High-dose chloroquine is metabolically cardiotoxic by inducing lysosomes and mitochondria dysfunction in a rat model of pressure overload hypertrophy

Physiological Reports

Volumn 3, Issue 7, 2015, Pages

  Chaanine, Antoine H ^a   Gordon, Ronald E ^a   Nonnenmacher, Mathieu ^a   Kohlbrenner, Erik ^a   Benard, Ludovic ^a   Hajjar, Roger J ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Autophagy; Chloroquine and 3 methyladenine; Heart failure; Pathological hypertrophy

Indexed keywords

3 METHYLADENINE; ANTIOXIDANT; CARDIOTOXIN; CHLOROQUINE; MANGANESE SUPEROXIDE DISMUTASE; REACTIVE OXYGEN METABOLITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOPHAGOSOME; CARDIOTOXICITY; CELL ULTRASTRUCTURE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG MECHANISM; DRUG MEGADOSE; GENE EXPRESSION REGULATION; HEART HEMODYNAMICS; HEART RIGHT VENTRICLE ENDSYSTOLIC VOLUME; HEART VENTRICLE HYPERTROPHY; HEART VENTRICLE PRESSURE; HUMAN; HUMAN CELL; LYSOSOME; MUSCLE CONTRACTILITY; NONHUMAN; OXIDATIVE STRESS; POLYACRYLAMIDE GEL ELECTROPHORESIS; RAT; TRANSMISSION ELECTRON MICROSCOPY; TRANSTHORACIC ECHOCARDIOGRAPHY; WESTERN BLOTTING;

EID: 85006129703     PISSN: None     EISSN: 2051817X     Source Type: Journal    
DOI: 10.14814/phy2.12413     Document Type: Article

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