Fecal microbiota transplantation: Expanding horizons for Clostridium difficile infections and beyond

Antibiotics

Volumn 4, Issue 3, 2015, Pages 254-266

  Borody, Thomas J ^a   Peattie, Debra ^b   Mitchell, Scott W ^a  

^a Centre for Digestive Diseases   (Australia)

^b Pleiades Advisors   (United States)

Author keywords

Clostridium difficile; Colitis; Crohn s; Fecal microbiota transplantation; IBD; Inflammatory bowel disease; Irritable bowel

Indexed keywords

CLINICAL PRACTICE; CLOSTRIDIUM DIFFICILE INFECTION; CROHN DISEASE; EXPERIMENTAL TRANSPLANTATION; FECES MICROFLORA; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INFLAMMATORY BOWEL DISEASE; IRRITABLE COLON; MICROBIOTA TRANSPLANTATION; NONHUMAN; PRIORITY JOURNAL; REVIEW;

CLOSTRIDIUM DIFFICILE;

EID: 85006214960     PISSN: None     EISSN: 20796382     Source Type: Journal    
DOI: 10.3390/antibiotics4030254     Document Type: Review

References (48)

1. Van Nood, E.; Vrieze, A.; Nieuwdorp, M.; Fuentes, S.; Zoetendal, E.G.; de Vos, W.M.; Visser, C.E.; Kuijper, E.J.; Bartelsman, J.F.; Tijssen, J.G.; et al. Duodenal infusion of donor feces for recurrent Clostridium difficile. N. Engl. J. Med. 2013, 368, 407-415.
2. Eiseman, B.; Silen, W.; Bascom, G.S.; Kauvar, A.J. Fecal enema as an adjunct in the treatment of pseudomembranous enterocolitis. Surgery 1958, 44, 854-859.
3. Collins, D.C. Pseudomembranous enterocolitis. Further observations on the value of donor fecal enemata as an adjunct in the treatment of pseudomembranous enterocolitis. Am. J. Proctol. 1960, 2, 389-391.
4. Cutolo, L.C.; Kleppel, N.H.; Freund, H.R.; Holker, J. Fecal feedings as a therapy in Staphylococcus enterocolitis. NY State J. Med. 1959, 59, 3831-3833.
5. Fenton, S.; Stephenson, D.; Weder, C. Pseudomembranous colitis associated with antibiotic therapy-An emerging entity. Can. Med. Assoc. J. 1974, 111, 1110-1111, 1114.
6. Bowden, T.A., Jr.; Mansberger, A.R., Jr.; Lykins, L.E. Pseudomembraneous enterocolitis: Mechanism for restoring floral homeostasis. Am. Surg. 1981, 47, 178-183.
7. Schwan, A.; Sjolin, S.; Trottestam, U.; Aronsson, B. Relapsing Clostridium difficile enterocolitis cured by rectal infusion of homologous faeces. Lancet 1983, 2, 845.
8. Froberg, M.K.; Palavecino, E.; Dykoski, R.; Gerding, D.N.; Peterson, L.R.; Johnson, S. Staphylococcus aureus and Clostridium difficile cause distinct pseudomembranous intestinal diseases. Clin. Infect. Dis. 2004, 39, 747-750.
9. Bakken, J.S.; Borody, T.; Brandt, L.J.; Brill, J.V.; Demarco, D.C.; Franzos, M.A.; Kelly, C.; Khoruts, A.; Louie, T.; Martinelli, L.P.; et al. Treating Clostridium difficile infection with fecal microbiota transplantation. Clin. Gastroenterol Hepatol. 2011, 9, 1044-1049.
10. Alang, N.; Kelly, C.R. Weight gain after fecal microbiota transplantation. Open Forum Infect. Dis. 2015, doi:10.1093/ofid/ofv004.
11. Gough, E.; Shaikh, H.; Manges, A.R. Systematic review of intestinal microbiota transplantation (fecal bacteriotherapy) for recurrent Clostridium difficile infection. Clin. Infect. Dis. 2011, 53, 994-1002.
12. Borody, T.; Leis, S.; Pang, G.; Wettstein, A. Fecal microbiota transplantation in the treatment of recurrent Clostridium difficile infection. Available online: http://www.uptodate.com/contents/fecal-microbiota-transplantation-in-the-treatment-of-recurrent-clostridium-difficile-infection (accessed on 26 April 2015).
13. Landy, J.; Al-Hassi, H.O.; McLaughlin, S.D.; Walker, A.W.; Ciclitira, P.J.; Nicholls, R.J.; Clark, S.K.; Hart, A.L. Review article: Faecal transplantation therapy for gastrointestinal disease. Aliment. Pharmacol. Ther. 2011, 34, 409-415.
14. Brandt, L.J. American journal of gastroenterology lecture: Intestinal microbiota and the role of fecal microbiota transplant (FMT) in treatment of C. difficile infection. Am. J. Gastroenterol. 2013, 108, 177-185.
15. Dutta, S.K.; Girotra, M.; Garg, S.; Dutta, A.; von Rosenvinge, E.C.; Maddox, C.; Song, Y.; Bartlett, J.G.; Vinayek, R.; Fricke, W.F. Efficacy of combined jejunal and colonic fecal microbiota transplantation for recurrent Clostridium difficile infection. Clin. Gastroenterol. Hepatol. 2014, 12, 1572-1576.
16. Brandt, L.J.; Aroniadis, O.C.; Mellow, M.; Kanatzar, A.; Kelly, C.; Park, T.; Stollman, N.; Rohlke, F.; Surawicz, C. Long-term follow-up of colonoscopic fecal microbiota transplant for recurrent Clostridium difficile infection. Am. J. Gastroenterol. 2012, 107, 1079-1087.
17. Blumberg, R.; Powrie, F. Microbiota, disease, and back to health: A metastable journey. Sci. Transl. Med. 2012, 4, doi:10.1126/scitranslmed.3004184.
18. Borody, T.J.; Peattie, D.; Kapur, A. Could fecal microbiota transplantation cure all Clostridium difficile infections? Future Microbiol. 2014, 9, 1-3.
19. Longstreth, W.T., Jr.; Meschke, J.S.; Davidson, S.K.; Smoot, L.M.; Smoot, J.C.; Koepsell, T.D. Hypothesis: A motor neuron toxin produced by a clostridial species residing in gut causes ALS. Med. Hypotheses 2005, 64, 1153-1156.
20. Scher, J.U.; Sczesnak, A.; Longman, R.S.; Segata, N.; Ubeda, C.; Bielski, C.; Rostron, T.; Cerundolo, V.; Pamer, E.G.; Abramson, S.B.; et al. Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis. Elife 2013, 2, e01202.
21. Hsiao, E.Y.; McBride, S.W.; Hsien, S.; Sharon, G.; Hyde, E.R.; McCue, T.; Codelli, J.A.; Chow, J.; Reisman, S.E.; Petrosino, J.F.; et al. Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell 2013, 155, 1451-1463.
22. Grehan, M.J.; Borody, T.J.; Leis, S.M.; Campbell, J.; Mitchell, H.; Wettstein, A. Durable alteration of the colonic microbiota by the administration of donor fecal flora. J. Clin. Gastroenterol. 2010, 44, 551-561.
23. Khanna, S.; Pardi, D.S.; Kelly, C.; Pindar, C.; Kammer, D.; McKenney, J.; Vuliv, M.; Lombardo, M.; Henn, M.; Aunins, J.; et al. Clinical evaluation of ser-109, a rationally designed, oral microbiome-based therapeutic for the treatment of recurrent Clostridium difficile. Available online: http://www.gastro.org/pressroom/James_W._Freston_Abstract_Orally_Delivered_Microbes.pdf (accessed on 26 April 2015).
24. Kelly, C.R.; Kunde, S.S.; Khoruts, A. Guidance on preparing an investigational new drug application for fecal microbiota transplantation studies. Clin. Gastroenterol. Hepatol. 2014, 12, 283-288.
25. Pepin, J.; Alary, M.E.; Valiquette, L.; Raiche, E.; Ruel, J.; Fulop, K.; Godin, D.; Bourassa, C. Increasing risk of relapse after treatment of Clostridium difficile colitis in Quebec, Canada. Clin. Infect. Dis. 2005, 40, 1591-1597.
26. Lessa, F.C.; Mu, Y.; Bamberg, W.M.; Beldavs, Z.G.; Dumyati, G.K.; Dunn, J.R.; Farley, M.M.; Holzbauer, S.M.; Meek, J.I.; Phipps, E.C.; et al. Burden of Clostridium difficile infection in the United States. N. Engl. J. Med. 2015, 372, 825-834.
27. Agrawal, M.; Aroniadis, O.C.; Brandt, L.J.; Kelly, C.; Freeman, S.; Surawicz, C.; Broussard, E.; Stollman, N.; Giovanelli, A.; Smith, B.A. A long-term follow-up study of the efficacy and safety of fecal microbiota transplant (FMT) for recurrent/severe/complicated C. difficile infection (CDI) in the elderly. Gastroenterology 2014, 146, doi:10.1016/S0016-5085(14)60147-5.
28. Aroniadis, O.C.; Brandt, L.J.; Greenberg, A.; Borody, T.J.; Kelly, C.; Mellow, M.; Surawicz, C.; Cagle, L.A.; Neshatian, L. Long-term follow-up study of fecal microbiota transplantation (FMT) for severe or complicated Clostridium difficile infection (CDI). Gastroenterology 2013, 144, S185.
29. Kelly, C.R.; Ihunnah, C.; Fischer, M.; Khoruts, A.; Surawicz, C.; Afzali, A.; Aroniadis, O.; Barto, A.; Borody, T.; Giovanelli, A.; et al. Fecal microbiota transplant for treatment of Clostridium difficile infection in immunocompromised patients. Am. J. Gastroenterol. 2014, 109, 1065-1071.
30. Brandt, L.; Aroniadis, O.; Greenberg, A.; Borody, T.; Finlayson, S.; Furnari, V.; Kelly, C. Safety of fecal microbiota transplantation (FMT) in immunocompromised (IC) patients with inflammatory bowel disease (IBD). Am. J. Gastroenterol. 2013, 108, S556-S556.
31. Miao, C.L.; Mowery, A.D.; Khara, H.S.; Shellenberger, M.J.; Komar, M. C. Difficile small bowel enteritis after total proctocolectomy successfully treated with fecal transplant. Presented at the American College of Gastroenterologists, Philadelphia, PA, USA, 20 October 2014.
32. Borody, T.J.; Wettstein, A.R.; Leis, S.; Hills, L.A.; Campbell, J.; Torres, M. Clostridium difficile complicating inflammatory bowel disease: Pre-and post-treatment findings. Gastroenterology 2008, 134, A361.
33. Borody, T.; Wettstein, A.; Nowak, A. Fecal microbiota transplantation (FMT) eradicates Clostridium difficile infection (CDI) in inflammatory bowel disease (IBD). UEG J. 2013, 1, A57.
34. Singh, N.; Suskind, D.; Wahbeh, G. Fecal bacteriotherapy in a 6 year old patient with ulcerative colitis and Clostridium difficile: P-136 yi. Inflamm. Bowel. Dis. 2012, 18, S69.
35. Borody, T.J.; George, L.; Andrews, P.; Brandl, S.; Noonan, S.; Cole, P.; Hyland, L.; Morgan, A.; Maysey, J.; Moore-Jones, D. Bowel-flora alteration: A potential cure for inflammatory bowel disease and irritable bowel syndrome? Med. J. Aust. 1989, 150, 604.
36. Borody, T.J.; Campbell, J. Fecal microbiota transplantation: Techniques, applications, and issues. Gastroenterol. Clin. North Am. 2012, 41, 781-803.
37. Borody, T.; Wettstein, A.; Campbell, J.; Leis, S.; Torres, M.; Finlayson, S.; Nowak, A. Fecal microbiota transplantation in ulcerative colitis: Review of 24 years experience. Am. J. Gastroenterol. 2012, 107, S665-S665.
38. Moayyedi, P.; Surette, M.G.; Kim, P.T.; Libertucci, J.; Wolfe, M.; Onischi, C.; Armstrong, D.; Marshall, J.K.; Kassam, Z.; Reinisch, W.; et al. Fecal microbiota transplantation induces remission in patients with active ulcerative colitis in a randomized controlled trial. Gastroenterology 2015, 149, 102-106.
39. Rossen, N.G.; Fuentes, S.; van der Spek, M.J.; Tijssen, J.; Hartman, J.H.; Duflou, A.; Lowenberg, M.; van den Brink, G.R.; Mathus-Vliegen, E.M.; de Vos, W.M.; et al. Findings from a randomized controlled trial of fecal transplantation for patients with ulcerative colitis. Gastroenterology 2015, 149, 110-118.
40. Zhang, F.M.; Wang, H.G.; Wang, M.; Cui, B.T.; Fan, Z.N.; Ji, G.Z. Fecal microbiota transplantation for severe enterocolonic fistulizing crohn's disease. World J. Gastroenterol. 2013, 19, 7213-7216.
41. Kostic, A.D.; Xavier, R.J.; Gevers, D. The microbiome in inflammatory bowel disease: Current status and the future ahead. Gastroenterology 2014, 146, 1489-1499.
42. Kump, P.; Gröchenig, H.; Spindelböck, W.; Hoffmann, C.; Gorkiewicz, G.; Wenzl, H. Preliminary clinical results of repeatedly fecal microbiota transplantation (FMT) in chronic active ulcerative colitis. United European Gastroenterol. J. 2013, 1, A57.
43. Kump, P.K.; Grochenig, H.P.; Lackner, S.; Trajanoski, S.; Reicht, G.; Hoffmann, K.M.; Deutschmann, A.; Wenzl, H.H.; Petritsch, W.; Krejs, G.J.; et al. Alteration of intestinal dysbiosis by fecal microbiota transplantation does not induce remission in patients with chronic active ulcerative colitis. Inflamm. Bowel. Dis. 2013, 19, 2155-2165.
44. Singh, R.; van Nood, E.; Nieuwdorp, M.; van Dam, B.; ten Berge, I.J.; Geerlings, S.E.; Bemelman, F.J. Donor feces infusion for eradication of extended spectrum beta-lactamase producing Escherichia coli in a patient with end stage renal disease. Clin. Microbiol. Infect. 2014, 20, O977-O978.
45. Freedman, A. Use of Stool Transplant to Clear Fecal Colonization with Carbapenem-Resistant Enterobacteraciae (cre): Proof of Concept; Infectious Diseases Society of America: Philadelphia, PA, USA, 2014.
46. Hamilton, M.J.; Weingarden, A.R.; Sadowsky, M.J.; Khoruts, A. Standardized frozen preparation for transplantation of fecal microbiota for recurrent Clostridium difficile infection. Am. J. Gastroenterol. 2012, 107, 761-767.
47. Youngster, I.; Russell, G.H.; Pindar, C.; Ziv-Baran, T.; Sauk, J.; Hohmann, E.L. Oral, capsulized, frozen fecal microbiota transplantation for relapsing Clostridium difficile infection. JAMA 2014, 312, 1772-1778.
48. Smits, L.P.; Bouter, K.E.; de Vos, W.M.; Borody, T.J.; Nieuwdorp, M. Therapeutic potential of fecal microbiota transplantation. Gastroenterology 2013, 145, 946-953.