Could fecal microbiota transplantation cure all Clostridium difficile infections?

Future Microbiology

Volumn 9, Issue 1, 2014, Pages 1-3

  Borody, Thomas J ^a   Peattie, Debra ^b   Kapur, Amit ^c  

^a Centre for Digestive Diseases   (Australia)

^b Pleiades Advisors   (United States)

^c PRINCE OF WALES HOSPITAL   (Australia)

Author keywords

Clostridium difficile; fecal microbiota; microbiome; microbiota; transplantation

Indexed keywords

FIDAXOMICIN; METRONIDAZOLE; VANCOMYCIN;

ABDOMINAL DISCOMFORT; ABDOMINAL PAIN; ANAL COMPLAINT; ANTIBIOTIC THERAPY; BLOATING; BORBORYGMI; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM DIFFICILE INFECTION; CONSTIPATION; CROHN DISEASE; DIARRHEA; FECAL MICROBIOTA TRANSPLANTATION; FECES MICROFLORA; FOOD AND DRUG ADMINISTRATION; HOSPITALIZATION; HUMAN; IDIOPATHIC THROMBOCYTOPENIC PURPURA; IMMUNOCOMPROMISED PATIENT; IMMUNOSUPPRESSIVE TREATMENT; IN VIVO STUDY; INTESTINE FLORA; INTESTINE FUNCTION; INTESTINE SOUND; IRRITABLE COLON; LEUKOCYTOSIS; MEDICAL PRACTICE; PATIENT SAFETY; PERIPHERAL NEUROPATHY; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; PSEUDOMEMBRANOUS COLITIS; REVIEW; RHEUMATOID ARTHRITIS; SJOEGREN SYNDROME; TRANSPLANTATION; WEIGHT REDUCTION;

BIOLOGICAL THERAPY; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM INFECTIONS; FECES; TREATMENT OUTCOME;

EID: 84890589967     PISSN: 17460913     EISSN: 17460921     Source Type: Journal    
DOI: 10.2217/fmb.13.146     Document Type: Review

References (18)

1. Zhang F, Luo W, Shi Y et al. Should we standardize the 1,700 year old fecal microbiota transplantation?. Am. J. Gastroenterol. 107(11), 1755-1756 (2012).
2. Eiseman B, Silen W, Bascom GS et al. Fecal enema as an adjunct in the treatment of pseudomembranous enterocolitis. Surgery 44(5), 854-859 (1958).
3. Bowden TA, Mansberger AR, Lykins LE. Pseudomembranous enterocolitis: Mechanism of restoring floral homeostasis. Am. Surg. 47, 178-183 (1981).
4. Schwan A, Sjoln S, Trottestam U et al. Relapsing Clostridium difficile enterocolitis cured by rectal infusion of normal faeces. Scand. J. Infect. Dis. 16, 211-215 (1984).
5. Borody TJ, George L, Andrews P et al. Bowel-flora alteration: A potential cure for inflammatory bowel disease and irritable bowel syndrome?. Med. J. Aust. 150, 604 (1989).
6. McDonald LC, Owings M, Jernigan DB. Clostridium difficile infection in patients discharged from US short-stay hospitals. Emerg. Infect. Dis. 12, 409-415 (2006).
7. Dupont HL. Diagnosis and management of Clostridium difficile infection. Clin. Gastroenterol. Hepatol. 11, 1216-1223 (2013).
8. Borody TJ, Khoruts A. Fecal microbiota transplantation and emerging applications. Nat. Rev. Gastroenterol. Hepatol. 9, 88-96 (2011).
9. van Nood E, Vrieze A, Nieuwdorp M et al. Duodenal infusion of donor feces for recurrent Clostridium difficile. N. Engl. J. Med. 368(5), 407-415 (2013).
10. Surawicz CM, Brandt LJ, Binion DG et al. Guidelines for diagnosis, treatment and prevention of Clostridium difficile infections.Am. J. Gastroenterol. 108, 478-498 (2013).
11. Brandt LJ, Aroniadis OC. An overview of fecal microbiota transplantation: Techniques, indications, and outcomes. Gastrointest. Endosc. 78(2), 240-249 (2013).
12. You DM, Franzos MA, Holman RP.Successful treatment of fulminant Clostridium difficile infection with fecal bacteriotherapy.Ann. Intern. Med. 148(8), 632-633 (2008).
13. Borody TJ, Wettstein A, Nowak A et al. Fecal microbiota transplantation eradicates Clostridium difficile infection in inflammatory bowel disease. Presented at: 21st United European Gastroenterology Week. Berlin, Germany, 12-16 October 2013.
14. Brandt L, Aroniadis O, Greenberg A et al. Safety of fecal microbiota transplantation (FMT) in immunocompromised (IC) patients with inflammatory bowel disease (IBD). Am. J. Gastroenterol. 108(Suppl. 1), S556 (2013).
15. Schwartz M, Gluck M, Koon S. Norovirus gastroenteritis after fecal microbiota transplantation for treatment of Clostridium difficile infection despite asymptomatic donors and lack of sick contacts. Am. J. Gastroenterol. 108, 1367 (2013).
16. De Leon LM, Watson JB, Kelly CR. Transient flare of ulcerative colitis after fecal microbiota transplantation for recurrent Clostridium difficile infection. Clin. Gastroenterol. Hepatol. 11, 1036-1038 (2013).
17. Brandt LJ, Aroniadis O, Mellow M et al. Long-Term follow-up of colonoscopic fecal microbiota transplant for recurrent Clostridium difficile infection. Am. J. Gastroenterol. 107, 1079-1087 (2012).
18. Borody TJ, Peattie D, Campbell J. Therapeutic potential of the human gastrointestinal microbiome. Drug Dev. Res. 74(6), 385-392 (2013).