Chloroquine cardiotoxicity: Clinicopathologic features in three patients and comparison with three patients with Fabry disease

Cardiovascular Pathology

Volumn 11, Issue 5, 2002, Pages 277-283

  Roos, James M ^a   Aubry, Marie Christine ^b   Edwards, William D ^b  

^a MAYO CLINIC COLLEGE OF MEDICINE   (United States)

^b MAYO CLINIC   (United States)

Author keywords

Cardiac ultrastructure; Chloroquine cardiotoxicity; Fabry disease; Transmission electron microscopy

Indexed keywords

CHLOROQUINE;

ADULT; AGED; ARTICLE; AUTOPSY; CARDIOTOXICITY; CASE REPORT; CELL SIZE; CELL ULTRASTRUCTURE; CELL VACUOLE; CLINICAL FEATURE; COMPARATIVE STUDY; CONTROLLED STUDY; DIFFERENTIAL DIAGNOSIS; DYSPNEA; ELECTRON MICROSCOPY; FABRY DISEASE; FAMILY HISTORY; FEMALE; HEART DISEASE; HEART MUSCLE BIOPSY; HEMANGIOKERATOMA; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MALE; MEDICAL RECORD; MICROSCOPY; MUSCLE CELL; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SYMPTOM; SYSTEMIC LUPUS ERYTHEMATOSUS; TRANSMISSION ELECTRON MICROSCOPY;

AGED; ANTIMALARIALS; CARDIOMYOPATHIES; CHLOROQUINE; FABRY DISEASE; FEMALE; HEART; HUMANS; INCLUSION BODIES; MALE; MIDDLE AGED; MYELIN SHEATH; MYOCARDIUM; MYOCYTES, CARDIAC; RETROSPECTIVE STUDIES;

EID: 0036754329     PISSN: 10548807     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1054-8807(02)00118-7     Document Type: Article

References (48)

1. Fox R. Anti-malarial drugs: possible mechanisms of action in autoimmune disease and prospects for drug development. Lupus. 5(Suppl. 1):1996;S4-S10.
2. Estes M.L., Ewing-Wilson D., Chou S.M., Mitsumoto H., Hanson M., Shirey E., Ratliff N.B. Chloroquine neuromyotoxicity. Clinical and pathologic perspective. Am J Med. 82:1987;447-455.
3. Hughes J.T., Esiri M., Oxbury J.M., Whitty C.W. Chloroquine myopathy. Q J Med. 40:1971;85-93.
4. Jones S.K. Ocular toxicity and hydroxychloroquine: guidelines for screening. Br J Dermatol. 140:1999;3-7.
5. Nucci A., Queiroz L.S., Samara A.M. Chloroquine neuromyopathy. Clin Neuropathol. 15:1996;256-258.
6. Wasay M., Wolfe G.I., Herrold J.M., Burns D.K., Barohn R.J. Chloroquine myopathy and neuropathy with elevated CSF protein. Neurology. 51:1998;1226-1227.
7. August C., Holzhausen H.J., Schmoldt A., Pompecki R., Schroder S. Histological and ultrastructural findings in chloroquine-induced cardiomyopathy. J Mol Med. 73:1995;73-77.
8. Baguet J.P., Tremel F., Fabre M. Chloroquine cardiomyopathy with conduction disorders. Heart. 81:1999;221-223.
9. Ferrans V.J., Hall R.J., McAllister H.A. Images in cardiovascular medicine. Chloroquine-induced cardiomyopathy. Circulation. 88:1993;785-786.
10. Iglesias Cubero G., Rodriguez Reguero J.J., Rojo Ortega J.M. Restrictive cardiomyopathy caused by chloroquine. Br Heart J. 69:1993;451-452.
11. Magnussen I., de Fine Olivarius B. Cardiomyopathy after chloroquine treatment. Acta Med Scand. 202:1977;429-431.
12. McAllister H.A., Ferrans V.J., Hall R.J., Strickman N.E., Bossart M.I. Chloroquine-induced cardiomyopathy. Arch Pathol Lab Med. 111:1987;953-956.
13. Ratliff N.B., Estes M.L., Myles J.L., Shirey E.K., McMahon J.T. Diagnosis of chloroquine cardiomyopathy by endomyocardial biopsy. N Engl J Med. 316:1987;191-193.
14. Reuss-Borst M., Berner B., Wulf G., Muller G.A. Complete heart block as a rare complication of treatment with chloroquine. J Rheumatol. 26:1999;1394-1395.
15. Veinot J.P., Mai K.T., Zarychanski R. Chloroquine related cardiac toxicity. J Rheumatol. 25:1998;1221-1225.
16. Ratliff N.B., Estes M.L., McMahon J.T., Myles J.L. Chloroquine-induced cardiomyopathy. Arch Pathol Lab Med. 112:1988;578.
17. Don Michael T.A., Aiwazzadeh S. The effects of acute chloroquine poisoning with special reference to the heart. Am Heart J. 79:1970;831-842.
18. Hruban Z., Slesers A., Hopkins E. Drug-induced and naturally occurring myeloid bodies. Lab Invest. 27:1972;62-70.
19. Broadbent J.C., Edwards W.D., Gordon H., Hartzler G.O., Krawisz J.E. Fabry cardiomyopathy in the female confirmed by endomyocardial biopsy. Mayo Clin Proc. 56:1981;623-628.
20. Cantor W.J., Butany J., Iwanochko M., Liu P. Restrictive cardiomyopathy secondary to Fabry's disease. Circulation. 98:1998;1457-1459.
21. Carter N., Milroy C.M., Shepherd R.T. Sudden death in elderly women with Fabry's disease. Am J Forensic Med Pathol. 16:1995;21-26.
22. Chimenti C., Ricci R., Pieroni M., Natale L., Russo M.A., Frustaci A. Cardiac variant of Fabry's disease mimicking hypertrophic cardiomyopathy. Cardiologia. 44:1999;469-473.
23. Colucci W.S., Lorell B.H., Schoen F.J., Warhol M.J., Grossman W. Hypertrophic obstructive cardiomyopathy due to Fabry's disease. N Engl J Med. 307:1982;926-928.
24. Elleder M., Bradova V., Smid F., Budesinsky M., Harzer K., Kustermann-Kuhn B., Ledvinova J., Belohlavek, Kral V., Dorazilova V. Cardiocyte storage and hypertrophy as a sole manifestation of Fabry's disease. Report on a case simulating hypertrophic non-obstructive cardiomyopathy. Virchows Arch, A Pathol Anat Histopathol. 417:1990;449-455.
25. Faraggiana T., Churg J., Grishman E., Strauss L., Prado A., Bishop D.F., Schuchman E., Desnick R.J. Light-and electron-microscopic histochemistry of Fabry's disease. Am J Pathol. 103:1981;247-262.
26. Ferrans V.J., Hibbs R.G., Burda C.D. The heart in Fabry's disease. A histochemical and electron microscopic study. Am J Cardiol. 24:1969;95-110.
27. Ko Y.H., Kim H.J., Roh Y.S., Park C.K., Kwon C.K., Park M.H. Atypical Fabry's disease. An oligosymptomatic variant. Arch Pathol Lab Med. 120:1996;86-89.
28. Linhart A., Palecek T., Bultas J., Ferguson J.J., Hrudova J., Karetova D., Zeman J., Ledvinova J., Poupetova H., Elleder M., Aschermann M. New insights in cardiac structural changes in patients with Fabry's disease. Am Heart J. 139:2000;1101-1108.
29. Maben P., Evans R., Lin J., Vaughan D. Endomyocardial biopsy. Diagnosis of Fabry's disease in congestive cardiomyopathy. J Kans Med Soc. 84:1983;556-557.
30. Nakao S., Takenaka T., Maeda M., Kodama C., Tanaka A., Tahara M., Yoshida A., Kuriyama M., Hayashibe H., Sakuraba H. An atypical variant of Fabry's disease in men with left ventricular hypertrophy. N Engl J Med. 333:1995;288-293.
31. Savi M., Olivetti G., Neri T.M., Curtoni C. Clinical, histopathological, and biochemical findings in Fabry's disease. A case report and family study. Arch Pathol Lab Med. 101:1977;536-539.
32. Uchino M., Uyama E., Kawano H., Hokamaki J., Kugiyama K., Murakami Y., Yasue H., Ando M. A histochemical and electron microscopic study of skeletal and cardiac muscle from a Fabry disease patient and carrier. Acta Neuropathol. 90:1995;334-338.
33. von Scheidt W., Eng C.M., Fitzmaurice T.F., Erdmann E., Hubner G., Olsen E.G., Christomanou H., Kandolf R., Bishop D.F., Desnick R.J. An atypical variant of Fabry's disease with manifestations confined to the myocardium. N Engl J Med. 324:1991;395-399.
34. Nagao Y., Nakashima H., Fukuhara Y., Shimmoto M., Oshima A., Ikari Y., Mori Y., Sakuraba H., Suzuki Y. Hypertrophic cardiomyopathy in late-onset variant of Fabry disease with high residual activity of alpha-galactosidase A. Clin Genet. 39:1991;233-237.
35. Yanagawa Y., Sakuraba H. Cardiovascular manifestations in Fabry's disease-age-related changes in hemizygotes and heterozygotes. Acta Paediatr Jpn. 30:1988;38-48.
36. Alizad A., Seward J.B. Echocardiographic features of genetic diseases: Part 2. Storage disease. J Am Soc Echocardiogr. 13:2000;164-170.
37. Brady R.O., Schiffmann R. Clinical features of and recent advances in therapy for Fabry disease. JAMA. 284:2000;2771-2775.
38. Cohen I.S., Fluri-Lundeen J., Wharton T.P. Two dimensional echocardiographic similarity of Fabry's disease to cardiac amyloidosis: a function of ultrastructural analogy? J Clin Ultrasound. 11:1983;437-441.
39. Goldman M.E., Cantor R., Schwartz M.F., Baker M., Desnick R.J. Echocardiographic abnormalities and disease severity in Fabry's disease. J Am Coll Cardiol. 7:1986;1157-1161.
40. Neville H.E., Maunder-Sewry C.A., McDougall J., Sewell J.R., Dubowitz V. Chloroquine-induced cytosomes with curvilinear profiles in muscle. Muscle Nerve. 2:1979;376-381.
41. Blieden L.C., Moller J.H. Cardiac involvement in inherited disorders of metabolism. Prog Cardiovasc Dis. 16:1974;615-631.
42. Koitabashi N., Utsugi T., Seki R., Okamoto E., Sando Y., Kaneko Y., Nagai R. Biopsy-proven cardiomyopathy in heterozygous Fabry's disease. Jpn Circ J. 63:1999;572-575.
43. Ridaura-Sanz C. The pathologist's approach to the diagnosis of metabolic disease. Pathol Res Pract. 190:1994;1109-1122.
44. Schatzki P.F., Kipreos B., Payne J. Fabry's disease. Primary diagnosis by electron microscopy. Am J Surg Pathol. 3:1979;211-219.
45. Rozenszajn L.A., Epstein Y., Fischer D. Myelin figures in blood cells, lysosomes, and lipidoses. Am J Clin Pathol. 52:1969;473-476.
46. Eng C.M., Guffon N., Wilcox W.R., Germain D.P., Lee P., Waldek S., Caplan L., Linthorst G.E., Desnick R.J. Safety and efficacy of recombinant human alpha-galactosidase A - replacement therapy in Fabry's disease. N Engl J Med. 345:2001;9-16.
47. Pastores G.M., Thadhani R. Enzyme-replacement therapy for Anderson-Fabry disease. Lancet. 358:2001;601-603.
48. Schiffmann R., Kopp J.B., Austin H.A., Sabnis S., Moore D.F., Weibel T., Balow J.E., Brady R.O. Enzyme replacement therapy in Fabry disease: a randomized controlled trial. JAMA. 285:2001;2743-2749.