RD, Old LJ, Smyth MJ. Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion. Science 2011;331:1565-70.
-
(2011)
Science
, vol.331
, pp. 1565-1570
-
-
Schreiber, R.D.1
Old, L.J.2
Smyth, M.J.3
-
69
-
-
84884561907
-
Molecular pathways: coexpression of immune checkpoint molecules: signaling pathways and implications for cancer immunotherapy
-
Nirschl CJ, Drake CG. Molecular pathways: coexpression of immune checkpoint molecules: signaling pathways and implications for cancer immunotherapy. Clin Cancer Res 2013;19:4917-24.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 4917-4924
-
-
Nirschl, C.J.1
Drake, C.G.2
-
70
-
-
77955292303
-
Phase II study of the anti-cytotoxic T-lymphocyte-associated antigen 4 monoclonal antibody, tremelimumab, in patients with refractory metastatic colorectal cancer
-
Chung KY, Gore I, Fong L, et al. Phase II study of the anti-cytotoxic T-lymphocyte-associated antigen 4 monoclonal antibody, tremelimumab, in patients with refractory metastatic colorectal cancer. J Clin Oncol 2010;28:3485-90.
-
(2010)
J Clin Oncol
, vol.28
, pp. 3485-3490
-
-
Chung, K.Y.1
Gore, I.2
Fong, L.3
-
71
-
-
84934343141
-
Clinical Development of Immune Checkpoint Inhibitors
-
Ito A, Kondo S, Tada K, et al. Clinical Development of Immune Checkpoint Inhibitors. Biomed Res Int 2015;2015:605478.
-
(2015)
Biomed Res Int
, vol.2015
-
-
Ito, A.1
Kondo, S.2
Tada, K.3
-
72
-
-
84862903106
-
Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
-
Brahmer JR, Tykodi SS, Chow LQ, et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med 2012;366:2455-65.
-
(2012)
N Engl J Med
, vol.366
, pp. 2455-2465
-
-
Brahmer, J.R.1
Tykodi, S.S.2
Chow, L.Q.3
-
73
-
-
84920956735
-
Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients
-
Herbst RS, Soria JC, Kowanetz M, et al. Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients. Nature 2014;515:563-7.
-
(2014)
Nature
, vol.515
, pp. 563-567
-
-
Herbst, R.S.1
Soria, J.C.2
Kowanetz, M.3
-
74
-
-
84879759020
-
Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma
-
Hamid O, Robert C, Daud A, et al. Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma. N Engl J Med 2013;369:134-44.
-
(2013)
N Engl J Med
, vol.369
, pp. 134-144
-
-
Hamid, O.1
Robert, C.2
Daud, A.3
-
75
-
-
84923078390
-
MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer
-
Powles T, Eder JP, Fine GD, et al. MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer. Nature 2014;515:558-62.
-
(2014)
Nature
, vol.515
, pp. 558-562
-
-
Powles, T.1
Eder, J.P.2
Fine, G.D.3
-
76
-
-
84862859820
-
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
-
Topalian SL, Hodi FS, Brahmer JR, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med 2012;366:2443-54.
-
(2012)
N Engl J Med
, vol.366
, pp. 2443-2454
-
-
Topalian, S.L.1
Hodi, F.S.2
Brahmer, J.R.3
-
77
-
-
84898973055
-
Survival, Durable Tumor Remission, and Long-Term Safety in Patients With Advanced Melanoma Receiving Nivolumab
-
Topalian SL, Sznol M, McDermott DF, et al. Survival, Durable Tumor Remission, and Long-Term Safety in Patients With Advanced Melanoma Receiving Nivolumab. J Clin Oncol 2014;32:1020-30.
-
(2014)
J Clin Oncol
, vol.32
, pp. 1020-1030
-
-
Topalian, S.L.1
Sznol, M.2
McDermott, D.F.3
-
78
-
-
84932628341
-
PD-1 Blockade in Tumors with Mismatch-Repair Deficiency
-
Le DT, Uram JN, Wang H, et al. PD-1 Blockade in Tumors with Mismatch-Repair Deficiency. N Engl J Med 2015;372:2509-20.
-
(2015)
N Engl J Med
, vol.372
, pp. 2509-2520
-
-
Le, D.T.1
Uram, J.N.2
Wang, H.3
-
79
-
-
84879777241
-
Nivolumab plus ipilimumab in advanced melanoma
-
Wolchok JD, Kluger H, Callahan MK, et al. Nivolumab plus ipilimumab in advanced melanoma. N Engl J Med 2013;369:122-33.
-
(2013)
N Engl J Med
, vol.369
, pp. 122-133
-
-
Wolchok, J.D.1
Kluger, H.2
Callahan, M.K.3
-
80
-
-
84925379870
-
Identification and management of toxicities from immune checkpoint-blocking drugs
-
Teply BA, Lipson EJ. Identification and management of toxicities from immune checkpoint-blocking drugs. Oncology (Williston Park) 2014;28:30-8.
-
(2014)
Oncology (Williston Park)
, vol.28
, pp. 30-38
-
-
Teply, B.A.1
Lipson, E.J.2
-
81
-
-
84964313298
-
Bevacizumab plus ipilimumab in patients with metastatic melanoma
-
Hodi FS, Lawrence D, Lezcano C, et al. Bevacizumab plus ipilimumab in patients with metastatic melanoma. Cancer Immunol Res 2014;2:632-42.
-
(2014)
Cancer Immunol Res
, vol.2
, pp. 632-642
-
-
Hodi, F.S.1
Lawrence, D.2
Lezcano, C.3
|